DK2813512T3 - Fremgangsmåde til cyklisering af en peptidforbindelse - Google Patents
Fremgangsmåde til cyklisering af en peptidforbindelse Download PDFInfo
- Publication number
- DK2813512T3 DK2813512T3 DK12861199.3T DK12861199T DK2813512T3 DK 2813512 T3 DK2813512 T3 DK 2813512T3 DK 12861199 T DK12861199 T DK 12861199T DK 2813512 T3 DK2813512 T3 DK 2813512T3
- Authority
- DK
- Denmark
- Prior art keywords
- cyclizing
- procedure
- peptide connection
- peptide
- connection
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011288865 | 2011-12-28 | ||
| JP2012156943 | 2012-07-12 | ||
| PCT/JP2012/084103 WO2013100132A1 (ja) | 2011-12-28 | 2012-12-28 | ペプチド化合物の環化方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2813512T3 true DK2813512T3 (da) | 2021-04-26 |
Family
ID=48697609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12861199.3T DK2813512T3 (da) | 2011-12-28 | 2012-12-28 | Fremgangsmåde til cyklisering af en peptidforbindelse |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9409952B2 (da) |
| EP (2) | EP2813512B1 (da) |
| JP (6) | JP6294080B2 (da) |
| DK (1) | DK2813512T3 (da) |
| HU (1) | HUE054006T2 (da) |
| TW (6) | TWI640541B (da) |
| WO (1) | WO2013100132A1 (da) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI640541B (zh) | 2011-12-28 | 2018-11-11 | 中外製藥股份有限公司 | Peptide compound having an annular portion and pharmaceutical composition thereof |
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| US20160367961A1 (en) * | 2015-04-23 | 2016-12-22 | Roche Sequencing Solutions, Inc. | Method and composition for peptide cyclization and protease treatment |
| US10011631B2 (en) * | 2015-12-01 | 2018-07-03 | The University Of Hong Kong | Stapled helical peptides and methods of synthesis |
| WO2017150732A1 (ja) * | 2016-03-03 | 2017-09-08 | 中外製薬株式会社 | チオール基をアミノ基近傍に有するアミノ酸をｎ末端に持つ非環状ペプチド－核酸複合体、そのライブラリー、およびそれから誘導される環状ペプチド－核酸複合体ライブラリーの製造方法 |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| CA3044645A1 (en) * | 2016-12-09 | 2018-06-14 | Fujifilm Corporation | Mixed mode affinity chromatography carrier |
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| EP4663653A1 (en) | 2023-03-20 | 2025-12-17 | Chugai Seiyaku Kabushiki Kaisha | Method for producing eutectic of cyclic peptide |
| WO2024209857A1 (ja) * | 2023-04-03 | 2024-10-10 | 富士フイルム株式会社 | 核酸ディスプレイライブラリの作製方法、スクリーニング方法、及びポリペプチドの作製方法 |
| WO2024214303A1 (ja) | 2023-04-14 | 2024-10-17 | 中外製薬株式会社 | 複数種類の標的分子との複合体を形成し得る目的分子のスクリーニング方法、及び当該スクリーニング方法を含む目的分子の製造方法 |
| CN120897751A (zh) | 2023-04-19 | 2025-11-04 | 中外制药株式会社 | 含有环肽化合物和表面活性剂的组合物 |
| WO2024263911A2 (en) * | 2023-06-22 | 2024-12-26 | Dana-Farber Cancer Institute, Inc. | Methods for the synthesis and linearization of peptidomimetic macrocycles |
| CN121532404A (zh) | 2023-09-28 | 2026-02-13 | 中外制药株式会社 | 用于使用混合酸酐程序生产肽化合物的方法 |
| WO2025079184A1 (ja) | 2023-10-11 | 2025-04-17 | 中外製薬株式会社 | 複数のライブラリを用いたペプチドのスクリーニング方法 |
| WO2025100405A1 (ja) | 2023-11-06 | 2025-05-15 | 中外製薬株式会社 | 細胞膜透過性と代謝安定性を有する大環状ペプチド化合物、及びこれを含むライブラリ |
| WO2025143077A1 (ja) | 2023-12-27 | 2025-07-03 | 中外製薬株式会社 | スタンドアローン型縮合剤を用いたペプチド化合物の製造方法 |
| WO2025226861A1 (en) * | 2024-04-24 | 2025-10-30 | Circle Pharma, Inc. | Cyclin inhibitors |
| CN119455452B (zh) * | 2024-10-16 | 2026-04-28 | 国电投核素同创(重庆)科技有限公司 | 一种通过辐照钍靶生产Ac-225母液的方法 |
| CN119708146B (zh) * | 2024-12-30 | 2026-03-17 | 五邑大学 | 一种环肽Lagunamide D的制备方法 |
Family Cites Families (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57159747A (en) | 1981-03-27 | 1982-10-01 | Kenji Okawa | Synthesis of amino acid derivative |
| JPS60169451A (ja) | 1984-02-13 | 1985-09-02 | Mitsui Toatsu Chem Inc | Ｌ−フエニルアラニンの分離精製法 |
| FR2583432B1 (fr) | 1985-06-13 | 1988-11-04 | Inst Francais Du Petrole | Procede de production enzymatique de l-a-aminoacides a partir d'a-cetoacides |
| ES8607214A1 (es) | 1985-10-16 | 1986-06-01 | Gema Sa | Procedimiento enzimatico de resolucion de n-fenilacetil-ami-nocompuestos y purificacion de sus isomeros opticamente ac- tivos |
| US4859736A (en) | 1987-03-30 | 1989-08-22 | Ciba-Geigy Corporation | Synthetic polystyrene resin and its use in solid phase peptide synthesis |
| DE3733198A1 (de) | 1987-10-01 | 1989-04-13 | Kernforschungsanlage Juelich | Enzymatisches verfahren zur herstellung von dipeptiden |
| JPH0681759B2 (ja) | 1988-03-31 | 1994-10-19 | 信越化学工業株式会社 | ポリペプチドの製造方法 |
| GB9022788D0 (en) | 1990-10-19 | 1990-12-05 | Cortecs Ltd | Pharmaceutical formulations |
| US7045363B2 (en) * | 1996-05-01 | 2006-05-16 | Fujirebio Inc. | Nucleic acid-bound polypeptide method of producing nucleic acid-bound polypeptide and immunoassay using the polypeptide |
| DK0971946T3 (da) * | 1997-01-21 | 2006-10-30 | Gen Hospital Corp | Selektion af proteiner ved anvendelse af RNA-protein-fusioner |
| US20020068301A1 (en) | 1997-05-28 | 2002-06-06 | Hung-Sen Lai | Cyclic peptide libraries and methods of use thereof to identify binding motifs |
| WO1998056381A1 (en) | 1997-06-09 | 1998-12-17 | Bridge Pharma, Inc. | Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use |
| US6281175B1 (en) | 1997-09-23 | 2001-08-28 | Scimed Life Systems, Inc. | Medical emulsion for lubrication and delivery of drugs |
| PT1123084E (pt) | 1998-10-02 | 2005-05-31 | Schering Ag | Utilizacao de esteres de testosterona e/ou testosterona para a preparacao de sistemas bioadesivos aplicaveis por via bucal com agentes activos medicamentosos de accao retardada |
| US6977083B1 (en) | 1998-10-02 | 2005-12-20 | Jenapharm Gmbh & Co. Kg | Bioadhesive tablet containing testosterone/testosterone ester mixtures and method for producing a predetermined testosterone time-release profile with same |
| US6057289A (en) | 1999-04-30 | 2000-05-02 | Pharmasolutions, Inc. | Pharmaceutical composition comprising cyclosporin in association with a carrier in a self-emulsifying drug delivery system |
| JP4502293B2 (ja) | 1999-06-04 | 2010-07-14 | 長瀬産業株式会社 | 軸不斉を有する光学活性な４級アンモニウム塩、その製法およびα−アミノ酸誘導体の不斉合成への応用 |
| DE19942624A1 (de) * | 1999-08-28 | 2001-03-08 | Chemotopix Gmbh | Verfahren zur Herstellung von zyklischen Peptidomimetika |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| GB0001449D0 (en) | 2000-01-21 | 2000-03-08 | Cortendo Ab | Compositions |
| NZ521456A (en) | 2000-04-19 | 2004-07-30 | Schering Corp | Macrocyclic NS3-Serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties |
| EP1277755A4 (en) | 2000-04-21 | 2006-01-11 | Nagase & Co Ltd | OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT BY AXIAL ASYMMETRY, METHOD FOR THE PRODUCTION THEREOF, AND THEIR APPLICATION IN THE ASYMMETRIC SYNTHESIS OF ALPHA-AMINO-ACID DERIVATIVES |
| KR100401296B1 (ko) * | 2000-12-27 | 2003-10-11 | 드림바이오젠 주식회사 | 수식물질에 의해 수식된 단백질 변이체 및 이것의 제조방법 |
| JP4061043B2 (ja) | 2000-12-28 | 2008-03-12 | 株式会社ポストゲノム研究所 | ｉｎｖｉｔｒｏ転写／翻訳系によるペプチド等の製造方法 |
| IL158418A0 (en) | 2001-04-19 | 2004-05-12 | Scripps Research Inst | In vivo incorporation of unnatural amino acids |
| CA2452818C (en) | 2001-08-01 | 2010-06-29 | Japan Science And Technology Agency | Tyrosyl-trna synthetase variants |
| US7288372B2 (en) | 2002-01-17 | 2007-10-30 | Ambergen, Inc. | Methods for the preparation of chemically misaminoacylated tRNA via protective groups |
| AU2003225085A1 (en) | 2002-04-19 | 2003-11-03 | California Institute Of Technology | Unnatural amino acid containing display libraries |
| US7385038B2 (en) * | 2002-07-18 | 2008-06-10 | Protein Express Co., Ltd. | Non-natural labeled amino acid and method of constructing amino acid/tRNA complex |
| JP4490663B2 (ja) | 2003-09-22 | 2010-06-30 | 株式会社東京大学Ｔｌｏ | イソロイシンｔＲＮＡ（ｔＲＮＡＩｌｅ）のライシジン合成酵素（ＴｉｌＳ）としてのｍｅｓＪ遺伝子産物及びその相同性遺伝子（ＣＯＧ００３７） |
| ATE376556T1 (de) | 2003-12-31 | 2007-11-15 | Hoffmann La Roche | Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel |
| EP1725250A2 (en) | 2004-02-18 | 2006-11-29 | Frutarom Ltd. | Method for the preparation of peptide-oligonucleotide conjugates |
| KR20070084531A (ko) | 2004-11-24 | 2007-08-24 | 머크 앤드 캄파니 인코포레이티드 | 치환된 아미드의 경구 투여용 액체 및 반고체 약제학적제형 |
| WO2007066627A1 (ja) | 2005-12-06 | 2007-06-14 | The University Of Tokyo | 多目的アシル化触媒とその用途 |
| EP1999259B1 (en) | 2006-03-03 | 2014-06-25 | California Institute of Technology | Site-specific incorporation of amino acids into molecules |
| US8754192B2 (en) | 2006-04-11 | 2014-06-17 | Sloan-Kettering Institute For Cancer Research | Compositions comprising homogeneously glycosylated erythropoietin |
| JP2007319064A (ja) | 2006-05-31 | 2007-12-13 | Japan Science & Technology Agency | 修飾化アミノ酸を部位特異的に導入したタンパク質を発現させる方法 |
| JP5200241B2 (ja) | 2006-11-17 | 2013-06-05 | 国立大学法人 東京大学 | Ｎ末端に非天然骨格をもつポリペプチドの翻訳合成とその応用 |
| US9090668B2 (en) | 2007-03-26 | 2015-07-28 | The University Of Tokyo | Process for synthesizing cyclic peptide compound |
| JP2009096791A (ja) | 2007-09-26 | 2009-05-07 | Kaneka Corp | アミノ酸の製造方法 |
| EA201070483A1 (ru) | 2007-10-16 | 2010-10-29 | Сан Фарма Адвансед Ресьёрч Компани Лимитед | Новые офтальмологические композиции |
| EP2177533A1 (en) | 2008-10-09 | 2010-04-21 | TU München | Multiple N-methylated cyclic hexapeptides for treatment of neurogenic inflammation |
| TWI468375B (zh) | 2008-10-27 | 2015-01-11 | Janssen Pharmaceutica Nv | 製備經保護之ｌ－丙胺酸衍生物之方法 |
| WO2010053050A1 (ja) | 2008-11-04 | 2010-05-14 | 株式会社カネカ | Ｏ－アルキルセリンおよびｎ－ベンジル－ｏ－アルキルセリンの製造法 |
| CN102239176A (zh) | 2008-12-03 | 2011-11-09 | 弗·哈夫曼-拉罗切有限公司 | 用于制备治疗性肽的方法 |
| EP2424888A2 (en) | 2009-05-01 | 2012-03-07 | F. Hoffmann-La Roche AG | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
| EP2492344B1 (en) | 2009-10-22 | 2016-04-06 | PeptiDream Inc. | Rapid display method in translational synthesis of peptide |
| GB0919194D0 (en) | 2009-11-02 | 2009-12-16 | Lytix Biopharma As | Compounds |
| US20110118314A1 (en) | 2009-11-16 | 2011-05-19 | Weiya Yun | Piperidine analogs as glycogen synthase activators |
| JP2011139667A (ja) | 2010-01-07 | 2011-07-21 | Tottori Univ | プロリンおよびβ−アラニンをＮ末端に有するジペプチド、及びその環化ジペプチドの酵素合成法 |
| EP2523655A2 (en) | 2010-01-12 | 2012-11-21 | Novo Nordisk A/S | Pharmaceutical compositions for oral administration of insulin peptides |
| US20130065272A1 (en) * | 2010-03-24 | 2013-03-14 | Medical Research Council | Synthesis of Site Specifically-Linked Ubiquitin |
| EP2380596A1 (en) | 2010-04-20 | 2011-10-26 | Technische Universität München | Cyclopentapeptide derivatives and uses thereof |
| JP5725467B2 (ja) | 2010-08-27 | 2015-05-27 | 国立大学法人 東京大学 | 新規人工翻訳合成系 |
| JP5818237B2 (ja) * | 2010-09-09 | 2015-11-18 | 国立大学法人 東京大学 | Ｎ−メチルアミノ酸およびその他の特殊アミノ酸を含む特殊ペプチド化合物ライブラリーの翻訳構築と活性種探索法 |
| EP2647720B1 (en) | 2010-12-03 | 2019-06-19 | The University of Tokyo | Peptide library production method, peptide library, and screening method |
| ES2586411T3 (es) | 2011-03-04 | 2016-10-14 | New York University | Macrociclos sustitutos de enlace de hidrógeno como moduladores de Ras |
| US9133245B2 (en) | 2011-06-13 | 2015-09-15 | Trustees Of Boston College | Cyclic lactadherin peptide mimetics and their uses |
| TWI640541B (zh) | 2011-12-28 | 2018-11-11 | 中外製藥股份有限公司 | Peptide compound having an annular portion and pharmaceutical composition thereof |
| GB201215538D0 (en) | 2012-08-31 | 2012-10-17 | Stetsenko Dmitry | Method and compositions for removing acid-labile protecting groups |
| EP2897971B1 (en) | 2012-09-24 | 2017-05-31 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Method for producing a cyclic peptide |
| JP6440055B2 (ja) | 2013-05-10 | 2018-12-19 | 国立大学法人 東京大学 | ペプチドライブラリの製造方法、ペプチドライブラリ、及びスクリーニング方法 |
| EP3030545B1 (en) | 2013-08-05 | 2020-10-07 | MedImmune Limited | Amino acid derivatives |
| WO2015019999A1 (ja) | 2013-08-05 | 2015-02-12 | 国立大学法人東京大学 | 荷電性非タンパク質性アミノ酸含有ペプチドの製造方法 |
| JP6754997B2 (ja) | 2013-08-26 | 2020-09-16 | 国立大学法人 東京大学 | 大環状ペプチド、その製造方法、及び大環状ペプチドライブラリを用いるスクリーニング方法 |
| WO2015155676A1 (en) | 2014-04-08 | 2015-10-15 | Novartis Ag | Novel aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| TW201622746A (zh) | 2014-04-24 | 2016-07-01 | 諾華公司 | 改善或加速髖部骨折術後身體復原之方法 |
| US10736932B2 (en) | 2014-05-20 | 2020-08-11 | Ohio State Innovation Foundation | Small molecule Ras inhibitors |
| WO2015185162A1 (en) | 2014-06-06 | 2015-12-10 | Technische Universität München | Modified cyclopentapeptides and uses thereof |
| EP3157508B1 (en) | 2014-06-19 | 2020-12-09 | Solural Pharma Aps | Solid oral dosage form of lipophilic compounds |
| WO2016115168A1 (en) | 2015-01-12 | 2016-07-21 | Synthorx, Inc. | Incorporation of unnatural nucleotides and methods thereof |
| US10815489B2 (en) | 2015-03-13 | 2020-10-27 | Chugai Seiyaku Kabushiki Kaisha | Modified aminoacyl-tRNA synthetase and use thereof |
| CN107614689A (zh) | 2015-03-27 | 2018-01-19 | 昆士兰大学 | 用于将非天然氨基酸并入蛋白质中的平台 |
| JP2017043615A (ja) | 2015-08-27 | 2017-03-02 | 塩野義製薬株式会社 | 環状ペプチドの膜透過性および／または代謝安定性を改善するシクロプロパンアミノ酸ユニット |
| EP3411413A4 (en) | 2016-02-04 | 2019-09-18 | The Johns Hopkins University | SYNTHESIS AND COMPOSITION OF RAPAFUCINE LIBRARIES |
| WO2017150732A1 (ja) | 2016-03-03 | 2017-09-08 | 中外製薬株式会社 | チオール基をアミノ基近傍に有するアミノ酸をｎ末端に持つ非環状ペプチド－核酸複合体、そのライブラリー、およびそれから誘導される環状ペプチド－核酸複合体ライブラリーの製造方法 |
| EP3442991A4 (en) | 2016-04-15 | 2019-11-20 | RA Pharmaceuticals, Inc. | RAS-BINDING PEPTIDES AND METHODS OF USE |
| IT201600122363A1 (it) | 2016-12-02 | 2018-06-02 | Dolores Fregona | Composti di coordinazione, sintesi, nanoformulazione ed uso degli stessi in oncologia |
| WO2018124162A1 (ja) | 2016-12-28 | 2018-07-05 | 中外製薬株式会社 | 化合物の膜透過性を改善するための自己乳化型製剤 |
| US12391971B2 (en) | 2017-01-31 | 2025-08-19 | Chugai Seiyaku Kabushiki Kaisha | Method for synthesizing peptides in cell-free translation system |
| GB201702938D0 (en) | 2017-02-23 | 2017-04-12 | Univ Southampton | Methods of generating and screening compartmentalised peptides libraries |
| US20200131669A1 (en) | 2017-06-09 | 2020-04-30 | Chugai Seiyaku Kabushiki Kaisha | Cyclic peptide compound having high membrane permeability, and library containing same |
| KR20250007021A (ko) | 2017-06-09 | 2025-01-13 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
| CN111479819B (zh) | 2017-12-15 | 2024-06-14 | 中外制药株式会社 | 制备肽的方法和处理碱的方法 |
| EP3878836B1 (en) | 2018-11-07 | 2025-07-23 | Chugai Seiyaku Kabushiki Kaisha | O-substituted serine derivative production method |
| WO2020111238A1 (ja) | 2018-11-30 | 2020-06-04 | 中外製薬株式会社 | ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法 |
| CN118184532A (zh) | 2018-12-12 | 2024-06-14 | 中外制药株式会社 | 具有能形成分子内氢键的官能团的氨基酸、包含该氨基酸的肽化合物、及其制备方法 |
| WO2020138336A1 (ja) | 2018-12-26 | 2020-07-02 | 中外製薬株式会社 | コドン拡張のための変異ｔＲＮＡ |
| CN113692401A (zh) | 2019-03-15 | 2021-11-23 | 中外制药株式会社 | 芳香族氨基酸衍生物的制备方法 |
| EP4056580A4 (en) | 2019-11-07 | 2023-12-06 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID |
| JP6880352B1 (ja) | 2019-11-07 | 2021-06-02 | 中外製薬株式会社 | Ｋｒａｓ阻害作用を有する環状ペプチド化合物 |
| WO2021117848A1 (ja) | 2019-12-12 | 2021-06-17 | 中外製薬株式会社 | 非天然アミノ酸を含むペプチドの製造方法 |
| KR20220121831A (ko) | 2019-12-26 | 2022-09-01 | 추가이 세이야쿠 가부시키가이샤 | 번역용 조성물 및 펩타이드의 제조 방법 |
| TWI873263B (zh) | 2019-12-27 | 2025-02-21 | 日商中外製藥股份有限公司 | 胜肽化合物的合成法 |
| TW202210498A (zh) | 2020-06-03 | 2022-03-16 | 日商中外製藥股份有限公司 | 高難度序列之有效率的胜肽縮合法 |
| JPWO2021261577A1 (da) | 2020-06-25 | 2021-12-30 | ||
| TW202229306A (zh) | 2020-11-05 | 2022-08-01 | 日商中外製藥股份有限公司 | 抑制由二酮哌嗪形成所導致之缺陷的胜肽合成方法 |
| TW202228654A (zh) | 2020-12-22 | 2022-08-01 | 日商中外製藥股份有限公司 | 包含使用混合溶劑之冷凍乾燥步驟之醫藥品的製造方法 |
| WO2022138891A1 (ja) | 2020-12-25 | 2022-06-30 | 中外製薬株式会社 | Ｎ－置換－アミノ酸残基を含むペプチド化合物の製造方法 |
| CN116547295A (zh) | 2020-12-28 | 2023-08-04 | 中外制药株式会社 | 氨基酸向固相合成用树脂的担载方法 |
| KR102666765B1 (ko) | 2021-05-07 | 2024-05-16 | 추가이 세이야쿠 가부시키가이샤 | 환상 펩타이드 화합물의 의약 용도 |
| CN117279933A (zh) | 2021-05-07 | 2023-12-22 | 中外制药株式会社 | 相对于hras和nras具有选择性kras抑制作用的环状化合物 |
| AR125800A1 (es) | 2021-05-07 | 2023-08-16 | Chugai Pharmaceutical Co Ltd | Métodos para producir compuestos cíclicos que comprendan residuos de aminoácidos sustituidos con n |
| WO2022234639A1 (ja) | 2021-05-07 | 2022-11-10 | 中外製薬株式会社 | 変異型ｒａｓ（ｇ１２ｄ）に対する選択的結合性を示す結合分子 |
| EP4299069A4 (en) | 2021-05-07 | 2025-03-05 | Chugai Seiyaku Kabushiki Kaisha | Preparation containing cyclic peptide compound and method for producing same |
| JPWO2023054636A1 (da) | 2021-09-30 | 2023-04-06 | ||
| KR20240070705A (ko) | 2021-10-13 | 2024-05-21 | 추가이 세이야쿠 가부시키가이샤 | 펩타이드 화합물 및 계면활성제를 포함하는 조성물 |
| KR102844018B1 (ko) | 2021-12-28 | 2025-08-07 | 추가이 세이야쿠 가부시키가이샤 | N-알킬 아미노산, 및 n-알킬 아미노산을 포함하는 펩타이드의 제조 방법 |
| WO2023190283A1 (ja) | 2022-03-28 | 2023-10-05 | 中外製薬株式会社 | ポリオキシエチレン構造を含む油性成分を含有する化合物製剤 |
| WO2023195516A1 (ja) | 2022-04-08 | 2023-10-12 | 中外製薬株式会社 | ペプチド化合物の製造方法 |
| KR20250002095A (ko) | 2022-05-02 | 2025-01-07 | 추가이 세이야쿠 가부시키가이샤 | 계면활성제와 병용하기 위한 펩타이드 화합물을 포함하는 조성물 |
| KR20250006193A (ko) | 2022-05-02 | 2025-01-10 | 추가이 세이야쿠 가부시키가이샤 | 디케토피페라진 형성에 의한 결손을 억제하는 펩티드 합성 방법 |
| AU2023264918A1 (en) | 2022-05-06 | 2025-01-09 | Chugai Seiyaku Kabushiki Kaisha | Cyclic compound having selective kras inhibitory effect on hras and nras |
| TW202430539A (zh) | 2022-10-13 | 2024-08-01 | 日商中外製藥股份有限公司 | 包含ｎ－取代胺基酸殘基的環狀胜肽化合物的製造方法 |
-
2012
- 2012-12-28 TW TW106103188A patent/TWI640541B/zh active
- 2012-12-28 HU HUE12861199A patent/HUE054006T2/hu unknown
- 2012-12-28 EP EP12861199.3A patent/EP2813512B1/en active Active
- 2012-12-28 TW TW107130626A patent/TWI713889B/zh active
- 2012-12-28 EP EP21165014.8A patent/EP3974563A1/en active Pending
- 2012-12-28 TW TW101150926A patent/TWI579296B/zh active
- 2012-12-28 TW TW109139943A patent/TWI787670B/zh active
- 2012-12-28 JP JP2013551857A patent/JP6294080B2/ja active Active
- 2012-12-28 TW TW111144798A patent/TWI852183B/zh active
- 2012-12-28 TW TW113126390A patent/TW202446781A/zh unknown
- 2012-12-28 DK DK12861199.3T patent/DK2813512T3/da active
- 2012-12-28 US US14/368,564 patent/US9409952B2/en active Active
- 2012-12-28 WO PCT/JP2012/084103 patent/WO2013100132A1/ja not_active Ceased
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2016
- 2016-05-27 US US15/166,550 patent/US20160311858A1/en not_active Abandoned
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2018
- 2018-02-15 JP JP2018024856A patent/JP2018118968A/ja not_active Ceased
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2020
- 2020-03-31 JP JP2020062647A patent/JP6961742B2/ja active Active
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2021
- 2021-10-13 JP JP2021167863A patent/JP7297027B2/ja active Active
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2023
- 2023-06-13 JP JP2023096892A patent/JP7749619B2/ja active Active
- 2023-09-01 US US18/460,300 patent/US12415835B2/en active Active
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2025
- 2025-09-24 JP JP2025158195A patent/JP2025186468A/ja active Pending
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