DK2906227T3 - Galactose-holdige kulhydratforbindelser til behandlingen af diabetisk nefropati og associerede lidelser - Google Patents
Galactose-holdige kulhydratforbindelser til behandlingen af diabetisk nefropati og associerede lidelser Download PDFInfo
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- DK2906227T3 DK2906227T3 DK13844631.5T DK13844631T DK2906227T3 DK 2906227 T3 DK2906227 T3 DK 2906227T3 DK 13844631 T DK13844631 T DK 13844631T DK 2906227 T3 DK2906227 T3 DK 2906227T3
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- reduction
- rhamnogalacturonate
- residues
- galactoarabino
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Claims (9)
1. Sammensætning til parenteral eller enteral administration omfattende et galactoarabino-rhamnogalacturonat i en farmaceutisk acceptabel bærer, hvor galactoarabino-rhamnogalacturonatet er et galactoarabino-rhamnogalacturonat omfattende en 1,4-forbundet galacturonsyre (GalA) og methylgalacturonat-(MeGalA)-rester backbone forbundet til forgrenede heteropolymerer af skiftevis oligomerer af a-l,2-forbundne rhamnose og a-1,4-forbundne GalA-rester, hvor rhamnose-resterne bærer en primær forgrening af oligomerer af l,4-p-D-galactose rester, 1,5-a-L-arabinose rester, eller kombinationer deraf, hvor molprocenten af l,4-p-D-Gal-, 1,5-a-L-Ara-resterne og kombination deraf er mindst 8 % af de totale molære kulhydrater, hvor l,4-p-D-Gal- og 1,5-a-L-Ara-resterne er til stede i et forhold i området fra 1:1 til 3:1, hvor galactoarabino-rhamnogalacturonatet har en grad af methoxylering i området fra 40 % til 70 %, til anvendelse i en fremgangsmåde omfattende at administrere til et individ med behov deraf en effektiv dosis af sammensætningen, som resulterer i mindst én af de følgende: mindst en 10 % reduktion i proteinuri eller mindst en 10 % reduktion i tilvækstraten af proteinuri; mindst en 10 % stigning i glomerulær filtreringshastighed eller mindst en 10 % reduktion i nedgangsraten af glomerulær filtreringshastighed; mindst en 10 % reduktion af mesangial ekstracellulær matrix eller mindst en 10 % reduktion i tilvækstraten af mesangial ekstracellulær matrix; mindst en 5 % reduktion i den glomerulære kapillære basalmembrantykkelse; mindst en 10 % reduktion i det fraktionale volumen af mesangiet eller mindst en 10 % reduktion i tilvækstraten af det fraktionale volumen af mesangiet; mindst en 10 % reduktion i det interstitielle rørvolumen eller mindst en 10 % reduktion i tilvækstraten i det interstitielle volumen; mindst en 10 % reduktion i mængden af kollagen i det interstitielle rørrum eller mindst en 10 % reduktion i tilvækstraten af kollagenet i det interstitielle rørrum; mindst 10 % ændring i niveauet af serumbiomarkørerne af diabetisk nefropati; hvor individet med behov deraf har mindst én af de følgende: en primær glomerulopatisk sygdom, en sekundær glomerulopatisk sygdom, og nyrekanal-interstitiel lidelse.
2. Sammensætning omfattende en effektiv dosis af galactoarabino- rhamnogalacturonat i en acceptabel farmaceutisk bærer til anvendelse i behandling af diabetisk nefropati, hvor galactoarabino-rhamnogalacturonatet omfatter en 1,4-forbundet galacturonsyre (GalA) og methylgalacturonat-(MeGalA)-rester backbone forbundet til forgrenede heteropolymerer af skiftevis oligomerer af a-1,2 forbundet rhamnose og a-l,4-forbundet GalA-rester, rhamnose-resterne bærer en primær forgrening af oligomerer af 1,4-β-ϋ-galactose rester, 1,5-a-L-arabinose rester, eller kombinationer deraf, hvor molprocenten af 1,4^-D-Gal, 1,5-a-L-Ara-resterne og kombination deraf er mindst 8 % af de totale molære kulhydrater, hvor 1,4^-D-Gal og 1,5-a-L-Ara-resterne er til stede i et forhold i området fra 1:1 til 3:1, hvor galactoarabino-rhamnogalacturonatet har en grad af methoxylering i området fra 40 % til 70 %.
3. Sammensætningen til anvendelse ifølge krav 1 eller krav 2, hvor galactoarabino-rhamnogalacturonatet har en gennemsnitlig molekylevægtfordeling på 20.000 til 70.000 Dalton, som bestemt ved SEC-RI og/eller SEC-MALLS-fremgangsmåderne.
4. Sammensætningen til anvendelse ifølge krav 1 eller krav 2, hvor galactoarabino-rhamnogalacturonatet har et forhold af methylgalacturonat plus galacturonsyre til galactose i området fra 4:1 til 7:1.
5. Sammensætningen til anvendelse ifølge krav 1 eller krav 2, hvor sammensætningen yderligere omfatter en eller flere galectin-inhibitorer, hvor galectin-inhibitorerne eventuelt omfatter små organiske inhibitorer af galectin, monoklonale antistoffer, RNA-inhibitorer, små bindingspeptider, protein-inhibitorer eller kombinationer deraf.
6. Sammensætningen ifølge krav 1 eller krav 2, hvor galactoarabino- rhamnogalacturonatet er afledt fra æblepektin.
7. Sammensætningen til anvendelse ifølge krav 1 eller krav 2, hvor galactoarabino-rhamnogalacturonatet har en gennemsnitlig molekylevægtfordeling på 2.000 til 80.000 Dalton, som bestemt ved SEC-RI og/eller SEC-MALLS-fremgangsmåderne.
8. Sammensætningen til anvendelse ifølge krav 1 eller krav 2, hvor galactoarabino-rhamnogalacturonatet har en gennemsnitlig molekylevægtfordeling på 5.000 til 55.000 Dalton, som bestemt ved SEC-RI og/eller SEC-MALLS-fremgangsmåderne.
9. Sammensætningen til anvendelse ifølge krav 1 eller krav 2, hvor den effektive dosis af galactoarabino-rhamnogalacturonat er ækvivalent med en dyredosis på 0,1 mg/kg til 1,99 mg/kg dyrekropsvægt og eventuelt i området fra 0,05 til 0,19 mg/kg kropsvægt.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261711929P | 2012-10-10 | 2012-10-10 | |
| PCT/US2013/064322 WO2014059135A1 (en) | 2012-10-10 | 2013-10-10 | Galactose-pronged carbohydrate compounds for the treatment of diabetic nephropathy and associated disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2906227T3 true DK2906227T3 (da) | 2018-12-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13844631.5T DK2906227T3 (da) | 2012-10-10 | 2013-10-10 | Galactose-holdige kulhydratforbindelser til behandlingen af diabetisk nefropati og associerede lidelser |
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| US (1) | US8828971B2 (da) |
| EP (1) | EP2906227B1 (da) |
| JP (1) | JP6055928B2 (da) |
| KR (1) | KR102231732B1 (da) |
| CN (1) | CN104822382B9 (da) |
| AU (1) | AU2013329148B2 (da) |
| BR (1) | BR112015007985A8 (da) |
| CA (1) | CA2926917C (da) |
| DK (1) | DK2906227T3 (da) |
| ES (1) | ES2698101T3 (da) |
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| MX (1) | MX363178B (da) |
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| JP6707548B2 (ja) | 2015-01-16 | 2020-06-10 | ガレクト・バイオテック・エイビイ | ガレクチンの新規なガラクトシド阻害剤 |
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| CA3000924A1 (en) | 2015-11-09 | 2017-05-18 | Galecto Biotech Ab | Novel galactoside inhibitors of galectins |
| US10988502B2 (en) | 2016-07-12 | 2021-04-27 | Galecto Biotech Ab | Alpha-D-galactoside inhibitors of galectins |
| CA3025867A1 (en) | 2016-07-12 | 2018-01-18 | Galecto Biotech Ab | Alpha-d-galactoside inhibitors of galectins |
| EP3621973A4 (en) | 2017-05-12 | 2021-10-27 | Galectin Sciences, LLC | COMPOUNDS FOR THE PREVENTION AND TREATMENT OF DISEASES AND USES THEREOF |
| WO2019067702A1 (en) | 2017-09-27 | 2019-04-04 | Bristol-Myers Squibb Company | INHIBITORS WITH SMALL MOLECULES OF GALECTIN-3 |
| US11072626B2 (en) | 2017-10-11 | 2021-07-27 | Bristol-Myers Squibb Company | Small molecule inhibitors of Galectin-3 |
| JP2021510692A (ja) | 2018-01-10 | 2021-04-30 | ガレクト バイオテック エービー | ガレクチンの新規なガラクトシド阻害剤 |
| CN112292386B (zh) | 2018-06-15 | 2024-06-11 | 百时美施贵宝公司 | 作为半乳凝素-3抑制剂的基于四氢吡喃的硫代二糖模拟物 |
| CN113286632A (zh) | 2018-10-15 | 2021-08-20 | 格莱克特生物技术公司 | 半乳糖凝集素的半乳糖苷抑制剂前药 |
| JP2022508720A (ja) | 2018-10-15 | 2022-01-19 | ガレクト バイオテック エービー | ガレクチンのガラクトシド阻害剤 |
| WO2020104335A1 (en) | 2018-11-21 | 2020-05-28 | Galecto Biotech Ab | Alpha-d-galactoside inhibitors of galectins |
| KR20210100139A (ko) | 2018-12-06 | 2021-08-13 | 브리스톨-마이어스 스큅 컴퍼니 | 갈렉틴-3의 소분자 억제제 |
| EP3947407B1 (en) | 2019-03-26 | 2024-06-12 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| US12269819B2 (en) | 2019-04-10 | 2025-04-08 | Bristol-Myers Squibb Company | Small molecule inhibitors of Galectin-3 |
| US12410207B2 (en) | 2019-07-03 | 2025-09-09 | Galecto Biotech Ab | Galactoside inhibitor of galectins |
| JP7674276B2 (ja) | 2019-07-03 | 2025-05-09 | ガレクト バイオテック エービー | ガレクチンの新規なガラクトシド阻害剤 |
| WO2021004940A1 (en) | 2019-07-05 | 2021-01-14 | Galecto Biotech Ab | Novel galactoside inhibitor of galectins |
| WO2021028323A1 (en) | 2019-08-09 | 2021-02-18 | Idorsia Pharmaceuticals Ltd | (2-acetamidyl)thio-beta-d-galactopyranoside derivatives |
| CN114206893A (zh) | 2019-08-09 | 2022-03-18 | 爱杜西亚药品有限公司 | (杂)芳基-甲基-硫代-β-D-吡喃半乳糖苷衍生物 |
| MA56883B1 (fr) | 2019-08-15 | 2025-04-30 | Idorsia Pharmaceuticals Ltd | Dérivés de 2-hydroxycycloalcane-1-carbamoyle |
| CN114585619B (zh) | 2019-08-29 | 2024-09-27 | 爱杜西亚药品有限公司 | α-D-吡喃半乳糖苷衍生物 |
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| US12286424B2 (en) | 2020-05-11 | 2025-04-29 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| KR20230018431A (ko) | 2020-05-28 | 2023-02-07 | 브리스톨-마이어스 스큅 컴퍼니 | 갈렉틴-3 억제제 |
| US12312362B2 (en) | 2020-10-06 | 2025-05-27 | Idorsia Pharmaceuticals Ltd | Spiro derivatives of Alpha-D-galactopyranosides |
| EP4237419A1 (en) | 2020-11-02 | 2023-09-06 | Idorsia Pharmaceuticals Ltd | Galectin-3 inhibiting 2-hydroxycycloalkane-1 -carbamoyl derivatives |
| CN116806219A (zh) | 2021-02-09 | 2023-09-26 | 爱杜西亚药品有限公司 | 羟基杂环烷-氨甲酰基衍生物 |
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| BR112015007985A8 (pt) | 2019-08-27 |
| JP6055928B2 (ja) | 2016-12-27 |
| IL238180A0 (en) | 2015-05-31 |
| US8828971B2 (en) | 2014-09-09 |
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| JP2015533166A (ja) | 2015-11-19 |
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| EP2906227B1 (en) | 2018-10-03 |
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| EP2906227A1 (en) | 2015-08-19 |
| US20140099319A1 (en) | 2014-04-10 |
| KR102231732B1 (ko) | 2021-03-23 |
| AU2013329148A1 (en) | 2015-04-30 |
| MX2015004644A (es) | 2016-01-12 |
| CN104822382A (zh) | 2015-08-05 |
| CN104822382B (zh) | 2018-10-30 |
| CA2926917C (en) | 2021-01-05 |
| AU2013329148B2 (en) | 2018-03-29 |
| EP2906227A4 (en) | 2016-06-08 |
| BR112015007985A2 (pt) | 2017-07-04 |
| MX363178B (es) | 2019-03-13 |
| KR20150081431A (ko) | 2015-07-14 |
| CN104822382B9 (zh) | 2019-01-18 |
| CA2926917A1 (en) | 2014-04-17 |
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