DK3064508T4 - Fremgangsmåde til fremstilling af rekombinant vwf med høj molekylevægt i cellekultur - Google Patents

Fremgangsmåde til fremstilling af rekombinant vwf med høj molekylevægt i cellekultur Download PDF

Info

Publication number
DK3064508T4
DK3064508T4 DK16153131.4T DK16153131T DK3064508T4 DK 3064508 T4 DK3064508 T4 DK 3064508T4 DK 16153131 T DK16153131 T DK 16153131T DK 3064508 T4 DK3064508 T4 DK 3064508T4
Authority
DK
Denmark
Prior art keywords
procedure
production
molecular weight
cell culture
high molecular
Prior art date
Application number
DK16153131.4T
Other languages
English (en)
Other versions
DK3064508T3 (da
Inventor
Leopold Grillberger
Manfred Reiter
Wolfgang Mundt
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44514323&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3064508(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Application granted granted Critical
Publication of DK3064508T3 publication Critical patent/DK3064508T3/da
Publication of DK3064508T4 publication Critical patent/DK3064508T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24087—ADAMTS13 endopeptidase (3.4.24.87)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00—Cells for large scale production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK16153131.4T 2010-07-08 2011-07-08 Fremgangsmåde til fremstilling af rekombinant vwf med høj molekylevægt i cellekultur DK3064508T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36263510P 2010-07-08 2010-07-08
EP11736502.3A EP2590998B1 (en) 2010-07-08 2011-07-08 METHOD OF PRODUCING RECOMBINANT HIGH MOLECULAR WEIGHT vWF IN CELL CULTURE

Publications (2)

Publication Number Publication Date
DK3064508T3 DK3064508T3 (da) 2019-11-25
DK3064508T4 true DK3064508T4 (da) 2023-04-11

Family

ID=44514323

Family Applications (4)

Application Number Title Priority Date Filing Date
DK16153131.4T DK3064508T4 (da) 2010-07-08 2011-07-08 Fremgangsmåde til fremstilling af rekombinant vwf med høj molekylevægt i cellekultur
DK11736502.3T DK2590998T3 (da) 2010-07-08 2011-07-08 FREMGANGSMÅDE TIL FREMSTILLING AF REKOMBINANT vWF MED HØJ MOLEKYLEVÆGT I CELLEKULTUR
DK11738351.3T DK2591094T3 (da) 2010-07-08 2011-07-08 Fremgangsmåde til fremstilling af rekombinant adamts13 i cellekultur
DK19191438.1T DK3626736T3 (da) 2010-07-08 2011-07-08 Fremgangsmåde til fremstilling af en rekombinant høj molekylevægt vwf i cellekultur

Family Applications After (3)

Application Number Title Priority Date Filing Date
DK11736502.3T DK2590998T3 (da) 2010-07-08 2011-07-08 FREMGANGSMÅDE TIL FREMSTILLING AF REKOMBINANT vWF MED HØJ MOLEKYLEVÆGT I CELLEKULTUR
DK11738351.3T DK2591094T3 (da) 2010-07-08 2011-07-08 Fremgangsmåde til fremstilling af rekombinant adamts13 i cellekultur
DK19191438.1T DK3626736T3 (da) 2010-07-08 2011-07-08 Fremgangsmåde til fremstilling af en rekombinant høj molekylevægt vwf i cellekultur

Country Status (25)

Country Link
US (8) US8852888B2 (da)
EP (7) EP4628093A3 (da)
JP (3) JP5953502B2 (da)
KR (4) KR102027991B1 (da)
CN (4) CN108060154A (da)
AU (6) AU2011274470B2 (da)
BR (1) BR112013000515B1 (da)
CA (2) CA2805557A1 (da)
CO (2) CO6680636A2 (da)
DK (4) DK3064508T4 (da)
EA (5) EA202090220A3 (da)
ES (5) ES3037386T3 (da)
FI (2) FI3064508T4 (da)
HR (4) HRP20192089T4 (da)
HU (4) HUE046443T2 (da)
IL (5) IL223930A (da)
MX (3) MX2013000166A (da)
NZ (2) NZ605403A (da)
PL (5) PL3392271T3 (da)
PT (4) PT2591094T (da)
SG (3) SG10201809632XA (da)
SI (4) SI3064508T2 (da)
TR (1) TR201815211T4 (da)
TW (4) TWI609890B (da)
WO (2) WO2012006591A1 (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2685503T3 (es) 2008-12-05 2018-10-09 Baxalta GmbH Métodos de medida de la división in vivo de Factor von Willebrand mediada por ADAMTS13 y utilización de los mismos
AU2010202125B1 (en) 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
WO2011150284A2 (en) 2010-05-26 2011-12-01 Baxter International Inc. Removal of serine proteases by treatment with finely divided silicon dioxide
CA2805557A1 (en) 2010-07-08 2012-01-12 Baxter International Inc. Method of producing recombinant high molecular weight vwf in cell culture
ES2682249T3 (es) * 2011-06-10 2018-09-19 Baxalta GmbH Tratamiento de una enfermedad de la coagulación mediante la administración de VWF recombinante
US9030963B2 (en) * 2012-12-03 2015-05-12 Honeywell International Inc. Analyzing a network topology
UY35343A (es) * 2013-02-26 2014-09-30 Bayer Healthcare Llc Formulaciones y procedimientos para la producción de proteína recombinante aumentada
US9677105B2 (en) 2013-03-14 2017-06-13 Momenta Pharmaceuticals, Inc. Methods of cell culture
US20140271622A1 (en) * 2013-03-14 2014-09-18 Momenta Pharmaceuticals, Inc. Methods of cell culture
US8956830B2 (en) 2013-03-14 2015-02-17 Momenta Pharmaceuticals, Inc. Methods of cell culture
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
AU2013203062C1 (en) 2013-03-15 2018-06-28 Takeda Pharmaceutical Company Limited Subcutaneous administration of adamts13
EP3131929B1 (en) 2014-04-16 2022-06-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies for the prevention or the treatment of bleeding episodes
PL3158055T3 (pl) * 2014-06-13 2020-03-31 Csl Limited Ulepszone wytwarzanie rekombinowanego czynnika von Willebranda w bioreaktorze
MA41685A (fr) 2014-10-17 2017-08-22 Biogen Ma Inc Supplémentation en cuivre pour la régulation de la glycosylation dans un procédé de culture cellulaire de mammifère
CA2973343C (en) * 2015-02-05 2023-08-08 R.P. Scherer Technologies, Llc Activated formylglycine-generating enzymes and methods of producing and using the same
AR104050A1 (es) 2015-03-26 2017-06-21 Chugai Pharmaceutical Co Ltd Proceso de producción con iones de cobre controlados
TW202440904A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法（二）
US11191818B2 (en) 2016-08-04 2021-12-07 Takeda Pharmaceutical Company Limited Use of ADAMTS13 for treating, ameliorating and/or preventing vaso-occlusive crisis in sickle cell disease, acute lung injury and/or acute respiratory distress syndrome
CN106957815B (zh) * 2017-03-16 2021-05-07 杨涛 一种用于人类多潜能干细胞的无血清培养基的配方
CA3069295A1 (en) 2017-07-07 2019-01-10 Baxalta Incorporated Treatment of gastrointestinal bleeding in patients with severe von willebrand disease by administration of recombinant vwf
US20190091298A1 (en) 2017-07-07 2019-03-28 Baxalta Incorporated Treatment of patients with severe von willebrand disease undergoing elective surgery by administration of recombinant vwf
CA3094644A1 (en) 2018-03-21 2019-09-26 Baxalta Incorporated Separation of vwf and vwf propeptide by chromatographic methods
US12128090B2 (en) 2019-02-01 2024-10-29 Takeda Pharmaceutical Company Limited Methods of prophylactic treatment using recombinant VWF (rVWF)
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
US10961500B1 (en) 2019-04-23 2021-03-30 Regeneron Pharmaceuticals, Inc. Cell culture medium for eukaryotic cells
US20220401524A1 (en) 2019-09-11 2022-12-22 Takeda Pharmaceutical Company Limited Methods of treatment related to complexes of von willebrand factor and complement c1q
WO2021067668A1 (en) 2019-10-04 2021-04-08 The Children's Medical Center Corporation Adamts13 treatment to enhance graft survival
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
KR20220150303A (ko) 2020-02-04 2022-11-10 다케다 야쿠힌 고교 가부시키가이샤 재조합 vwf의 투여에 의한 중증 폰 빌레브란트병 환자의 월경과다 치료
EP4150045A1 (en) * 2020-05-12 2023-03-22 PBS Biotech, Inc. Material transfer devices and related systems and methods
JP2023526546A (ja) 2020-05-22 2023-06-21 武田薬品工業株式会社 コロナウイルス疾患の合併症の治療及び診断のための、ａｄａｍｔｓ１３組成物及び方法

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
NL8500961A (nl) 1985-04-01 1986-11-03 Stichting Vrienden Van De Stic Cdna-codering voor de humane von willebrand-factor, plasmiden met een dergelijke cdna-codering respektievelijk fragmenten ervan, alsmede micro-organismen, welke dergelijke plasmiden bevatten.
JPS62502589A (ja) 1985-04-11 1987-10-08 ザ・チヤイルドレンズ・メデイカル・センタ−・コ−ポレ−シヨン フオン・ビルブラント因子
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
ES2378409T3 (es) 1994-11-10 2012-04-12 Baxter Healthcare S.A. Método para producir sustancias biológicas en cultivo sin proteínas
DE69608668T2 (de) 1995-02-23 2001-02-01 Quest International B.V., Naarden Peptide für gewebe- und zellkulturmedien
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
EP1482031B1 (en) 1996-08-30 2015-10-28 Life Technologies Corporation Serum-free mammalian cell culture medium, and uses thereof
US6458574B1 (en) * 1996-09-12 2002-10-01 Transkaryotic Therapies, Inc. Treatment of a α-galactosidase a deficiency
JP4543402B2 (ja) 1996-10-10 2010-09-15 ライフ テクノロジーズ コーポレーション 植物由来栄養素を含む動物細胞培養培地
WO1998041611A1 (en) * 1997-03-20 1998-09-24 Regents Of The University Of Minnesota Process for the continuous culture of cells
US5804420A (en) 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
AT407255B (de) 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
US6531577B1 (en) 1997-12-15 2003-03-11 Hemasure Denmark A/S von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations
US6528286B1 (en) * 1998-05-29 2003-03-04 Genentech, Inc. Mammalian cell culture process for producing glycoproteins
US6406909B1 (en) 1998-07-10 2002-06-18 Chugai Seiyaku Kabushiki Kaisha Serum-free medium for culturing animal cells
AT409379B (de) 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
JP2001120262A (ja) * 1999-10-26 2001-05-08 Welfide Corp 生理活性物質の産生増強方法
US6926894B2 (en) * 2000-11-22 2005-08-09 Baxter Aktiengesellschaft Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
HUP0402226A2 (hu) * 2001-11-28 2005-02-28 Sandoz Ag. Eljárás sejttenyésztésre
KR100982922B1 (ko) 2002-01-17 2010-09-20 론자 바이올로직스 피엘씨 단백질을 생산할 수 있으며 무글루타민 배지에서 성장할 수있는 글루타민-요구성 인간세포
US20050084828A1 (en) 2003-10-21 2005-04-21 The University Of North Carolina At Chapel Hill Apparatus and method for braille instruction
EP1593388A1 (en) 2004-05-05 2005-11-09 ZLB Behring GmbH Therapeutic plasma protein-concentrates containing von willebrand factor as high molecular weight multimers
TWI384069B (zh) * 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
US20060094104A1 (en) * 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
US8273553B2 (en) * 2004-11-02 2012-09-25 Ares Trading S.A. Production of growth hormone in serum-free cell culture medium for mammalian cells
SI1807504T1 (sl) * 2004-11-02 2011-05-31 Ares Trading Sa Brezserumski celiäśni kultivacijski medij za celice sesalcev
US20070049557A1 (en) 2005-08-24 2007-03-01 Hashim Ahmed Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers
EP3653699A1 (en) 2006-01-04 2020-05-20 Baxalta Incorporated Oligopeptide-free cell culture media
US20070190057A1 (en) * 2006-01-23 2007-08-16 Jian Wu Methods for modulating mannose content of recombinant proteins
CN101490239A (zh) * 2006-07-14 2009-07-22 帝斯曼知识产权资产管理有限公司 改进的细胞培养方法
TWI456062B (zh) * 2006-09-13 2014-10-11 Abbvie Inc 細胞培養改良
US7960869B2 (en) 2006-09-22 2011-06-14 Siemens Industry, Inc. Internal intelligence for remote operated relay
MX2009007145A (es) * 2006-12-27 2009-08-27 Nektar Therapeutics Al Corp Conjugados de polimero con factor viii y factor de von willebrand que tienen una ligadura liberable.
CA2679941C (en) * 2007-03-02 2016-09-20 Wyeth Use of copper and glutamate in cell culture for production of polypeptides
DE102007046611A1 (de) * 2007-09-28 2009-04-02 Osram Opto Semiconductors Gmbh Lichtquelle mit Konversionselement und Lichtwellenleiter, Verfahren zur Herstellung der Lichtquelle und deren Verwendung
PL2235197T3 (pl) 2007-12-27 2018-01-31 Baxalta GmbH Sposoby hodowli komórek
ES2735173T3 (es) 2007-12-31 2019-12-16 Baxalta GmbH Furina recombinante sustancialmente libre de proteína animal y métodos para producir la misma
JP4458167B2 (ja) * 2008-01-11 2010-04-28 住友金属工業株式会社 熱間塑性加工用潤滑剤を用いる継目無管製造における外面潤滑方法
US20110086813A1 (en) 2008-03-19 2011-04-14 Gad Glaser Compounds for treating bacterial infections
EP2310523B1 (en) 2008-04-17 2015-06-10 Wyeth LLC Methods for enhanced production of bone morphogenetic proteins
US8486699B2 (en) 2008-05-23 2013-07-16 The United States Of America As Represented By The Secretary Of Agriculture Immortal unipotent porcine PICM-19H and PICM-19B stem cell lines
US8580554B2 (en) * 2009-07-31 2013-11-12 Baxter International Inc. Method of producing a polypeptide or virus of interest in a continuous cell culture
CN104962539B (zh) * 2009-07-31 2019-09-17 百深公司 用于adamts蛋白表达的细胞培养基
CA2805557A1 (en) * 2010-07-08 2012-01-12 Baxter International Inc. Method of producing recombinant high molecular weight vwf in cell culture
TWI408228B (zh) 2010-10-29 2013-09-11 Univ Nat Chunghsing 用於生產一標的蛋白質的核酸建構物、重組型載體以及方法

Also Published As

Publication number Publication date
HUE038193T2 (hu) 2018-09-28
HRP20192089T1 (hr) 2020-03-20
KR20180099922A (ko) 2018-09-05
ES3037386T3 (en) 2025-10-01
TWI670073B (zh) 2019-09-01
EP3064508A1 (en) 2016-09-07
AU2011274467B2 (en) 2015-01-15
WO2012006591A1 (en) 2012-01-12
PL2590998T3 (pl) 2018-05-30
BR112013000512A2 (pt) 2016-05-17
JP2017217004A (ja) 2017-12-14
EP3909977A1 (en) 2021-11-17
KR20130091328A (ko) 2013-08-16
SG186935A1 (en) 2013-02-28
JP6138683B2 (ja) 2017-05-31
EA035066B1 (ru) 2020-04-23
AU2011274470A1 (en) 2013-01-24
KR102007773B1 (ko) 2019-08-06
HRP20181657T1 (hr) 2019-03-08
EP4628093A2 (en) 2025-10-08
EA202090220A3 (ru) 2020-08-31
IL255327B (en) 2020-04-30
BR112013000515B1 (pt) 2021-11-03
CA2804275A1 (en) 2012-01-12
US20170008948A1 (en) 2017-01-12
BR112013000515A2 (pt) 2016-05-17
CA2805557A1 (en) 2012-01-12
AU2015207811A1 (en) 2015-08-20
CN103097522A (zh) 2013-05-08
CO6680636A2 (es) 2013-05-31
KR20180130587A (ko) 2018-12-07
EP2590998A1 (en) 2013-05-15
JP5953502B2 (ja) 2016-07-20
US20150018525A1 (en) 2015-01-15
ES2694518T3 (es) 2018-12-21
IL223930A (en) 2017-01-31
EA029503B1 (ru) 2018-04-30
HRP20250948T1 (hr) 2025-10-10
US20120034674A1 (en) 2012-02-09
AU2011274470B2 (en) 2015-08-13
EP3626736B1 (en) 2025-06-11
TWI617575B (zh) 2018-03-11
PT3626736T (pt) 2025-08-11
US20150056657A1 (en) 2015-02-26
EP2590998B1 (en) 2017-11-15
AU2022200035A1 (en) 2022-01-20
NZ605403A (en) 2014-10-31
EA201390080A1 (ru) 2013-06-28
EP3064508B1 (en) 2019-08-28
EP3064508B2 (en) 2023-03-15
MX2013000165A (es) 2013-06-05
AU2011274467A1 (en) 2013-01-24
SI3064508T2 (sl) 2023-05-31
HRP20180136T1 (hr) 2018-04-06
MX339632B (es) 2016-06-02
IL286298B (en) 2022-08-01
KR101924120B1 (ko) 2018-11-30
AU2015207811B2 (en) 2017-10-19
EA202090220A2 (ru) 2020-05-31
JP2016025873A (ja) 2016-02-12
ES2875772T3 (es) 2021-11-11
PT2590998T (pt) 2018-02-13
US20210115110A1 (en) 2021-04-22
EP2591094A1 (en) 2013-05-15
WO2012006594A1 (en) 2012-01-12
JP6284919B2 (ja) 2018-02-28
EP3626736A1 (en) 2020-03-25
US9409971B2 (en) 2016-08-09
TW201204744A (en) 2012-02-01
EA035147B1 (ru) 2020-05-06
PL3064508T5 (pl) 2024-04-08
US10100099B2 (en) 2018-10-16
PL3392271T3 (pl) 2021-11-15
SI3064508T1 (sl) 2019-12-31
EP3392271B8 (en) 2021-06-16
FI3626736T3 (fi) 2025-08-22
US8852888B2 (en) 2014-10-07
PT3064508T (pt) 2019-12-05
AU2018200206B2 (en) 2020-05-28
TWI609890B (zh) 2018-01-01
TR201815211T4 (tr) 2018-11-21
CN107286235A (zh) 2017-10-24
EA201792340A2 (ru) 2018-02-28
AU2020203565A1 (en) 2020-06-18
MX2013000166A (es) 2013-06-05
ES2761692T5 (es) 2023-07-05
EP3392271B1 (en) 2021-05-05
HUE11738351T2 (hu) 2019-03-28
IL273304B (en) 2021-09-30
IL223929A (en) 2017-11-30
AU2018200206A1 (en) 2018-04-05
TW201206953A (en) 2012-02-16
SG10201809632XA (en) 2018-12-28
FI3064508T4 (fi) 2023-04-25
DK2590998T3 (da) 2018-02-12
US20190085052A1 (en) 2019-03-21
EA202090067A3 (ru) 2020-07-31
US10822394B2 (en) 2020-11-03
DK3626736T3 (da) 2025-08-18
TW201900207A (zh) 2019-01-01
EA201390082A1 (ru) 2013-06-28
ES2761692T3 (es) 2020-05-20
IL286298A (en) 2021-10-31
HRP20192089T4 (hr) 2023-04-28
JP2013538046A (ja) 2013-10-10
AU2020203565B2 (en) 2021-09-30
SI2591094T1 (sl) 2018-12-31
DK2591094T3 (da) 2018-11-26
HUE046443T2 (hu) 2020-03-30
US9458222B2 (en) 2016-10-04
EP2591094B1 (en) 2018-09-05
PT2591094T (pt) 2018-11-20
EP3392271A1 (en) 2018-10-24
KR20130091329A (ko) 2013-08-16
PL3064508T3 (pl) 2020-02-28
KR101894604B1 (ko) 2018-09-03
PL3626736T3 (pl) 2025-10-13
CO6690745A2 (es) 2013-06-17
HUE072809T2 (hu) 2025-12-28
EA202090067A2 (ru) 2020-04-30
US11780904B2 (en) 2023-10-10
IL255327A0 (en) 2017-12-31
PL2591094T3 (pl) 2019-02-28
JP2013533748A (ja) 2013-08-29
US20180044405A1 (en) 2018-02-15
CN108060154A (zh) 2018-05-22
SI2590998T1 (en) 2018-06-29
KR102027991B1 (ko) 2019-10-02
IL273304A (en) 2020-04-30
CN103097409A (zh) 2013-05-08
SI3626736T1 (sl) 2025-10-30
NZ605404A (en) 2014-08-29
US9834591B2 (en) 2017-12-05
US20120035110A1 (en) 2012-02-09
DK3064508T3 (da) 2019-11-25
EA201792340A3 (ru) 2018-07-31
SG186936A1 (en) 2013-02-28
TWI646972B (zh) 2019-01-11
MX353409B (es) 2018-01-11
TW201637665A (zh) 2016-11-01
EP4628093A3 (en) 2025-12-10
ES2664392T3 (es) 2018-04-19

Similar Documents

Publication Publication Date Title
DK3064508T4 (da) Fremgangsmåde til fremstilling af rekombinant vwf med høj molekylevægt i cellekultur
IL288509A (en) Mammalian cell culture
ZA201707452B (en) Cell culture compositions and methods for polypeptide production
FI20106121A7 (fi) Soluviljelymateriaali
DK3101127T3 (da) Alfa-amylasevarianter med forbedret stabilitet
EP2681306A4 (en) CELL CULTURE SYSTEM
DK2558538T3 (da) Zwitterion-holdige polymerer med høj moolekylvægt
PT2785359T (pt) Células estromais mesenquimatosas e usos relacionados com as mesmas
PL3321355T3 (pl) Sposoby i kompozycje do klinicznego pozyskiwania komórek alogenicznych oraz zastosowania terapeutyczne
EP3719852C0 (en) SOLAR CELL
HRP20200794T1 (hr) Keramidaza i diferencijacija stanica
DK2676555T3 (da) Polymer med høj molekylvægt til anvendelse
DK2776552T3 (da) Anordning til dyrkning af celler