DK3744835T5 - Dna modificerende fusionsproteiner og metoder til anvendelse deraf - Google Patents

Dna modificerende fusionsproteiner og metoder til anvendelse deraf Download PDF

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Publication number
DK3744835T5
DK3744835T5 DK20183740.8T DK20183740T DK3744835T5 DK 3744835 T5 DK3744835 T5 DK 3744835T5 DK 20183740 T DK20183740 T DK 20183740T DK 3744835 T5 DK3744835 T5 DK 3744835T5
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Prior art keywords
methods
fusion proteins
dna modifying
modifying fusion
dna
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DK20183740.8T
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English (en)
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DK3744835T3 (da
Inventor
Keith J Joung
Morgan Maeder
James Angstman
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Massachusetts Gen Hospital
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK20183740.8T 2012-05-29 2013-05-29 Dna modificerende fusionsproteiner og metoder til anvendelse deraf DK3744835T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261652711P 2012-05-29 2012-05-29
US13/838,520 US9890364B2 (en) 2012-05-29 2013-03-15 TAL-Tet1 fusion proteins and methods of use thereof
EP13797024.0A EP2879693B1 (en) 2012-05-29 2013-05-29 Dna modifying fusion proteins and methods of use thereof

Publications (2)

Publication Number Publication Date
DK3744835T3 DK3744835T3 (da) 2024-05-06
DK3744835T5 true DK3744835T5 (da) 2024-08-26

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DK20183740.8T DK3744835T5 (da) 2012-05-29 2013-05-29 Dna modificerende fusionsproteiner og metoder til anvendelse deraf

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US (4) US9890364B2 (da)
EP (4) EP4368249A3 (da)
DK (1) DK3744835T5 (da)
ES (1) ES2979326T3 (da)
PT (1) PT3744835T (da)
WO (1) WO2013181228A1 (da)

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Also Published As

Publication number Publication date
EP4368249A3 (en) 2024-07-24
EP3747999A1 (en) 2020-12-09
EP3747999B1 (en) 2021-09-15
US20180187168A1 (en) 2018-07-05
EP2879693B1 (en) 2020-07-08
PT3744835T (pt) 2024-05-31
US20210155907A1 (en) 2021-05-27
EP3744835B1 (en) 2024-01-31
US10894950B2 (en) 2021-01-19
US12152254B2 (en) 2024-11-26
WO2013181228A1 (en) 2013-12-05
DK3744835T3 (da) 2024-05-06
US20130323220A1 (en) 2013-12-05
US20250115884A1 (en) 2025-04-10
EP3744835A1 (en) 2020-12-02
EP2879693A1 (en) 2015-06-10
US9890364B2 (en) 2018-02-13
EP4368249A2 (en) 2024-05-15
EP2879693A4 (en) 2016-04-13
ES2979326T3 (es) 2024-09-25

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