ATE483472T1 - Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten - Google Patents

Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten

Info

Publication number
ATE483472T1
ATE483472T1 AT03756297T AT03756297T ATE483472T1 AT E483472 T1 ATE483472 T1 AT E483472T1 AT 03756297 T AT03756297 T AT 03756297T AT 03756297 T AT03756297 T AT 03756297T AT E483472 T1 ATE483472 T1 AT E483472T1
Authority
AT
Austria
Prior art keywords
treatment
binding proteins
immune diseases
cd16a binding
cd16a
Prior art date
Application number
AT03756297T
Other languages
English (en)
Inventor
Leslie Johnson
Ling Huang
Hua Li
Nadine Tuaillon
Original Assignee
Macrogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Application granted granted Critical
Publication of ATE483472T1 publication Critical patent/ATE483472T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT03756297T 2002-05-30 2003-05-29 Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten ATE483472T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38468902P 2002-05-30 2002-05-30
US43932003P 2003-01-10 2003-01-10
PCT/US2003/017111 WO2003101485A1 (en) 2002-05-30 2003-05-29 Cd16a binding proteins and use for the treatment of immune disorders

Publications (1)

Publication Number Publication Date
ATE483472T1 true ATE483472T1 (de) 2010-10-15

Family

ID=29715346

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03756297T ATE483472T1 (de) 2002-05-30 2003-05-29 Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten

Country Status (9)

Country Link
US (4) US7351803B2 (de)
EP (1) EP1513554B9 (de)
JP (1) JP4524181B2 (de)
AT (1) ATE483472T1 (de)
AU (1) AU2003232456B2 (de)
BR (1) BR0311471A (de)
CA (1) CA2487932A1 (de)
DE (1) DE60334453D1 (de)
WO (1) WO2003101485A1 (de)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1513554B9 (de) * 2002-05-30 2011-11-09 Macrogenics, Inc. Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten
DE60318065T2 (de) 2002-06-07 2008-11-20 Trillium Therapeutics Inc., Toronto Fcyriia-transgenes tiermodell für autoimmunkrankheit
EP2052713A3 (de) 2003-01-13 2009-05-20 Macrogenics, Inc. Lösliche FcgammaR-Fusionsproteine und Verfahren zu deren Verwendung
KR20120090094A (ko) * 2003-06-13 2012-08-16 바이오겐 아이덱 엠에이 인코포레이티드 아글리코실 항-cd154(cd40 리간드) 항체 및 이의 용도
AU2011224032B2 (en) * 2003-06-13 2013-01-31 Biogen Ma Inc. Aglycosyl Anti-CD154 (CD40 Ligand) Antibodies and Uses Thereof
NZ545776A (en) * 2003-08-22 2009-05-31 Biogen Idec Inc Improved antibodies having altered effector function and methods for making the same
JP4691650B2 (ja) * 2004-03-04 2011-06-01 国立大学法人広島大学 ニワトリ型モノクローナル抗体の生産方法、および当該生産方法によって生産されるニワトリ型モノクローナル抗体
DE602005022871D1 (de) * 2004-06-07 2010-09-23 Univ Ramot Verfahren zur passiven immunisierung gegen eine durch amyloidaggregation gekennzeichnete krankheit oder erkrankung mit vermindertem nervenentzündungsrisiko
JP4839583B2 (ja) * 2004-07-15 2011-12-21 和光純薬工業株式会社 FcγレセプターIIIaに特異的な抗体およびそれを用いたFcγレセプターIIIaの測定方法
EP2399936A3 (de) 2004-07-26 2012-02-22 Biogen Idec MA Inc. Anti-CD154-Antikörper
MX2007007935A (es) 2004-12-28 2007-12-06 Innate Pharma Sa Anticuerpos monoclonales contra nkg2a.
CA2589860A1 (en) * 2005-01-24 2006-08-03 Amgen Inc. Humanized anti-amyloid antibody
US11254748B2 (en) 2005-04-15 2022-02-22 Macrogenics, Inc. Covalent diabodies and uses thereof
US9284375B2 (en) 2005-04-15 2016-03-15 Macrogenics, Inc. Covalent diabodies and uses thereof
US9963510B2 (en) 2005-04-15 2018-05-08 Macrogenics, Inc. Covalent diabodies and uses thereof
EP3479844B1 (de) 2005-04-15 2023-11-22 MacroGenics, Inc. Kovalente diabodies und verwendungen davon
GB0510790D0 (en) * 2005-05-26 2005-06-29 Syngenta Crop Protection Ag Anti-CD16 binding molecules
CN101627054A (zh) * 2005-07-11 2010-01-13 马克罗基因公司 用人源化抗cd16a抗体治疗自身免疫疾病的方法
JP2009529331A (ja) * 2006-03-10 2009-08-20 マクロジェニクス,インコーポレーテッド 変異型重鎖を有する抗体の同定および工学的改変ならびにその使用方法
AU2007276294B2 (en) 2006-06-30 2012-11-29 Novo Nordisk A/S Anti-NKG2A antibodies and uses thereof
ES2702087T3 (es) 2007-06-21 2019-02-27 Macrogenics Inc Diacuerpos covalentes y sus usos
JP5620106B2 (ja) * 2007-10-24 2014-11-05 株式会社糖鎖工学研究所 増強されたエフェクター機能を有するポリペプチド
JP5591712B2 (ja) 2007-12-14 2014-09-17 ノボ・ノルデイスク・エー/エス ヒトnkg2dに対する抗体とその使用
US8795667B2 (en) * 2007-12-19 2014-08-05 Macrogenics, Inc. Compositions for the prevention and treatment of smallpox
EP2261254A3 (de) 2007-12-21 2011-04-13 Amgen, Inc Antiamyloide Antikörper und deren Verwendungen
CN101952317B (zh) 2008-01-24 2015-07-22 诺沃-诺迪斯克有限公司 人化抗-人nkg2a单克隆抗体
WO2009095478A1 (en) 2008-01-31 2009-08-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies against human cd39 and use thereof for inhibiting t regulatory cells activity
PL2247304T3 (pl) 2008-04-02 2017-01-31 Macrogenics, Inc. Przeciwciała specyficzne wobec HER2/neu oraz sposoby ich zastosowania
US8669349B2 (en) 2008-04-02 2014-03-11 Macrogenics, Inc. BCR-complex-specific antibodies and methods of using same
WO2010033279A2 (en) 2008-06-04 2010-03-25 Macrogenics, Inc. Antibodies with altered binding to fcrn and methods of using same
US8394924B2 (en) * 2008-10-23 2013-03-12 Massachusetts Institute Of Technology Directed engagement of activating Fc receptors
SG172254A1 (en) 2008-12-19 2011-07-28 Macrogenics Inc Covalent diabodies and uses thereof
WO2010096394A2 (en) * 2009-02-17 2010-08-26 Redwood Biosciences, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
EP3320920A1 (de) 2009-05-08 2018-05-16 Vaccinex, Inc. Anti-cd100-antikörper und verfahren zur verwendung davon
CN102666874B (zh) 2009-10-07 2016-06-01 宏观基因有限公司 由于岩藻糖基化程度的改变而表现出改善的效应子功能的含Fc区的多肽及其使用方法
PH12012501751A1 (en) 2010-03-04 2012-11-12 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
DK2542256T3 (da) 2010-03-04 2019-08-26 Macrogenics Inc Antistoffer reagerende med b7-h3, immunologisk aktive fragmenter deraf og anvendelser deraf
CA2807127C (en) 2010-08-02 2019-02-12 Leslie S. Johnson Covalent diabodies and uses thereof
JP6097690B2 (ja) 2010-09-02 2017-03-15 ヴァクシネックス, インコーポレイテッド 抗cxcl13抗体およびそれを用いる方法
US9540438B2 (en) 2011-01-14 2017-01-10 Redwood Bioscience, Inc. Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
CN107827985A (zh) 2011-05-21 2018-03-23 宏观基因有限公司 能够与人和非人cd3结合的cd3结合分子
WO2012162068A2 (en) 2011-05-21 2012-11-29 Macrogenics, Inc. Deimmunized serum-binding domains and their use for extending serum half-life
EP2766093B1 (de) 2011-10-11 2018-02-21 Vaccinex, Inc. Verwendung von semaphorin-4d bindenden molekülen zur modulation der durchlässigkeit der blut-hirn-schranke
KR102090969B1 (ko) 2012-03-02 2020-03-19 백시넥스 인코포레이티드 B 세포-매개 염증 질환의 치료 방법
US9090709B2 (en) 2012-03-28 2015-07-28 Vaccinex, Inc. Anti-SEMA4D antibodies and epitopes
US10494440B2 (en) 2012-05-11 2019-12-03 Vaccinex, Inc. Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
US9790271B2 (en) 2013-01-31 2017-10-17 Vaccinex, Inc. Methods for increasing immunoglobulin A levels
US9487587B2 (en) 2013-03-05 2016-11-08 Macrogenics, Inc. Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
EP2968520B1 (de) 2013-03-14 2021-05-12 MacroGenics, Inc. Mit einen aktivierungsrezeptor exprimierenden immuneffektorzellen immunreaktive bispezifische moleküle
SG10201902380SA (en) 2013-06-25 2019-04-29 Vaccinex Inc Use of semaphorin-4d inhibitory molecules in combination with an immune modulating therapy to inhibit tumor growth and metastases
UA116479C2 (uk) 2013-08-09 2018-03-26 Макродженікс, Інк. БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ
US11384149B2 (en) 2013-08-09 2022-07-12 Macrogenics, Inc. Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof
EP2840091A1 (de) 2013-08-23 2015-02-25 MacroGenics, Inc. Bispezifische Diabodies, die gpA33 und CD3 binden können und Anwendungen dieser
EP2839842A1 (de) 2013-08-23 2015-02-25 MacroGenics, Inc. Bispezifische monovalente Diabodies mit Fähigkeit zur Bindung von CD123 und CD3 und Verwendungen davon
NZ630881A (en) 2013-10-10 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treatment of atherosclerosis
SG11201602979RA (en) * 2013-10-17 2016-05-30 Univ Singapore Chimeric receptor that triggers antibody-dependent cell cytotoxicity against multiple tumors
NZ630892A (en) 2013-10-21 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
PL3087095T3 (pl) 2013-12-24 2020-03-31 Argenx Bvba Antagoniści fcrn i sposoby stosowania
EP3662928A1 (de) * 2014-04-10 2020-06-10 OBI Pharma Inc. Antikörper, die an tumor assoziierte kohlehydrat-antigene binden, pharmazeutische zusammensetzungen und deren anwendung
TWI742423B (zh) 2014-05-29 2021-10-11 美商宏觀基因股份有限公司 特異性結合多種癌症抗原的三特異性結合分子和其使用方法
HRP20201656T1 (hr) 2014-09-16 2021-03-05 Innate Pharma Neutralizacija inhibitornih putova u limfocitima
US10717778B2 (en) 2014-09-29 2020-07-21 Duke University Bispecific molecules comprising an HIV-1 envelope targeting arm
KR102536786B1 (ko) 2014-10-10 2023-05-26 이나뜨 파르마 에스.에이. Cd73 차단
JP6889660B2 (ja) 2014-10-23 2021-06-18 イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. 抗nkg2a剤を用いた癌の処置
ES2882999T3 (es) 2015-03-09 2021-12-03 Argenx Bvba Métodos para reducir los niveles séricos de agentes que contienen Fc mediante el uso de antagonistas de FcRn
CN113604435A (zh) * 2015-03-27 2021-11-05 南克维斯特公司 用于治疗癌症的被遗传修饰的nk-92细胞和单克隆抗体
PL3988117T3 (pl) * 2015-04-13 2025-03-10 Pfizer Inc. Przeciwciała terapeutyczne i ich zastosowania
TWI773646B (zh) 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 結合lag-3的分子和其使用方法
EP4272757A3 (de) 2015-06-10 2023-12-27 ImmunityBio, Inc. Modifizierte nk-92-zellen zur behandlung von krebs
TWI870335B (zh) 2015-06-12 2025-01-21 美商宏觀基因股份有限公司 變異的嵌合4d5抗體及其與抗pd-1抗體聯合用於治療癌症的應用
WO2017064043A1 (en) 2015-10-12 2017-04-20 Innate Pharma Cd73 blocking agents
EA201891178A1 (ru) 2015-12-14 2019-01-31 Макродженикс, Инк. Биспецифичные молекулы, обладающие иммунореактивностью в отношении pd-1 и ctla-4, и способы их применения
PL3405495T3 (pl) 2016-01-21 2021-10-11 Innate Pharma Neutralizacja szlaków inhibitorowych w limfocytach
UY37127A (es) 2016-02-17 2017-08-31 Macrogenics Inc Moléculas de unión a ror1, y métodos de uso de las mismas
AU2017230850B2 (en) 2016-03-08 2024-04-18 Innate Pharma Siglec neutralizing antibodies
WO2017157948A1 (en) 2016-03-14 2017-09-21 Innate Pharma Anti-cd39 antibodies
TWI781098B (zh) 2016-04-15 2022-10-21 美商宏觀基因股份有限公司 新穎的b7-h3-結合分子、其抗體藥物綴合物及其使用方法
CN109071634A (zh) 2016-04-26 2018-12-21 R.P.谢勒技术有限责任公司 抗体偶联物及其制备和使用方法
US20200255524A1 (en) 2016-06-07 2020-08-13 Macrogenics, Inc. Combination therapy
WO2018065552A1 (en) 2016-10-06 2018-04-12 Innate Pharma Anti-cd39 antibodies
WO2018083080A2 (en) 2016-11-04 2018-05-11 Innate Pharma Nkp46 ligand
US11242402B2 (en) 2016-12-23 2022-02-08 Macrogenics, Inc. ADAM9-binding molecules, and methods of use thereof
US20200023071A1 (en) 2017-02-06 2020-01-23 Innate Pharma Immunomodulatory antibody drug conjugates binding to a human mica polypeptide
KR102584011B1 (ko) 2017-03-16 2023-09-27 이나뜨 파르마 에스.에이. 암 치료를 위한 조성물 및 방법
WO2019011852A1 (en) 2017-07-10 2019-01-17 Innate Pharma POLYTHERAPY USING ANTIBODY AGAINST SIGLEC-9 HUMAN AND ANTIBODY AGAINST NKG2A HUMAN FOR THE TREATMENT OF CANCER
KR102677225B1 (ko) 2017-07-10 2024-06-24 이나뜨 파르마 에스.에이. Siglec-9 중화 항체
CA3081144A1 (en) 2017-12-08 2019-06-13 Argenx Bvba Use of fcrn antagonists for treatment of generalized myasthenia gravis
TW202003582A (zh) 2018-03-13 2020-01-16 法商天賜製藥公司 頭頸癌之治療
IT201800004853A1 (it) 2018-04-24 2019-10-24 Metodi per trattare il cancro
CA3099820A1 (en) 2018-05-15 2019-11-21 Medimmune Limited Treatment of cancer
MY209122A (en) 2018-06-08 2025-06-23 argenx BV Compositions and methods for treating immune thrombocytopenia
PT3807316T (pt) 2018-06-18 2024-07-29 Innate Pharma Composições e métodos para tratamento de cancro
AU2019302152B2 (en) * 2018-07-10 2025-07-10 Daiichi Sankyo Company, Limited Anti-sirpalpha antibody
JP7241161B2 (ja) 2018-08-01 2023-03-16 イミュニティーバイオ、インコーポレイテッド 細胞免疫療法の安定した遺伝子改変のための、ホーミング受容体又はサイトカインとキメラ抗原受容体とを含むクアドリシストロニックシステム
WO2020035345A1 (en) 2018-08-14 2020-02-20 Innate Pharma Treatment of colorectal cancer by a combination of an anti-mica antibody and an anti-nkg2a antibody
US20200376135A1 (en) * 2018-10-23 2020-12-03 Magenta Therapeutics, Inc. Fc silenced antibody drug conjugates (adcs) and uses thereof
WO2020136147A1 (en) 2018-12-26 2020-07-02 Innate Pharma Compounds and methods for treatment of head and neck cancer
GB2589049C (en) 2019-04-11 2024-02-21 argenx BV Anti-IgE antibodies
MX2021012769A (es) 2019-04-23 2021-11-18 Innate Pharma Anticuerpos bloqueadores cd73.
WO2020225552A1 (en) 2019-05-06 2020-11-12 Medimmune Limited Combination of monalizumab, durvalumab, chemotherapy and bevacizumab or cetuximab for the treatment of colorectal cancer
CN114126647A (zh) 2019-06-07 2022-03-01 阿尔金克斯有限公司 适用于皮下施用的FcRn抑制剂的药物制剂
US20230227559A1 (en) * 2019-12-10 2023-07-20 Institut Pasteur New antibody blocking human fcgriiia and fcgriiib
ES2992247T3 (es) 2020-01-08 2024-12-11 argenx BV Antagonistas del receptor de Fc neonatal humano (FcRn) para el tratamiento de trastornos del pénfigo
US11230699B2 (en) 2020-01-28 2022-01-25 Immunitybio, Inc. Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors
KR20230050378A (ko) 2020-08-13 2023-04-14 이나뜨 파르마 에스.에이. 항-cd73 항체를 사용하여 암을 치료하는 방법
CN116745324A (zh) * 2021-01-27 2023-09-12 信达生物制药(苏州)有限公司 针对cd16a的单域抗体及其用途
CN117580865A (zh) * 2021-06-29 2024-02-20 山东先声生物制药有限公司 Cd16抗体及其应用
CN117858902A (zh) * 2021-08-25 2024-04-09 南京金斯瑞生物科技有限公司 针对人CD16a的抗体及其变体
KR20240134139A (ko) 2021-12-20 2024-09-06 비토퀴놀 에스에이 항-갯과 인터루킨-31-수용체 a (il-31ra) 항체 및 이의 용도
CN114805592A (zh) * 2022-05-13 2022-07-29 南京吉盛澳玛生物医药有限公司 一种三特异性抗体的设计、制备及用途
KR20250017209A (ko) 2022-05-25 2025-02-04 이나뜨 파르마 에스.에이. 넥틴-4 결합제
CA3258004A1 (en) 2022-06-15 2023-12-21 argenx BV FCRN/HSA BONDING MOLECULES AND METHODS OF USE
CN115960234B (zh) * 2022-10-27 2023-12-29 合肥天港免疫药物有限公司 抗cd16a的抗体及其应用
JP2026504499A (ja) * 2023-02-06 2026-02-05 レプ バイオファーマ カンパニー, リミテッド 抗cd16a抗体およびその使用
WO2025114614A1 (en) 2023-11-30 2025-06-05 Vetoquinol Sa Anti-canine interleukine-4-receptor alpha (il-4rα) antibodies and the uses thereof
GB202319605D0 (en) 2023-12-20 2024-01-31 argenx BV Monovalent binding molecules and methods of use
WO2025218645A1 (zh) * 2024-04-16 2025-10-23 深圳众格生物科技有限公司 抗cd16a抗体及其用途
WO2025229224A1 (en) 2024-05-03 2025-11-06 argenx BV Monovalent anti-iga binding molecules and methods of use
WO2025233264A1 (en) 2024-05-07 2025-11-13 Innate Pharma Use of cd73 blocking agents in combination with anti-cd20 x cd3 t cell engagers
WO2025233266A1 (en) 2024-05-07 2025-11-13 Innate Pharma Use of cd39 blocking agents in combination with anti-cd20 x cd3 t cell engagers

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4946788A (en) * 1985-06-11 1990-08-07 Ciba-Geigy Corporation Purified immunoglobulin-related factor, novel monoclonal antibodies, hybridoma cell lines, processes and applications
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5985599A (en) 1986-05-29 1999-11-16 The Austin Research Institute FC receptor for immunoglobulin
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US6121424A (en) 1991-11-25 2000-09-19 Enzon, Inc. Multivalent antigen-binding proteins
FR2611913B1 (fr) * 1987-02-24 1994-04-15 Khayat David Procede de dosage des recepteurs fc gamma solubles seriques, coffret de dosage correspondant et applications
AU600575B2 (en) * 1987-03-18 1990-08-16 Sb2, Inc. Altered antibodies
AU612370B2 (en) 1987-05-21 1991-07-11 Micromet Ag Targeted multifunctional proteins
EP0791653B9 (de) 1988-05-27 2006-08-30 Applied Research Systems ARS Holding N.V. Menschlicher Fc-gamma-Rezeptor III
IL162181A (en) * 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5399493A (en) 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
US5437994A (en) 1989-06-15 1995-08-01 Regents Of The University Of Michigan Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
ES2108048T3 (es) 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
US5837821A (en) 1992-11-04 1998-11-17 City Of Hope Antibody construct
DE69433379T2 (de) * 1993-04-08 2004-10-14 The Trustees Of Columbia University In The City Of New York Verfahren zur Herstellung von 4- und/oder 5-(di)substituierten 2-Aminoimidazolen aus 2-Aminoimidazolen und Aldehyden
US5641875A (en) 1993-09-30 1997-06-24 University Of Pennsylvania DNA encoding chimeric IgG Fc receptor
JPH09512705A (ja) 1994-03-29 1997-12-22 セルテック セラピューティクス リミテッド E−セレクチンに対する抗体
DE19619068A1 (de) * 1996-05-13 1997-11-27 Siemens Ag Vorrichtung zur Überwachung des Transportprozesses von flachen Sendungen
US5834597A (en) * 1996-05-20 1998-11-10 Protein Design Labs, Inc. Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
US6025158A (en) 1997-02-21 2000-02-15 Genentech, Inc. Nucleic acids encoding humanized anti-IL-8 monoclonal antibodies
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
US6528624B1 (en) 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
US6737056B1 (en) * 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
KR101077001B1 (ko) 1999-01-15 2011-10-26 제넨테크, 인크. 효과기 기능이 변화된 폴리펩티드 변이체
MXPA03005273A (es) 2000-12-14 2003-09-25 Genentech Inc Anticuerpos producidos procarioticamente y sus usos.
EP1513554B9 (de) * 2002-05-30 2011-11-09 Macrogenics, Inc. Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten
CN101627054A (zh) * 2005-07-11 2010-01-13 马克罗基因公司 用人源化抗cd16a抗体治疗自身免疫疾病的方法

Also Published As

Publication number Publication date
CA2487932A1 (en) 2003-12-11
US20070244303A1 (en) 2007-10-18
HK1074991A1 (en) 2005-12-02
US20040010124A1 (en) 2004-01-15
AU2003232456B2 (en) 2009-06-04
US7618628B2 (en) 2009-11-17
AU2003232456A1 (en) 2003-12-19
US7838635B2 (en) 2010-11-23
DE60334453D1 (de) 2010-11-18
EP1513554B1 (de) 2010-10-06
US20080050371A1 (en) 2008-02-28
EP1513554B9 (de) 2011-11-09
JP4524181B2 (ja) 2010-08-11
WO2003101485A1 (en) 2003-12-11
EP1513554A4 (de) 2006-06-28
US7351803B2 (en) 2008-04-01
JP2005532342A (ja) 2005-10-27
BR0311471A (pt) 2007-04-27
EP1513554A1 (de) 2005-03-16
US20110152504A1 (en) 2011-06-23

Similar Documents

Publication Publication Date Title
DE60334453D1 (de) Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten
MX2008000030A (es) Metodos para el tratamiento de enfermedad autoinmune utilizando anticuerpos anti-cd16a humanizados.
MX2021004147A (es) Proteínas de unión triespecíficas anti-cd38, anti-cd28 y anti-cd3 y métodos de uso para tratar una infección viral.
EP1603949B8 (de) Antikörper gegen il21-rezeptor und deren verwendung
WO2003078600A3 (en) Human monoclonal antibodies to influenza m2 protein and methods of making and using same
WO2019195623A3 (en) Heterodimeric antibodies that bind fibroblast activation protein
DE60334141D1 (de) VERÄNDERUNG VON FcRn-BINDUNGSAFFINITÄTEN ODER VON SERUMHALBWERTSZEITEN VON ANTIKÖRPERN MITTELS MUTAGENESE
EA200700847A1 (ru) Материалы, связывающие прионные белки, и способы их применения
ATE423571T1 (de) Verwendung von bispezifischen antikörpern gegen einen aktivierenden rezeptor fcepsilonri und gegen einen inhibierenden rezeptor ox2ra (cd200ra) zur regulierung der immunantworten
CY1110557T1 (el) Αντισωματα ιντερλευκινης-10
WO2004067568A3 (en) Human il-1 beta antagonists
EA200501017A1 (ru) Астма и модуляторы аллергических воспалений
WO2006118772A3 (en) Fcrn antibodies and uses thereof
DE69433406T2 (de) Antikörper gegen cd40
ATE468755T1 (de) Verfahren und zusammensetzungen mit molkeproteinisolaten
MY146664A (en) Antibodies against human il-22 and uses therefor
ZA200408456B (en) Motif-grafted hybrid polypeptides and uses thereof
WO2004035742A3 (en) Sets of digital antibodies directed against short epitopes, and methods using same
WO2004082608A3 (en) Ligands for tgf-beta binding proteins and uses thereof
WO2004113500A3 (en) B7s1: an immune modulator
WO2005019270A3 (en) Endotheliase-2 ligands
EP4181909A4 (de) Bispezifische antagonisten des retinolbindenden proteins 4 zur stabilisierung von transthyretintetrameren, ihre herstellung und verwendung bei der behandlung von gemeinsamen altersbedingten komorbiditäten
WO2019094533A8 (en) Angptl8-binding agents and methods of use thereof
GB0324656D0 (en) A protein involved in ovarian cancer
WO2003057821A3 (en) Mut-il-18 or mut-il-18r proteins, antibodies, compositions, methods and uses

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties