NO177499C - Insulin-forstadier, DNA-sekvenser, replikerbare ekspresjonsvektorer og vertsceller - Google Patents

Insulin-forstadier, DNA-sekvenser, replikerbare ekspresjonsvektorer og vertsceller

Info

Publication number: NO177499C
Authority: NO; Norway
Prior art keywords: insulin; amino acid; acid residues; precursors; replicable expression
Prior art date: 1988-06-20

Application number

NO905470A

Other languages

English (en)

Other versions

NO177499B (no

NO905470L (no

NO905470D0 (no

Inventor

Ib Jonassen

Ib Groth Clausen

Ejner Bech Jensen

Allan Svendsen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-20

Filing date

1990-12-19

Publication date

1995-09-27

1990-12-19 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1990-12-19 Publication of NO905470D0 publication Critical patent/NO905470D0/no

1991-02-18 Publication of NO905470L publication Critical patent/NO905470L/no

1995-06-19 Publication of NO177499B publication Critical patent/NO177499B/no

1995-09-27 Publication of NO177499C publication Critical patent/NO177499C/no

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 11
102000004877 Insulin Human genes 0.000 title abstract 5
108090001061 Insulin Proteins 0.000 title abstract 5
229940125396 insulin Drugs 0.000 title abstract 5
239000002243 precursor Substances 0.000 title abstract 5
108091028043 Nucleic acid sequence Proteins 0.000 title abstract 2
239000013604 expression vector Substances 0.000 title 1
125000000539 amino acid group Chemical group 0.000 abstract 5
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 3
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 3
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
150000001413 amino acids Chemical group 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
239000001963 growth medium Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

NO905470A 1988-06-20 1990-12-19 Insulin-forstadier, DNA-sekvenser, replikerbare ekspresjonsvektorer og vertsceller NO177499C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK336188A DK336188D0 (da)	1988-06-20	1988-06-20	Propeptider
PCT/DK1989/000152 WO1989012647A1 (en)	1988-06-20	1989-06-19	Insulin precursors

Publications (4)

Publication Number	Publication Date
NO905470D0 NO905470D0 (no)	1990-12-19
NO905470L NO905470L (no)	1991-02-18
NO177499B NO177499B (no)	1995-06-19
NO177499C true NO177499C (no)	1995-09-27

Family

ID=8122004

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO905470A NO177499C (no)	1988-06-20	1990-12-19	Insulin-forstadier, DNA-sekvenser, replikerbare ekspresjonsvektorer og vertsceller

Country Status (17)

Country	Link
US (2)	US5202415A (no)
EP (1)	EP0347845B1 (no)
JP (1)	JP2766999B2 (no)
KR (1)	KR0140238B1 (no)
AT (1)	ATE93239T1 (no)
AU (1)	AU618612B2 (no)
CA (1)	CA1337976C (no)
DE (1)	DE68908491T2 (no)
DK (1)	DK336188D0 (no)
ES (1)	ES2059627T3 (no)
FI (1)	FI102294B1 (no)
IE (1)	IE64303B1 (no)
NO (1)	NO177499C (no)
NZ (1)	NZ229615A (no)
PT (1)	PT90897B (no)
WO (1)	WO1989012647A1 (no)
ZA (1)	ZA894639B (no)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK105489D0 (da) *	1989-03-03	1989-03-03	Novo Nordisk As	Polypeptid
DK134189D0 (da) *	1989-03-20	1989-03-20	Nordisk Gentofte	Insulinforbindelser
DK72793D0 (da) *	1993-06-21	1993-06-21	Novo Nordisk As	Nyt produkt
US6001604A (en) *	1993-12-29	1999-12-14	Bio-Technology General Corp.	Refolding of proinsulins without addition of reducing agents
KR0150565B1 (ko) *	1995-02-15	1998-08-17	김정재	유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
GB9513967D0 (en) *	1995-07-08	1995-09-06	Univ Leicester	Insulin
KR100253916B1 (ko) *	1997-12-29	2000-05-01	김충환	사람 인슐린 전구체의 제조방법
US7169889B1 (en) *	1999-06-19	2007-01-30	Biocon Limited	Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6521738B2 (en)	1999-12-29	2003-02-18	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogs
US6777207B2 (en)	1999-12-29	2004-08-17	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
JP4795599B2 (ja)	1999-12-29	2011-10-19	ノボノルディスクアクティーゼルスカブ	酵母において改良された発酵収率を有するインスリン前駆体及びインスリン前駆体類似体の製造方法
US7378390B2 (en)	1999-12-29	2008-05-27	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
KR100449454B1 (ko) *	2000-10-02	2004-09-21	이현철	단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
EP1346726A4 (en) *	2000-12-25	2004-09-15	Shiseido Co Ltd	Sympathetic-activating perfume composition
US6867183B2 (en) *	2001-02-15	2005-03-15	Nobex Corporation	Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) *	2001-02-15	2006-06-13	Nobex Corporation	Methods of treating diabetes mellitus
EP1377608B1 (en) *	2001-04-02	2009-09-16	Novo Nordisk A/S	Insulin precursors and a process for their preparation
US7105314B2 (en)	2001-04-02	2006-09-12	Novo Nordisk A/S	Method for making human insulin precursors
WO2002079251A2 (en) *	2001-04-02	2002-10-10	Novo Nordisk A/S	Method for making human insulin precursors
US6713452B2 (en)	2001-06-04	2004-03-30	Nobex Corporation	Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) *	2001-06-04	2005-02-22	Nobex Corporation	Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) *	2001-06-04	2004-12-28	Nobex Corporation	Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828297B2 (en) *	2001-06-04	2004-12-07	Nobex Corporation	Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) *	2001-06-04	2004-12-07	Nobex Corporation	Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) *	2001-06-04	2010-05-11	Biocon Limited	Calcitonin drug-oligomer conjugates, and uses thereof
AU2002316807A1 (en) *	2001-06-08	2002-12-23	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogs
US20030040601A1 (en) *	2001-06-08	2003-02-27	Ivan Diers	Method for making insulin precursors and insulin analog precursors
US7312192B2 (en) *	2001-09-07	2007-12-25	Biocon Limited	Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) *	2001-09-07	2007-03-27	Biocon Limited	Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7166571B2 (en) *	2001-09-07	2007-01-23	Biocon Limited	Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) *	2001-09-07	2005-07-05	Nobex Corporation	Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
WO2003105768A2 (en) *	2002-06-13	2003-12-24	Nobex Corporation	Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
WO2004085472A1 (en) *	2003-03-27	2004-10-07	Novo Nordisk A/S	Method for making human insulin precursors and human insulin
TWI345587B (en)	2003-06-17	2011-07-21	Sembiosys Genetics Inc	Methods for the production of insulin in plants
CN101027318B (zh) *	2004-07-19	2016-05-25	比奥孔有限公司	胰岛素-低聚物共轭物，制剂及其用途
CN101541830A (zh)	2006-09-22	2009-09-23	诺沃-诺迪斯克有限公司	蛋白酶抗性的胰岛素类似物
US9241908B2 (en) *	2007-10-16	2016-01-26	Biocon Limited	Orally administrable solid pharmaceutical composition and a process thereof
ES2543705T3 (es)	2009-06-26	2015-08-21	Novo Nordisk A/S	Preparación que contiene insulina, nicotinamida y arginina
KR20140030125A (ko)	2010-12-14	2014-03-11	노보 노르디스크 에이/에스	인슐린, 니코틴아미드 및 아미노산을 포함하는 제제
WO2012080320A1 (en)	2010-12-14	2012-06-21	Novo Nordisk A/S	Fast-acting insulin in combination with long-acting insulin
WO2013186138A1 (en)	2012-06-14	2013-12-19	Novo Nordisk A/S	Preparation comprising insulin, nicotinamide and arginine
BR112022013009A2 (pt)	2019-12-30	2022-09-06	Gan & Lee Pharmaceuticals Co Ltd	Derivados de insulina, composição farmacêutica, uso do derivado da insulina e métodos para tratar ou prevenir diabetes, para aumentar a capacidade de um derivado de insulina e para aumentar a potência de um derivado de insulina
AU2020418207A1 (en)	2019-12-30	2022-08-25	Gan & Lee Pharmaceuticals Co., Ltd.	Long-acting GLP-1 compound
WO2023143458A1 (zh)	2022-01-28	2023-08-03	甘李药业股份有限公司	酰化胰岛素

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL127843B1 (en) *	1980-03-27	1983-11-30	Lilly Co Eli	Process for preparing insulin precursor
US4430266A (en) *	1980-11-28	1984-02-07	Eli Lilly And Company	Process for producing an insulin precursor
US5015575A (en) *	1983-04-07	1991-05-14	Chiron Corporation	Hybrid DNA synthesis of insulin
DE3327928A1 (de) *	1983-08-03	1985-02-21	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von insulin-derivaten
DK58285D0 (da) *	1984-05-30	1985-02-08	Novo Industri As	Peptider samt fremstilling og anvendelse deraf
DK347086D0 (da) *	1986-07-21	1986-07-21	Novo Industri As	Novel peptides
US4946828A (en) *	1985-03-12	1990-08-07	Novo Nordisk A/S	Novel insulin peptides
DK129385A (da) *	1985-03-22	1986-09-23	Novo Industri As	Peptider og fremstilling deraf
DK437786D0 (da) *	1986-09-12	1986-09-12	Nordisk Gentofte	Insulinprecursorer
WO1990001038A1 (en) *	1988-07-20	1990-02-08	Nordisk Gentofte A/S	Human insulin analogs and preparations containing them
HUT56857A (en) *	1988-12-23	1991-10-28	Novo Nordisk As	Human insulin analogues

1988
- 1988-06-20 DK DK336188A patent/DK336188D0/da not_active Application Discontinuation
1989
- 1989-06-19 JP JP1507202A patent/JP2766999B2/ja not_active Expired - Fee Related
- 1989-06-19 PT PT90897A patent/PT90897B/pt not_active IP Right Cessation
- 1989-06-19 AU AU38600/89A patent/AU618612B2/en not_active Ceased
- 1989-06-19 IE IE197689A patent/IE64303B1/en not_active IP Right Cessation
- 1989-06-19 US US07/623,739 patent/US5202415A/en not_active Expired - Lifetime
- 1989-06-19 WO PCT/DK1989/000152 patent/WO1989012647A1/en not_active Ceased
- 1989-06-19 CA CA000603208A patent/CA1337976C/en not_active Expired - Fee Related
- 1989-06-19 ZA ZA894639A patent/ZA894639B/xx unknown
- 1989-06-20 DE DE89111221T patent/DE68908491T2/de not_active Expired - Lifetime
- 1989-06-20 NZ NZ229615A patent/NZ229615A/en unknown
- 1989-06-20 ES ES89111221T patent/ES2059627T3/es not_active Expired - Lifetime
- 1989-06-20 AT AT89111221T patent/ATE93239T1/de not_active IP Right Cessation
- 1989-06-20 EP EP89111221A patent/EP0347845B1/en not_active Expired - Lifetime
1990
- 1990-02-20 KR KR90700348A patent/KR0140238B1/ko not_active Expired - Fee Related
- 1990-12-19 NO NO905470A patent/NO177499C/no unknown
- 1990-12-19 FI FI906285A patent/FI102294B1/fi not_active IP Right Cessation
1992
- 1992-09-23 US US07/952,696 patent/US5324641A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI906285A0 (fi)	1990-12-19
ES2059627T3 (es)	1994-11-16
NO177499B (no)	1995-06-19
AU3860089A (en)	1990-01-12
NZ229615A (en)	1991-03-26
CA1337976C (en)	1996-01-23
DE68908491T2 (de)	1994-01-20
FI102294B (fi)	1998-11-13
AU618612B2 (en)	1992-01-02
IE64303B1 (en)	1995-07-26
US5202415A (en)	1993-04-13
JP2766999B2 (ja)	1998-06-18
DE68908491D1 (de)	1993-09-23
JPH03505206A (ja)	1991-11-14
EP0347845A3 (en)	1991-07-03
EP0347845A2 (en)	1989-12-27
US5324641A (en)	1994-06-28
KR900701841A (ko)	1990-12-04
PT90897A (pt)	1989-12-29
ZA894639B (en)	1991-12-24
EP0347845B1 (en)	1993-08-18
PT90897B (pt)	1995-03-31
WO1989012647A1 (en)	1989-12-28
NO905470L (no)	1991-02-18
FI102294B1 (fi)	1998-11-13
IE891976L (en)	1989-12-20
ATE93239T1 (de)	1993-09-15
NO905470D0 (no)	1990-12-19
KR0140238B1 (en)	1998-07-01
DK336188D0 (da)	1988-06-20

Publication	Publication Date	Title
FI102294B1 (fi)	1998-11-13	Insuliiniprekursorit
DK323687A (da)	1987-06-25	Insulinprecursorer og fremgangsmaade til fremstilling deraf
NO885659D0 (no)	1988-12-20	Mycobakterielle rekombinanter og peptider.
SG49097A1 (en)	1998-05-18	Nucleotide sequences coding for a protein with urease activity
ES2009238A6 (es)	1989-09-16	Metodo para producir proteinas de mycobacterium tuberculosis y peptidos antigenicos de las mismas.
AU5945086A (en)	1987-01-08	Hybrid polypeptides by recombinant dna technology
NO924234D0 (no)	1992-11-04	Variant cd44-overflateproteiner, dna-sekvenser som koder for proteinene, antistoffer mot proteinene, samt anvendelser av proteinene i diagnose og terapi
DE69334350D1 (de)	2011-04-21	P- Selectin Ligandenprotein
DK0476233T3 (da)	1996-03-11	Humant MK gen og proteinsekvens
DK301090A (da)	1990-12-19	Insulinprecursorer
NZ232178A (en)	1991-10-25	Preparation of insulin precursor
DK238585A (da)	1985-12-01	Peptider og fremstilling deraf