DK3433270T3 - T celle receptorer - Google Patents

T celle receptorer Download PDF

Info

Publication number
DK3433270T3
DK3433270T3 DK17715521.5T DK17715521T DK3433270T3 DK 3433270 T3 DK3433270 T3 DK 3433270T3 DK 17715521 T DK17715521 T DK 17715521T DK 3433270 T3 DK3433270 T3 DK 3433270T3
Authority
DK
Denmark
Prior art keywords
cell receptors
receptors
cell
Prior art date
Application number
DK17715521.5T
Other languages
English (en)
Inventor
Tara Mahon
Yi Li
Original Assignee
Immunocore Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunocore Ltd filed Critical Immunocore Ltd
Application granted granted Critical
Publication of DK3433270T3 publication Critical patent/DK3433270T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
DK17715521.5T 2016-03-23 2017-03-22 T celle receptorer DK3433270T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1604953.8A GB201604953D0 (en) 2016-03-23 2016-03-23 T cell receptors
PCT/GB2017/050805 WO2017163064A1 (en) 2016-03-23 2017-03-22 T cell receptors

Publications (1)

Publication Number Publication Date
DK3433270T3 true DK3433270T3 (da) 2023-12-11

Family

ID=55968783

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17715521.5T DK3433270T3 (da) 2016-03-23 2017-03-22 T celle receptorer

Country Status (20)

Country Link
US (2) US11440944B2 (da)
EP (1) EP3433270B1 (da)
JP (1) JP7051699B2 (da)
CN (1) CN109563147A (da)
AU (1) AU2017236415B2 (da)
BR (1) BR112018069275A2 (da)
CA (1) CA3018467A1 (da)
DK (1) DK3433270T3 (da)
ES (1) ES2965715T3 (da)
FI (1) FI3433270T3 (da)
GB (1) GB201604953D0 (da)
HR (1) HRP20231645T1 (da)
HU (1) HUE064591T2 (da)
LT (1) LT3433270T (da)
PL (1) PL3433270T3 (da)
PT (1) PT3433270T (da)
RS (1) RS64952B1 (da)
SI (1) SI3433270T1 (da)
SM (1) SMT202300448T1 (da)
WO (1) WO2017163064A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020006643A2 (pt) 2017-10-03 2020-09-24 Juno Therapeutics Inc moléculas de ligação específica ao hpv
CA3094468A1 (en) * 2018-04-05 2019-10-10 Juno Therapeutics, Inc. Methods of producing cells expressing a recombinant receptor and related compositions
KR20210020873A (ko) * 2018-04-05 2021-02-24 주노 쎄러퓨티크스 인코퍼레이티드 재조합 수용체를 발현하는 τ 세포, 관련 폴리뉴클레오티드 및 방법
CA3126422A1 (en) * 2019-01-14 2020-07-23 Nanjing Legend Biotech Co., Ltd. Chimeric receptor polypeptides and uses thereof
GB201902277D0 (en) 2019-02-19 2019-04-03 King S College London Therapeutic agents
GB202010329D0 (en) * 2020-07-06 2020-08-19 Immunocore Ltd Specific binding molecules
KR20240149435A (ko) 2022-02-20 2024-10-14 이뮤노코어 리미티드 Hiv 특이적 결합 분자
US12103971B2 (en) 2022-02-20 2024-10-01 Immunocore Limited HIV specific binding molecules
CN120775790A (zh) * 2024-04-04 2025-10-14 香雪生命科学技术(广东)有限公司 一种分泌型效应细胞

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6685698A (en) 1997-03-07 1998-09-22 Sunol Molecular Corporation Fusion proteins comprising bacteriophage coat protein and a single-chain t cell receptor
WO1999018129A1 (en) 1997-10-02 1999-04-15 Sunol Molecular Corporation Soluble single-chain t-cell receptor proteins
JP4972264B2 (ja) 1999-12-06 2012-07-11 ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ 高親和性tcrタンパク質および方法
WO2001062908A2 (en) 2000-02-22 2001-08-30 Ahuva Nissim Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof
AU2002321581C1 (en) 2001-08-31 2008-09-18 Adaptimmune Limited Soluble T cell receptor
AU2003271904B2 (en) 2002-10-09 2009-03-05 Adaptimmune Limited Single chain recombinant T cell receptors
DE60327795D1 (de) 2002-11-09 2009-07-09 Immunocore Ltd T zell rezeptor "display"
NZ561338A (en) 2005-04-01 2010-04-30 Immunocore Ltd High affinity HIV T cell receptors
EP2087000A2 (en) 2006-09-29 2009-08-12 Immunocore Ltd. T cell therapies
GB0908613D0 (en) 2009-05-20 2009-06-24 Immunocore Ltd T Cell Reseptors
GB0911566D0 (en) 2009-07-03 2009-08-12 Immunocore Ltd T cell receptors
GB201223172D0 (en) 2012-12-21 2013-02-06 Immunocore Ltd Method
CN106478807B (zh) 2015-10-30 2018-06-01 广东香雪精准医疗技术有限公司 识别mage-a3的t细胞受体

Also Published As

Publication number Publication date
US20230192806A1 (en) 2023-06-22
BR112018069275A2 (pt) 2019-01-22
AU2017236415A1 (en) 2018-11-15
JP2019512252A (ja) 2019-05-16
WO2017163064A1 (en) 2017-09-28
FI3433270T3 (fi) 2023-12-18
LT3433270T (lt) 2023-10-25
GB201604953D0 (en) 2016-05-04
RS64952B1 (sr) 2024-01-31
SI3433270T1 (sl) 2023-11-30
CN109563147A (zh) 2019-04-02
PL3433270T3 (pl) 2024-03-04
HRP20231645T1 (hr) 2024-03-15
ES2965715T3 (es) 2024-04-16
SMT202300448T1 (it) 2024-05-14
HUE064591T2 (hu) 2024-03-28
AU2017236415B2 (en) 2023-05-11
CA3018467A1 (en) 2017-09-28
EP3433270A1 (en) 2019-01-30
US11440944B2 (en) 2022-09-13
PT3433270T (pt) 2023-12-22
EP3433270B1 (en) 2023-09-20
JP7051699B2 (ja) 2022-04-11
US20190106475A1 (en) 2019-04-11

Similar Documents

Publication Publication Date Title
IL271435A (en) T cell receptors
IL262128A (en) T cell receptors
IL262124A (en) T cell receptors
IL262146A (en) T cell receptors
HUE059159T2 (hu) T-sejt-receptorok
DK3448882T3 (da) Anti-kk-lc-1-t-cellereceptorer
IL251524A0 (en) T cell receptors
DK3303568T3 (da) Celle
DK3560953T3 (da) Celle
IL252258B (en) Anti-mutated kras t cell receptors
EP3858365C0 (en) T CAR CELLS OPTIMIZED WITH GOLD
PL3547392T3 (pl) Akumulator
DK3433270T3 (da) T celle receptorer
EP3286210C0 (en) T CELL RECEPTOR
DK3427323T3 (da) Brændselscelle
EP3613123A4 (en) PERFORMANCE-BASED BATTERY CONFIGURATIONS
HUE072082T2 (hu) Akkumulátor
IT201700089514A1 (it) Celle di permeazione
PL3549187T3 (pl) Struktura baterii
UA36271S (uk) Акумуляторна батарея
UA36268S (uk) Акумуляторна батарея
UA35811S (uk) Акумуляторна батарея
UA35997S (uk) Акумуляторна батарея
UA34266S (uk) Акумуляторна батарея
UA35581S (uk) Акумуляторна батарея