DK2786996T3 - Hydrochlorid med purinonderivat - Google Patents

Hydrochlorid med purinonderivat Download PDF

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Publication number
DK2786996T3
DK2786996T3 DK12852725.6T DK12852725T DK2786996T3 DK 2786996 T3 DK2786996 T3 DK 2786996T3 DK 12852725 T DK12852725 T DK 12852725T DK 2786996 T3 DK2786996 T3 DK 2786996T3
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Denmark
Prior art keywords
compound
hydrochloride
examples
disease
crystal
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DK12852725.6T
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English (en)
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Shingo Yamamoto
Toshio Yoshizawa
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Ono Pharmaceutical Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)

Claims (7)

  1. HYDROCHLORID MED PURINONDERIVAT
  2. 6-Amino-9-[(3R)-l-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8F[-purin-8-on hydrochloric!.
    2. Krystal af 6-amino-9-[(3R)-l-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-on hydrochlorid.
    3. Krystal ifølge krav 2, hvilket krystal har mindst 2 eller flere peaks ved vinkel 2Θ udvalgt fra ca. 8,11, 8,43, 11,57, 12,73, 13,85, 14,20, 14,67, 14,91, 15,94, 16,64, 18,06, 19,74, 20,42, 21,05, 22,57, 23,21, 23,85 og 24,70 grader i et røntgenpulverdiffraktionsspektrum.
    4. Krystal ifølge krav 2 eller 3, hvilket krystal har peaks ved vinkel 2Θ på ca. 8,11, 8,43, 14,20, 14,67, 14,91 og 23,21 grader i et røntgenpulverdiffraktionsspektrum.
    5. Krystal ifølge et hvilket som helst af kravene 2 til 4, hvilket krystal har peaks ved vinkel 2Θ udvalgt fra ca. 8,11, 8,43, 11,57, 12,73, 13,85, 14,20, 14,67, 14,91, 15,94, 16,64, 18,06, 19,74, 20,42, 21,05, 22,57, 23,21, 23,85 og 24,70 grader i et røntgenpulverdiffraktionsspektrum.
    6. Krystal ifølge et hvilket som helst af kravene 2 til 5, hvilket krystal har et endotermisk peak ved en peak-temperatur på 216 °C i differentiel scanningskalorimetri.
  3. 7. Farmaceutisk sammensætning omfattende 6-amino-9-[(3R)-l-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-on hydrochlorid.
  4. 8. Farmaceutisk sammensætning ifølge krav 7 til anvendelse som en Btk-hæmmer.
  5. 9. Farmaceutisk sammensætning ifølge krav 8 til anvendelse til forebyggelse og/eller behandling af en Btk-relateret sygdom.
  6. 10. Farmaceutisk sammensætning til anvendelse ifølge krav 9, hvor den Btk-relaterede sygdom er en allergisk sygdom, en autoimmun sygdom, en inflammatorisk sygdom, en tromboembolisk sygdom, en knoglerelateret sygdom eller cancer.
  7. 11. Farmaceutisk sammensætning til anvendelse ifølge krav 10, hvor canceren er non-Flodgkins lymfom.
DK12852725.6T 2011-11-29 2012-11-28 Hydrochlorid med purinonderivat DK2786996T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011259662 2011-11-29
PCT/JP2012/080769 WO2013081016A1 (ja) 2011-11-29 2012-11-28 プリノン誘導体塩酸塩

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DK2786996T3 true DK2786996T3 (da) 2016-12-19

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Country Status (29)

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US (9) US9199997B2 (da)
EP (1) EP2786996B1 (da)
JP (1) JP5704252B2 (da)
KR (3) KR101636631B1 (da)
CN (1) CN103958513B (da)
AU (2) AU2012344839B2 (da)
BR (2) BR112014012727B1 (da)
CA (1) CA2857150C (da)
CY (1) CY1118376T1 (da)
DK (1) DK2786996T3 (da)
ES (1) ES2601219T3 (da)
HR (1) HRP20161377T1 (da)
HU (1) HUE031094T2 (da)
IL (1) IL232822B (da)
LT (1) LT2786996T (da)
MX (2) MX353548B (da)
MY (1) MY170062A (da)
NZ (1) NZ626750A (da)
PH (1) PH12014501503A1 (da)
PL (1) PL2786996T3 (da)
PT (1) PT2786996T (da)
RS (1) RS55542B1 (da)
RU (2) RU2615999C2 (da)
SG (1) SG11201402658YA (da)
SI (1) SI2786996T1 (da)
SM (2) SMT201600426T1 (da)
TW (1) TW201329078A (da)
WO (1) WO2013081016A1 (da)
ZA (1) ZA201404792B (da)

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