DK2930236T3 - Polynukleotid, der koder for en acyl-CoA-syntetasehomolog, samt fremgangsmåde til dets anvendelse - Google Patents

Polynukleotid, der koder for en acyl-CoA-syntetasehomolog, samt fremgangsmåde til dets anvendelse Download PDF

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DK2930236T3
DK2930236T3 DK15153586.1T DK15153586T DK2930236T3 DK 2930236 T3 DK2930236 T3 DK 2930236T3 DK 15153586 T DK15153586 T DK 15153586T DK 2930236 T3 DK2930236 T3 DK 2930236T3
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Misa Ochiai
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Suntory Holdings Ltd
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Claims (11)

1. Polynukleotid i overensstemmelse med et vilkårligt blandt (a) til (e) nedenfor valgt kendetegn: (a) et polynukleotid, der omfatter en nukleotidsekvens ifølge SEQ ID NO: 56; (b) et polynukleotid, der koder for et protein, som består af aminosyresekvensen ifølge SEQ ID NO: 57; (c) et polynukleotid, der koder for et protein, som består af en aminosyresekvens, hvori 1 til 100 aminosyrer er fjernet, erstattet, indsat og/eller tilføjet i aminosyresekvensen ifølge SEQ ID NO: 57, og har acyl-CoA-syntetaseaktivitet eller aktivitet til forøgelse af mængden eller ændring af sammensætningen af de i en værtscelle producerede fedtsyrer, når det udtrykkes i værtscellen; (d) et polynukleotid, der koder for et protein, der har en aminosyresekvens med mindst 60% identitet med aminosyresekvensen ifølge SEQ ID NO: 57 og har acyl-CoA-syntetaseaktivitet eller aktivitet til forøgelse af mængden eller ændring af sammensætningen af de i en værtscelle producerede fedtsyrer, når det udtrykkes i værtscellen; og (e) et polynukleotid, der hybridiserer til et polynukleotid, som består af en nukleotidsekvens, som er komplementær til nukleotidsekvensen ifølge SEQ ID NO: 56 under betingelserne 5x SSC, 5x Denhardt’s opløsning, 0,5% SDS, 50% formamid ved 50°C eller 0,2x SSC, 0,1% SDS ved 65°C, og som koder for et protein med acyl-CoA-syntetaseaktivitet eller aktivitet til forøgelse af mængden eller ændring af sammensætningen af de i en værtscelle producerede fedtsyrer, når det udtrykkes i værtscellen.
2. Polynukleotid ifølge krav 1, som er det ene eller det andet i (f) eller (g) nedenfor definerede: (f) et polynukleotid, der koder for et protein, som består af en aminosyresekvens, hvori 1 til 10 aminosyrer er fjernet, erstattet, indsat og/eller tilføjet i aminosyresekvensen ifølge SEQ ID NO: 57, og som har acyl-CoA-syntetaseaktivitet eller aktivitet til forøgelse af mængden eller ændring af sammensætningen af de i en værtscelle producerede fedtsyrer, når det udtrykkes i værtscellen; og (g) et polynukleotid, der koder for et protein, som har en aminosyresekvens med mindst 90% identitet med aminosyresekvensen ifølge SEQ ID NO: 57 og har acyl-CoA-syntetaseaktivitet eller aktivitet til forøgelse af mængden eller ændring af sammensætningen af i en værtscelle producerede fedtsyrer, når det udtrykkes i værtscellen.
3. Polynukleotid ifølge krav 1 omfattende nukleotidsekvensen ifølge SEQ ID NO: 56.
4. Polynukleotid ifølge krav 1, der koder for et protein, som består af aminosyre-sekvensen ifølge SEQ ID NO: 57.
5. Polynukleotid ifølge et hvilket som helst af kravene 1 til 4, som er DNA.
6. Protein, der kodes for af polynukleotidet ifølge et hvilket som helst af kravene 1 til 5.
7. Vektor omfattende polynukleotidet ifølge et hvilket som helst af kravene 1 til 5.
8. Værtscelle, i hvilken polynukleotidet ifølge et hvilket som helst af kravene 1 til 5 eller vektoren ifølge krav 7 er indført.
9. Fremgangsmåde til fremstilling af en lipid- eller fedtsyresammensætning, som omfatter opsamling af lipid- eller fedtsyresammensætningen fra kulturen af transformanten ifølge krav 8.
10. Fremgangsmåde ifølge krav 9, ved hvilken lipidet er en triacylglycerol.
11. Fremgangsmåde ifølge krav 9, ved hvilken fedtsyren er en flerumættet fedtsyre med mindst 18 carbonatomer.
DK15153586.1T 2010-02-01 2011-02-01 Polynukleotid, der koder for en acyl-CoA-syntetasehomolog, samt fremgangsmåde til dets anvendelse DK2930236T3 (da)

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JP2010019967 2010-02-01
EP11737218.5A EP2537927B1 (en) 2010-02-01 2011-02-01 Polynucleotide encoding acyl-coa synthetase homolog and method for using the same

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DK15153586.1T DK2930236T3 (da) 2010-02-01 2011-02-01 Polynukleotid, der koder for en acyl-CoA-syntetasehomolog, samt fremgangsmåde til dets anvendelse
DK14157739.5T DK2772538T3 (da) 2010-02-01 2011-02-01 Polynukleotid, som koder for en acyl-CoA-syntetasehomolog og fremgangsmåde til anvendelse heraf
DK11737218.5T DK2537927T3 (da) 2010-02-01 2011-02-01 Polynukleotid, der koder for en acyl-CoA-syntetasehomolog, samt fremgangsmåde til dets anvendelse

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DK11737218.5T DK2537927T3 (da) 2010-02-01 2011-02-01 Polynukleotid, der koder for en acyl-CoA-syntetasehomolog, samt fremgangsmåde til dets anvendelse

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KR (3) KR101709384B1 (da)
CN (3) CN104388438A (da)
AU (1) AU2011211291B2 (da)
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US9820504B2 (en) 2013-03-08 2017-11-21 Axiom Foods, Inc. Rice protein supplement and methods of use thereof
WO2014138304A1 (en) 2013-03-08 2014-09-12 Axiom Foods, Inc., Rice protein supplements
EP3369823A4 (en) * 2015-10-30 2019-04-03 Suntory Holdings Limited METHOD FOR PRODUCING STEVIOL AND STEVIOL GLYCOSIDE WITH AN AOBGL3 HOMOLOG
CN109477126B (zh) * 2016-07-19 2023-06-20 三得利控股株式会社 罗汉果醇或罗汉果醇糖苷的生产方法
EP3634155A4 (en) 2017-05-12 2021-02-17 Axiom Foods Inc. RICE PRODUCTS AND SYSTEMS AND PROCESSES FOR THEIR PRODUCTION

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