DK2844667T3 - Målrettede/immunomodulatoriske fusionsproteiner og fremgangsmåder til fremstilling deraf - Google Patents

Målrettede/immunomodulatoriske fusionsproteiner og fremgangsmåder til fremstilling deraf Download PDF

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DK2844667T3
DK2844667T3 DK13734158.2T DK13734158T DK2844667T3 DK 2844667 T3 DK2844667 T3 DK 2844667T3 DK 13734158 T DK13734158 T DK 13734158T DK 2844667 T3 DK2844667 T3 DK 2844667T3
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Nagaraj Govindappa
Kedarnath Sastry
Maria Melina Soares
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Biocon Ltd
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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Claims (3)

1. Kimærisk fusionsprotein, som består af en målretningsenhed rettet mod en cancercelle, en immunomodulerende enhed, som modvirker immunologisk tolerance, og en aminosyrespacer, hvor målretningsenheden og den immunomodulerende enhed er forbundne med en aminosyrespacer med tilstrækkelig længde af aminosyrerester, således at begge enheder kan lykkes med at forbindes til deres individuelle mål, hvor den immunomodulerende enhed er TGF-pRIl, som består af aminosyresekvensen SEQ ID NO: 4; hvor aminosyrespaceren er SEQ ID NO: 3 eller SEQ ID NO:11; og hvor målretningsenheden er Anti-EGFR1, som består af en tungkæde SEQ ID NO: 5 og en letkæde SEQ ID NO: 6; hvor SEQ ID NO:4 er bundet via aminosyrespaceren til C-terminus af SEQ ID NO:5 eller SEQ ID NO:6 af Anti-EGFFM.
2. Polynukleotidsekvens, omfattende en nukleinsyresekvens, som koder for et kimærisk fusionsprotein ifølge krav 1.
3. Kimærisk fusionsprotein ifølge krav 1 til anvendelse i behandlingen af en neoplastisk sygdom hos et individ.
DK13734158.2T 2012-04-30 2013-03-13 Målrettede/immunomodulatoriske fusionsproteiner og fremgangsmåder til fremstilling deraf DK2844667T3 (da)

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IN1689CH2012 2012-04-30
IN1690CH2012 2012-04-30
PCT/IB2013/001155 WO2013164694A1 (en) 2012-04-30 2013-03-13 Targeted/immunomodulatory fusion proteins and methods for making same

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US (10) US8815247B2 (da)
EP (4) EP4219536A3 (da)
JP (4) JP6357467B2 (da)
CN (4) CN108503711A (da)
AU (2) AU2013255542C1 (da)
CA (4) CA2871706C (da)
DK (2) DK2844667T3 (da)
ES (2) ES2938182T3 (da)
HK (2) HK1202295A1 (da)
MY (1) MY174248A (da)
NZ (4) NZ722585A (da)
PL (2) PL2844667T3 (da)
PT (2) PT3489254T (da)
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US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
CA2898100C (en) 2013-01-14 2023-10-10 Xencor, Inc. Novel heterodimeric proteins
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
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