DK2858664T3 - Hgh-xten-fusionsprotein og anvendelse deraf i behandling af væksthormonmangel - Google Patents

Hgh-xten-fusionsprotein og anvendelse deraf i behandling af væksthormonmangel Download PDF

Info

Publication number
DK2858664T3
DK2858664T3 DK13712656.1T DK13712656T DK2858664T3 DK 2858664 T3 DK2858664 T3 DK 2858664T3 DK 13712656 T DK13712656 T DK 13712656T DK 2858664 T3 DK2858664 T3 DK 2858664T3
Authority
DK
Denmark
Prior art keywords
hgh
treatment
application
fusion protein
growth hormone
Prior art date
Application number
DK13712656.1T
Other languages
English (en)
Inventor
Jeffrey L Cleland
George M Bright
Eric Humphriss
Volker Schellenberger
Joshua Silverman
Willem P Stemmer
Benjamin Spink
Chia-Wei Wang
Nathan Geething
Original Assignee
Amunix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amunix Pharmaceuticals Inc filed Critical Amunix Pharmaceuticals Inc
Application granted granted Critical
Publication of DK2858664T3 publication Critical patent/DK2858664T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK13712656.1T 2012-06-05 2013-03-14 Hgh-xten-fusionsprotein og anvendelse deraf i behandling af væksthormonmangel DK2858664T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261689390P 2012-06-05 2012-06-05
US201261663475P 2012-06-22 2012-06-22
US201361763753P 2013-02-12 2013-02-12
PCT/US2013/031673 WO2013184216A1 (en) 2012-06-05 2013-03-14 Hgh-xten fusion protein and its use in the treatment of growth hormone deficiency

Publications (1)

Publication Number Publication Date
DK2858664T3 true DK2858664T3 (da) 2019-07-08

Family

ID=47998551

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13712656.1T DK2858664T3 (da) 2012-06-05 2013-03-14 Hgh-xten-fusionsprotein og anvendelse deraf i behandling af væksthormonmangel

Country Status (17)

Country Link
US (2) US20140162949A1 (da)
EP (1) EP2858664B1 (da)
JP (2) JP2015520188A (da)
KR (1) KR20150021072A (da)
CN (2) CN107320719A (da)
AU (1) AU2013272220A1 (da)
BR (1) BR112014030404A2 (da)
CA (1) CA2875827A1 (da)
DK (1) DK2858664T3 (da)
ES (1) ES2733220T3 (da)
HK (1) HK1208629A1 (da)
IL (1) IL236070A0 (da)
MX (1) MX2014014927A (da)
NZ (1) NZ702557A (da)
PH (1) PH12014502738A1 (da)
SG (1) SG11201408152VA (da)
WO (1) WO2013184216A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
CN108530543B (zh) 2009-02-03 2023-06-23 阿穆尼克斯制药公司 延伸重组多肽和包含该延伸重组多肽的组合物
US9849188B2 (en) 2009-06-08 2017-12-26 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
CN105209055A (zh) * 2013-03-11 2015-12-30 阿穆尼克斯运营公司 用人生长激素类似物治疗小儿生长激素缺乏症
IL319047A (en) 2015-08-28 2025-04-01 Amunix Operating Inc Chimeric polypeptide composition and methods for its preparation and use
WO2017136583A1 (en) 2016-02-02 2017-08-10 Versartis, Inc. Growth hormone treatment adherence system
WO2017142331A1 (en) * 2016-02-17 2017-08-24 Genexine, Inc. Pharmaceutical composition comprising recombinant hgh for the treatment of growth hormone deficiency
CN109152816B (zh) * 2016-02-17 2022-08-16 株式会社吉耐森 用于治疗生长激素缺乏症的包含重组hgh的药物组合物
EP3491012A4 (en) * 2016-07-27 2020-07-01 Amunix Operating Inc. TREATING ADULT GROWTH HORMONE WITH ANALOGUE OF HUMAN GROWTH HORMONE
CA3034240C (en) 2016-08-30 2024-04-23 Genexine,Inc. Pharmaceutical composition for treating growth hormone deficiency containing hgh fusion protein
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
JP2021507706A (ja) 2017-12-21 2021-02-25 アムニクス ファーマシューティカルズ， インコーポレイテッド 放出セグメントおよびそれを含む結合組成物
CN120795059A (zh) 2018-08-27 2025-10-17 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
CN116925237A (zh) 2019-12-31 2023-10-24 北京质肽生物医药科技有限公司 Glp-1和gdf15的融合蛋白以及其缀合物
WO2021139744A1 (en) 2020-01-11 2021-07-15 Beijing Ql Biopharmaceutical Co., Ltd. Conjugates of fusion proteins of glp-1 and fgf21
EP4222176A4 (en) 2020-09-30 2024-02-28 Beijing QL Biopharmaceutical Co., Ltd. POLYPEPTIDE CONJUGATES AND METHODS OF USE
CN116554343B (zh) * 2022-01-30 2024-07-12 领诺(上海)医药科技有限公司 一种长效重组人生长激素及其应用
KR20240163717A (ko) 2022-03-30 2024-11-19 베이징 큐엘 바이오파마슈티컬 컴퍼니 리미티드 폴리펩티드 접합체의 액체 약학 조성물 및 그의 사용 방법
CN116003632B (zh) * 2022-12-07 2026-02-24 北京大学 长效缓释型人重组生长激素融合蛋白及其药物组合物和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4898830A (en) 1979-07-05 1990-02-06 Genentech, Inc. Human growth hormone DNA
US5206161A (en) 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
WO1998052976A1 (en) 1997-05-21 1998-11-26 Biovation Limited Method for the production of non-immunogenic proteins
US6406632B1 (en) 1998-04-03 2002-06-18 Symyx Technologies, Inc. Rapid characterization of polymers
GB9815157D0 (en) 1998-07-13 1998-09-09 Metron Designs Ltd High resolution pulse width setting from relatively low frequency clocks
US20030228309A1 (en) 2000-11-08 2003-12-11 Theodora Salcedo Antibodies that immunospecifically bind to TRAIL receptors
WO2002079415A2 (en) 2001-03-30 2002-10-10 Lexigen Pharmaceuticals Corp. Reducing the immunogenicity of fusion proteins
US7294513B2 (en) 2002-07-24 2007-11-13 Wyatt Technology Corporation Method and apparatus for characterizing solutions of small particles
CN108530543B (zh) * 2009-02-03 2023-06-23 阿穆尼克斯制药公司 延伸重组多肽和包含该延伸重组多肽的组合物
US8680050B2 (en) * 2009-02-03 2014-03-25 Amunix Operating Inc. Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same
US8703717B2 (en) * 2009-02-03 2014-04-22 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
DK2440241T3 (da) 2009-06-08 2017-10-02 Amunix Operating Inc Væksthormon-polypeptider og fremgangsmåder til fremstilling og anvendelse deraf

Also Published As

Publication number Publication date
IL236070A0 (en) 2015-01-29
JP2017125051A (ja) 2017-07-20
JP2015520188A (ja) 2015-07-16
KR20150021072A (ko) 2015-02-27
NZ702557A (en) 2017-06-30
WO2013184216A1 (en) 2013-12-12
PH12014502738A1 (en) 2015-02-02
EP2858664B1 (en) 2019-05-08
CN107320719A (zh) 2017-11-07
SG11201408152VA (en) 2015-01-29
MX2014014927A (es) 2015-05-15
US20180051063A1 (en) 2018-02-22
EP2858664A1 (en) 2015-04-15
CN104519903A (zh) 2015-04-15
BR112014030404A2 (pt) 2017-06-27
ES2733220T3 (es) 2019-11-28
AU2013272220A1 (en) 2015-01-15
CA2875827A1 (en) 2013-12-12
HK1208629A1 (en) 2016-03-11
US20140162949A1 (en) 2014-06-12

Similar Documents

Publication Publication Date Title
IL269020B (en) Therapeutic nuclease compositions and methods
DK3744835T5 (da) Dna modificerende fusionsproteiner og metoder til anvendelse deraf
DK3489254T3 (da) Målrettede/immunmodulatoriske fusionsproteiner og fremgangsmåder til fremstilling deraf
DK3310805T3 (da) Pd-1-cd28-fusionsproteiner og anvendelse deraf i medicin
DK3604339T3 (da) Terapeutiske antistoffer mod ror-1-protein og fremgangsmåder til anvendelse af samme
DK3321287T3 (da) Fusionsproteiner og kombinationsvacciner
CL2014003605A1 (es) Proteínas de fusión de interleuquina-10 y usos de las mismas
DK3434775T3 (da) Protein med nukleaseaktivitet, fusionsproteiner og anvendelser deraf
SI2726092T1 (sl) Serpin fuzijski polipeptidi in načini njihove uporabe
IL236070A0 (en) The intraxten-hgh protein and its use in the treatment of growth hormone deficiency
DK2970398T3 (da) Præfusions-rsv-f-proteiner og anvendelse deraf
DK3199547T3 (da) Antistoflignende bindingsproteiner med dobbelt variabel region og overkrydsende orientering af bindingsregion
DK3019533T3 (da) Dobbeltspiraliserede immunoglobulinfusionproteiner og sammensætninger deraf
DK3060237T3 (da) Modificeret omprogrammeringsprotein til anvendelse i behandling af cancer
DK2780022T4 (da) Farmaceutiske præparater af humane rpe-celler og anvendelser deraf
DK2945647T3 (da) Immunogene wt-1-peptider og anvendelsesmetoder deraf
DK2806892T3 (da) Kombineret terapeutisk anvendelse af antistoffer og endoglycosidaser
DK3358011T3 (da) Peptid til inducering af regenerering af væv og anvendelse deraf
DK2547771T3 (da) Fremstilling af proteiner og polypeptider
IL229723A0 (en) Human fusion proteins including interferons and modified targeted ubiquitin proteins
DK3173102T3 (da) FGFR-FC-fusionsprotein og anvendelse deraf
DK3074008T3 (da) Forbindelser, farmaceutisk sammensætning og fremgangsmåder til anvendelse i behandling af inflammation
DK2782598T3 (da) Rekombinante proteiner og terapeutiske anvendelser deraf
DK2914630T3 (da) Hidtil ukendte antigen-bindende proteiner og deres anvendelse som adresseringsprodukt til behandling af kræft
HRP20181210T1 (hr) Fuzijski protein koji sadrži interleukin 4 i interleukin 10