DK2990420T3 - Anvendelse af interleukin-4-receptor-antistoffer samt sammensætninger deraf - Google Patents

Anvendelse af interleukin-4-receptor-antistoffer samt sammensætninger deraf Download PDF

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DK2990420T3
DK2990420T3 DK15168899.1T DK15168899T DK2990420T3 DK 2990420 T3 DK2990420 T3 DK 2990420T3 DK 15168899 T DK15168899 T DK 15168899T DK 2990420 T3 DK2990420 T3 DK 2990420T3
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DK15168899.1T
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Arvia E Morris
John D Pluenneke
Richard J Armitage
Jose Carlos Escobar
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Immunex Corp
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Priority claimed from US09/785,934 external-priority patent/US20020002132A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pulmonology (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (8)

1. Menneskeligt monoklonalt antistof, hvilket er i stand til inhibitering af en IL-4-induceret biologisk aktivitet, der konkurrerer med et reference-antistof til binding til en celle, eksprimerer menneskelig 11-4-receptor (IL-4R), hvor: a) den lette kæde af reference-antistoffet omfatter sekvensen SEQ ID NO:6, og den tunge kæde af reference-antistoffet omfatter sekvensen SEQ ID NO:8; eller b) den lette kæde af reference-antistoffet omfatter sekvensen SEQ ID NO:26, og den tunge kæde af reference-antistoffet omfatter sekvensen SEQ ID NO:24.
2. Antistof ifølge krav 1, hvor antistoffet yderligere er i stand til inhibering af en IL-13-induceret biologisk aktivitet.
3. Antistof ifølge krav 1 eller 2 til anvendelse ved en fremgangsmåde til behandling af dermatitis, atopisk dermatitis, kontakt-dermatitis eller astma.
4. Antistof til anvendelse ifølge krav 3, hvor antistoffet foreligger i form af en sammensætning, som yderligere indebefatter et fortyndingsmiddel, en excipient eller et bæremiddel.
5. Antistof ifølge krav 1 eller 2 eller til anvendelse ifølge krav 3 eller 4, hvor IL-4R omfatter aminosyrer 1 til 197 af SEQ ID NO:2.
6. Nukleinsyre, der koder den lette kæde af antistoffet således som angivet i krav 1 eller 2.
7. Nukleinsyre, der koder den tunge kæde af antistoffet således som angivet i krav 1 eller 2.
8. Værtscelle, der inkluderer nukleinsyren ifølge krav 6 eller 7.
DK15168899.1T 2000-05-26 2001-05-25 Anvendelse af interleukin-4-receptor-antistoffer samt sammensætninger deraf DK2990420T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US57980800A 2000-05-26 2000-05-26
US66534300A 2000-09-19 2000-09-19
US09/785,934 US20020002132A1 (en) 2000-05-26 2001-02-15 Use of interleukin-4 antagonists and compositions thereof
US84781601A 2001-05-01 2001-05-01
EP10185626.8A EP2292665B1 (en) 2000-05-26 2001-05-25 Use of interleukin-4 antibodies and compositions thereof

Publications (1)

Publication Number Publication Date
DK2990420T3 true DK2990420T3 (da) 2017-04-03

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ID=27504940

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DK15168899.1T DK2990420T3 (da) 2000-05-26 2001-05-25 Anvendelse af interleukin-4-receptor-antistoffer samt sammensætninger deraf

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US (8) US7186809B2 (da)
EP (4) EP3190126A1 (da)
AT (1) ATE551363T1 (da)
AU (1) AU2001272925A1 (da)
CA (1) CA2409267C (da)
CY (1) CY1118951T1 (da)
DE (1) DE16192152T1 (da)
DK (1) DK2990420T3 (da)
ES (3) ES2549767T3 (da)
MX (1) MXPA02011682A (da)
PT (1) PT2990420T (da)
WO (1) WO2001092340A2 (da)

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