DK297185D0 - Fremstilling af biologisk aktive proteiner, sammensat af flere underenheder, ved rekombinant metodologi - Google Patents

Fremstilling af biologisk aktive proteiner, sammensat af flere underenheder, ved rekombinant metodologi

Info

Publication number
DK297185D0
DK297185D0 DK297185A DK297185A DK297185D0 DK 297185 D0 DK297185 D0 DK 297185D0 DK 297185 A DK297185 A DK 297185A DK 297185 A DK297185 A DK 297185A DK 297185 D0 DK297185 D0 DK 297185D0
Authority
DK
Denmark
Prior art keywords
preparation
biological active
active proteins
recombinant methodology
hormone
Prior art date
Application number
DK297185A
Other languages
English (en)
Other versions
DK297185A (da
DK171489B1 (da
Inventor
Vemuri B Reddy
Nancy Hsiung
Anton K Beck
Edward George Bernstine
Original Assignee
Integrated Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24187868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK297185(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Integrated Genetics Inc filed Critical Integrated Genetics Inc
Publication of DK297185A publication Critical patent/DK297185A/da
Publication of DK297185D0 publication Critical patent/DK297185D0/da
Application granted granted Critical
Publication of DK171489B1 publication Critical patent/DK171489B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Steroid Compounds (AREA)
DK297185A 1983-11-02 1985-07-01 Fremgangsmåde til fremstilling af et biologisk aktivt, posttranslationelt modificeret proteinhormon sammensat af flere underenheder, eukaryotisk celle, som er transficeret med en eller flere udtrykkelsesvektorer og er i stand til at producere et sådant hormon, udtrykkelsesvektor omfattende heterolog DNA, som koder for underenhederne af hormonet, et sæt af udtrykkelsesvektorer, hvor hver vektor omf DK171489B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US54821183A 1983-11-02 1983-11-02
US54821183 1983-11-02
PCT/US1984/001771 WO1985001959A1 (en) 1983-11-02 1984-10-31 Production of heterodimeric human fertlity hormones
US8401771 1984-10-31

Publications (3)

Publication Number Publication Date
DK297185A DK297185A (da) 1985-07-01
DK297185D0 true DK297185D0 (da) 1985-07-01
DK171489B1 DK171489B1 (da) 1996-11-25

Family

ID=24187868

Family Applications (2)

Application Number Title Priority Date Filing Date
DK297185A DK171489B1 (da) 1983-11-02 1985-07-01 Fremgangsmåde til fremstilling af et biologisk aktivt, posttranslationelt modificeret proteinhormon sammensat af flere underenheder, eukaryotisk celle, som er transficeret med en eller flere udtrykkelsesvektorer og er i stand til at producere et sådant hormon, udtrykkelsesvektor omfattende heterolog DNA, som koder for underenhederne af hormonet, et sæt af udtrykkelsesvektorer, hvor hver vektor omf
DK297285A DK297285A (da) 1983-11-02 1985-07-01 Fremstilling af heterodimere humane fertilitetshormoner ved rekombinant metodologi

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK297285A DK297285A (da) 1983-11-02 1985-07-01 Fremstilling af heterodimere humane fertilitetshormoner ved rekombinant metodologi

Country Status (8)

Country Link
EP (3) EP0578328B1 (da)
AT (2) ATE169334T1 (da)
DE (4) DE10199028I2 (da)
DK (2) DK171489B1 (da)
LU (1) LU90770I2 (da)
MX (1) MX9203334A (da)
NL (1) NL300044I2 (da)
WO (1) WO1985001959A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
JPS60145098A (ja) * 1984-01-09 1985-07-31 Suntory Ltd 糖付加ポリペプチドの製造法
EP0224574A4 (en) * 1985-06-04 1988-04-26 Biotech Res Partners Ltd SELF-ANTIGEN VACCINES.
CA1340740C (en) * 1987-12-08 1999-09-14 Eileen R. Mulvihill Co-expression in eukaryotic cells
US5648254A (en) * 1988-01-15 1997-07-15 Zymogenetics, Inc. Co-expression in eukaryotic cells
DE122010000006I2 (de) * 1989-02-21 2012-06-21 Univ Washington Modifizierte formen von fortpflanzungshormonen.
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
US5705478A (en) * 1989-02-21 1998-01-06 Washington University Covalently linked β subunits of the glycoprotein hormones as antagonists
US5792460A (en) * 1989-02-21 1998-08-11 Washington University Modified glycoprotein hormones having a CTP at the amino terminus
US6028177A (en) * 1991-10-04 2000-02-22 Washington University Methods of detecting single-chain forms of the glycoprotein hormone quartet
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
US6737515B2 (en) 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
US6238890B1 (en) 1994-02-18 2001-05-29 Washington University Single chain forms of the glycoprotein hormone quartet
RU2213099C2 (ru) * 1994-08-12 2003-09-27 Вашингтон Юниверсити Одноцепочечный белок, модулятор гормонов лютеинизирующего, фолликулостимулирующего, тиреостимулирующего и хорионического гонадотропина (варианты), молекула нуклеиновой кислоты (варианты), вектор (варианты), линия трансформированных клеток сно (варианты), способ продуцирования одноцепочечного белка (варианты)
BR9506313A (pt) * 1994-08-12 1997-08-05 Univ Washington Formas de cadeia simples do quarteto de hormônio de glicoproteína
DK0725795T3 (da) * 1994-08-12 2004-05-17 Univ Washington Enkelt-kæde form af glycoprotein-hormon-kvartetten
US6635256B1 (en) 1998-10-19 2003-10-21 Washington University Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
US6103501A (en) * 1997-11-17 2000-08-15 Washington University Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
EP1013281A1 (en) 1998-12-15 2000-06-28 Applied Research Systems ARS Holding N.V. hCG therapy for the treatment of breast cancer
AU779869B2 (en) 1999-04-13 2005-02-17 Nektar Therapeutics Pulmonary administration of dry powder formulations for treating infertility
IL161804A0 (en) * 2001-11-08 2005-11-20 Yongna Xing Protein knobs
US7081446B2 (en) 2002-01-31 2006-07-25 The Trustees Of Columbia University In The City Of New York Long-acting follicle stimulating hormone analogues and uses thereof
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
CN101304736A (zh) 2005-09-07 2008-11-12 雪兰诺实验室公司 治疗子宫内膜异位症的ikk抑制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2048894A (en) * 1979-05-11 1980-12-17 Gist Brocades Nv Plasmid
US4419446A (en) * 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations

Also Published As

Publication number Publication date
DK297185A (da) 1985-07-01
NL300044I1 (nl) 2001-07-02
EP0578328B1 (en) 1999-12-29
DE10199035I2 (de) 2006-03-16
DE10199035I1 (de) 2001-11-08
NL300044I2 (nl) 2001-12-01
DE3486474D1 (de) 2000-02-03
DE10199028I1 (de) 2001-09-20
EP0160699A4 (en) 1987-10-20
DE10199028I2 (de) 2004-07-01
EP0160699A1 (en) 1985-11-13
DK171489B1 (da) 1996-11-25
EP0578328A1 (en) 1994-01-12
MX9203334A (es) 1992-09-01
DE3486469T2 (de) 1999-04-15
ATE169334T1 (de) 1998-08-15
LU90770I2 (fr) 2001-07-03
DE3486469D1 (de) 1998-09-10
EP0160699B1 (en) 1992-08-12
WO1985001959A1 (en) 1985-05-09
ATE190461T1 (de) 2000-04-15
DK297285D0 (da) 1985-07-01
EP0957167A1 (en) 1999-11-17
DE3486474T2 (de) 2000-08-03
DK297285A (da) 1985-07-01

Similar Documents

Publication Publication Date Title
MX9203334A (es) Proteinas heteropolimericas.
CY1110670T1 (el) Βελτιωση της ομοιογενειας και εκκρισης των ανασυνδυασμενων πρωτεϊνων σε συστηματα θηλαστικων
DK645887D0 (da) Gamma-hesteinterferon, fremgangsmaade til fremstilling af, samt anvendelse af en saadan forbindelse
DK20984D0 (da) Fremgangsmade til fremstilling af et oensket modent protein i en hvirveldyrvaertscelle,polycistromisk udtrykkelsesvektor for det oenskede protein, fremgangsmade til selektering af transfilerede hvirveldyrceller og hvirveldyrcellekultur transformeret med vektoren
AU3069889A (en) Pox virus vectors
EP0722461A4 (en) EXPRESSION OF FUSION POLYPEPTIDES TRANSPORTED OUT OF CYTOPLASM WITHOUT HEAD SEQUENCE
ES2000278A6 (es) Procedimiento para preparar una proteina de fusion y para preparar una proteina eucariotica.
DK491487D0 (da) Dna-sekvens til ekspressionering af biologisk aktivt faktor xiii og anvendelse af samme
DK463586A (da) Fsh
PT99313A (pt) Processo para a preparacao de proteinas, de viros recombinantes e de vectores de transferencia uteis para a expressao dessas proteinas
NO177540C (no) Fremgangsmåte for fremstilling av heterologe proteiner i Bombyx mori samt plasmid og rekombinant Bombyx mori nukleært polyhedrosevirus (BmNPV)
EP1029918A4 (en) RECEPTOR OF KILLING T CELLS THAT DETECT HUMAN IMMUNODEFICIENCY VIRUS
DK0434605T3 (da) Ny fremgangsmåde til fremstilling af ikke-fusioneret protein i E.coli
GR3007909T3 (da)
DE3877136D1 (de) Rekombinantes histidinreiches protein von plasmodium falciparum, seine herstellung und verwendung.
DK128687D0 (da) Proteiner samt deres fremstilling og anvendelse
ATE177474T1 (de) Rekombinanter impfstoff zur geburtenkontrolle

Legal Events

Date Code Title Description
PUP Patent expired