DK293890A - 3-oe2,(4-arylpiperazin1-yl)-ethoxylaap-cymen, derivater deraf, som er ortho-, meta- og paramonosubstituerede eller -disubstituerede paa phenylringen, fremgangsmaade til fremstilling af saadanne derivater samt laegemidler, hvori forbindelserne er til stede som det aktive middel - Google Patents
3-oe2,(4-arylpiperazin1-yl)-ethoxylaap-cymen, derivater deraf, som er ortho-, meta- og paramonosubstituerede eller -disubstituerede paa phenylringen, fremgangsmaade til fremstilling af saadanne derivater samt laegemidler, hvori forbindelserne er til stede som det aktive middel Download PDFInfo
- Publication number
- DK293890A DK293890A DK293890A DK293890A DK293890A DK 293890 A DK293890 A DK 293890A DK 293890 A DK293890 A DK 293890A DK 293890 A DK293890 A DK 293890A DK 293890 A DK293890 A DK 293890A
- Authority
- DK
- Denmark
- Prior art keywords
- paze
- paramonous
- ethoxylap
- cymene
- ortho
- Prior art date
Links
- 229930007927 cymene Natural products 0.000 title 1
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- -1 phenoxy, benzyloxy Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8807864 | 1988-06-13 | ||
| FR8807864A FR2632641B1 (fr) | 1988-06-13 | 1988-06-13 | ((aryl-4-piperazinyl-1)-2 ethoxy)-3 p-cymene, les derives ortho, meta, para monosubstitues ou disubstitues sur le noyau phenyle dudit produit, le procede de preparation desdits derives, et les medicaments contenant lesdits composes comme principe actif |
| FR8900298 | 1989-06-13 | ||
| PCT/FR1989/000298 WO1989012634A1 (fr) | 1988-06-13 | 1989-06-13 | [(aryl-4-piperazinyl-1)-2 ethoxy]-3 p-cymene, les derives ortho, meta, para monosubstitues ou disubstitues sur le noyau phenyle dudit produit, le procede de preparation desdits derives, et les medicaments contenant lesdits composes comme principe actif |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK293890D0 DK293890D0 (da) | 1990-12-11 |
| DK293890A true DK293890A (da) | 1990-12-11 |
| DK168071B1 DK168071B1 (da) | 1994-01-31 |
Family
ID=9367221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK293890A DK168071B1 (da) | 1988-06-13 | 1990-12-11 | 3-oe2-(4-phenylpiperazin-l-yl)-ethoxyaa-p-cymen, derivater deraf, som er ortho-, meta- og para-monosubstituerede eller -disubstituerede paa phenylringen, fremgangsmaade til fremstilling af saadanne derivater, laegemidler, hvori forbindelserne er til stede som det aktive middel samt anvendelse af derivaterne til fremstilling af laegemidler |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5110816A (da) |
| EP (2) | EP0445116A1 (da) |
| JP (1) | JPH03505456A (da) |
| AT (1) | ATE89276T1 (da) |
| DE (1) | DE68906466T2 (da) |
| DK (1) | DK168071B1 (da) |
| FR (1) | FR2632641B1 (da) |
| WO (1) | WO1989012634A1 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4410822A1 (de) * | 1994-03-24 | 1995-09-28 | Schering Ag | Neue Piperidin-Derivate |
| DE69521687T2 (de) | 1994-03-30 | 2001-10-25 | Zeria Pharmaceutical Co., Ltd. | 4-indol-1-yl-buttersäure derivate, deren herstellung und deren verwendung als inhibitoren für alpha1-adrenerge rezeptoren und testosteron 5alpha-reduktasen |
| ATE294778T1 (de) * | 1995-01-23 | 2005-05-15 | Daiichi Suntory Pharma Co Ltd | Verbesserung oder heilung von durch ischämischen krankheiten hervorgerufenen symtomen und dafür verwendbare phenylpiperidinverbingungen |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1349636A (fr) * | 1962-02-26 | 1964-01-17 | Soc Ind Fab Antibiotiques Sifa | Nouveaux dérivés de la pipérazine, et procédé de préparation |
| CA967965A (en) * | 1968-12-24 | 1975-05-20 | Hoffmann-La Roche Limited | Aromatic ethers and process for the manufacture thereof |
| FR2515648A1 (fr) * | 1981-11-03 | 1983-05-06 | Cortial | Nouvelles (phenyl-4 piperazinylethyl)-2 anilines, leur methode de preparation et leur application therapeutique |
| FR2515647A1 (fr) * | 1981-11-03 | 1983-05-06 | Cortial | Nouvelles imines derivees de (phenyl-4 piperazinylethyl)-2 anilines, leur methode de preparation et leur application therapeutique |
| EP0173634B1 (fr) * | 1984-08-07 | 1988-08-31 | Cortial S.A. | Nouveaux dérivés d'(arylpipérazinyléthylaminoéthoxy)-4 phénol, leur méthode de préparation et leur application thérapeutique |
| FR2568878B1 (fr) * | 1984-08-07 | 1986-11-21 | Cortial | Nouveaux derives de (phenylpiperazinylethylamine ethoxy)-4 phenol, leur methode de preparation et leur application therapeutique |
| EP0179009A1 (fr) * | 1984-09-19 | 1986-04-23 | Cortial S.A. | Nouvelles n1-(aminoalcoxy)-4 isopropyl-5 phénoxy)-2 éthyl n4-phényl pipérazines, leur méthode de préparation et leur application thérapeutique |
| DE3604941A1 (de) * | 1986-02-17 | 1987-08-20 | Heumann Pharma Gmbh & Co | Phenylpiperazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| FR2595357B1 (fr) * | 1986-03-04 | 1988-07-08 | Irceba | (piperidino-3 propoxy)-5 p.cymene, les derives acetyl, acetoxy et hydroxy dudit produit, les sels de ces produits, un procede de preparation desdits produits et les medicaments contenant au moins un de ces produits comme principe actif |
-
1988
- 1988-06-13 FR FR8807864A patent/FR2632641B1/fr not_active Expired - Lifetime
-
1989
- 1989-06-13 DE DE8989401640T patent/DE68906466T2/de not_active Expired - Fee Related
- 1989-06-13 EP EP89907194A patent/EP0445116A1/fr active Pending
- 1989-06-13 WO PCT/FR1989/000298 patent/WO1989012634A1/fr not_active Ceased
- 1989-06-13 JP JP1507008A patent/JPH03505456A/ja active Pending
- 1989-06-13 EP EP89401640A patent/EP0347305B1/fr not_active Expired - Lifetime
- 1989-06-13 AT AT89401640T patent/ATE89276T1/de active
- 1989-06-13 US US07/623,718 patent/US5110816A/en not_active Expired - Fee Related
-
1990
- 1990-12-11 DK DK293890A patent/DK168071B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK293890D0 (da) | 1990-12-11 |
| FR2632641B1 (fr) | 1990-10-12 |
| EP0347305A1 (fr) | 1989-12-20 |
| EP0347305B1 (fr) | 1993-05-12 |
| DK168071B1 (da) | 1994-01-31 |
| ATE89276T1 (de) | 1993-05-15 |
| WO1989012634A1 (fr) | 1989-12-28 |
| DE68906466D1 (de) | 1993-06-17 |
| JPH03505456A (ja) | 1991-11-28 |
| EP0445116A1 (fr) | 1991-09-11 |
| US5110816A (en) | 1992-05-05 |
| DE68906466T2 (de) | 1993-09-09 |
| FR2632641A1 (fr) | 1989-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |