ATE190461T1 - Produkte und methoden für die herstellung einer heterodimerer menschlicher lh mit einem met42 val55 alpha untereinheit - Google Patents

Produkte und methoden für die herstellung einer heterodimerer menschlicher lh mit einem met42 val55 alpha untereinheit

Info

Publication number: ATE190461T1
Authority: AT; Austria
Prior art keywords: met42; val55; products; producing; methods
Prior art date: 1983-11-02

Application number

AT93202294T

Other languages

English (en)

Inventor

Vemuri B Reddy

Nancy Hsing

Anton K Beck

Edward G Bernstine

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-11-02

Filing date

1984-10-31

Publication date

2000-04-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24187868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE190461(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1984-10-31 Application filed by Applied Research Systems filed Critical Applied Research Systems

2000-04-15 Application granted granted Critical

2000-04-15 Publication of ATE190461T1 publication Critical patent/ATE190461T1/de

Links

238000000034 method Methods 0.000 title abstract 2
102000012673 Follicle Stimulating Hormone Human genes 0.000 abstract 2
108010079345 Follicle Stimulating Hormone Proteins 0.000 abstract 2
102000009151 Luteinizing Hormone Human genes 0.000 abstract 2
108010073521 Luteinizing Hormone Proteins 0.000 abstract 2
102000011923 Thyrotropin Human genes 0.000 abstract 2
108010061174 Thyrotropin Proteins 0.000 abstract 2
229940028334 follicle stimulating hormone Drugs 0.000 abstract 2
229940040129 luteinizing hormone Drugs 0.000 abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
241000700605 Viruses Species 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
210000003527 eukaryotic cell Anatomy 0.000 abstract 1
239000013604 expression vector Substances 0.000 abstract 1
229940088597 hormone Drugs 0.000 abstract 1
239000005556 hormone Substances 0.000 abstract 1
239000013612 plasmid Substances 0.000 abstract 1
230000003362 replicative effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Pregnancy & Childbirth (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Gynecology & Obstetrics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Steroid Compounds (AREA)

AT93202294T 1983-11-02 1984-10-31 Produkte und methoden für die herstellung einer heterodimerer menschlicher lh mit einem met42 val55 alpha untereinheit ATE190461T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US54821183A	1983-11-02	1983-11-02

Publications (1)

Publication Number	Publication Date
ATE190461T1 true ATE190461T1 (de)	2000-04-15

Family

ID=24187868

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT93202294T ATE190461T1 (de)	1983-11-02	1984-10-31	Produkte und methoden für die herstellung einer heterodimerer menschlicher lh mit einem met42 val55 alpha untereinheit
AT92200198T ATE169334T1 (de)	1983-11-02	1984-10-31	Herstellung heterodimirer menschlicher fruchtbarkeitshormone

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT92200198T ATE169334T1 (de)	1983-11-02	1984-10-31	Herstellung heterodimirer menschlicher fruchtbarkeitshormone

Country Status (8)

Country	Link
EP (3)	EP0578328B1 (de)
AT (2)	ATE190461T1 (de)
DE (4)	DE3486474T2 (de)
DK (2)	DK297285D0 (de)
LU (1)	LU90770I2 (de)
MX (1)	MX9203334A (de)
NL (1)	NL300044I2 (de)
WO (1)	WO1985001959A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4923805A (en) *	1983-11-02	1990-05-08	Integrated Genetics, Inc.	Fsh
US5639639A (en) *	1983-11-02	1997-06-17	Genzyme Corporation	Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
JPS60145098A (ja) *	1984-01-09	1985-07-31	Suntory Ltd	糖付加ポリペプチドの製造法
EP0224574A4 (de) *	1985-06-04	1988-04-26	Biotech Res Partners Ltd	Autoantigene impfstoffe.
CA1340740C (en) *	1987-12-08	1999-09-14	Eileen R. Mulvihill	Co-expression in eukaryotic cells
US5648254A (en) *	1988-01-15	1997-07-15	Zymogenetics, Inc.	Co-expression in eukaryotic cells
US5792460A (en) *	1989-02-21	1998-08-11	Washington University	Modified glycoprotein hormones having a CTP at the amino terminus
US6225449B1 (en)	1991-10-04	2001-05-01	Washington University	Hormone analogs with multiple CTP extensions
US5705478A (en) *	1989-02-21	1998-01-06	Washington University	Covalently linked β subunits of the glycoprotein hormones as antagonists
CA2053864C (en) *	1989-02-21	2001-11-20	Irving Boime	Modified forms of reproductive hormones
US6028177A (en) *	1991-10-04	2000-02-22	Washington University	Methods of detecting single-chain forms of the glycoprotein hormone quartet
IT1250075B (it) *	1991-12-18	1995-03-30	Serono Cesare Ist Ricerca	Composizioni farmaceutiche contenenti gonadotropine.
US6737515B2 (en)	1993-11-19	2004-05-18	Washington University	Follicle stimulating hormone-glycosylation analogs
US6238890B1 (en)	1994-02-18	2001-05-29	Washington University	Single chain forms of the glycoprotein hormone quartet
BR9506313A (pt) *	1994-08-12	1997-08-05	Univ Washington	Formas de cadeia simples do quarteto de hormônio de glicoproteína
RU2213099C2 (ru) *	1994-08-12	2003-09-27	Вашингтон Юниверсити	Одноцепочечный белок, модулятор гормонов лютеинизирующего, фолликулостимулирующего, тиреостимулирующего и хорионического гонадотропина (варианты), молекула нуклеиновой кислоты (варианты), вектор (варианты), линия трансформированных клеток сно (варианты), способ продуцирования одноцепочечного белка (варианты)
DK0725795T3 (da) *	1994-08-12	2004-05-17	Univ Washington	Enkelt-kæde form af glycoprotein-hormon-kvartetten
US6635256B1 (en)	1998-10-19	2003-10-21	Washington University	Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
US6103501A (en) *	1997-11-17	2000-08-15	Washington University	Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
EP1013281A1 (de)	1998-12-15	2000-06-28	Applied Research Systems ARS Holding N.V.	hCG Therapie für Behandlung von Brustkrebs
US7112341B1 (en)	1999-04-13	2006-09-26	Nektar Therapeutics	Pulmonary administration of dry powder formulations for treating infertility
CA2466595A1 (en) *	2001-11-08	2003-05-15	William R. Moyle	Protein knobs
US7081446B2 (en)	2002-01-31	2006-07-25	The Trustees Of Columbia University In The City Of New York	Long-acting follicle stimulating hormone analogues and uses thereof
BRPI0613042A2 (pt)	2005-07-15	2010-12-14	Serono Lab	inibidores de jnk para o tratamento de endometriose
KR20080044836A (ko)	2005-07-15	2008-05-21	라보라뚜와르 세로노 에스. 에이.	자궁내막증 치료용 ｊｎｋ 억제제
WO2007030362A1 (en)	2005-09-07	2007-03-15	Laboratoires Serono Sa.	Ikk inhibitors for the treatment of endometriosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2048894A (en) *	1979-05-11	1980-12-17	Gist Brocades Nv	Plasmid
US4419446A (en) *	1980-12-31	1983-12-06	The United States Of America As Represented By The Department Of Health And Human Services	Recombinant DNA process utilizing a papilloma virus DNA as a vector
GB8308235D0 (en) *	1983-03-25	1983-05-05	Celltech Ltd	Polypeptides
US4816567A (en) *	1983-04-08	1989-03-28	Genentech, Inc.	Recombinant immunoglobin preparations

1984
- 1984-10-31 AT AT93202294T patent/ATE190461T1/de active
- 1984-10-31 AT AT92200198T patent/ATE169334T1/de active
- 1984-10-31 DE DE3486474T patent/DE3486474T2/de not_active Expired - Lifetime
- 1984-10-31 EP EP93202294A patent/EP0578328B1/de not_active Expired - Lifetime
- 1984-10-31 MX MX9203334A patent/MX9203334A/es unknown
- 1984-10-31 WO PCT/US1984/001771 patent/WO1985001959A1/en not_active Ceased
- 1984-10-31 EP EP85900268A patent/EP0160699B1/de not_active Expired - Lifetime
- 1984-10-31 DE DE2001199028 patent/DE10199028I2/de active Active
- 1984-10-31 EP EP99107952A patent/EP0957167A1/de not_active Withdrawn
- 1984-10-31 DE DE2001199035 patent/DE10199035I2/de active Active
- 1984-10-31 DE DE3486469T patent/DE3486469T2/de not_active Expired - Lifetime
1985
- 1985-07-01 DK DK297285A patent/DK297285D0/da not_active Application Discontinuation
- 1985-07-01 DK DK297185A patent/DK171489B1/da not_active IP Right Cessation
2001
- 2001-05-03 LU LU90770C patent/LU90770I2/fr unknown
- 2001-05-10 NL NL300044C patent/NL300044I2/nl unknown

Also Published As

Publication number	Publication date
MX9203334A (es)	1992-09-01
LU90770I2 (fr)	2001-07-03
EP0160699A4 (de)	1987-10-20
DK297285A (da)	1985-07-01
ATE169334T1 (de)	1998-08-15
EP0160699B1 (de)	1992-08-12
NL300044I1 (nl)	2001-07-02
DE10199028I2 (de)	2004-07-01
DK297285D0 (da)	1985-07-01
DE10199028I1 (de)	2001-09-20
EP0160699A1 (de)	1985-11-13
DE3486474T2 (de)	2000-08-03
DE3486474D1 (de)	2000-02-03
WO1985001959A1 (en)	1985-05-09
EP0578328B1 (de)	1999-12-29
DE10199035I1 (de)	2001-11-08
DK297185A (da)	1985-07-01
EP0957167A1 (de)	1999-11-17
NL300044I2 (nl)	2001-12-01
DK297185D0 (da)	1985-07-01
DE3486469D1 (de)	1998-09-10
DE10199035I2 (de)	2006-03-16
DK171489B1 (da)	1996-11-25
DE3486469T2 (de)	1999-04-15
EP0578328A1 (de)	1994-01-12

Publication	Publication Date	Title
ATE190461T1 (de)	2000-04-15	Produkte und methoden für die herstellung einer heterodimerer menschlicher lh mit einem met42 val55 alpha untereinheit
US4780451B1 (en)	1995-04-04	Composition and method for producing superovulation in cattle
DE3479321D1 (en)	1989-09-14	Biosynthetically produced human nerve growth factor, process for producing it, compositions containing it, dna sequence encoding it, vectors containing the sequence and host cells transformed thereby
CA2053864A1 (en)	1990-08-22	Modified forms of reproductive hormones
DE3786592D1 (de)	1993-08-26	Transformation von trichoderma.
DK13788A (da)	1988-03-15	Fremgangsmaade til fremstilling af et polypeptid
DK0559884T3 (da)	2000-10-02	Rekombinante virusvektorer til ekspression i muskelceller
DE10075011I1 (de)	2003-06-12	Rezeptoren fuer Tumornekrosisfaktor-alpha und - beta
FI99116B (fi)	1997-06-30	Menetelmä valmistaa hevosen -interferonia
NO892630D0 (no)	1989-06-23	Interleukin-7.
AR241794A1 (es)	1992-12-30	Procedimiento para obtener inteerleucina-2 humana, en una celula de ovario de hamster de la china.
GB2171703B (en)	1989-11-15	Expression-secretion vector for gene expression and protein secretion, recombinant dna including the vector, and method of producing proteins by use of the re
IL82207A0 (en)	1987-10-30	Production of peptides,recombinant plasmid used therefor and animal cells transformed therewith
DE69637375D1 (en)	2008-01-31	Glycoprotein hormone (tsh) superagonists
DK35888A (da)	1988-07-29	Fremgangsmaade til fremstilling af rekombinant polypeptider
DE3587721D1 (de)	1994-02-24	Hormone und Verfahren zur Herstellung, Verwendung und Prüfung derselben.
ES2039390T3 (es)	1993-10-01	Un procedimiento para producir un factor de diferenciacion de celulas b humanas.
DE3877136D1 (de)	1993-02-11	Rekombinantes histidinreiches protein von plasmodium falciparum, seine herstellung und verwendung.
DE69032996D1 (de)	1999-04-15	Rekombinanter impfstoff zur geburtenkontrolle