DK3145536T3 - Modificeret tyrosinammoniaklyase - Google Patents
Modificeret tyrosinammoniaklyase Download PDFInfo
- Publication number
- DK3145536T3 DK3145536T3 DK15779558.4T DK15779558T DK3145536T3 DK 3145536 T3 DK3145536 T3 DK 3145536T3 DK 15779558 T DK15779558 T DK 15779558T DK 3145536 T3 DK3145536 T3 DK 3145536T3
- Authority
- DK
- Denmark
- Prior art keywords
- ammoniaklyase
- tyrosin
- modified
- tyrosin ammoniaklyase
- modified tyrosin
- Prior art date
Links
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Chemical class OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
- C12P13/225—Tyrosine; 3,4-Dihydroxyphenylalanine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y403/00—Carbon-nitrogen lyases (4.3)
- C12Y403/01—Ammonia-lyases (4.3.1)
- C12Y403/01023—Tyrosine ammonia-lyase (4.3.1.23)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Photolithography (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461980167P | 2014-04-16 | 2014-04-16 | |
| PCT/US2015/026080 WO2015161019A1 (en) | 2014-04-16 | 2015-04-16 | Engineered tyrosine ammonia lyase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3145536T3 true DK3145536T3 (da) | 2022-01-03 |
Family
ID=54321492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15779558.4T DK3145536T3 (da) | 2014-04-16 | 2015-04-16 | Modificeret tyrosinammoniaklyase |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US9605252B2 (da) |
| EP (2) | EP3928787A1 (da) |
| CA (1) | CA2943432A1 (da) |
| DK (1) | DK3145536T3 (da) |
| HU (1) | HUE056444T2 (da) |
| WO (1) | WO2015161019A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3928787A1 (en) | 2014-04-16 | 2021-12-29 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| WO2019241132A1 (en) * | 2018-06-12 | 2019-12-19 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| AU2019397401A1 (en) * | 2018-12-14 | 2021-06-17 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| US20230383535A1 (en) * | 2022-05-26 | 2023-11-30 | Green Canopy NODE Technologies, INC | Modular wall component and a method for manufacturing a modular wall component |
| WO2024130475A1 (zh) * | 2022-12-19 | 2024-06-27 | 深圳柏垠生物科技有限公司 | 防治非酒精性脂肪性肝炎的工程菌及其构建方法与应用 |
| CN117467651B (zh) * | 2023-12-27 | 2024-04-19 | 苏州优信合生技术有限公司 | 一种表达芳香族氨基酸降解酶重组多肽和重组细胞及其应用 |
| CN121022812B (zh) * | 2025-10-29 | 2026-02-17 | 浙江绿创生物科技有限公司 | 一种酪氨酸解氨酶突变体及其在生产对香豆酸中的应用 |
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| US603344A (en) | 1898-05-03 | Trough for well-curbs | ||
| US753653A (en) | 1903-09-14 | 1904-03-01 | American Car & Foundry Co | Hopper-bottom car. |
| US1114009A (en) | 1912-09-05 | 1914-10-20 | William A Linquist | Automobile-fender. |
| US6309883B1 (en) | 1994-02-17 | 2001-10-30 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US6995017B1 (en) | 1994-02-17 | 2006-02-07 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| US5928905A (en) | 1995-04-18 | 1999-07-27 | Glaxo Group Limited | End-complementary polymerase reaction |
| US6406855B1 (en) | 1994-02-17 | 2002-06-18 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| US6395547B1 (en) | 1994-02-17 | 2002-05-28 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US6165793A (en) | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US20060257890A1 (en) | 1996-05-20 | 2006-11-16 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| KR970703426A (ko) | 1994-06-03 | 1997-07-03 | 제임스 쉐한 | 정제된 Myceliophthora 락카제 및 그것을 암호화 하는 핵산(PURIFIED MYCELIOPHTHORA LACCASES AND NUCLEIC ACIDS ENCODING SAME) |
| EP0777737B1 (en) | 1994-06-30 | 2005-05-04 | Novozymes Biotech, Inc. | Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein |
| FI104465B (fi) | 1995-06-14 | 2000-02-15 | Valio Oy | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
| US6506602B1 (en) | 1996-03-25 | 2003-01-14 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US6096548A (en) | 1996-03-25 | 2000-08-01 | Maxygen, Inc. | Method for directing evolution of a virus |
| US7148054B2 (en) | 1997-01-17 | 2006-12-12 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
| US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
| KR100568008B1 (ko) | 1997-01-17 | 2006-04-07 | 맥시겐, 인크. | 반복적 서열 재조합에 의한 전세포 및 유기체의 개량 방법 |
| EP1036198B1 (en) | 1997-12-08 | 2012-09-26 | California Institute Of Technology | Method for creating polynucleotide and polypeptide sequences |
| US6365408B1 (en) | 1998-06-19 | 2002-04-02 | Maxygen, Inc. | Methods of evolving a polynucleotides by mutagenesis and recombination |
| JP4221100B2 (ja) | 1999-01-13 | 2009-02-12 | エルピーダメモリ株式会社 | 半導体装置 |
| US6436675B1 (en) | 1999-09-28 | 2002-08-20 | Maxygen, Inc. | Use of codon-varied oligonucleotide synthesis for synthetic shuffling |
| US6917882B2 (en) | 1999-01-19 | 2005-07-12 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
| US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US6368861B1 (en) | 1999-01-19 | 2002-04-09 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US7024312B1 (en) | 1999-01-19 | 2006-04-04 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
| US7702464B1 (en) | 2001-08-21 | 2010-04-20 | Maxygen, Inc. | Method and apparatus for codon determining |
| US6961664B2 (en) | 1999-01-19 | 2005-11-01 | Maxygen | Methods of populating data structures for use in evolutionary simulations |
| JP2002534966A (ja) | 1999-01-19 | 2002-10-22 | マキシジェン， インコーポレイテッド | オリゴヌクレオチド媒介核酸組換え |
| AU3719500A (en) | 1999-03-05 | 2000-09-21 | Maxygen, Inc. | Recombination of insertion modified nucleic acids |
| US7430477B2 (en) | 1999-10-12 | 2008-09-30 | Maxygen, Inc. | Methods of populating data structures for use in evolutionary simulations |
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| DK2278509T3 (da) | 2002-03-01 | 2014-12-15 | Codexis Mayflower Holdings Llc | Fremgangsmåder, systemer og software til identificering af funktionelle biomolekyler |
| US20050084907A1 (en) | 2002-03-01 | 2005-04-21 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
| US7747391B2 (en) | 2002-03-01 | 2010-06-29 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
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| EP1814984A2 (en) | 2004-09-17 | 2007-08-08 | Biomarin Pharmaceutical Inc. | Variants and chemically-modified variants of phenylalanine ammonia-lyase |
| EP1869174B1 (en) | 2005-03-10 | 2015-02-18 | BASF Enzymes LLC | Lyase enzymes, nucleic acids encoding them and methods for making and using them |
| US7534595B2 (en) | 2006-06-12 | 2009-05-19 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
| US7531341B1 (en) | 2006-06-12 | 2009-05-12 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
| WO2008069958A2 (en) * | 2006-12-01 | 2008-06-12 | The Salk Institute For Biological Studies | Substrate switched ammonia lyases and mutases |
| US7560263B2 (en) * | 2007-08-17 | 2009-07-14 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof |
| EP2285958B1 (en) | 2008-06-13 | 2016-03-09 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
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| US8383346B2 (en) | 2008-06-13 | 2013-02-26 | Codexis, Inc. | Combined automated parallel synthesis of polynucleotide variants |
| WO2010014225A2 (en) * | 2008-07-30 | 2010-02-04 | Biomarin Pharmaceutical Inc. | Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase |
| ES2690542T3 (es) * | 2010-02-04 | 2018-11-21 | Biomarin Pharmaceutical Inc. | Método para purificar variantes de fenilalanina amoníaco-liasa procariotas |
| EP2635685A4 (en) | 2010-11-05 | 2014-05-21 | Basf Plant Science Co Gmbh | PROCESS FOR INCREASING EARNINGS AND FINE CHEMICAL PRODUCTION IN PLANTS |
| US20130005012A1 (en) | 2011-06-23 | 2013-01-03 | Phytogene, Inc. | Enzymatic system for monomer synthesis |
| SMT201900315T1 (it) | 2013-04-18 | 2019-07-11 | Codexis Inc | Polipeptidi di fenilalanina ammoniaca liasi ingegnerizzati |
| EP3928787A1 (en) | 2014-04-16 | 2021-12-29 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
-
2015
- 2015-04-16 EP EP21181330.8A patent/EP3928787A1/en not_active Withdrawn
- 2015-04-16 US US14/688,126 patent/US9605252B2/en not_active Expired - Fee Related
- 2015-04-16 DK DK15779558.4T patent/DK3145536T3/da active
- 2015-04-16 EP EP15779558.4A patent/EP3145536B1/en active Active
- 2015-04-16 WO PCT/US2015/026080 patent/WO2015161019A1/en not_active Ceased
- 2015-04-16 HU HUE15779558A patent/HUE056444T2/hu unknown
- 2015-04-16 CA CA2943432A patent/CA2943432A1/en active Pending
-
2017
- 2017-02-14 US US15/432,429 patent/US10287567B2/en active Active
-
2019
- 2019-03-28 US US16/367,640 patent/US10533168B2/en not_active Expired - Fee Related
- 2019-11-20 US US16/689,503 patent/US11015184B2/en not_active Expired - Fee Related
-
2021
- 2021-04-27 US US17/242,181 patent/US20210254041A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US11015184B2 (en) | 2021-05-25 |
| US10533168B2 (en) | 2020-01-14 |
| WO2015161019A1 (en) | 2015-10-22 |
| US20170159038A1 (en) | 2017-06-08 |
| HUE056444T2 (hu) | 2022-02-28 |
| US10287567B2 (en) | 2019-05-14 |
| US20150299689A1 (en) | 2015-10-22 |
| CA2943432A1 (en) | 2015-10-22 |
| EP3145536A4 (en) | 2018-11-14 |
| US9605252B2 (en) | 2017-03-28 |
| US20210254041A1 (en) | 2021-08-19 |
| US20190211320A1 (en) | 2019-07-11 |
| EP3145536B1 (en) | 2021-10-27 |
| EP3145536A1 (en) | 2017-03-29 |
| US20200071688A1 (en) | 2020-03-05 |
| EP3928787A1 (en) | 2021-12-29 |
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