DK3110442T3 - Modificerede meningokok-fhbp-polypeptider - Google Patents

Modificerede meningokok-fhbp-polypeptider Download PDF

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Publication number
DK3110442T3
DK3110442T3 DK15707351.1T DK15707351T DK3110442T3 DK 3110442 T3 DK3110442 T3 DK 3110442T3 DK 15707351 T DK15707351 T DK 15707351T DK 3110442 T3 DK3110442 T3 DK 3110442T3
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DK
Denmark
Prior art keywords
meningokok
polypeptider
fhbp
modified
modified meningokok
Prior art date
Application number
DK15707351.1T
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English (en)
Inventor
Matthew Bottomley
Enrico Malito
Manuele Martinelli
Maria Scarselli
Original Assignee
Glaxosmithkline Biologicals Sa
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Publication of DK3110442T3 publication Critical patent/DK3110442T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/101—Plasmid DNA for bacteria

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
DK15707351.1T 2014-02-28 2015-02-27 Modificerede meningokok-fhbp-polypeptider DK3110442T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14157399 2014-02-28
EP14177566 2014-07-17
PCT/EP2015/054174 WO2015128480A1 (en) 2014-02-28 2015-02-27 Modified meningococcal fhbp polypeptides

Publications (1)

Publication Number Publication Date
DK3110442T3 true DK3110442T3 (da) 2020-12-14

Family

ID=52596977

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15707351.1T DK3110442T3 (da) 2014-02-28 2015-02-27 Modificerede meningokok-fhbp-polypeptider

Country Status (23)

Country Link
US (5) US10392424B2 (da)
EP (2) EP3782643A1 (da)
JP (3) JP6786394B2 (da)
KR (2) KR102779223B1 (da)
CN (1) CN106661092B (da)
AU (2) AU2015222121B2 (da)
CA (1) CA2940447C (da)
CY (1) CY1123622T1 (da)
DK (1) DK3110442T3 (da)
EA (1) EA034954B1 (da)
ES (1) ES2841378T3 (da)
HR (1) HRP20202080T1 (da)
HU (1) HUE052293T2 (da)
IL (1) IL247125B (da)
LT (1) LT3110442T (da)
MX (2) MX373277B (da)
PL (1) PL3110442T3 (da)
RS (1) RS61246B1 (da)
SG (2) SG11201606478YA (da)
SI (1) SI3110442T1 (da)
SM (1) SMT202000704T1 (da)
WO (1) WO2015128480A1 (da)
ZA (1) ZA201605534B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106661092B (zh) 2014-02-28 2021-07-06 葛兰素史密丝克莱恩生物有限公司 修饰的脑膜炎球菌fHbp多肽
MX2017000776A (es) * 2014-07-17 2017-05-04 Glaxosmithkline Biologicals Sa Polipeptidos fhbp meningococicos modificados.
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BR112017001417B1 (pt) 2014-07-23 2023-11-07 Children's Hospital & Research Center At Oakland Variantes da proteína de ligação ao fator h (fhbp), composição imunogênica e uso de uma fhbp variante referência cruzada
GB201614687D0 (en) * 2016-08-31 2016-10-12 Univ Oxford Innovation Ltd fHbp scaffold
SG11201906519RA (en) * 2017-01-31 2019-08-27 Pfizer Neisseria meningitidis compositions and methods thereof
EP3607967A1 (en) * 2018-08-09 2020-02-12 GlaxoSmithKline Biologicals S.A. Modified meningococcal fhbp polypeptides
MX2021010555A (es) 2019-03-08 2022-04-06 Glaxosmithkline Biologicals Sa Derivados carbocíclicos y derivados conjugados de los mismos y su uso en vacunas.
GB202013262D0 (en) 2020-08-25 2020-10-07 Glaxosmithkline Biologicals Sa Vaccine Composition
TW202245836A (zh) 2021-02-19 2022-12-01 美商賽諾菲巴斯德公司 重組ｂ型腦膜炎球菌疫苗
GB202115151D0 (en) 2021-10-21 2021-12-08 Glaxosmithkline Biologicals Sa Methods
GB202208093D0 (en) 2022-06-01 2022-07-13 Glaxosmithkline Biologicals Sa Immunogenic composition
GB202208089D0 (en) 2022-06-01 2022-07-13 Glaxosmithkline Biologicals Sa Immunogenic composition
TW202423477A (zh) 2022-08-03 2024-06-16 美商賽諾菲巴斯德公司 針對腦膜炎奈瑟氏菌b的含佐劑免疫原性組成物

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Also Published As

Publication number Publication date
RS61246B1 (sr) 2021-01-29
JP6786394B2 (ja) 2020-11-18
SMT202000704T1 (it) 2021-01-05
MX2020004419A (es) 2020-07-29
JP2022177111A (ja) 2022-11-30
JP7555785B2 (ja) 2024-09-25
WO2015128480A1 (en) 2015-09-03
EP3110442A1 (en) 2017-01-04
SG10201907875TA (en) 2019-09-27
EP3110442B1 (en) 2020-10-14
SG11201606478YA (en) 2016-09-29
CN106661092B (zh) 2021-07-06
PL3110442T3 (pl) 2021-04-19
US20240218026A1 (en) 2024-07-04
IL247125A0 (en) 2016-09-29
SI3110442T1 (sl) 2021-01-29
MX2016011176A (es) 2017-02-23
CA2940447C (en) 2023-07-11
CY1123622T1 (el) 2022-03-24
US20170008933A1 (en) 2017-01-12
MX373277B (es) 2020-05-20
HRP20202080T1 (hr) 2021-02-19
HUE052293T2 (hu) 2021-04-28
EA034954B1 (ru) 2020-04-10
AU2015222121A1 (en) 2016-10-13
LT3110442T (lt) 2020-12-28
ZA201605534B (en) 2022-05-25
US12415838B2 (en) 2025-09-16
AU2018202431A1 (en) 2018-04-26
KR20230035455A (ko) 2023-03-13
IL247125B (en) 2021-12-01
US20260146067A1 (en) 2026-05-28
US20190315812A1 (en) 2019-10-17
EA201691429A1 (ru) 2017-02-28
US11021522B2 (en) 2021-06-01
US11932671B2 (en) 2024-03-19
CA2940447A1 (en) 2015-09-03
BR112016019735A2 (pt) 2017-10-17
ES2841378T3 (es) 2021-07-08
EP3782643A1 (en) 2021-02-24
AU2015222121B2 (en) 2018-01-18
JP2017512060A (ja) 2017-05-18
CN106661092A (zh) 2017-05-10
KR20160127104A (ko) 2016-11-02
US10392424B2 (en) 2019-08-27
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KR102779223B1 (ko) 2025-03-07
US20210253647A1 (en) 2021-08-19

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