DK29587A - Pyrrolooe1,2-aaaoe4,1aabenzoxazepiner og salte deraf samt deres fremstilling og anvendelse - Google Patents

Pyrrolooe1,2-aaaoe4,1aabenzoxazepiner og salte deraf samt deres fremstilling og anvendelse

Info

Publication number: DK29587A
Authority: DK; Denmark
Prior art keywords: lower alkyl; image; represents hydrogen; halogen; salts
Prior art date: 1986-01-21

Application number

DK029587A

Other languages

English (en)

Other versions

DK169239B1 (da

DK29587D0 (da

Inventor

Jan William Francis Wasley

Jon Norman

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-01-21

Filing date

1987-01-20

Publication date

1987-07-22

1987-01-20 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1987-01-20 Publication of DK29587D0 publication Critical patent/DK29587D0/da

1987-07-22 Publication of DK29587A publication Critical patent/DK29587A/da

1994-09-19 Application granted granted Critical

1994-09-19 Publication of DK169239B1 publication Critical patent/DK169239B1/da

Links

125000000217 alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
150000002431 hydrogen Chemical group 0.000 abstract 3
125000003282 alkyl amino group Chemical group 0.000 abstract 2
102000000584 Calmodulin Human genes 0.000 abstract 1
108010041952 Calmodulin Proteins 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK029587A 1986-01-21 1987-01-20 Pyrrolo[1,2-a][4,1]benzoxazepiner og salte deraf, deres fremstilling og farmaceutiske præparater med indhold deraf DK169239B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US82111086		1986-01-21
US06/821,110 US4758559A (en)	1986-01-21	1986-01-21	Pyrrolo[1,2-a] [4,1]benzoxazepine derivatives useful as calmodulin and histamine inhibitors

Publications (3)

Publication Number	Publication Date
DK29587D0 DK29587D0 (da)	1987-01-20
DK29587A true DK29587A (da)	1987-07-22
DK169239B1 DK169239B1 (da)	1994-09-19

Family

ID=25232538

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK029587A DK169239B1 (da)	1986-01-21	1987-01-20	Pyrrolo[1,2-a][4,1]benzoxazepiner og salte deraf, deres fremstilling og farmaceutiske præparater med indhold deraf

Country Status (25)

Country	Link
US (1)	US4758559A (da)
EP (1)	EP0233483B1 (da)
JP (2)	JPH0780888B2 (da)
KR (1)	KR900004148B1 (da)
AT (1)	ATE62244T1 (da)
AU (1)	AU598510B2 (da)
CA (1)	CA1273335A (da)
CY (1)	CY1749A (da)
DD (1)	DD257430A5 (da)
DE (1)	DE3768978D1 (da)
DK (1)	DK169239B1 (da)
ES (1)	ES2039363T3 (da)
FI (1)	FI86636C (da)
GR (1)	GR3001737T3 (da)
HK (1)	HK24194A (da)
HU (1)	HU198061B (da)
IE (1)	IE59653B1 (da)
IL (1)	IL81302A (da)
MA (1)	MA20857A1 (da)
MY (1)	MY100914A (da)
PH (1)	PH25148A (da)
PT (1)	PT84136B (da)
TN (1)	TNSN87003A1 (da)
ZA (1)	ZA87389B (da)
ZW (1)	ZW787A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0567026B1 (en) *	1992-04-20	2003-03-26	Takeda Chemical Industries, Ltd.	4,1-Benzoxazepin derivatives as squalene synthase inhibitors and their use in the treatment of hypercholesteremia and as fungicides
US5452434A (en) *	1992-07-14	1995-09-19	Advanced Micro Devices, Inc.	Clock control for power savings in high performance central processing units
USRE39300E1 (en)	1993-01-28	2006-09-19	Virginia Commonwealth University Medical College Of Virginia	Inhibiting the development of tolerance to and/or dependence on an addictive substance
US5321012A (en) *	1993-01-28	1994-06-14	Virginia Commonwealth University Medical College	Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
US5439524A (en) *	1993-04-05	1995-08-08	Vlsi Technology, Inc.	Plasma processing apparatus
US5698518A (en) *	1994-03-30	1997-12-16	Oklahoma Medical Research Foundation	Method for regulating inflammation and tumor growth with calmodulin, calmodulin analogues or calmodulin antagonists
US5624902A (en) *	1995-06-07	1997-04-29	Torrey Pines Institute For Molecular Studies	Peptide inhibitors of calmodulin
US6423329B1 (en)	1999-02-12	2002-07-23	The Procter & Gamble Company	Skin sanitizing compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4029672A (en) *	1976-02-26	1977-06-14	American Hoechst Corporation	Aminoalkylpyrrolobenzoxazalkanes
US4045448A (en) *	1976-02-26	1977-08-30	American Hoechst Corporation	Pyrrolo[2,1-c][1,4]benzoxazepine and benzoxazocine derivatives
US4053599A (en) *	1976-02-26	1977-10-11	American Hoechst Corporation	Piperazionalkylpyrrolobenzoxazalkanes
US4169095A (en) *	1977-01-19	1979-09-25	American Hoechst Corporation	Process for preparing aminoalkylpyrrolobenzoxazalkanes
US4608374A (en) *	1983-11-07	1986-08-26	Hoechst-Roussel Pharmaceuticals Inc.	11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents

1986
- 1986-01-21 US US06/821,110 patent/US4758559A/en not_active Expired - Lifetime
1987
- 1987-01-05 MY MYPI87000013A patent/MY100914A/en unknown
- 1987-01-14 PH PH34722A patent/PH25148A/en unknown
- 1987-01-19 FI FI870207A patent/FI86636C/fi not_active IP Right Cessation
- 1987-01-19 ES ES87100598T patent/ES2039363T3/es not_active Expired - Lifetime
- 1987-01-19 DE DE8787100598T patent/DE3768978D1/de not_active Expired - Lifetime
- 1987-01-19 CA CA000527583A patent/CA1273335A/en not_active Expired - Lifetime
- 1987-01-19 PT PT84136A patent/PT84136B/pt unknown
- 1987-01-19 IL IL81302A patent/IL81302A/xx not_active IP Right Cessation
- 1987-01-19 DD DD87299332A patent/DD257430A5/de unknown
- 1987-01-19 EP EP87100598A patent/EP0233483B1/de not_active Expired - Lifetime
- 1987-01-19 AT AT87100598T patent/ATE62244T1/de not_active IP Right Cessation
- 1987-01-20 IE IE13987A patent/IE59653B1/en not_active IP Right Cessation
- 1987-01-20 DK DK029587A patent/DK169239B1/da not_active IP Right Cessation
- 1987-01-20 HU HU87152A patent/HU198061B/hu not_active IP Right Cessation
- 1987-01-20 AU AU67813/87A patent/AU598510B2/en not_active Ceased
- 1987-01-20 TN TNTNSN87003A patent/TNSN87003A1/fr unknown
- 1987-01-20 ZW ZW7/87A patent/ZW787A1/xx unknown
- 1987-01-20 MA MA21090A patent/MA20857A1/fr unknown
- 1987-01-20 ZA ZA87389A patent/ZA87389B/xx unknown
- 1987-01-20 JP JP62009181A patent/JPH0780888B2/ja not_active Expired - Fee Related
- 1987-01-21 KR KR1019870000454A patent/KR900004148B1/ko not_active Expired
1991
- 1991-04-04 GR GR91400317T patent/GR3001737T3/el unknown
1993
- 1993-12-22 JP JP5324407A patent/JPH0826028B2/ja not_active Expired - Lifetime
1994
- 1994-03-17 HK HK241/94A patent/HK24194A/xx not_active IP Right Cessation
- 1994-06-03 CY CY174994A patent/CY1749A/xx unknown

Also Published As

Publication number	Publication date
CA1273335A (en)	1990-08-28
MY100914A (en)	1991-05-31
ATE62244T1 (de)	1991-04-15
KR870007181A (ko)	1987-08-17
AU6781387A (en)	1987-07-23
US4758559A (en)	1988-07-19
IE870139L (en)	1987-07-21
ES2039363T3 (es)	1995-04-01
EP0233483B1 (de)	1991-04-03
FI86636C (fi)	1992-09-25
KR900004148B1 (ko)	1990-06-16
DD257430A5 (de)	1988-06-15
JPH0789966A (ja)	1995-04-04
AU598510B2 (en)	1990-06-28
DK169239B1 (da)	1994-09-19
JPH0780888B2 (ja)	1995-08-30
PT84136A (en)	1987-02-01
HK24194A (en)	1994-03-25
DE3768978D1 (de)	1991-05-08
TNSN87003A1 (fr)	1990-01-01
PH25148A (en)	1991-03-13
DK29587D0 (da)	1987-01-20
FI870207A7 (fi)	1987-07-22
HU198061B (en)	1989-07-28
CY1749A (en)	1994-06-03
JPH0826028B2 (ja)	1996-03-13
ZW787A1 (en)	1987-08-12
ZA87389B (en)	1987-11-25
JPS62169791A (ja)	1987-07-25
FI86636B (fi)	1992-06-15
HUT45259A (en)	1988-06-28
IL81302A0 (en)	1987-08-31
GR3001737T3 (en)	1992-11-23
PT84136B (pt)	1989-07-31
FI870207A0 (fi)	1987-01-19
EP0233483A2 (de)	1987-08-26
MA20857A1 (fr)	1987-10-01
IL81302A (en)	1990-11-29
EP0233483A3 (en)	1988-10-19
IE59653B1 (en)	1994-03-09

Legal Events

Date	Code	Title	Description
1994-09-19	B1	Patent granted (law 1993)
2003-09-01	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
KR0179054B1 (en)	1999-03-20	Heterocyclic-cyclic amine derivatives
DK0556329T3 (da)	1996-05-06	Substituerede piperaziner som midler til behandling af centralnervesystemet
DK418486A (da)	1987-03-04	3,4-dihydro-2h-(1)-(benzopyran og benzothiopyran)-3-aminer og salte deraf samt deres fremstilling og anvendelse
DK29587D0 (da)	1987-01-20	Pyrrolooe1,2-aaaoe4,1aabenzoxazepiner og salte deraf samt deres fremstilling og anvendelse
DK526887A (da)	1988-04-10	Aralkyl-4h-1,2,4-triazolderivater samt deres fremstilling og anvendelse
MX10256A (es)	1993-11-01	Procedimiento para preparar nuevas 3-fenil-7h-tiazolo(3, 2-b) (1, 2, 4) triazin-7-onas.
PT79273A (en)	1984-10-01	2-(n-pyrrolidino)-3-isobutoxy-n-substituted-phenyl-n-benzil-propylamines their preparation and pharmaceutical use
DE3678015D1 (en)	1991-04-18	N-carboxyalcoyl-2-oxo-3-diaryl-5-6 triazine als heilmittel.
BG50775A1 (en)	1992-11-16	Derivatives of 2, 3- dimethyl- 1- phenyl- 4- (2- phenylmorpholinomethyl)- 5- pyrazolones and method for their preparation
DK248787A (da)	1988-11-15	5-(2-(pyrrolidin-1-yl)ethoxy)-p-cymenderivater, fremgangsmaade til fremstilling deraf samt laegemidler indeholdende disse