DK3016665T3 - Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser - Google Patents
Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser Download PDFInfo
- Publication number
- DK3016665T3 DK3016665T3 DK14753019T DK14753019T DK3016665T3 DK 3016665 T3 DK3016665 T3 DK 3016665T3 DK 14753019 T DK14753019 T DK 14753019T DK 14753019 T DK14753019 T DK 14753019T DK 3016665 T3 DK3016665 T3 DK 3016665T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- stem cells
- conditioned medium
- human adult
- adult liver
- Prior art date
Links
- 239000003636 conditioned culture medium Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 210000004185 liver Anatomy 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/14—Coculture with; Conditioned medium produced by hepatocytes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Physiology (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13175442 | 2013-07-05 | ||
| PCT/EP2014/064437 WO2015001124A1 (en) | 2013-07-05 | 2014-07-07 | Conditioned medium from human adult liver stem cells and its use in the treatment of liver disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3016665T3 true DK3016665T3 (da) | 2019-11-25 |
Family
ID=48792979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14753019T DK3016665T3 (da) | 2013-07-05 | 2014-07-07 | Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20160129047A1 (da) |
| EP (1) | EP3016665B1 (da) |
| JP (1) | JP6474394B2 (da) |
| DK (1) | DK3016665T3 (da) |
| ES (1) | ES2759228T3 (da) |
| WO (1) | WO2015001124A1 (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3016665T3 (da) | 2013-07-05 | 2019-11-25 | Univ Catholique Louvain | Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser |
| PL3140393T3 (pl) * | 2014-08-28 | 2023-11-06 | Cellaïon SA | Sposób wytwarzania komórek progenitorowych dorosłej wątroby |
| CL2015002971A1 (es) * | 2015-10-05 | 2016-06-24 | Univ Del Desarrollo | Composición biofarmacológica que comprende componentes producidos y/o secretados por células troncales mesenquimales (msc), que permite recuperar la capacidad regenerativa tisular, en una situación de esteatosis hepática, o donde la capacidad de regeneración endógena del tejido hepático se encuentra inhibida |
| SG11201807041PA (en) | 2016-03-02 | 2018-09-27 | Univ Catholique Louvain | Improved preparations of adult liver progenitor cells |
| EP3452100B1 (en) * | 2016-05-06 | 2020-12-16 | Unicyte EV AG | Pharmaceutical carriers containing mirnas for use in the treatment of fibrotic diseases caused by hyperglycemia |
| JP7452934B2 (ja) * | 2019-03-26 | 2024-03-19 | セライオン エスエイ | 慢性肝不全の急性憎悪の治療のための成人肝前駆細胞 |
| JP2022551293A (ja) * | 2019-10-09 | 2022-12-08 | セライオン エスアー | 血管透過性亢進を特徴とする疾患における肝臓前駆細胞または幹細胞、その溶解物、および／または馴化培地の使用 |
| EP3881853A1 (en) * | 2020-03-20 | 2021-09-22 | Promethera Therapeutics Sa | Human allogeneic liver-derived progenitor cells for use in the treatment of inflammatory and infectious lung diseases and systemic inflammation |
| CN113621557A (zh) * | 2021-09-02 | 2021-11-09 | 中国烟草总公司郑州烟草研究院 | 一种人肝微粒体与细胞共培养体系及其构建方法和应用 |
| CN114748505A (zh) * | 2022-01-17 | 2022-07-15 | 桂林医学院 | 骨髓间充质干细胞外泌体的应用 |
| WO2023180122A1 (en) | 2022-03-24 | 2023-09-28 | Université Catholique de Louvain | Use of human allogenic liver-derived progenitor cells for treating and/or preventing cellular senescence |
| WO2024200809A1 (en) | 2023-03-31 | 2024-10-03 | Université Catholique de Louvain | Use of human allogenic liver-derived progenitor cells for treating and/or preventing hepatocellular carcinoma |
| CN119842594B (zh) * | 2024-12-30 | 2025-11-04 | 合肥综合性国家科学中心大健康研究院 | 一种含间质的肝类器官的制备方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0400047B1 (en) | 1988-02-05 | 1997-04-23 | Whitehead Institute For Biomedical Research | Modified hepatocytes and uses therefor |
| US6069005A (en) | 1991-08-07 | 2000-05-30 | Albert Einstein College Of Medicine Of Yeshwa University | Hapatoblasts and method of isolating same |
| PT671923E (pt) | 1992-10-09 | 2001-10-30 | Advanced Tissue Sciences Inc | Celulas de reserva do figado |
| JP2002505095A (ja) | 1998-03-03 | 2002-02-19 | マガイニン ファーマシューティカルズ インコーポレイテッド | 喘息及び関連疾患を含むアトピー性アレルギーを治療するための標的としての喘息関連因子 |
| US8778899B2 (en) | 1999-06-01 | 2014-07-15 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| US6774120B1 (en) | 1999-06-01 | 2004-08-10 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| EP1252293B1 (en) | 2000-01-19 | 2012-10-03 | University Of North Carolina At Chapel Hill | Liver tissue source |
| GB0014136D0 (en) | 2000-06-10 | 2000-08-02 | Astrazeneca Ab | Combination therapy |
| US7211404B2 (en) | 2001-06-22 | 2007-05-01 | Stem Cells, Inc. | Liver engrafting cells, assays, and uses thereof |
| WO2003033697A1 (en) | 2001-10-18 | 2003-04-24 | Ixion Biotechnology, Inc. | Conversion of liver stem and progenitor cells to pancreatic functional cells |
| DE10202982A1 (de) | 2002-01-26 | 2003-07-31 | Augustinus Bader | Verfahren und Vorrichtung zum Einbringen von lebenden Zellen in eine biologische Körperflüssigkeit |
| WO2004098646A1 (en) | 2003-05-12 | 2004-11-18 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| CA2444292A1 (en) | 2003-10-03 | 2005-04-03 | Inserm | Bipotential liver cell lines from wild-type mammalian liver tissue |
| WO2005035738A1 (en) | 2003-10-07 | 2005-04-21 | Biomaster Inc. | Cell differentiation of adipose-derived precursor cells |
| US20060222640A1 (en) | 2005-03-29 | 2006-10-05 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions for treatment of thrombosis |
| BRPI0520280A2 (pt) | 2005-05-10 | 2009-04-28 | Us Of America Dept Of Veteran | terapia de disfunÇÕes renais e falÊncia méltipla de àrgços com cÉlulas-tronco mesenquimais e meio condicionado por exposiÇço a cÉlulas-tronco mesenquimais |
| WO2006126219A1 (en) | 2005-05-26 | 2006-11-30 | Fresenius Medical Care Deutschland G.M.B.H. | Liver progenitor cells |
| EP1996013A4 (en) | 2005-09-21 | 2010-03-10 | Dask Technologies Llc | METHODS AND COMPOSITIONS FOR FUNCTIONALITY OF ORGANS AND TISSUES |
| ATE498005T1 (de) | 2005-12-21 | 2011-02-15 | Univ Catholique Louvain | Isolierte leberstammzellen |
| ES2583371T3 (es) | 2006-10-11 | 2016-09-20 | The General Hospital Corporation | Composiciones, métodos, y dispositivos para tratar enfermedades hepáticas |
| WO2008070868A1 (en) | 2006-12-07 | 2008-06-12 | American Symbolic, Llc | Stem cell secretions and related methods |
| US8568771B2 (en) | 2007-10-29 | 2013-10-29 | Fresenius Medical Care Deutschland G.M.B.H. | Use of microvesicles (MVs) derived from stem cells for preparing a medicament for endo/epithellal regeneration of damaged or injured tissues or organs, and related in vitro and in vivo methods |
| PL2254586T3 (pl) | 2008-02-22 | 2015-09-30 | Agency For Science Tech And Research Astarstar | Cząstki mezenchymalnych komórek macierzystych |
| BRPI0909866B1 (pt) | 2008-06-11 | 2021-08-24 | Fresenius Medical Care Deutschland Gmbh | Método de produção de um meio condicionado de células progenitoras de fígado, meio condicionado e composição farmacêutica |
| FI20095409A0 (fi) | 2009-04-14 | 2009-04-14 | Helsingin Yliopisto | Soluviljelysupplementti |
| SG10201403202XA (en) | 2009-07-23 | 2014-08-28 | Agency Science Tech & Res | Pre-natal mesenchymal stem cells |
| EP2333047A1 (en) | 2009-12-09 | 2011-06-15 | Fresenius Medical Care Deutschland GmbH | Adult stem cell derived conditioned medium and/or adult stem cells for use in the therapeutic treatment of a tumor disease |
| US8415149B2 (en) | 2010-05-06 | 2013-04-09 | Gwo Xi Stem Cell Applied Technology Co., Ltd. | Hepatic progenitor cells and uses thereof |
| CN103402527B (zh) | 2011-01-25 | 2016-04-20 | 鲁汶大学 | 用于细胞移植的组合物和方法 |
| JP6034406B2 (ja) | 2012-01-25 | 2016-11-30 | ユニヴェルシテ カソリック ド ルーヴァンＵｎｉｖｅｒｓｉｔｅ Ｃａｔｈｏｌｉｑｕｅ Ｄｅ Ｌｏｕｖａｉｎ | 細胞移植のための組成物および方法 |
| DK3016665T3 (da) | 2013-07-05 | 2019-11-25 | Univ Catholique Louvain | Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser |
| SG11201807041PA (en) | 2016-03-02 | 2018-09-27 | Univ Catholique Louvain | Improved preparations of adult liver progenitor cells |
-
2014
- 2014-07-07 DK DK14753019T patent/DK3016665T3/da active
- 2014-07-07 WO PCT/EP2014/064437 patent/WO2015001124A1/en not_active Ceased
- 2014-07-07 EP EP14753019.0A patent/EP3016665B1/en active Active
- 2014-07-07 JP JP2016522658A patent/JP6474394B2/ja not_active Expired - Fee Related
- 2014-07-07 ES ES14753019T patent/ES2759228T3/es active Active
- 2014-07-07 US US14/899,661 patent/US20160129047A1/en not_active Abandoned
-
2018
- 2018-03-29 US US15/940,897 patent/US10874699B2/en active Active
-
2020
- 2020-11-25 US US17/104,202 patent/US11793837B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20180289747A1 (en) | 2018-10-11 |
| JP6474394B2 (ja) | 2019-02-27 |
| US20210077537A1 (en) | 2021-03-18 |
| EP3016665A1 (en) | 2016-05-11 |
| US10874699B2 (en) | 2020-12-29 |
| ES2759228T3 (es) | 2020-05-08 |
| US11793837B2 (en) | 2023-10-24 |
| US20160129047A1 (en) | 2016-05-12 |
| WO2015001124A1 (en) | 2015-01-08 |
| JP2016523883A (ja) | 2016-08-12 |
| EP3016665B1 (en) | 2019-09-18 |
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