DK297285A - Fremstilling af heterodimere humane fertilitetshormoner ved rekombinant metodologi - Google Patents

Fremstilling af heterodimere humane fertilitetshormoner ved rekombinant metodologi Download PDF

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Publication number
DK297285A
DK297285A DK297285A DK297285A DK297285A DK 297285 A DK297285 A DK 297285A DK 297285 A DK297285 A DK 297285A DK 297285 A DK297285 A DK 297285A DK 297285 A DK297285 A DK 297285A
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Denmark
Prior art keywords
preparation
recombinant methodology
hormone
human fertility
subunit
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DK297285A
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English (en)
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DK297285D0 (da
Inventor
Vemuri B Reddy
Nancy Hsiung
Anton K Beck
Edward George Bernstine
Original Assignee
Vemuri B Reddy
Nancy Hsiung
Anton K Beck
Edward George Bernstine
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24187868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK297285(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US1984/001766 external-priority patent/WO1985001958A1/en
Application filed by Vemuri B Reddy, Nancy Hsiung, Anton K Beck, Edward George Bernstine filed Critical Vemuri B Reddy
Publication of DK297285A publication Critical patent/DK297285A/da
Publication of DK297285D0 publication Critical patent/DK297285D0/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Steroid Compounds (AREA)
DK297285A 1983-11-02 1985-07-01 Fremstilling af heterodimere humane fertilitetshormoner ved rekombinant metodologi DK297285D0 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54821183A 1983-11-02 1983-11-02
PCT/US1984/001766 WO1985001958A1 (en) 1983-11-02 1984-10-31 Production of heterodimeric human fertility hormones

Publications (2)

Publication Number Publication Date
DK297285A true DK297285A (da) 1985-07-01
DK297285D0 DK297285D0 (da) 1985-07-01

Family

ID=24187868

Family Applications (2)

Application Number Title Priority Date Filing Date
DK297285A DK297285D0 (da) 1983-11-02 1985-07-01 Fremstilling af heterodimere humane fertilitetshormoner ved rekombinant metodologi
DK297185A DK171489B1 (da) 1983-11-02 1985-07-01 Fremgangsmåde til fremstilling af et biologisk aktivt, posttranslationelt modificeret proteinhormon sammensat af flere underenheder, eukaryotisk celle, som er transficeret med en eller flere udtrykkelsesvektorer og er i stand til at producere et sådant hormon, udtrykkelsesvektor omfattende heterolog DNA, som koder for underenhederne af hormonet, et sæt af udtrykkelsesvektorer, hvor hver vektor omf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK297185A DK171489B1 (da) 1983-11-02 1985-07-01 Fremgangsmåde til fremstilling af et biologisk aktivt, posttranslationelt modificeret proteinhormon sammensat af flere underenheder, eukaryotisk celle, som er transficeret med en eller flere udtrykkelsesvektorer og er i stand til at producere et sådant hormon, udtrykkelsesvektor omfattende heterolog DNA, som koder for underenhederne af hormonet, et sæt af udtrykkelsesvektorer, hvor hver vektor omf

Country Status (8)

Country Link
EP (3) EP0578328B1 (da)
AT (2) ATE190461T1 (da)
DE (4) DE3486474T2 (da)
DK (2) DK297285D0 (da)
LU (1) LU90770I2 (da)
MX (1) MX9203334A (da)
NL (1) NL300044I2 (da)
WO (1) WO1985001959A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
JPS60145098A (ja) * 1984-01-09 1985-07-31 Suntory Ltd 糖付加ポリペプチドの製造法
EP0224574A4 (en) * 1985-06-04 1988-04-26 Biotech Res Partners Ltd SELF-ANTIGEN VACCINES.
CA1340740C (en) * 1987-12-08 1999-09-14 Eileen R. Mulvihill Co-expression in eukaryotic cells
US5648254A (en) * 1988-01-15 1997-07-15 Zymogenetics, Inc. Co-expression in eukaryotic cells
US5792460A (en) * 1989-02-21 1998-08-11 Washington University Modified glycoprotein hormones having a CTP at the amino terminus
US6225449B1 (en) 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
US5705478A (en) * 1989-02-21 1998-01-06 Washington University Covalently linked β subunits of the glycoprotein hormones as antagonists
CA2053864C (en) * 1989-02-21 2001-11-20 Irving Boime Modified forms of reproductive hormones
US6028177A (en) * 1991-10-04 2000-02-22 Washington University Methods of detecting single-chain forms of the glycoprotein hormone quartet
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
US6737515B2 (en) 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
US6238890B1 (en) 1994-02-18 2001-05-29 Washington University Single chain forms of the glycoprotein hormone quartet
BR9506313A (pt) * 1994-08-12 1997-08-05 Univ Washington Formas de cadeia simples do quarteto de hormônio de glicoproteína
RU2213099C2 (ru) * 1994-08-12 2003-09-27 Вашингтон Юниверсити Одноцепочечный белок, модулятор гормонов лютеинизирующего, фолликулостимулирующего, тиреостимулирующего и хорионического гонадотропина (варианты), молекула нуклеиновой кислоты (варианты), вектор (варианты), линия трансформированных клеток сно (варианты), способ продуцирования одноцепочечного белка (варианты)
DK0725795T3 (da) * 1994-08-12 2004-05-17 Univ Washington Enkelt-kæde form af glycoprotein-hormon-kvartetten
US6635256B1 (en) 1998-10-19 2003-10-21 Washington University Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
US6103501A (en) * 1997-11-17 2000-08-15 Washington University Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
EP1013281A1 (en) 1998-12-15 2000-06-28 Applied Research Systems ARS Holding N.V. hCG therapy for the treatment of breast cancer
US7112341B1 (en) 1999-04-13 2006-09-26 Nektar Therapeutics Pulmonary administration of dry powder formulations for treating infertility
CA2466595A1 (en) * 2001-11-08 2003-05-15 William R. Moyle Protein knobs
US7081446B2 (en) 2002-01-31 2006-07-25 The Trustees Of Columbia University In The City Of New York Long-acting follicle stimulating hormone analogues and uses thereof
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
WO2007030362A1 (en) 2005-09-07 2007-03-15 Laboratoires Serono Sa. Ikk inhibitors for the treatment of endometriosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2048894A (en) * 1979-05-11 1980-12-17 Gist Brocades Nv Plasmid
US4419446A (en) * 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations

Also Published As

Publication number Publication date
ATE190461T1 (de) 2000-04-15
MX9203334A (es) 1992-09-01
LU90770I2 (fr) 2001-07-03
EP0160699A4 (en) 1987-10-20
ATE169334T1 (de) 1998-08-15
EP0160699B1 (en) 1992-08-12
NL300044I1 (nl) 2001-07-02
DE10199028I2 (de) 2004-07-01
DK297285D0 (da) 1985-07-01
DE10199028I1 (de) 2001-09-20
EP0160699A1 (en) 1985-11-13
DE3486474T2 (de) 2000-08-03
DE3486474D1 (de) 2000-02-03
WO1985001959A1 (en) 1985-05-09
EP0578328B1 (en) 1999-12-29
DE10199035I1 (de) 2001-11-08
DK297185A (da) 1985-07-01
EP0957167A1 (en) 1999-11-17
NL300044I2 (nl) 2001-12-01
DK297185D0 (da) 1985-07-01
DE3486469D1 (de) 1998-09-10
DE10199035I2 (de) 2006-03-16
DK171489B1 (da) 1996-11-25
DE3486469T2 (de) 1999-04-15
EP0578328A1 (en) 1994-01-12

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