DK3000810T3 - N3-alkyleret benzimidazolderivat som mek-inhibitor - Google Patents

N3-alkyleret benzimidazolderivat som mek-inhibitor Download PDF

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DK3000810T3
DK3000810T3 DK15177189.6T DK15177189T DK3000810T3 DK 3000810 T3 DK3000810 T3 DK 3000810T3 DK 15177189 T DK15177189 T DK 15177189T DK 3000810 T3 DK3000810 T3 DK 3000810T3
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cancer
fluoro
mmol
phenylamino
bromo
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DK15177189.6T
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Eli M Wallace
Joseph P Lyssikatos
Brian T Hurley
Allison L Marlow
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Array Biopharma Inc
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
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  • Plural Heterocyclic Compounds (AREA)
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Claims (13)

  1. PAT E NT K RAV
    1. Forbindelse valgt blandt 6-(4-Brom-2-fluor-phenylamino)-7-fluor-3-methyl-3H-benzoimidazol-5-carboxylsyre (2-hydroxy-ethoxy)-amid og farmaceutisk acceptable salte deraf til anvendelse ved behandling af en cancer valgt blandt melanom, kræft i æggestokkene, kolorektal cancer, lungecancer, pancreascancer, brystcancer, kræft i skjoldbruskkirtlen, gastrisk cancer, akut myeloid leukæmi, neoplasmer i centralnervesystemet, pladeepithelcarcinom, blærecellecancer, hovedcellecancer, halscellecancer, renalcellecancer, nyrecellecancer, prostata-cellecancer, øsofaguscellecancer, testikelcellecancer eller cancer i tyndtarmen hos et pattedyr.
  2. 2. Farmaceutisk sammensætning omfattende forbindelsen til anvendelse ifølge krav 1 og en farmaceutisk acceptabel bærer.
  3. 3. Farmaceutisk sammensætning til anvendelse ifølge krav 2 eller forbindelse til anvendelse ifølge krav 1, hvor forbindelsen er 6-(4-Brom-2-fluor-phenylamino)-7-fluor-3-methyl-3H-benzoimidazol-5-carboxylsyre (2-hydroxy-ethoxy)-amid.
  4. 4. Farmaceutisk sammensætning til anvendelse ifølge krav 2 eller forbindelse til anvendelse ifølge krav 1, hvor canceren er valgt blandt melanom, kræft i æggestokkene, kolorektal cancer, lungecancer, pancreascancer, brystcancer, kræft i skjoldbruskkirtlen, gastrisk cancer, akut myeloid leukæmi og neoplasmer i centralnervesystemet.
  5. 5. Farmaceutisk sammensætning eller forbindelse til anvendelse ifølge krav 4, hvor canceren er melanom.
  6. 6. Farmaceutisk sammensætning eller forbindelse til anvendelse ifølge krav 4, hvor canceren er kræft i æggestokkene.
  7. 7. Farmaceutisk sammensætning eller forbindelse til anvendelse ifølge krav 4, hvor canceren er kolorektal cancer.
  8. 8. Farmaceutisk sammensætning eller forbindelse til anvendelse ifølge krav 4, hvor canceren er lungecancer.
  9. 9. Farmaceutisk sammensætning eller forbindelse til anvendelse ifølge krav 4, hvor canceren er akut myeloid leukæmi.
  10. 10. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af kravene 1 eller 3-10, hvor sammensætningen er formuleret til oral indgift.
  11. 11. Farmaceutisk sammensætning til anvendelse ifølge krav 10, hvor sammensætningen er formuleret som en tablet eller kapsel.
  12. 12. Farmaceutisk sammensætning eller forbindelse til anvendelse ifølge et hvilket som helst af kravene 1-11, hvor 0,001 til 100 mg af forbindelsen pr. kg kropsvægt af pattedyret indgives til pattedyret pr. dag i en enkelt eller opdelt dosis.
  13. 13. Farmaceutisk sammensætning eller forbindelse til anvendelse ifølge krav 12, hvor 1 til 35 mg af forbindelsen pr. kg kropsvægt af pattedyret indgives til pattedyret pr. dag i en enkelt eller opdelt dosis.
DK15177189.6T 2002-03-13 2003-03-13 N3-alkyleret benzimidazolderivat som mek-inhibitor DK3000810T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36400702P 2002-03-13 2002-03-13
EP10011691.2A EP2275102B1 (en) 2002-03-13 2003-03-13 N3 alkylated benzimidazole derivatives as MEK inhibitors

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DK15177189.6T DK3000810T3 (da) 2002-03-13 2003-03-13 N3-alkyleret benzimidazolderivat som mek-inhibitor
DK10011691.2T DK2275102T3 (da) 2002-03-13 2003-03-13 N3-alkylerede benzimidazolderivater som mek-hæmmere
DK09011389.5T DK2130537T3 (da) 2002-03-13 2003-03-13 N3-alkylerede benzimidazolderivater som MEK-inhibitorer
DK03714148.8T DK1482932T3 (da) 2002-03-13 2003-03-13 N3-alkylerede benzimidazolderivater som MEK-inhibitorer

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DK10011691.2T DK2275102T3 (da) 2002-03-13 2003-03-13 N3-alkylerede benzimidazolderivater som mek-hæmmere
DK09011389.5T DK2130537T3 (da) 2002-03-13 2003-03-13 N3-alkylerede benzimidazolderivater som MEK-inhibitorer
DK03714148.8T DK1482932T3 (da) 2002-03-13 2003-03-13 N3-alkylerede benzimidazolderivater som MEK-inhibitorer

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US (11) US20030232869A1 (da)
EP (5) EP1482932B1 (da)
JP (4) JP4093966B2 (da)
KR (3) KR100984573B1 (da)
CN (4) CN101486682B (da)
AR (3) AR038971A1 (da)
AT (1) ATE449605T1 (da)
AU (2) AU2003218157C1 (da)
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CL (2) CL2012002381A1 (da)
CY (3) CY1109727T1 (da)
DE (1) DE60330227D1 (da)
DK (4) DK3000810T3 (da)
DO (4) DOP2003000613A (da)
ES (5) ES2394347T3 (da)
FR (1) FR19C1014I2 (da)
HU (2) HUE025767T2 (da)
IL (4) IL163995A0 (da)
IS (4) IS2748B (da)
LT (1) LTC1482932I2 (da)
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PA (1) PA8569301A1 (da)
PL (5) PL233177B1 (da)
PT (4) PT2275102E (da)
SG (3) SG194238A1 (da)
SI (4) SI2130537T1 (da)
TW (3) TWI350285B (da)
UA (1) UA77765C2 (da)
WO (1) WO2003077914A1 (da)
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DK3000810T3 (da) * 2002-03-13 2017-10-16 Array Biopharma Inc N3-alkyleret benzimidazolderivat som mek-inhibitor
US7235537B2 (en) * 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
US20060084682A1 (en) * 2002-12-13 2006-04-20 Heerding Dirk A Thrombopoietin mimetics
ATE429250T1 (de) * 2003-02-26 2009-05-15 Kowa Co Mittel zur behandlung der allergischen kontaktdermatitis
MXPA06000921A (es) * 2003-07-24 2006-03-30 Warner Lambert Co Derivados de benzamidazoles como inhibidores de mek.
US7144907B2 (en) * 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
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