DK3840832T3 - Imidazo[1,2-b]pyridaziner som trk-inhibitorer - Google Patents

Imidazo[1,2-b]pyridaziner som trk-inhibitorer Download PDF

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Publication number
DK3840832T3
DK3840832T3 DK19759716.4T DK19759716T DK3840832T3 DK 3840832 T3 DK3840832 T3 DK 3840832T3 DK 19759716 T DK19759716 T DK 19759716T DK 3840832 T3 DK3840832 T3 DK 3840832T3
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DK
Denmark
Prior art keywords
pyridazines
imidazo
trk inhibitors
trk
inhibitors
Prior art date
Application number
DK19759716.4T
Other languages
English (en)
Inventor
Alan Brown
Angela Glen
Original Assignee
Benevolentai Bio Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Benevolentai Bio Ltd filed Critical Benevolentai Bio Ltd
Application granted granted Critical
Publication of DK3840832T3 publication Critical patent/DK3840832T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK19759716.4T 2018-08-23 2019-08-23 Imidazo[1,2-b]pyridaziner som trk-inhibitorer DK3840832T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1813791.9A GB201813791D0 (en) 2018-08-23 2018-08-23 Organic compounds
PCT/GB2019/052378 WO2020039209A1 (en) 2018-08-23 2019-08-23 Imidazo[1,2-b]pyridazines as trk inhibitors

Publications (1)

Publication Number Publication Date
DK3840832T3 true DK3840832T3 (da) 2024-01-15

Family

ID=63715095

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19759716.4T DK3840832T3 (da) 2018-08-23 2019-08-23 Imidazo[1,2-b]pyridaziner som trk-inhibitorer

Country Status (22)

Country Link
US (1) US20210253572A1 (da)
EP (1) EP3840832B1 (da)
JP (1) JP7417594B2 (da)
KR (1) KR20210049089A (da)
CN (1) CN112805062B (da)
AU (1) AU2019325375A1 (da)
BR (1) BR112021003026A2 (da)
CA (1) CA3106431A1 (da)
DK (1) DK3840832T3 (da)
EA (1) EA202190323A1 (da)
ES (1) ES2968695T3 (da)
FI (1) FI3840832T3 (da)
GB (1) GB201813791D0 (da)
HU (1) HUE065655T2 (da)
IL (1) IL280513B2 (da)
MA (1) MA53432A (da)
MX (1) MX2021002051A (da)
PL (1) PL3840832T3 (da)
PT (1) PT3840832T (da)
SG (1) SG11202100338PA (da)
WO (1) WO2020039209A1 (da)
ZA (1) ZA202100159B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021209418A1 (en) * 2020-01-22 2022-07-21 Benevolentai Bio Limited Topical pharmaceutical compositions comprising imidazo[1,2-b]pyridazine compounds
WO2021148807A1 (en) * 2020-01-22 2021-07-29 Benevolentai Bio Limited Pharmaceutical compositions and their uses
CN112979646B (zh) * 2021-03-08 2022-01-14 北京富龙康泰生物技术有限公司 一种咪唑并吡啶类衍生物
WO2022234287A1 (en) 2021-05-06 2022-11-10 Benevolentai Bio Limited Imidazopyridazine derivatives useful as trk inhibitors
CN113444070A (zh) * 2021-07-28 2021-09-28 深圳市真味生物科技有限公司 一种由手性叔丁基亚磺酰胺合成手性尼古丁的制备方法
WO2024051631A1 (zh) * 2022-09-07 2024-03-14 苏州朗睿生物医药有限公司 一种大环咪唑并[1,2-b]哒嗪衍生物及其制备方法和用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
JP2007524596A (ja) 2003-02-28 2007-08-30 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 共結晶医薬組成物
GB0405937D0 (en) 2004-03-16 2004-04-21 Glaxo Group Ltd Compounds
GB0412467D0 (en) 2004-06-04 2004-07-07 Astrazeneca Ab Chemical compounds
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
CA2835835C (en) 2011-05-13 2019-04-02 Array Biopharma Inc. Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors
AU2012351748B2 (en) 2011-12-12 2016-04-14 Dr. Reddy's Laboratories Ltd. Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors
TW201350479A (zh) 2012-04-26 2013-12-16 Ono Pharmaceutical Co Ｔｒｋ阻害化合物
WO2014175370A1 (ja) 2013-04-25 2014-10-30 塩野義製薬株式会社 ピロリジン誘導体およびそれらを含有する医薬組成物
SG11202005237SA (en) 2017-12-15 2020-07-29 Pyramid Biosciences Inc 5-(2-(2,5-difluorophenyl)pyrrolidin-1 -yl)-3-(1h-pyrazol-1-yl)pyrazolo[1,5-a]pyrimidine derivatives and related compounds as trk kinase inhibitors for treating cancer
GB201811825D0 (en) * 2018-07-19 2018-09-05 Benevolentai Bio Ltd Organic compounds

Also Published As

Publication number Publication date
FI3840832T3 (fi) 2024-01-12
CN112805062A (zh) 2021-05-14
KR20210049089A (ko) 2021-05-04
HUE065655T2 (hu) 2024-06-28
MA53432A (fr) 2021-06-30
CN112805062B (zh) 2024-06-04
PL3840832T3 (pl) 2024-03-25
AU2019325375A1 (en) 2021-02-04
IL280513B1 (en) 2024-07-01
WO2020039209A1 (en) 2020-02-27
ES2968695T3 (es) 2024-05-13
JP7417594B2 (ja) 2024-01-18
IL280513A (en) 2021-03-01
EP3840832B1 (en) 2023-10-11
MX2021002051A (es) 2021-06-23
EP3840832A1 (en) 2021-06-30
ZA202100159B (en) 2024-07-31
BR112021003026A2 (pt) 2021-05-11
CA3106431A1 (en) 2020-02-27
IL280513B2 (en) 2024-11-01
JP2021535125A (ja) 2021-12-16
US20210253572A1 (en) 2021-08-19
EA202190323A1 (ru) 2021-05-28
PT3840832T (pt) 2024-01-15
GB201813791D0 (en) 2018-10-10
SG11202100338PA (en) 2021-03-30

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