DK2766093T3 - Anvendelse af semaphorin-4d-bindende molekyler til modulering af permeabiliteten af blod-hjerne-barrieren - Google Patents

Anvendelse af semaphorin-4d-bindende molekyler til modulering af permeabiliteten af blod-hjerne-barrieren Download PDF

Info

Publication number
DK2766093T3
DK2766093T3 DK12839601.7T DK12839601T DK2766093T3 DK 2766093 T3 DK2766093 T3 DK 2766093T3 DK 12839601 T DK12839601 T DK 12839601T DK 2766093 T3 DK2766093 T3 DK 2766093T3
Authority
DK
Denmark
Prior art keywords
antibody
sema4d
antigen
bbb
ser
Prior art date
Application number
DK12839601.7T
Other languages
English (en)
Inventor
Ernest S Smith
Maurice Zauderer
Original Assignee
Vaccinex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaccinex Inc filed Critical Vaccinex Inc
Application granted granted Critical
Publication of DK2766093T3 publication Critical patent/DK2766093T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (12)

1. Effektiv mængde af et isoleret antistof eller et antigenbindende fragment deraf, der binder specifikt til semaphorin-4D (SEMA4D), til anvendelse til behandling til reducering af permeabiliteten af blod-hjerne-barrieren (BBB) hos et individ med forøget BBB-permeabilitet og en neuroinflammatorisk forstyrrelse, hvor det isolerede antistof eller det antigenbindende fragment deraf specifikt hæmmer semaphorin 4D (SEMA4D)'s interaktion med SEMA4D-receptoren plexin Bl.
2. Antistof eller antigenbindende fragment deraf til anvendelse ifølge krav 1, hvor individet er et pattedyr.
3. Antistof eller antigenbindende fragment deraf til anvendelse ifølge krav 2, hvor pattedyret er et menneske.
4. Antistof eller antigenbindende fragment deraf til anvendelse ifølge et hvilket som helst af kravene 1 til 3, hvor antistoffet eller det antigenbindende fragment deraf hæmmer kompetitivt et reference-monoklonalt antistof, der omfatter 1) den variable tunge kæde (VH) med aminosyresekvensen ifølge SEQ ID NO: 9 og den variable lette kæde (VL) med aminosyresekvensen ifølge SEQ ID NO: 17 eller 2) VH-aminosyresekvensen ifølge SEQ ID NO: 10 og VL-aminosyresekvensen ifølge SEQ ID NO: 18.
5. Antistof eller antigenbindende fragment deraf til anvendelse ifølge et hvilket som helst af kravene 1 til 4, hvor antistoffet eller det antigenbindende fragment deraf binder specifikt til den samme SEMA4D-epitop som et reference-monoklonalt antistof, der omfatter 1) VH-aminosyresekvensen ifølge SEQ ID NO: 9 og VL-aminosyresekvensen ifølge SEQ ID NO: 17 eller 2) VH-aminosyresekvensen ifølge SEQ ID NO: 10 og VL-aminosyresekvensen ifølge SEQ ID NO: 18.
6. Antistof eller antigenbindende fragment deraf til anvendelse ifølge et hvilket som helst af kravene 1 til 5, hvor antistoffet eller det antigenbindende fragment deraf er humant eller humaniseret.
7. Antistof eller antigenbindende fragment deraf til anvendelse ifølge et hvilket som helst af kravene 1 til 6, hvor antistoffet eller det antigenbindende fragment deraf omfatter en VH, der omfatter VH-CDR'erne 1-3, der omfatter henholdsvis SEQ ID NO: 6, 7 og 8, og en VL, der omfatter VL-CDR'erne 1-3, der omfatter henholdsvis SEQ ID NO: 14, 15 og 16.
8. Antistof eller antigenbindende fragment deraf til anvendelse ifølge krav 7, hvor antistoffet eller det antigenbindende fragment deraf omfatter 1) VH-aminosyresekvensen ifølge SEQ ID NO: 9 og VL-aminosyresekvensen ifølge SEQ ID NO: 17 eller 2) VH-aminosyresekvensen ifølge SEQ ID NO: 10 og VL-aminosyresekvensen ifølge SEQ ID NO: 18.
9. Effektiv mængde af et isoleret antistof eller et antigenbindende fragment deraf, der binder specifikt til semaphorin-4D (SEMA4D), til anvendelse ifølge krav 1, og en effektiv mængde af et isoleret antistof eller et antigenbindende fragment deraf, der binder specifikt til plexin-Bl, til anvendelse til behandling af et indvid med forøget BBB-permeabilitet og en neuroinflammatorisk forstyrrelse, hvor SEMA4D- og plexin-Bl-antistofferne eller de antigenbindende fragmenter deraf kan reducere permeabilitetet af BBB.
10. Antistof eller antigenbindende fragment deraf til anvendelse ifølge et hvilket som helst af kravene 1 til 9, hvor den neuroinflammatoriske forstyrrelse er valgt fra gruppen, der består af multipel sklerose, amyotrofisk lateral sklerose, epilepsi, Alzheimers sygdom, Parkinsons sygdom, meningitis, hjerneødem og hjernetraume.
11. Antistof eller antigenbindende fragment deraf til anvendelse ifølge et hvilket som helst af kravene 1 til 10, hvor den effektive mængde af antistoffet eller det antigenbindende fragment deraf fremkalder en forøgelse af den specifikke modstand i BBB'en, en forøgelse af antallet, densiteten eller koncentrationen af endotelceller, der er til stede på BBB'en, en ændring i morfologien eller funktionen af endotelcellerne, en ændring i interaktioner mellem endotelceller eller astrocytter, en ændring i interaktioner mellem endotelceller og astrocytter, der danner BBB'en.
12. Antistof eller antigenbindende fragment deraf til anvendelse ifølge et hvilket som helst af kravene 1 til 11, hvor antistoffet eller det antigenbindende fragment deraf anvendes i kombination med en eller flere behandlinger mod neuroinflammatoriske forstyrrelser, hvor den yderligere terapi administreres før, under eller efter brugen af antistoffet eller det antigenbindende fragment deraf.
DK12839601.7T 2011-10-11 2012-10-11 Anvendelse af semaphorin-4d-bindende molekyler til modulering af permeabiliteten af blod-hjerne-barrieren DK2766093T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161545809P 2011-10-11 2011-10-11
US201161555726P 2011-11-04 2011-11-04
US201261593641P 2012-02-01 2012-02-01
PCT/US2012/059757 WO2013055922A1 (en) 2011-10-11 2012-10-11 Use of semaphorin-4d binding molecules for modulation of blood brain barrier permeability

Publications (1)

Publication Number Publication Date
DK2766093T3 true DK2766093T3 (da) 2018-06-06

Family

ID=48082436

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12839601.7T DK2766093T3 (da) 2011-10-11 2012-10-11 Anvendelse af semaphorin-4d-bindende molekyler til modulering af permeabiliteten af blod-hjerne-barrieren

Country Status (16)

Country Link
US (2) US20130095118A1 (da)
EP (1) EP2766093B1 (da)
JP (2) JP6395606B2 (da)
KR (1) KR101999872B1 (da)
CN (2) CN110105452A (da)
AU (1) AU2012322721B2 (da)
BR (1) BR112014008885B1 (da)
CA (1) CA2851805C (da)
DK (1) DK2766093T3 (da)
EA (1) EA029023B1 (da)
ES (1) ES2669209T3 (da)
IL (1) IL232072B (da)
MX (1) MX353550B (da)
PT (1) PT2766093T (da)
SG (1) SG11201401458UA (da)
WO (1) WO2013055922A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010129917A2 (en) 2009-05-08 2010-11-11 Vaccinex, Inc. Anti-cd100 antibodies and methods for using the same
US8790652B2 (en) 2011-12-06 2014-07-29 Vaccinex, Inc. Use of the combination of semaphorin-4D inhibitory molecules and VEGF inhibitory molecules to inhibit angiogenesis
US9090709B2 (en) 2012-03-28 2015-07-28 Vaccinex, Inc. Anti-SEMA4D antibodies and epitopes
US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
US10494440B2 (en) 2012-05-11 2019-12-03 Vaccinex, Inc. Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
BR112015032690B1 (pt) 2013-06-25 2020-03-10 Vaccinex, Inc. Uso de moléculas inibidoras de semaforina-4d em combinação com uma terapia imunomoduladora para inibir o crescimento tumoral e metástase
NZ630881A (en) * 2013-10-10 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treatment of atherosclerosis
NZ630892A (en) * 2013-10-21 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
US10973930B2 (en) 2016-02-18 2021-04-13 The Penn State Research Foundation Generating GABAergic neurons in brains
US10577427B2 (en) 2016-04-22 2020-03-03 Vaccinex, Inc. Integral membrane protein display on poxvirus extracellular enveloped virions
BR112019001944A2 (pt) 2016-08-02 2019-05-07 Vaccinex, Inc. métodos aperfeiçoados para produção de bibiliotecas de polinucleotídeo em células eucarióticas/vírus de vaccínia
RU2753441C2 (ru) * 2016-09-13 2021-08-16 Ангиокрин Биосайенс, Инк. Гематоэнцефалический барьер, содержащий сконструированные эндотелиальные клетки
EP3585435A4 (en) * 2017-02-22 2020-12-16 Vaccinex, Inc. EARLY DETECTION OF GLIAL CELL ACTIVATION IN NEURODEGENERATIVE OR NEURO-INFLAMMATORY DISEASES
CA3061963A1 (en) 2017-05-05 2018-11-08 Vaccinex, Inc. Human anti-semaphorin 4d antibody
WO2019060695A1 (en) * 2017-09-22 2019-03-28 Kite Pharma, Inc. CHIMERIC POLYPEPTIDES AND USES THEREOF
WO2019152857A1 (en) * 2018-02-02 2019-08-08 Gong Chen Methods and materials for treating brain injuries
KR20210131335A (ko) * 2019-01-22 2021-11-02 메사추세츠 인스티튜트 오브 테크놀로지 시험관내 인간 혈액 뇌 장벽
US20220220210A1 (en) * 2019-03-29 2022-07-14 Chugai Seiyaku Kabushiki Kaisha Anti-il-6 receptor antibody-containing inhibitor for inhibiting deterioration of bbb function
CN117597360A (zh) * 2020-06-25 2024-02-23 瓦西尼斯公司 脑信号蛋白-4d结合分子在rett综合征治疗中的应用
EP3973979A1 (en) * 2020-09-25 2022-03-30 The Provost, Fellows, Foundation Scholars, and The Other Members of Board, of The College of The Holy and Undivided Trinity of Queen Elizabeth A tight junction (zonulae occludentes) protein for use in treating or preventing epilepsy
CN113456813A (zh) * 2021-07-26 2021-10-01 苏州大学 Semaphorin7A单克隆抗体在制备用于治疗血栓及脑血管疾病药物方面的应用
WO2023012314A1 (en) * 2021-08-05 2023-02-09 Lifearc Anti-plexin-b1 antibodies
US20230101618A1 (en) * 2021-09-27 2023-03-30 Vaccinex, Inc. Predictive outcome profiling for use of an anti-semaphorin-4d binding molecule to treat neurodegenerative disorders
CN114539204B (zh) * 2022-03-23 2023-08-22 福建金兰厚普生物科技有限公司 己糖激酶抑制剂及其合成方法和应用
AU2024247601A1 (en) * 2023-03-28 2025-10-23 Nb Health Laboratory Co., Ltd. Antibody, nucleic acid, cell and drug

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ201918A (en) 1981-09-18 1987-04-30 Genentech Inc N-terminal methionyl analogues of bovine growth hormone
US4873192A (en) 1987-02-17 1989-10-10 The United States Of America As Represented By The Department Of Health And Human Services Process for site specific mutagenesis without phenotypic selection
US5070192A (en) 1988-03-23 1991-12-03 The Johns Hopkins University Cloned human topoisomerase i: cdna expression, and use for autoantibody detection
DE69120146T2 (de) 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
US6497872B1 (en) 1991-07-08 2002-12-24 Neurospheres Holdings Ltd. Neural transplantation using proliferated multipotent neural stem cells and their progeny
FR2686087A1 (fr) 1992-01-13 1993-07-16 Inst Nat Sante Rech Med Nouvel antigene lymphocytaire, anticorps correspondant et leurs applications.
US5639856A (en) 1993-09-13 1997-06-17 The Regents Of The University Of California Semaphorin gene family
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US6576754B2 (en) 1995-11-09 2003-06-10 Dana-Farber Cancer Institute CD100 antigen and uses therefor
US6884879B1 (en) 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
US20020032315A1 (en) 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
KR100816621B1 (ko) 1997-04-07 2008-03-24 제넨테크, 인크. 항-ｖｅｇｆ 항체
CA2286477A1 (en) 1997-04-11 1998-10-22 Dendreon Corporation Composition and method for inducing an immune response against tumour-related antigens
EP0892047A3 (de) * 1997-07-09 2000-03-08 Hoechst Marion Roussel Deutschland GmbH Humanes und murines Semaphorin L
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US6638501B1 (en) 1997-09-29 2003-10-28 Neurospheres Holdings Ltd. Use of multipotent neural stem cell progeny to augment non-neural tissues
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
ATE407206T1 (de) 1998-11-10 2008-09-15 Univ Rochester Methoden zu herstellung von genbanken
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
JP3787473B2 (ja) 1999-11-30 2006-06-21 独立行政法人科学技術振興機構 セマフォリン受容体
US6635742B1 (en) 2000-01-25 2003-10-21 Nuvelo, Inc. Antibodies specific for semaphorin-like polypeptides
US7468277B2 (en) 1999-12-23 2008-12-23 Cornell Research Foundation, Inc. Enriched preparation of human fetal multipotential neural stem cells
CN1329060A (zh) 2000-06-19 2002-01-02 上海博德基因开发有限公司 一种新的多肽——人semaphorin蛋白9和编码这种多肽的多核苷酸
CA2450793A1 (en) 2001-06-20 2002-12-27 Prochon Biotech Ltd. Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US20080219974A1 (en) 2002-03-01 2008-09-11 Bernett Matthew J Optimized antibodies that target hm1.24
EP1365018A1 (en) 2002-05-23 2003-11-26 Institut National De La Sante Et De La Recherche Medicale (Inserm) CD100 semaphorin in myelination
ATE483472T1 (de) 2002-05-30 2010-10-15 Macrogenics Inc Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
EP1442749A1 (en) 2003-01-31 2004-08-04 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of anti-CD100 antibodies for the treatment and the diagnosis of inflammatory disorder affecting the central nervous system
CN1788017B (zh) * 2003-02-10 2013-04-24 to-BBB控股股份有限公司 炎症状态下在血脑屏障中差异表达的核酸
UA101945C2 (uk) 2003-05-30 2013-05-27 Дженентек, Инк. Лікування злоякісного новоутворення за допомогою бевацизумабу
AU2004272607B2 (en) 2003-09-11 2008-11-06 Cornerstone Therapeutics Inc. Monoclonal antibodies against HMGB1
AU2004296184B2 (en) 2003-12-04 2010-12-16 Vaccinex, Inc. Methods of killing tumor cells by targeting internal antigens exposed on apoptotic tumor cells
CA2548282A1 (en) 2003-12-11 2005-06-30 Genentech, Inc. Methods and compositions for inhibiting c-met dimerization and activation
CA2575402A1 (en) 2004-08-05 2006-02-09 Genentech, Inc. Humanized anti-cmet antagonists
US20060147449A1 (en) 2004-11-15 2006-07-06 Brass Lawrence F Method of using CD100 (or Sema4D) to mediate platelet activation and inflammatory responses
US7919246B2 (en) 2005-04-07 2011-04-05 Novartis Vaccines And Diagnostics, Inc. SEMA4D in cancer diagnosis, detection and treatment
BRPI0618609A2 (pt) 2005-11-16 2011-09-06 Novartis Ag biomarcadores para tratamento com anticorpo anti-nogo-a em danos à medula espinhal
JP2007308465A (ja) 2006-05-15 2007-11-29 Boehringer Ingelheim Internatl Gmbh 炎症性疾患、自己免疫疾患又は骨吸収異常の治療方法
US8257706B2 (en) 2006-08-25 2012-09-04 Seattle Genetics, Inc. CD30 binding agents and uses thereof
US9382327B2 (en) 2006-10-10 2016-07-05 Vaccinex, Inc. Anti-CD20 antibodies and methods of use
WO2008081008A1 (en) * 2007-01-05 2008-07-10 University Of Zurich Method of providing disease-specific binding molecules and targets
US7919594B2 (en) 2007-02-14 2011-04-05 Vaccinex, Inc. Human anti-CD100 antibodies
AU2008219020B2 (en) 2007-02-21 2013-08-22 Vaccinex, Inc. Modulation of NKT cell activity with antigen-loaded CDId molecules
CA2710680C (en) 2007-12-26 2018-10-16 Vaccinex, Inc. Anti-c35 antibody combination therapies and methods
AR070134A1 (es) 2008-01-10 2010-03-17 Genentech Inc Agonistas de plexind1 que comprende un fragmento de semaforina 3e(sema3e) y su uso
WO2010129917A2 (en) 2009-05-08 2010-11-11 Vaccinex, Inc. Anti-cd100 antibodies and methods for using the same
CA3017298C (en) 2009-05-15 2021-09-28 Irx Therapeutics, Inc. Compositions comprising primary cell-derived biologics for enhancing immune responses in patients
JP5500944B2 (ja) 2009-10-29 2014-05-21 三菱電機株式会社 加熱調理器
NZ605260A (en) 2010-06-14 2013-12-20 Joseph King Allan Anti-vegf antibodies and uses thereof
SG188285A1 (en) 2010-09-02 2013-04-30 Vaccinex Inc Anti-cxcl13 antibodies and methods of using the same
MX343640B (es) 2011-05-13 2016-11-15 Nat Univ Corp Tokyo Medical & Dental Univ Promotor de osteogenesis.
US8790652B2 (en) 2011-12-06 2014-07-29 Vaccinex, Inc. Use of the combination of semaphorin-4D inhibitory molecules and VEGF inhibitory molecules to inhibit angiogenesis
NZ629828A (en) 2012-03-02 2017-05-26 Vaccinex Inc Methods for the treatment of b cell-mediated inflammatory diseases
US9090709B2 (en) 2012-03-28 2015-07-28 Vaccinex, Inc. Anti-SEMA4D antibodies and epitopes
US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
US10494440B2 (en) 2012-05-11 2019-12-03 Vaccinex, Inc. Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
CN105408355A (zh) 2013-01-31 2016-03-16 瓦克纳斯有限公司 用于提高免疫球蛋白a水平的方法
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
BR112015032690B1 (pt) 2013-06-25 2020-03-10 Vaccinex, Inc. Uso de moléculas inibidoras de semaforina-4d em combinação com uma terapia imunomoduladora para inibir o crescimento tumoral e metástase
NZ630881A (en) 2013-10-10 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treatment of atherosclerosis
NZ630892A (en) 2013-10-21 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
US10577427B2 (en) 2016-04-22 2020-03-03 Vaccinex, Inc. Integral membrane protein display on poxvirus extracellular enveloped virions
BR112019001944A2 (pt) 2016-08-02 2019-05-07 Vaccinex, Inc. métodos aperfeiçoados para produção de bibiliotecas de polinucleotídeo em células eucarióticas/vírus de vaccínia
EP3585435A4 (en) 2017-02-22 2020-12-16 Vaccinex, Inc. EARLY DETECTION OF GLIAL CELL ACTIVATION IN NEURODEGENERATIVE OR NEURO-INFLAMMATORY DISEASES

Also Published As

Publication number Publication date
EP2766093A4 (en) 2015-03-25
IL232072B (en) 2021-01-31
US20130095118A1 (en) 2013-04-18
IL232072A0 (en) 2014-05-28
BR112014008885A2 (pt) 2017-04-18
EP2766093B1 (en) 2018-02-21
KR20140076616A (ko) 2014-06-20
CA2851805C (en) 2021-12-28
JP2017193569A (ja) 2017-10-26
BR112014008885B1 (pt) 2021-02-17
PT2766093T (pt) 2018-05-18
JP2014530239A (ja) 2014-11-17
KR101999872B1 (ko) 2019-07-12
CN104168956A (zh) 2014-11-26
EA201490768A1 (ru) 2014-09-30
EA029023B1 (ru) 2018-01-31
JP6395606B2 (ja) 2018-09-26
SG11201401458UA (en) 2014-07-30
MX2014004457A (es) 2014-06-05
AU2012322721A1 (en) 2013-05-16
MX353550B (es) 2018-01-18
CN110105452A (zh) 2019-08-09
EP2766093A1 (en) 2014-08-20
CA2851805A1 (en) 2013-04-18
AU2012322721B2 (en) 2016-05-05
WO2013055922A1 (en) 2013-04-18
US20190358321A1 (en) 2019-11-28
US11534488B2 (en) 2022-12-27
ES2669209T3 (es) 2018-05-24
NZ623856A (en) 2016-04-29

Similar Documents

Publication Publication Date Title
DK2766093T3 (da) Anvendelse af semaphorin-4d-bindende molekyler til modulering af permeabiliteten af blod-hjerne-barrieren
AU2021202095B2 (en) Use of semaphorin-4D binding molecules for treating neurodegenerative disorders
KR102366682B1 (ko) 죽상경화증의 치료를 위한 세마포린-4d 결합 분자의 용도
AU2018225493B2 (en) Early detection of glial cell activation in neurodegenerative or neuroinflammatory diseases
NZ623856B2 (en) Use of semaphorin-4d binding molecules for modulation of blood brain barrier permeability