DK3408260T3 - Krystallinsk (2s,4r)-5-(5'-chlor-2-fluor-[1,1'-biphenyl]-4-yl)-2-(ethoxy¬methyl)-4-(3-hydroxyisoxazol-5-carboxamido)-2-methylpentansyre og anvendelser deraf - Google Patents

Krystallinsk (2s,4r)-5-(5'-chlor-2-fluor-[1,1'-biphenyl]-4-yl)-2-(ethoxy¬methyl)-4-(3-hydroxyisoxazol-5-carboxamido)-2-methylpentansyre og anvendelser deraf Download PDF

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Publication number
DK3408260T3
DK3408260T3 DK17712605.9T DK17712605T DK3408260T3 DK 3408260 T3 DK3408260 T3 DK 3408260T3 DK 17712605 T DK17712605 T DK 17712605T DK 3408260 T3 DK3408260 T3 DK 3408260T3
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DK
Denmark
Prior art keywords
ethoxymmethyl
crystally
hydroxyisoxazole
carboxamido
biphenyl
Prior art date
Application number
DK17712605.9T
Other languages
English (en)
Inventor
Adam D Hughes
Melissa Fleury
Miroslav Rapta
Venkat R Thalladi
Gene Timothy Fass
Michael Simeone
R Michael Baldwin
David L Bourdet
Original Assignee
Theravance Biopharma R&D Ip Llc
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Application filed by Theravance Biopharma R&D Ip Llc filed Critical Theravance Biopharma R&D Ip Llc
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Publication of DK3408260T3 publication Critical patent/DK3408260T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK17712605.9T 2016-03-08 2017-03-07 Krystallinsk (2s,4r)-5-(5'-chlor-2-fluor-[1,1'-biphenyl]-4-yl)-2-(ethoxy¬methyl)-4-(3-hydroxyisoxazol-5-carboxamido)-2-methylpentansyre og anvendelser deraf DK3408260T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662305393P 2016-03-08 2016-03-08
US201662346336P 2016-06-06 2016-06-06
PCT/US2017/021172 WO2017156009A1 (en) 2016-03-08 2017-03-07 Crystalline(2s,4r)-5-(5'-chloro-2'-fluoro-[1,1'-biphenyl]-4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid and uses thereof

Publications (1)

Publication Number Publication Date
DK3408260T3 true DK3408260T3 (da) 2021-08-02

Family

ID=58387911

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17712605.9T DK3408260T3 (da) 2016-03-08 2017-03-07 Krystallinsk (2s,4r)-5-(5'-chlor-2-fluor-[1,1'-biphenyl]-4-yl)-2-(ethoxy¬methyl)-4-(3-hydroxyisoxazol-5-carboxamido)-2-methylpentansyre og anvendelser deraf

Country Status (30)

Country Link
US (6) US10100021B2 (da)
EP (1) EP3408260B1 (da)
JP (2) JP7306828B2 (da)
KR (2) KR20180114225A (da)
CN (1) CN108779084A (da)
AU (1) AU2017229466C1 (da)
CA (1) CA3015505C (da)
CL (1) CL2018002539A1 (da)
CO (1) CO2018010568A2 (da)
CY (1) CY1124397T1 (da)
DK (1) DK3408260T3 (da)
ES (1) ES2880123T3 (da)
HR (1) HRP20211169T1 (da)
HU (1) HUE055546T2 (da)
IL (1) IL261244B (da)
LT (1) LT3408260T (da)
MX (1) MX377177B (da)
MY (1) MY198185A (da)
PH (1) PH12018501876A1 (da)
PL (1) PL3408260T3 (da)
PT (1) PT3408260T (da)
RS (1) RS62172B1 (da)
RU (1) RU2756223C2 (da)
SA (1) SA518392325B1 (da)
SG (1) SG11201807591VA (da)
SI (1) SI3408260T1 (da)
SM (1) SMT202100434T1 (da)
TW (1) TWI731943B (da)
WO (1) WO2017156009A1 (da)
ZA (1) ZA201805840B (da)

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SMT202100434T1 (it) 2016-03-08 2021-09-14 Theravance Biopharma R&D Ip Llc Acido (2s,4r)-5-(5’-cloro-2-fluoro-[1,1’-bifenil]-4-il)-2-(etossimetil)-4-(3-idrossiisossazol-5-carbossammido)-2-metilpentanoico cristallino e suoi usi
KR102752382B1 (ko) * 2019-09-20 2025-01-09 심천 사루브리스 퍼머수티칼스 컴퍼니 리미티드 안지오텐신 ii 수용체 길항제 대사물질 및 nep 억제제의 복합체의 심부전 치료에서의 용도
KR102485499B1 (ko) * 2022-07-15 2023-01-09 오가노이드사이언스 주식회사 신장 질환의 치료 또는 예방용 조성물

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Also Published As

Publication number Publication date
JP7306828B2 (ja) 2023-07-11
JP2022017433A (ja) 2022-01-25
SI3408260T1 (sl) 2021-08-31
US20190002416A1 (en) 2019-01-03
KR20220035991A (ko) 2022-03-22
PT3408260T (pt) 2021-07-23
HUE055546T2 (hu) 2021-12-28
CA3015505A1 (en) 2017-09-14
KR20180114225A (ko) 2018-10-17
US10472335B2 (en) 2019-11-12
US20170275259A1 (en) 2017-09-28
CN108779084A (zh) 2018-11-09
MY198185A (en) 2023-08-09
TW201741290A (zh) 2017-12-01
EP3408260A1 (en) 2018-12-05
AU2017229466C1 (en) 2021-02-11
US20240327360A1 (en) 2024-10-03
US10100021B2 (en) 2018-10-16
IL261244A (en) 2018-10-31
EP3408260B1 (en) 2021-05-05
MX2018010727A (es) 2019-01-24
PL3408260T3 (pl) 2021-11-08
BR112018068170A2 (pt) 2019-01-29
AU2017229466B2 (en) 2020-08-13
CY1124397T1 (el) 2022-07-22
ES2880123T3 (es) 2021-11-23
US11718591B2 (en) 2023-08-08
TWI731943B (zh) 2021-07-01
RU2756223C2 (ru) 2021-09-28
US11230536B2 (en) 2022-01-25
CO2018010568A2 (es) 2018-10-22
SA518392325B1 (ar) 2022-08-03
MX377177B (es) 2025-03-07
US20200157061A1 (en) 2020-05-21
CL2018002539A1 (es) 2018-10-26
LT3408260T (lt) 2021-07-26
ZA201805840B (en) 2019-07-31
IL261244B (en) 2022-02-01
RU2018135072A3 (da) 2020-10-15
RU2018135072A (ru) 2020-04-08
WO2017156009A1 (en) 2017-09-14
HRP20211169T1 (hr) 2021-11-12
US10752599B2 (en) 2020-08-25
US20210061776A1 (en) 2021-03-04
AU2017229466A1 (en) 2018-09-13
US12351561B2 (en) 2025-07-08
CA3015505C (en) 2024-03-05
US20220242836A1 (en) 2022-08-04
JP2019509286A (ja) 2019-04-04
SG11201807591VA (en) 2018-10-30
RS62172B1 (sr) 2021-08-31
PH12018501876A1 (en) 2019-01-28
SMT202100434T1 (it) 2021-09-14

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