ATE284894T1 - L-pyranosyl-nukleoside - Google Patents

L-pyranosyl-nukleoside

Info

Publication number: ATE284894T1
Authority: AT; Austria
Prior art keywords: pyranosyl; nucleosides; beta; alpha; methods
Prior art date: 1994-10-24

Application number

AT95938872T

Other languages

English (en)

Inventor

Alexander L Weis

Charles T Goodhue

Original Assignee

Genencor Int

Lipitek Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-24

Filing date

1995-10-24

Publication date

2005-01-15

1995-10-24 Application filed by Genencor Int, Lipitek Inc filed Critical Genencor Int

2005-01-15 Application granted granted Critical

2005-01-15 Publication of ATE284894T1 publication Critical patent/ATE284894T1/de

Links

239000002777 nucleoside Substances 0.000 title abstract 4
ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 2
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 2
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 2
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 abstract 2
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
229930024421 Adenine Natural products 0.000 abstract 1
UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 1
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
229960000643 adenine Drugs 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
229940104302 cytosine Drugs 0.000 abstract 1
125000003835 nucleoside group Chemical group 0.000 abstract 1
150000003212 purines Chemical class 0.000 abstract 1
-1 pyranosyl carbohydrate Chemical class 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
229940113082 thymine Drugs 0.000 abstract 1
229940035893 uracil Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Epidemiology (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT95938872T 1994-10-24 1995-10-24 L-pyranosyl-nukleoside ATE284894T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US32793294A	1994-10-24	1994-10-24
PCT/US1995/013717 WO1996012728A1 (en)	1994-10-24	1995-10-24	L-pyranosyl nucleosides

Publications (1)

Publication Number	Publication Date
ATE284894T1 true ATE284894T1 (de)	2005-01-15

Family

ID=23278709

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95938872T ATE284894T1 (de)	1994-10-24	1995-10-24	L-pyranosyl-nukleoside

Country Status (7)

Country	Link
US (1)	US5885972A (de)
EP (1)	EP0788507B1 (de)
JP (1)	JPH10507763A (de)
AT (1)	ATE284894T1 (de)
DE (1)	DE69533856T2 (de)
MX (1)	MX9702927A (de)
WO (1)	WO1996012728A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1196059A (zh) *	1995-06-23	1998-10-14	牛津糖科学(英国)有限公司	治疗化合物
DE19741738A1 (de) *	1997-09-22	1999-03-25	Hoechst Ag	Linker-Nucleosid, seine Herstellung und Verwendung
DE19741715A1 (de) *	1997-09-22	1999-03-25	Hoechst Ag	Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE19837387A1 (de)	1998-08-18	2000-02-24	Aventis Res & Tech Gmbh & Co	3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung
WO2011047194A1 (en) *	2009-10-14	2011-04-21	Adco Products, Inc.	Edge sealants having balanced properties
US8366909B2 (en) *	2009-02-26	2013-02-05	Chevron U.S.A. Inc.	Reforming process at low pressure

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1620185C3 (de) *	1966-03-02	1982-01-14	Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen	5-Äthyl- und 5-Propyl-2'-deoxyuridin, Verfahren zur Herstellung dieser Verbindungen und diese Verbindungen enthaltende Arzneimittel
US3457255A (en) *	1967-05-17	1969-07-22	Syntex Corp	Novel ribo and lyxo nucleoside derivatives and a process for their preparation
CS164401B1 (en) *	1971-10-07	1975-11-07	Jiri Beranek	Method of 1-beta-d-arabinofuranosylcytosine's preparation
US3817982A (en) *	1971-12-29	1974-06-18	Syntex Inc	2{40 ,3{40 -unsaturated nucleosides and method of making
CA1135258A (en) *	1979-06-15	1982-11-09	Richard D'souza	Process for the preparation of 5'deoxy-5-fluorouridine
FR2528311B1 (fr) *	1982-06-14	1985-06-14	Synthelabo	Compositions pharmaceutiques a base de xylosides et lyxosides de bases puriques et pyrimidiques
IE73219B1 (en) *	1985-03-16	1997-05-07	Wellcome Found	Therapeutic nucleosides
PT82580B (pt) *	1985-05-15	1989-01-17	Wellcome Found	Processo para a preparacao de 2',3'- didesoxinucleosidos e de composicoes farmaceuticas que os contem
SE8602981D0 (sv) *	1986-07-04	1986-07-04	Astra Laekemedel Ab	Novel medicinal use
KR960001372B1 (ko) *	1986-09-24	1996-01-26	예일 유니버시티	레트로비루스로 감염된 환자의 치료에 사용되는 2',3'-디디옥시사이티딘-2'-엔(2',3'-디디옥시-2',3'-디디하이드로사이티딘)의 항생물질
US4918056A (en) *	1986-10-14	1990-04-17	Health Research, Inc. (Roswell Park Division)	2-substituted arabinopyranosyl nucleosides and nucleotides
US4880782A (en) *	1986-11-21	1989-11-14	Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V.	Method of treating viral infections in humans and compositions therefor
SE8605503D0 (sv) *	1986-12-19	1986-12-19	Astra Laekemedel Ab	Novel medicinal use
IL85778A0 (en) *	1987-03-20	1988-09-30	Bristol Myers Co	Production of 2',3'-dideoxynucleosides and certain such novel compounds
SE8704298D0 (sv) *	1987-11-03	1987-11-03	Astra Ab	Compounds for use in therapy
SE8802687D0 (sv) *	1988-07-20	1988-07-20	Astra Ab	Nucleoside derivatives
DE3900964A1 (de) *	1989-01-14	1990-07-19	Boehringer Mannheim Gmbh	Neue nukleoside, verfahren zu deren herstellung sowie arzneimittel, die diese verbindungen enthalten
DD296281A5 (de) *	1990-07-01	1991-11-28	Akademie Der Wissenschaften Der Ddr,De	Verfahren zur herstellung von neuen purinnukleosiden
SE9003151D0 (sv) *	1990-10-02	1990-10-02	Medivir Ab	Nucleoside derivatives
IT1246983B (it) *	1990-11-13	1994-12-12	Consiglio Nazionale Ricerche	L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
WO1993003733A1 (en) *	1991-08-12	1993-03-04	Basco, Ltd.	Syntheses, pharmaceutical composition and method of application of (2'-5') oligoadenylate analogues

1995
- 1995-10-24 WO PCT/US1995/013717 patent/WO1996012728A1/en not_active Ceased
- 1995-10-24 JP JP8514120A patent/JPH10507763A/ja not_active Ceased
- 1995-10-24 DE DE69533856T patent/DE69533856T2/de not_active Expired - Lifetime
- 1995-10-24 AT AT95938872T patent/ATE284894T1/de not_active IP Right Cessation
- 1995-10-24 EP EP95938872A patent/EP0788507B1/de not_active Expired - Lifetime
- 1995-10-24 MX MX9702927A patent/MX9702927A/es not_active IP Right Cessation
1996
- 1996-10-02 US US08/720,853 patent/US5885972A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH10507763A (ja)	1998-07-28
EP0788507B1 (de)	2004-12-15
MX9702927A (es)	1998-04-30
EP0788507A1 (de)	1997-08-13
US5885972A (en)	1999-03-23
WO1996012728A1 (en)	1996-05-02
DE69533856T2 (de)	2005-12-08
DE69533856D1 (de)	2005-01-20

Legal Events

Date	Code	Title	Description
2005-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
Hocek et al.	2000	Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: application of the Suzuki− Miyaura cross-coupling reactions of 6-chloropurine derivatives with phenylboronic acids
Vittori et al.	2000	N-Cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A1 adenosine receptor
ATE336492T1 (de)	2006-09-15	Methonocarbacycloalkylanaloga von nucleosiden
NO975585L (no)	1998-02-05	C-4' modifiserte adenosin-kinase inhibitorer
FI932870A0 (fi)	1993-06-21	2'-deoxi-2'2'-difluor-(4-substituerad pyrimidin)nukleosider med virus-och cancerhaemmande aktivitet, samt mellanprodukter
FR2596761B1 (fr)	1988-05-20	Derives de nucleosides et leur utilisation pour la synthese d'oligonucleotides
Hattori et al.	1998	Nucleosides and Nucleotides. 175. Structural Requirements of the Sugar Moiety for the Antitumor Activities of New Nucleoside Antimetabolites, 1-(3-C-Ethynyl-β-d-r ibo-pentofuranosyl) cytosine and-uracil
DE3854297D1 (de)	1995-09-14	Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung.
DK0679657T3 (da)	2003-10-27	Nukleosider og oligonukleotider med 2'-ethergrupper
PT1539783E (pt)	2011-06-01	Inibidores de nucleósido fosforilases e de nucleosidases
FI920197A7 (fi)	1992-01-16	Viruksenvastaisia pyrimidiininukleosidejä
KR890008161A (ko)	1989-07-10	2',3'-디데옥시-2'-플루오로뉴클레오사이드류
DE69024804D1 (de)	1996-02-22	Antivirale zusammensetzung
IE900275L (en)	1990-07-24	Antivirals and methods of increasing the antiviral activity¹of azt
Yoshimura et al.	2000	Synthesis and biological activities of 2′-deoxy-2′-fluoro-4′-thioarabinofuranosylpyrimidine and-purine nucleosides
GB9205071D0 (en)	1992-04-22	Therapeutic nucleosides
DE69533856D1 (de)	2005-01-20	L-pyranosyl-nukleoside
FI932868A0 (fi)	1993-06-21	2'-deoxi-2'2'-difluor(2,6,8-substituerade) purinnukleosider med virus-och cancerhaemmande aktivitet, samt mellanprodukter
Jung et al.	1993	New approach to the synthesis of. beta.-2'-deoxyribonucleosides: intramolecular Vorbrueggen coupling
ES2166081T3 (es)	2002-04-01	Derivados de nucleosidos con grupos protectores fotolabiles.
DK0720604T3 (da)	1998-07-27	Konformationelt låste nukleosidanaloger
FI91763C (fi)	1994-08-10	Menetelmä terapeuttisesti käyttökelpoisen 2',3'-dideoksi-3'-fluoripyrimidiini- tai -puriininukleosidin valmistamiseksi
NO984124D0 (no)	1998-09-07	Fremgangsmåte for å hemme adenylsuksinatsyntetaseaktivitet i metyltioadenosinfosforylasemanglende celler
ES2144046T3 (es)	2000-06-01	Procedimiento de conjugacion de nucleosidos antivirales con albumina humana lactosaminada.
DE60044937D1 (de)	2010-10-21	Analoge des 5(e)bromovinyluracils und verwandte pyrimidinnucleoside als antivirale mittel und verwendungsmethoden