DK29491A - O-glycosyleret igf-1 - Google Patents

O-glycosyleret igf-1 Download PDF

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Publication number
DK29491A
DK29491A DK029491A DK29491A DK29491A DK 29491 A DK29491 A DK 29491A DK 029491 A DK029491 A DK 029491A DK 29491 A DK29491 A DK 29491A DK 29491 A DK29491 A DK 29491A
Authority
DK
Denmark
Prior art keywords
igf
glycosylated
glycosylated igf
expressed
obtaining
Prior art date
Application number
DK029491A
Other languages
English (en)
Other versions
DK29491D0 (da
DK175360B1 (da
Inventor
Anna Skottner-Lundin
Linda Fryklund
Paer Gellerfors
Original Assignee
Kabi Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab
Publication of DK29491D0 publication Critical patent/DK29491D0/da
Publication of DK29491A publication Critical patent/DK29491A/da
Application granted granted Critical
Publication of DK175360B1 publication Critical patent/DK175360B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK199100294A 1988-08-20 1991-02-20 O-glycosyleret IGF-1 og farmaceutisk sammensætning indeholdende O-glycosyleret IGF-1 samt fremgangsmåder til fremstilling af begge DK175360B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB888819826A GB8819826D0 (en) 1988-08-20 1988-08-20 Glycosylated igf-1
GB8819826 1988-08-20
EP8900972 1989-08-17
PCT/EP1989/000972 WO1990002198A1 (en) 1988-08-20 1989-08-17 O-glycosylated igf-1

Publications (3)

Publication Number Publication Date
DK29491D0 DK29491D0 (da) 1991-02-20
DK29491A true DK29491A (da) 1991-04-19
DK175360B1 DK175360B1 (da) 2004-09-13

Family

ID=10642464

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199100294A DK175360B1 (da) 1988-08-20 1991-02-20 O-glycosyleret IGF-1 og farmaceutisk sammensætning indeholdende O-glycosyleret IGF-1 samt fremgangsmåder til fremstilling af begge

Country Status (15)

Country Link
US (1) US5273966A (da)
EP (2) EP0429502A1 (da)
JP (1) JP2543998B2 (da)
AT (1) ATE109206T1 (da)
AU (1) AU623675B2 (da)
CA (1) CA1335802C (da)
DE (1) DE68917061T2 (da)
DK (1) DK175360B1 (da)
ES (1) ES2060778T3 (da)
FI (1) FI102282B1 (da)
GB (1) GB8819826D0 (da)
IE (1) IE65096B1 (da)
NO (1) NO180636C (da)
NZ (1) NZ230383A (da)
WO (1) WO1990002198A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8920381D0 (en) * 1989-09-08 1989-10-25 Greater Glasgow Health Board Treatment of insulin-resistant diabetes
US5612198A (en) * 1990-09-04 1997-03-18 The Salk Institute Production of insulin-like growth factor-1 in methylotrophic yeast cells
US5231178A (en) * 1991-01-16 1993-07-27 The Salk Institute Biotechnology/Industrial Associates, Inc. Method for the purification of intact, correctly-folded insulin-like growth factor-1
EP0578746B1 (en) * 1991-04-01 2002-07-03 Merck & Co., Inc. GENES WHICH INFLUENCE $i(PICHIA) PROTEOLYTIC ACTIVITY, AND USES THEREFOR
EP0600372B1 (de) * 1992-12-02 1997-02-05 Hoechst Aktiengesellschaft Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken
SE9402332D0 (sv) * 1994-07-01 1994-07-01 Pharmacia Ab Igf-1
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
CL2007001614A1 (es) * 2006-06-09 2008-08-08 Novartis Ag Polipeptido que comprende una proteina del precursor del factor de crecimiento tipo insulina, igf-1 humana, en la cual la escision del peptido e mediante una proteasa se reduce a traves de la modificacion de la proteina del precursor; y su uso para t
WO2011053545A1 (en) * 2009-10-30 2011-05-05 Merck Sharp & Dohme Corp. Granulocyte-colony stimulating factor produced in glycoengineered pichia pastoris
US20100172865A1 (en) * 2010-03-18 2010-07-08 Shantha Totada R Methods of enhancing hair growth
JP6200806B2 (ja) 2010-05-21 2017-09-20 メリマック ファーマシューティカルズ インコーポレーティッド 二重特異的融合タンパク質
KR20160091888A (ko) 2013-10-02 2016-08-03 노파르티스 아게 요법에 사용하기 위한 인슐린-유사 성장 인자 모방체
CN115960249A (zh) 2015-10-02 2023-04-14 银溪制药股份有限公司 用于组织修复的双特异性治疗性蛋白质

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3486216T2 (de) * 1983-04-25 1994-02-17 Chiron Corp Hybrid-DNS-Synthesis von reifen insulinähnlichen Wachstumsfaktoren.

Also Published As

Publication number Publication date
ES2060778T3 (es) 1994-12-01
FI102282B (fi) 1998-11-13
NO180636B (no) 1997-02-10
ATE109206T1 (de) 1994-08-15
GB8819826D0 (en) 1988-09-21
DK29491D0 (da) 1991-02-20
DE68917061T2 (de) 1994-11-17
EP0360411A1 (en) 1990-03-28
JPH05505514A (ja) 1993-08-19
DK175360B1 (da) 2004-09-13
EP0429502A1 (en) 1991-06-05
US5273966A (en) 1993-12-28
NO910669D0 (no) 1991-02-19
AU4051889A (en) 1990-03-23
NZ230383A (en) 1992-01-29
DE68917061D1 (de) 1994-09-01
EP0360411B1 (en) 1994-07-27
JP2543998B2 (ja) 1996-10-16
FI102282B1 (fi) 1998-11-13
IE65096B1 (en) 1995-10-04
FI910795A0 (fi) 1991-02-19
AU623675B2 (en) 1992-05-21
NO180636C (no) 1997-05-21
WO1990002198A1 (en) 1990-03-08
CA1335802C (en) 1995-06-06
NO910669L (no) 1991-02-19
IE892652L (en) 1990-02-20

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