DK2954892T3 - Faststofsammensætninger - Google Patents
Faststofsammensætninger Download PDFInfo
- Publication number
- DK2954892T3 DK2954892T3 DK15176068.3T DK15176068T DK2954892T3 DK 2954892 T3 DK2954892 T3 DK 2954892T3 DK 15176068 T DK15176068 T DK 15176068T DK 2954892 T3 DK2954892 T3 DK 2954892T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- composition
- solid
- pharmaceutically acceptable
- solid dispersion
- Prior art date
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Claims (16)
1. Faststofsammensætning til anvendelse i en fremgangsmåde til behandling af HCV-infektion, hvilken sammensætning omfatter (1) en forbindelse eller et farmaceutisk acceptabelt salt deraf i en amorf form, (2) en farmaceutisk acceptabel hydrofil polymer; og (3) eventuelt et farmaceutisk acceptabelt overfladeaktivt stof, hvor forbindelsen er valgt fra gruppen, der består af: dimethyl-(2S,2'S)-l,r-((2S,2'S)-2,2'-(4,4'-((2S,5S)-l-(4-tert-butylphenyl)pyrrolidin-2,5-diyl)-bis(4,l-phenylen))-bis(azandiyl)-bis(oxomethylen)-bis(pyrrolidin-2,l-diyl))-bis(3-methyl-l-oxobutan-2,l-diyl)dicarbamat (forbindelse Ia), methyl-[(2S)-l-{(2S)-2-[4-(4-{5-(4-{2-[(2S)-l-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-lH-imidazol-4-yl}phenyl)-l-[6-(piperidin-l-yl)pyridin-3-yl]-lH-pyrrol-2-yl}phenyl)-lH-imidazol-2-yl]pyrrolidin-l-yl}-3-methyl-l-oxobutan-2-yl]carbamat (forbindelse Ib), methyl-{(2S,3R)-l-[(2S)-2-{6-[(2R,5R)-l-(4-tert-butylphenyl)-5-(2-{(2S)-l-[N-(methoxycarbonyl)-O-methyl-L-threonyl]pyrrolidin-2-yl}-lH-benzimidazol-6-yl)pyrrolidin-2-yl]-lH-benzimidazol-2-yl}pyrrolidin-l-yl]-3-methoxy-l-oxobutan-2-yl}carbamat (forbindelse Ic) og methyl-{(2S)-l-[(2S)-2-{5-[(2R,5R)-l-[2,5-difluor-4-(trifluormethyl)phenyl]-5-{2-[(2S)-l-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl] -1 H-benzimidazol-5 -yl} pyrrolidin-2-yl] -1 H-benzimidazol-2-yl} pyrrolidin-1 -yl]-3-methyl-l-oxobutan-2-yl}carbamat (forbindelse ID), og hvor forbindelsen eller saltet og polymeren er i en faststofdispersion.
2. Sammensætning til anvendelse ifølge krav 1, hvor polymeren har en Tg på mindst 50 °C.
3. Sammensætning til anvendelse ifølge krav 2, hvilken sammensætning yderligere omfatter det overfladeaktive stof.
4. Sammensætning til anvendelse ifølge krav 3, hvor faststofdispersionen omfatter det overfladeaktive stof.
5. Sammensætning til anvendelse ifølge krav 3, hvor polymeren er en homopolymer eller copolymer af N-vinylpyrrolidon.
6. Sammensætning til anvendelse ifølge krav 3, hvor polymeren er copovidon.
7. Sammensætning til anvendelse ifølge krav 6, hvor det overfladeaktive stof er D-alfa-tocopherylpolyethylenglycol-1000-succinat.
8. Sammensætning til anvendelse ifølge krav 3, hvor faststofdispersionen er en amorf faststofdispersion.
9. Sammensætning til anvendelse ifølge krav 3, hvor faststofdispersionen er en faststofopløsning, der omfatter det overfladeaktive stof.
10. Sammensætning til anvendelse ifølge krav 1, hvilken sammensætning yderligere omfatter et andet anti-HCV-middel.
11. Sammensætning til anvendelse ifølge krav 1, hvilken sammensætning yderligere omfatter en HCV-proteaseinhibitor.
12. Sammensætning til anvendelse ifølge krav 1, hvilken sammensætning yderligere omfatter en HCV-polymeraseinhibitor.
13. Sammensætning til anvendelse ifølge krav 3, hvor forbindelsen er forbindelse Ia.
14. Sammensætning til anvendelse ifølge et af kravene 1-12, hvor forbindelsen er forbindelse IA.
15. Sammensætning til anvendelse ifølge krav 7, hvor faststofdispersionen omfatter det overfladeaktive stof, og forbindelsen er forbindelse Ia.
16. Sammensætning til anvendelse ifølge krav 15, hvor faststofdispersionen er en amorf faststofdispersion
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35355310P | 2010-06-10 | 2010-06-10 | |
| US12/813,301 US8691938B2 (en) | 2009-06-11 | 2010-06-10 | Anti-viral compounds |
| EP11727080.1A EP2579854B2 (en) | 2010-06-10 | 2011-06-09 | Solid compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2954892T3 true DK2954892T3 (da) | 2018-10-29 |
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