DK3240895T3 - Sammensætninger og fremgangsmåder til proteinglykosylering - Google Patents

Sammensætninger og fremgangsmåder til proteinglykosylering Download PDF

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Publication number
DK3240895T3
DK3240895T3 DK15822948.4T DK15822948T DK3240895T3 DK 3240895 T3 DK3240895 T3 DK 3240895T3 DK 15822948 T DK15822948 T DK 15822948T DK 3240895 T3 DK3240895 T3 DK 3240895T3
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DK
Denmark
Prior art keywords
compositions
methods
protein glycosylation
glycosylation
protein
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Application number
DK15822948.4T
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English (en)
Inventor
Jurgen Haas
Julian Ihssen
Michael Thomas Kowarik
Torsten Franz Schwede
Linda Christiane Thöny-Meyer
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Glaxosmithkline Biologicals Sa
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Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa
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Publication of DK3240895T3 publication Critical patent/DK3240895T3/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1081Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK15822948.4T 2014-12-30 2015-12-24 Sammensætninger og fremgangsmåder til proteinglykosylering DK3240895T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462098071P 2014-12-30 2014-12-30
US201462097975P 2014-12-30 2014-12-30
PCT/EP2015/081229 WO2016107818A1 (en) 2014-12-30 2015-12-24 Compositions and methods for protein glycosylation

Publications (1)

Publication Number Publication Date
DK3240895T3 true DK3240895T3 (da) 2022-04-11

Family

ID=55080101

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15822948.4T DK3240895T3 (da) 2014-12-30 2015-12-24 Sammensætninger og fremgangsmåder til proteinglykosylering

Country Status (18)

Country Link
US (3) US10150952B2 (da)
EP (2) EP3240895B1 (da)
JP (1) JP6850724B2 (da)
CN (1) CN107614679B (da)
BE (1) BE1022998B1 (da)
BR (1) BR112017014031B1 (da)
CA (1) CA2971653C (da)
CY (1) CY1125392T1 (da)
DK (1) DK3240895T3 (da)
ES (1) ES2907211T3 (da)
HR (1) HRP20220500T1 (da)
HU (1) HUE057726T2 (da)
LT (1) LT3240895T (da)
MX (1) MX389093B (da)
PL (1) PL3240895T3 (da)
PT (1) PT3240895T (da)
SI (1) SI3240895T1 (da)
WO (2) WO2016107818A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201807924T4 (tr) 2013-01-17 2018-06-21 Arsanis Biosciences Gmbh MDR e. koli spesifik antikor.
CN106535927B (zh) 2014-02-24 2019-09-20 葛兰素史密丝克莱恩生物有限公司 新颖多糖及其用途
LT3240895T (lt) 2014-12-30 2022-04-11 Glaxosmithkline Biologicals S.A. Kompozicijos ir būdai, skirti baltymų glikozilinimui
EP3262077B1 (en) 2015-02-26 2025-06-04 Vaxnewmo Llc Acinetobacter o-oligosaccharyltransferases and uses thereof
TWI715617B (zh) 2015-08-24 2021-01-11 比利時商葛蘭素史密斯克藍生物品公司 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物
AR109621A1 (es) 2016-10-24 2018-12-26 Janssen Pharmaceuticals Inc Formulaciones de vacunas contra glucoconjugados de expec
GB201704117D0 (en) 2017-03-15 2017-04-26 London School Hygiene & Tropical Medicine Oligosaccharyl Transferase polypeptide
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
WO2019241672A2 (en) 2018-06-16 2019-12-19 Vaxnewmo Llc Glycosylated comp pilin variants, methods of making and uses thereof
ES3055827T3 (en) 2018-12-21 2026-02-16 Vaxnewmo Llc O-linked glycosylation recognition motifs
CR20210522A (es) * 2019-03-18 2021-12-17 Janssen Pharmaceuticals Inc Bioconjugados de antígenos–polisacáridos de e. coli, métodos de producción y métodos de utilización de los mismos
IL286467B2 (en) * 2019-03-18 2026-02-01 Janssen Pharmaceuticals Inc Methods for producing bioconjugates of polysaccharides E. coli o-antigen, preparations thereof and methods for using them
EP3770269A1 (en) 2019-07-23 2021-01-27 GlaxoSmithKline Biologicals S.A. Quantification of bioconjugate glycosylation
CN114207122A (zh) * 2019-08-09 2022-03-18 葛兰素史克生物有限公司 突变的pglb寡糖基转移酶
EP3777884A1 (en) 2019-08-15 2021-02-17 GlaxoSmithKline Biologicals S.A. Immunogenic composition
CN110910960B (zh) * 2019-11-30 2022-07-08 浙江天科高新技术发展有限公司 一种鲍曼不动杆菌分子血清型快速分析方法
IL308201A (en) 2020-09-17 2024-01-01 Janssen Pharmaceuticals Inc Multivalent vaccine compositions and uses thereof
US20250270520A1 (en) * 2021-02-11 2025-08-28 Glaxosmithkline Biologicals Sa Mutated pglb oligosaccharyltransferase enzymes
KR20230164108A (ko) 2021-04-01 2023-12-01 얀센 파마슈티칼즈, 인코포레이티드 E. coli O18 생물접합체의 생산
WO2023118033A1 (en) 2021-12-22 2023-06-29 Glaxosmithkline Biologicals Sa Vaccine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2607595C (en) * 2005-05-11 2018-11-27 Eth Zuerich Recombinant n-glycosylated proteins from procaryotic cells
CN107119095B (zh) * 2008-01-03 2022-07-05 康乃尔研究基金会有限公司 原核生物中的糖基化蛋白表达
HRP20181259T1 (hr) * 2008-02-20 2018-10-05 Glaxosmithkline Biologicals S.A. Biokonjugati načinjeni iz rekombinantnih n-glikoziliranih proteina iz prokariotskih stanica
EP2501406B8 (en) * 2009-11-19 2018-01-24 GlaxoSmithKline Biologicals S.A. Biosynthetic system that produces immunogenic polysaccharides in prokaryotic cells
JP6339366B2 (ja) 2010-05-06 2018-06-06 グリコヴァキシン アーゲー 莢膜グラム陽性菌のバイオコンジュゲートワクチン
CN104080921A (zh) * 2011-11-04 2014-10-01 康奈尔大学 一种用于糖蛋白合成的基于原核生物的无细胞系统
CA2923957C (en) * 2013-01-18 2021-08-31 London School Of Hygiene And Tropical Medicine Glycosylation method
LT3240895T (lt) 2014-12-30 2022-04-11 Glaxosmithkline Biologicals S.A. Kompozicijos ir būdai, skirti baltymų glikozilinimui
GB201704117D0 (en) * 2017-03-15 2017-04-26 London School Hygiene & Tropical Medicine Oligosaccharyl Transferase polypeptide

Also Published As

Publication number Publication date
WO2016107818A8 (en) 2017-08-31
EP3240895A1 (en) 2017-11-08
BE1022998A1 (fr) 2016-10-28
CY1125392T1 (el) 2024-02-16
BE1022998B1 (fr) 2016-10-28
JP2018500912A (ja) 2018-01-18
US20180002679A1 (en) 2018-01-04
PT3240895T (pt) 2022-03-02
CN107614679A (zh) 2018-01-19
CN107614679B (zh) 2026-04-07
US10150952B2 (en) 2018-12-11
US20190078064A1 (en) 2019-03-14
MX2017008817A (es) 2017-10-24
EP4043561A1 (en) 2022-08-17
CA2971653A1 (en) 2016-07-07
EP3240895B1 (en) 2022-01-26
PL3240895T3 (pl) 2022-05-02
CA2971653C (en) 2024-06-11
ES2907211T3 (es) 2022-04-22
HUE057726T2 (hu) 2022-06-28
JP6850724B2 (ja) 2021-03-31
SI3240895T1 (sl) 2022-04-29
LT3240895T (lt) 2022-04-11
WO2016107819A1 (en) 2016-07-07
BR112017014031A2 (pt) 2018-01-16
MX389093B (es) 2025-03-20
US20200181586A1 (en) 2020-06-11
WO2016107818A1 (en) 2016-07-07
US10577592B2 (en) 2020-03-03
BR112017014031B1 (pt) 2023-11-07
HRP20220500T1 (hr) 2022-06-10
US11015177B2 (en) 2021-05-25

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