DK3350165T3 - Farnesoid-X-receptoragonister og anvendelser deraf - Google Patents
Farnesoid-X-receptoragonister og anvendelser deraf Download PDFInfo
- Publication number
- DK3350165T3 DK3350165T3 DK16847452.6T DK16847452T DK3350165T3 DK 3350165 T3 DK3350165 T3 DK 3350165T3 DK 16847452 T DK16847452 T DK 16847452T DK 3350165 T3 DK3350165 T3 DK 3350165T3
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- DK
- Denmark
- Prior art keywords
- farnesoid
- receptor agonists
- agonists
- receptor
- Prior art date
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- 229940121360 farnesoid X receptor (fxr) agonists Drugs 0.000 title 1
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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| US11939320B2 (en) | 2017-11-02 | 2024-03-26 | Abbvie Inc. | Modulators of the integrated stress pathway |
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| KR20210129684A (ko) | 2019-02-15 | 2021-10-28 | 브리스톨-마이어스 스큅 컴퍼니 | 파르네소이드 x 수용체 조정제로서 유용한 치환된 아미드 화합물 |
| AR118050A1 (es) * | 2019-02-15 | 2021-09-15 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos como moduladores del receptor farnesoide x |
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| MX2022007376A (es) | 2019-12-20 | 2022-09-02 | Tenaya Therapeutics Inc | Fluoroalqull-oxadiazoles y sus usos. |
| WO2021144330A1 (en) | 2020-01-15 | 2021-07-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of fxr agonists for treating an infection by hepatitis d virus |
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| IL296532A (en) | 2020-03-18 | 2022-11-01 | Metacrine Inc | Crystal forms of farnesoid x receptor agonist |
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| WO2021188690A1 (en) * | 2020-03-18 | 2021-09-23 | Metacrine, Inc. | Farnesoid x receptor agonists for the treatment of disease |
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| KR20230154806A (ko) | 2021-01-14 | 2023-11-09 | 엔요 파마 | Hbv 감염 치료를 위한 fxr 작용제 및 ifn의 상승작용효과 |
| CN117320722A (zh) | 2021-04-28 | 2023-12-29 | 埃尼奥制药公司 | 使用fxr激动剂作为联合治疗强烈增强tlr3激动剂的作用 |
| US20240252502A1 (en) | 2021-05-04 | 2024-08-01 | Tenaya Therapeutics, Inc. | Hdac6 inhibitors for treatment of metabolic disease and hfpef |
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| KR950702544A (ko) | 1992-08-11 | 1995-07-29 | 구사이 요시히로 | 비페닐메탄 유도체 및 이를 함유하는 약제 |
| DE60023492T2 (de) * | 1999-05-17 | 2006-07-20 | Novo Nordisk A/S | Glucagon antagonisten/inverse agonisten |
| WO2000071518A2 (en) | 1999-05-25 | 2000-11-30 | Sepracor, Inc. | Heterocyclic analgesic compounds and their use |
| US6511980B2 (en) * | 2000-05-05 | 2003-01-28 | Ortho Mcneil Pharmaceutical, Inc. | Substituted diamine derivatives useful as motilin antagonists |
| AU2001216218A1 (en) | 2000-05-25 | 2001-12-11 | Sepracor, Inc. | Heterocyclic analgesic compounds and method of use thereof |
| US20040102431A1 (en) | 2000-09-25 | 2004-05-27 | Christoph Boss | Substituted amino-aza-cycloalkanes useful against malaria |
| FR2815032B1 (fr) | 2000-10-10 | 2003-08-08 | Pf Medicament | Nouveaux derives d'aminophenyle piperazine ou d'amino phenyle piperide inhibiteurs de proteines prenyl transferase ainsi que leurs preparations |
| FR2825706B1 (fr) | 2001-06-06 | 2003-12-12 | Pf Medicament | Nouveaux derives de benzothienyle ou d'indole, leur preparation et leur utilisation comme inhibiteurs de proteines prenyl transferase |
| US20050228017A1 (en) | 2001-10-31 | 2005-10-13 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Novel anticancer compounds |
| FR2839974B1 (fr) | 2002-05-24 | 2004-07-16 | Pf Medicament | Derives de phenyl-furane ou de phenyl-thiophene,leur preparation et leur application a titre de medicament |
| WO2004009549A2 (en) * | 2002-07-18 | 2004-01-29 | Actelion Pharmaceuticals Ltd | Piperidines useful for the treatment of central nervous system disorders |
| WO2004026823A1 (en) | 2002-09-20 | 2004-04-01 | Pfizer Products Inc. | Amide and sulfonamide ligands for the estrogen receptor |
| AU2003290796A1 (en) | 2002-11-14 | 2004-06-15 | The Scripps Research Institute | Non-steroidal fxr agonists |
| US20050143449A1 (en) | 2002-11-15 | 2005-06-30 | The Salk Institute For Biological Studies | Non-steroidal farnesoid X receptor modulators and methods for the use thereof |
| GB0309781D0 (en) * | 2003-04-29 | 2003-06-04 | Glaxo Group Ltd | Compounds |
| US7759348B2 (en) | 2003-07-30 | 2010-07-20 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| PL1648874T3 (pl) | 2003-07-30 | 2012-04-30 | Xenon Pharmaceuticals Inc | Pochodne piperazyny i ich zastosowanie jako środków leczniczych |
| US7754711B2 (en) | 2003-07-30 | 2010-07-13 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| RS20060190A (sr) | 2003-10-14 | 2008-08-07 | Pfizer Products Inc., | Biciklični /3.1.0/ derivati kao inhibitori transportera glicina |
| WO2005058822A1 (en) * | 2003-12-17 | 2005-06-30 | Actelion Pharmaceuticals Ltd | Substituted amino-cycloalkanes |
| JP2007530582A (ja) * | 2004-03-26 | 2007-11-01 | ライジェル ファーマシューティカルズ, インコーポレイテッド | 代謝可能部分を含む複素環抗ウイルス化合物およびその使用 |
| JP2006199656A (ja) | 2005-01-24 | 2006-08-03 | Kowa Co | アミド基を有する環状アミン化合物 |
| MY144229A (en) | 2006-01-26 | 2011-08-15 | Xenon Pharmaceuticals Inc | Pyridazine derivatives and their use as therapeutic agents |
| WO2007093603A1 (en) | 2006-02-17 | 2007-08-23 | Neurosearch A/S | 1-phenethylpiperidine derivatives and their use as opioid receptor ligands |
| MX2008012404A (es) | 2006-03-28 | 2008-10-09 | Novartis Ag | Derivados de amida y su aplicacion para el tratamiento de enfermedades relacionadas con proteina-g. |
| US20080081824A1 (en) | 2006-09-29 | 2008-04-03 | Bristol-Myers Squibb Company | Substituted piperidines as modulators of chemokine receptor activity |
| WO2008065500A2 (en) * | 2006-11-30 | 2008-06-05 | Pfizer Products Inc. | Heteroaryl amides as type i glycine transport inhibitors |
| TW200838526A (en) | 2006-12-01 | 2008-10-01 | Astellas Pharma Inc | Carboxylic acid derivatives |
| WO2008073936A1 (en) | 2006-12-11 | 2008-06-19 | Wyeth | Carboxamide derivatives as ion channel modulators |
| WO2008156715A1 (en) | 2007-06-20 | 2008-12-24 | Merck & Co., Inc. | Cetp inhibitors derived from benzoxazole arylamides |
| CN101903351B (zh) * | 2007-12-19 | 2014-09-10 | 贝林格尔.英格海姆国际有限公司 | 病毒聚合酶抑制剂 |
| WO2010001869A1 (ja) * | 2008-06-30 | 2010-01-07 | 武田薬品工業株式会社 | 4置換ベンゼン化合物およびその用途 |
| JP2010077109A (ja) * | 2008-08-28 | 2010-04-08 | Takeda Chem Ind Ltd | 複素環化合物およびその用途 |
| JP2012532914A (ja) * | 2009-07-15 | 2012-12-20 | メルク セローノ ソシエテ アノニム | テトラゾール誘導体 |
| CN102471339A (zh) | 2009-07-15 | 2012-05-23 | 雅培制药有限公司 | 激酶的吡咯并吡啶抑制剂 |
| FR2963005B1 (fr) | 2010-07-23 | 2012-08-17 | Sanofi Aventis | Derives d'oxadiazoles et de pyridazines, leur preparation et leur application en therapeutique |
| SI2688403T1 (sl) | 2011-03-23 | 2017-08-31 | Trevena, Inc. | Ligandi opioidnih receptorjev in metode uporabe in izdelave istega |
| US9492763B2 (en) | 2011-07-13 | 2016-11-15 | M. Technique Co., Ltd. | Method for producing microparticles having controlled crystallite diameter |
| WO2014086852A1 (en) * | 2012-12-05 | 2014-06-12 | Chiesi Farmaceutici S.P.A. | Phenylethylpyridine derivatives as pde4-inhibitors |
| RU2543485C2 (ru) * | 2013-02-26 | 2015-03-10 | Андрей Александрович Иващенко | Гетероциклические агонисты рецепторов желчных кислот tgr5, фармацевтическая композиция, способы их получения и применения |
| GB201316824D0 (en) * | 2013-09-23 | 2013-11-06 | R & D Vernalis Ltd | New Chemical Entities |
| US20150258052A1 (en) | 2014-03-13 | 2015-09-17 | Salk Institute For Biological Studies | Methods of using fexaramine and agents that increase sympathetic nervous system activity to promote browning of white adipose tissue |
| US10077268B2 (en) | 2014-03-13 | 2018-09-18 | Salk Institute For Biological Studies | FXR agonists and methods for making and using |
| AU2015229055B2 (en) * | 2014-03-13 | 2019-09-12 | Salk Institute For Biological Studies | Analogs of fexaramine and methods of making and using |
| EP3116878A4 (en) | 2014-03-13 | 2018-02-14 | Salk Institute for Biological Studies | Fxr agonists and methods for making and using |
| US10301268B2 (en) | 2014-03-13 | 2019-05-28 | The Salk Institute For Biological Studies | Analogs of fexaramine and methods of making and using |
| JP2018510866A (ja) | 2015-03-13 | 2018-04-19 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腸受容体を活性化させるための、ファルネソイドx受容体アゴニストでの、成体の潜在性自己免疫性糖尿病の治療 |
| EP3350166A4 (en) | 2015-09-16 | 2019-05-01 | Metacrine, Inc. | FARNESOID-X RECEPTOR AGONISTS AND USES THEREOF |
| JP2018536016A (ja) | 2015-09-16 | 2018-12-06 | メタクリン,インク. | ファルネソイドx受容体アゴニストとその使用 |
| WO2017049173A1 (en) | 2015-09-16 | 2017-03-23 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| EP3350158A4 (en) | 2015-09-16 | 2019-05-08 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| WO2018170173A1 (en) | 2017-03-15 | 2018-09-20 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| WO2018170167A1 (en) | 2017-03-15 | 2018-09-20 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| IL269068B (en) | 2017-03-15 | 2022-09-01 | Metacrine Inc | Paranoid x receptor agonists and uses thereof |
| WO2018170165A1 (en) | 2017-03-15 | 2018-09-20 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| LT3609888T (lt) | 2017-03-15 | 2025-11-10 | Farnezoidinio x receptoriaus agonistai ir jų panaudojimas | |
| EA202190661A1 (ru) | 2018-09-18 | 2021-08-13 | Метакрайн, Инк. | Агонисты фарнезоидного х-рецептора для лечения заболевания |
| MA53671A (fr) | 2018-09-18 | 2021-07-28 | Metacrine Inc | Formes cristallines d'un agoniste du récepteur farnésoïde x |
-
2016
- 2016-09-16 WO PCT/US2016/052270 patent/WO2017049173A1/en not_active Ceased
- 2016-09-16 KR KR1020187009912A patent/KR20180052678A/ko not_active Ceased
- 2016-09-16 JP JP2018534463A patent/JP6905530B2/ja active Active
- 2016-09-16 CA CA2998493A patent/CA2998493A1/en active Pending
- 2016-09-16 DK DK16847452.6T patent/DK3350165T3/da active
- 2016-09-16 CN CN201680066917.9A patent/CN108349893B/zh active Active
- 2016-09-16 EA EA201890725A patent/EA201890725A1/ru unknown
- 2016-09-16 PH PH1/2018/500586A patent/PH12018500586B1/en unknown
- 2016-09-16 MX MX2018003388A patent/MX386752B/es unknown
- 2016-09-16 SG SG10202110242Y patent/SG10202110242YA/en unknown
- 2016-09-16 US US15/758,707 patent/US10703712B2/en active Active
- 2016-09-16 EP EP16847452.6A patent/EP3350165B1/en active Active
- 2016-09-16 AU AU2016323992A patent/AU2016323992B2/en active Active
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2018
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2020
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2021
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Also Published As
| Publication number | Publication date |
|---|---|
| IL258011A (en) | 2018-05-31 |
| CN108349893B (zh) | 2021-12-28 |
| AU2016323992B2 (en) | 2021-05-06 |
| MX2018003388A (es) | 2019-01-31 |
| US20210032195A1 (en) | 2021-02-04 |
| WO2017049173A1 (en) | 2017-03-23 |
| EA201890725A1 (ru) | 2018-08-31 |
| ZA201801750B (en) | 2022-09-28 |
| PH12018500586B1 (en) | 2023-08-11 |
| CN108349893A (zh) | 2018-07-31 |
| PH12018500586A1 (en) | 2018-10-15 |
| US11214538B2 (en) | 2022-01-04 |
| JP6905530B2 (ja) | 2021-07-21 |
| CA2998493A1 (en) | 2017-03-23 |
| EP3350165A1 (en) | 2018-07-25 |
| EP3350165A4 (en) | 2019-07-03 |
| IL258011B2 (en) | 2023-02-01 |
| US10703712B2 (en) | 2020-07-07 |
| EP3350165B1 (en) | 2023-07-26 |
| US20180282263A1 (en) | 2018-10-04 |
| KR20180052678A (ko) | 2018-05-18 |
| SG10202110242YA (en) | 2021-10-28 |
| JP2018536015A (ja) | 2018-12-06 |
| US20220081390A1 (en) | 2022-03-17 |
| AU2016323992A1 (en) | 2018-04-19 |
| MX386752B (es) | 2025-03-19 |
| IL258011B (en) | 2022-10-01 |
| HK1257751A1 (en) | 2019-10-25 |
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