DK3049099T3 - Amyloid-beta-bindende peptider og anvendelse deraf til terapi og diagnosticering af alzheimers demens - Google Patents
Amyloid-beta-bindende peptider og anvendelse deraf til terapi og diagnosticering af alzheimers demens Download PDFInfo
- Publication number
- DK3049099T3 DK3049099T3 DK14799955.1T DK14799955T DK3049099T3 DK 3049099 T3 DK3049099 T3 DK 3049099T3 DK 14799955 T DK14799955 T DK 14799955T DK 3049099 T3 DK3049099 T3 DK 3049099T3
- Authority
- DK
- Denmark
- Prior art keywords
- dementia
- alzheimer
- diagnosis
- therapy
- binding peptides
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102013016002.2A DE102013016002A1 (de) | 2013-09-26 | 2013-09-26 | Zyklische, Amyloid-Beta-bindende Peptide und deren Verwendung |
| DE102014003262.0A DE102014003262A1 (de) | 2014-03-12 | 2014-03-12 | Amyloid-Beta-bindende Peptide und deren Verwendung für die Therapie und die Diagnose der Alzheimerschen Demenz |
| PCT/DE2014/000477 WO2015043567A1 (de) | 2013-09-26 | 2014-09-23 | Amyloid-beta-bindende peptide und deren verwendung für die therapie und die diagnose der alzheimerschen demenz |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3049099T3 true DK3049099T3 (da) | 2020-09-21 |
Family
ID=51932152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14799955.1T DK3049099T3 (da) | 2013-09-26 | 2014-09-23 | Amyloid-beta-bindende peptider og anvendelse deraf til terapi og diagnosticering af alzheimers demens |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10995118B2 (da) |
| EP (2) | EP3049099B1 (da) |
| JP (1) | JP6660877B2 (da) |
| CN (1) | CN105745219B (da) |
| DK (1) | DK3049099T3 (da) |
| ES (2) | ES2953883T3 (da) |
| WO (1) | WO2015043567A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102016125645A1 (de) * | 2016-12-23 | 2018-06-28 | Forschungszentrum Jülich GmbH | D-enantiomere Peptide zur Therapie von chronischem und neuropathischem Schmerz |
| CN106866792B (zh) * | 2017-02-24 | 2020-09-04 | 中山大学 | 一类环十肽分子及其应用 |
| DE102017010842A1 (de) * | 2017-11-23 | 2019-05-23 | Forschungszentrum Jülich GmbH | Verfahren zur Quantifizierung von Proteinaggregaten einer Proteinfehlfaltungserkrankung in einer Probe |
| DE102021121435A1 (de) | 2021-08-18 | 2023-02-23 | Priavoid Gmbh | Aß-BINDENDE SUBSTANZEN |
| WO2025038979A1 (en) * | 2023-08-16 | 2025-02-20 | LVIS-Regain LP | Compositions and methods for prophylaxis and/or treatment of amyloid b peptide proteinopenia in alzheimer's and other diseases |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5854204A (en) | 1995-03-14 | 1998-12-29 | Praecis Pharmaceuticals, Inc. | Aβ peptides that modulate β-amyloid aggregation |
| US7384910B2 (en) | 1997-10-08 | 2008-06-10 | Castillo Gerardo M | Small peptides for the treatment of Alzheimer's disease and other beta-amyloid protein fibrillogenesis disorders |
| EP1141250B1 (en) | 1998-12-18 | 2006-03-01 | The Penn State Research Foundation | Intein-mediated cyclization of peptides |
| JP2004513873A (ja) * | 1999-11-05 | 2004-05-13 | アクソニックス,インコーポレイティド | アミロイド、アミロイド様沈着物またはそれらのβ−シートリッチな病理前駆体への異常タンパク質折り畳みに関係する疾患の治療における生体内使用に適するペプチド類似物および模倣物 |
| WO2001036431A1 (en) | 1999-11-15 | 2001-05-25 | Parker Hughes Institute | Diamino platinum (ii) antitumor complexes |
| DE10117281A1 (de) * | 2001-04-06 | 2002-10-24 | Inst Molekulare Biotechnologie | Peptid zur Diagnose und Therapie der Alzheimer-Demenz |
| CN101415724B (zh) * | 2003-06-30 | 2015-12-02 | 特拉维夫大学未来科技开发有限公司 | 肽、抗肽抗体以及用它们来诊断和治疗淀粉样蛋白相关疾病的方法 |
| GB0503434D0 (en) * | 2005-02-18 | 2005-03-30 | Senexis Ltd | Amyloid-binding peptides, analogues and uses thereof |
| DE102005049537B4 (de) | 2005-10-17 | 2010-04-22 | Forschungszentrum Karlsruhe Gmbh | Verfahren zur Herstellung zyklischer Peptide und Verwendung der derart hergestellten zyklischen Peptide |
| DE102006015140A1 (de) | 2006-03-31 | 2007-10-11 | Philipps-Universität Marburg | Heterozyklische Verbindungen mit Wirkung gegen neurodegenerative Erkrankungen |
| WO2007145589A1 (en) | 2006-06-15 | 2007-12-21 | Per Arvidsson | Peptides that are capable of binding to amyloid-beta peptide. |
| EP2139524A1 (en) | 2007-03-23 | 2010-01-06 | The Governors of the University of Alberta | Multivalent heterobifunctional polymers and methods of their use |
| DE102008037564A1 (de) * | 2008-11-19 | 2010-05-20 | Forschungszentrum Jülich GmbH | Zusammensetzung zur Herstellung von anti-Amyloid beta-Peptid-Antikörpern mit D-Peptiden |
| DE102010019336A1 (de) | 2010-05-05 | 2011-11-10 | Forschungszentrum Jülich GmbH | Mittel zur Behandlung der Alzheimerschen Demenz |
| DE102010017130B4 (de) | 2010-05-28 | 2018-11-29 | Forschungszentrum Jülich GmbH | Hybrid-Verbindung, deren Verwendung und Verfahren zu deren Herstellung |
| US9504759B2 (en) * | 2011-08-11 | 2016-11-29 | Bar-Ilan University | Surface modified proteinaceous spherical particles and uses thereof |
| CN108926749A (zh) | 2012-04-05 | 2018-12-04 | 于利希研究中心有限公司 | 处理血液、血液产品和器官的方法 |
| DK2834644T3 (da) | 2012-04-05 | 2019-11-04 | Forschungszentrum Juelich Gmbh | Polymerer, indeholdende multivalente amyloid-beta-bindende d-peptider og deres anvendelse |
| DE102012102999A1 (de) | 2012-04-05 | 2013-10-10 | Forschungszentrum Jülich GmbH | Verfahren zur Behandlung von Blut, Blutprodukten und Organen |
| DE102012102998B4 (de) | 2012-04-05 | 2013-12-05 | Forschungszentrum Jülich GmbH | Polymere, enthaltend multivalente Amyloid-Beta-bindende D-Peptide und deren Verwendung |
| WO2014177127A1 (de) | 2013-04-30 | 2014-11-06 | Forschungszentrum Jülich GmbH | Agenzien zur prävention und therapie von hiv und anderer viraler infektionen |
-
2014
- 2014-09-23 US US15/022,749 patent/US10995118B2/en active Active
- 2014-09-23 WO PCT/DE2014/000477 patent/WO2015043567A1/de not_active Ceased
- 2014-09-23 ES ES20180219T patent/ES2953883T3/es active Active
- 2014-09-23 ES ES14799955T patent/ES2818929T3/es active Active
- 2014-09-23 EP EP14799955.1A patent/EP3049099B1/de active Active
- 2014-09-23 EP EP20180219.6A patent/EP3747454B9/de active Active
- 2014-09-23 JP JP2016517288A patent/JP6660877B2/ja active Active
- 2014-09-23 DK DK14799955.1T patent/DK3049099T3/da active
- 2014-09-23 CN CN201480053169.1A patent/CN105745219B/zh active Active
-
2020
- 2020-06-22 US US16/908,606 patent/US11274125B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20200317734A1 (en) | 2020-10-08 |
| JP6660877B2 (ja) | 2020-03-11 |
| EP3747454A1 (de) | 2020-12-09 |
| EP3747454C0 (de) | 2023-06-07 |
| ES2818929T3 (es) | 2021-04-14 |
| EP3049099B1 (de) | 2020-06-17 |
| JP2016539911A (ja) | 2016-12-22 |
| WO2015043567A1 (de) | 2015-04-02 |
| CN105745219B (zh) | 2020-10-09 |
| ES2953883T3 (es) | 2023-11-16 |
| US20200002379A9 (en) | 2020-01-02 |
| EP3049099A1 (de) | 2016-08-03 |
| EP3747454B1 (de) | 2023-06-07 |
| US10995118B2 (en) | 2021-05-04 |
| US11274125B2 (en) | 2022-03-15 |
| US20160297852A1 (en) | 2016-10-13 |
| CN105745219A (zh) | 2016-07-06 |
| EP3747454B9 (de) | 2023-10-04 |
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