DK3444238T3 - Fremgangsmåde til fremstilling af difluormethylenforbindelser - Google Patents
Fremgangsmåde til fremstilling af difluormethylenforbindelser Download PDFInfo
- Publication number
- DK3444238T3 DK3444238T3 DK18195988.3T DK18195988T DK3444238T3 DK 3444238 T3 DK3444238 T3 DK 3444238T3 DK 18195988 T DK18195988 T DK 18195988T DK 3444238 T3 DK3444238 T3 DK 3444238T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- difluoromethylene compounds
- difluoromethylene
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012166658 | 2012-07-27 | ||
| EP13823704.5A EP2878594B1 (en) | 2012-07-27 | 2013-07-26 | Difluoromethylene compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3444238T3 true DK3444238T3 (da) | 2022-01-03 |
Family
ID=49997447
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18195988.3T DK3444238T3 (da) | 2012-07-27 | 2013-07-26 | Fremgangsmåde til fremstilling af difluormethylenforbindelser |
| DK13823704.5T DK2878594T3 (da) | 2012-07-27 | 2013-07-26 | Difluormethylenforbindelse |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13823704.5T DK2878594T3 (da) | 2012-07-27 | 2013-07-26 | Difluormethylenforbindelse |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9512119B2 (da) |
| EP (2) | EP3444238B1 (da) |
| JP (2) | JP5965484B2 (da) |
| KR (2) | KR102148355B1 (da) |
| CA (2) | CA3128846C (da) |
| DK (2) | DK3444238T3 (da) |
| ES (2) | ES2712717T3 (da) |
| WO (1) | WO2014017643A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014017643A1 (ja) * | 2012-07-27 | 2014-01-30 | 佐藤製薬株式会社 | ジフルオロメチレン化合物 |
| JP6426694B2 (ja) | 2013-03-15 | 2018-11-21 | グローバル ブラッド セラピューティクス インコーポレイテッド | ヘモグロビンの修飾のための化合物及びその使用 |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| CN108299425B (zh) * | 2015-03-24 | 2020-09-18 | 上海璎黎药业有限公司 | 稠环衍生物、其制备方法、中间体、药物组合物及应用 |
| EA037280B1 (ru) * | 2015-09-10 | 2021-03-03 | Цзянсу Атом Байосайенс Энд Фармасьютикал Ко., Лтд. | Группа соединений, применяющихся для лечения или предупреждения гиперурикемии или подагры |
| CN107759588B (zh) * | 2016-08-19 | 2020-10-23 | 江苏新元素医药科技有限公司 | 一类苯基-(吡唑并[1,5-a]吡啶-3-基)甲酮衍生物 |
| WO2018089928A1 (en) | 2016-11-11 | 2018-05-17 | Whitehead Institute For Biomedical Research | Human plasma-like medium |
| EP3562828B1 (en) | 2016-12-28 | 2026-03-18 | Dart Neuroscience LLC | Substituted pyrazolopyrimidinone compounds as pde2 inhibitors |
| TWI774755B (zh) * | 2017-04-28 | 2022-08-21 | 日商佐藤製藥股份有限公司 | 二氟甲烯化合物之製造法 |
| MX2020005447A (es) | 2017-11-27 | 2020-12-03 | Dart Neuroscience Llc | Compuestos de furanopirimidina sustituida como inhibidores de pde1. |
| CN113368073A (zh) * | 2020-07-23 | 2021-09-10 | 太阳升(亳州)生物医药科技有限公司 | 制备用于降低血液尿酸水平的药物制剂的方法 |
| CN115925611A (zh) * | 2022-12-02 | 2023-04-07 | 齐鲁工业大学 | 一种氟烷基取代吲哚衍生物及其合成方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3599403B2 (ja) * | 1995-02-24 | 2004-12-08 | 山之内製薬株式会社 | ベンズアゼピン誘導体の新規製造法 |
| EP0882718B1 (en) | 1995-12-28 | 2005-08-31 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| WO1998015530A1 (en) | 1996-10-08 | 1998-04-16 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives |
| WO1999000372A1 (fr) | 1997-06-27 | 1999-01-07 | Fujisawa Pharmaceutical Co., Ltd. | Sulfamides et leur utilisation medicale |
| US6265434B1 (en) * | 1999-04-06 | 2001-07-24 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| WO2001005758A2 (en) * | 1999-07-15 | 2001-01-25 | Nps Allelix Corp. | Indoles and indazoles for the treatment of migraine |
| US7482366B2 (en) * | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| WO2005092890A2 (en) | 2004-03-25 | 2005-10-06 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
| US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| EA200700243A1 (ru) * | 2004-07-14 | 2007-08-31 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы лечения гепатита с |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7514463B2 (en) | 2004-08-20 | 2009-04-07 | University Of Kansas | Lonidamine analogues and their use in male contraception and cancer treatment |
| US8362031B2 (en) | 2004-08-20 | 2013-01-29 | University Of Kansas | Lonidamine analogues and treatment of polycystic kidney disease |
| AR051780A1 (es) | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
| CA2623327A1 (en) | 2005-10-07 | 2007-04-19 | Kissei Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same |
| RS55630B1 (sr) * | 2005-12-21 | 2017-06-30 | Janssen Pharmaceutica Nv | Triazolopiridazini kao modulatori tirozin kinaze |
| US20070197512A1 (en) | 2006-01-27 | 2007-08-23 | Japan Tobacco Inc. | Carboxylic Acid Compounds and Use Thereof |
| WO2007086504A1 (ja) | 2006-01-27 | 2007-08-02 | Japan Tobacco Inc. | カルボン酸化合物及びその用途 |
| US7829713B2 (en) | 2006-02-28 | 2010-11-09 | Helicon Therapeutics, Inc. | Therapeutic piperazines |
| US8927546B2 (en) * | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
| MX2008011127A (es) | 2006-03-02 | 2008-10-31 | Astellas Pharma Inc | INHIBIDOR DE 17ß HSD TIPO 5. |
| CN101679251B (zh) | 2007-04-11 | 2013-10-02 | 橘生药品工业株式会社 | (氮杂)吲哚衍生物及其医药用途 |
| US9149463B2 (en) * | 2007-09-18 | 2015-10-06 | The Board Of Trustees Of The Leland Standford Junior University | Methods and compositions of treating a Flaviviridae family viral infection |
| US8829058B2 (en) | 2008-03-13 | 2014-09-09 | Wellstat Therapeutics Corporation | Compounds and method for reducing uric acid |
| SG175048A1 (en) * | 2009-04-06 | 2011-11-28 | Schering Corp | Indole derivatives and methods for antiviral treatment |
| US8269013B2 (en) * | 2009-05-28 | 2012-09-18 | Vertex Pharmaceuticals Incorporated | Substituted pyrazole inhibitors of c-Met protein kinase |
| KR20140070637A (ko) | 2009-07-06 | 2014-06-10 | 유니버시티 오브 캔사스 | 생식력 제어를 위한 로니다민 유사체 |
| WO2011050245A1 (en) * | 2009-10-23 | 2011-04-28 | Yangbo Feng | Bicyclic heteroaryls as kinase inhibitors |
| JP5619907B2 (ja) * | 2009-10-29 | 2014-11-05 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | α７ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン化合物 |
| LT2496567T (lt) * | 2009-11-05 | 2017-11-27 | Rhizen Pharmaceuticals S.A. | Nauji benzopirano kinazės moduliatoriai |
| TWI516262B (zh) * | 2010-04-06 | 2016-01-11 | 健康網路大學 | 激酶抑制劑及以其治療癌症的方法 |
| WO2011146287A1 (en) * | 2010-05-20 | 2011-11-24 | Takeda Pharmaceutical Company Limited | Pyrazolo[4,3-b]pyridine-7-amine inhibitors of alk5 |
| DE102010040233A1 (de) * | 2010-09-03 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Bicyclische Aza-Heterocyclen und ihre Verwendung |
| GB201018124D0 (en) * | 2010-10-27 | 2010-12-08 | Glaxo Group Ltd | Polymorphs and salts |
| DE102010043379A1 (de) * | 2010-11-04 | 2012-05-10 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung |
| CN103402996B (zh) * | 2011-01-04 | 2015-02-11 | 诺瓦提斯公司 | 可用于治疗年龄相关性黄斑变性(amd)的吲哚化合物或其类似物 |
| WO2012095781A1 (en) * | 2011-01-13 | 2012-07-19 | Pfizer Limited | Indazole derivatives as sodium channel inhibitors |
| JP5990106B2 (ja) * | 2011-01-28 | 2016-09-07 | 佐藤製薬株式会社 | 縮環化合物 |
| CN102584830A (zh) * | 2011-12-30 | 2012-07-18 | 北京赛林泰医药技术有限公司 | 二氢化茚酰胺化合物、其药物组合物及其用途 |
| WO2014017643A1 (ja) * | 2012-07-27 | 2014-01-30 | 佐藤製薬株式会社 | ジフルオロメチレン化合物 |
-
2013
- 2013-07-26 WO PCT/JP2013/070359 patent/WO2014017643A1/ja not_active Ceased
- 2013-07-26 CA CA3128846A patent/CA3128846C/en active Active
- 2013-07-26 EP EP18195988.3A patent/EP3444238B1/en active Active
- 2013-07-26 DK DK18195988.3T patent/DK3444238T3/da active
- 2013-07-26 CA CA2880178A patent/CA2880178C/en active Active
- 2013-07-26 US US14/417,488 patent/US9512119B2/en active Active
- 2013-07-26 EP EP13823704.5A patent/EP2878594B1/en active Active
- 2013-07-26 ES ES13823704T patent/ES2712717T3/es active Active
- 2013-07-26 ES ES18195988T patent/ES2904321T3/es active Active
- 2013-07-26 DK DK13823704.5T patent/DK2878594T3/da active
- 2013-07-26 KR KR1020157003725A patent/KR102148355B1/ko active Active
- 2013-07-26 JP JP2014527032A patent/JP5965484B2/ja active Active
- 2013-07-26 KR KR1020207023773A patent/KR102226489B1/ko active Active
-
2016
- 2016-07-01 JP JP2016131633A patent/JP6229020B2/ja active Active
- 2016-10-27 US US15/336,214 patent/US9650380B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA3128846A1 (en) | 2014-01-30 |
| EP3444238B1 (en) | 2021-12-08 |
| US9512119B2 (en) | 2016-12-06 |
| KR102148355B1 (ko) | 2020-08-26 |
| ES2904321T3 (es) | 2022-04-04 |
| US20150191463A1 (en) | 2015-07-09 |
| ES2712717T3 (es) | 2019-05-14 |
| EP2878594A1 (en) | 2015-06-03 |
| JP5965484B2 (ja) | 2016-08-03 |
| US9650380B2 (en) | 2017-05-16 |
| KR102226489B1 (ko) | 2021-03-11 |
| EP3444238A3 (en) | 2019-05-15 |
| CA2880178C (en) | 2021-10-26 |
| JP2016169241A (ja) | 2016-09-23 |
| CA3128846C (en) | 2025-05-06 |
| JPWO2014017643A1 (ja) | 2016-07-11 |
| WO2014017643A1 (ja) | 2014-01-30 |
| KR20150036561A (ko) | 2015-04-07 |
| EP2878594A4 (en) | 2016-01-13 |
| DK2878594T3 (da) | 2019-02-04 |
| CA2880178A1 (en) | 2014-01-30 |
| US20170044158A1 (en) | 2017-02-16 |
| JP6229020B2 (ja) | 2017-11-08 |
| KR20200100873A (ko) | 2020-08-26 |
| EP3444238A2 (en) | 2019-02-20 |
| EP2878594B1 (en) | 2018-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3520805T3 (da) | Sammensætninger til behandling af myelofibrose | |
| DK2718404T3 (da) | Fremgangsmåde til fremstilling af flydende carbonhydrider | |
| HUE037048T2 (hu) | Eljárások 4-cikloalkiloxibenzolszulfonamidok elõállítására | |
| SMT201600271B (it) | BENZOSSAZEPINONI FUSI COME MODULATORI DI CANALl IONICI | |
| DK3225604T3 (da) | Fremgangsmåde til fremstilling af flerlagsruder | |
| DK2895156T3 (da) | Fremgangsmåde til fremstilling af terapeutiske nanopartikler | |
| DK2841623T3 (da) | Fremgangsmåder til fremstilling af lithiumhydroxid | |
| DK2837629T3 (da) | Fremgangsmåde til syntetisering af sapropterindihydrochlorid | |
| DK2879718T3 (da) | Proces til fremstilling af kulhydratkonjugerede RNA-stoffer | |
| DK3299356T3 (da) | Fremgangsmåde til fremstilling af pleuromutiliner | |
| DK2386683T3 (da) | Fremgangsmåde til fremstilling af gel-baserede kompositmaterialer | |
| SI3513806T1 (sl) | Sestava imunogena | |
| DK2836460T3 (da) | Fremgangsmåde til fremstilling af graphen | |
| DK2728009T3 (da) | Fremgangsmåde til fremstilling af monosaccharider | |
| DK3010895T3 (da) | Fremgangsmåde til fremstilling af 4-propargyleret aminobenzoxazinoner | |
| DK3434113T3 (da) | Fremgangsmåde til fremstilling af drikkevarer ved fjernelse af syre | |
| EP2878594A4 (en) | DIFLUORMETHYLENVERBINDUNG | |
| DK2732707T3 (da) | Fremgangsmåde til fremstilling af en sammensætning indeholdende caseinomacropeptid | |
| DK2809782T3 (da) | Forbedret fremgangsmåde til fremstilling af makrokugler | |
| LT2812013T (lt) | Kompozicija, skirta džs gydymui | |
| IL236450A0 (en) | Process for the preparation of 5-fluoro-h1-pyrazoles | |
| DK3398594T3 (da) | Sammensætninger til forbedring af hjernefunktion | |
| DK2916661T3 (da) | Fremgangsmåde til opnåelse af bloom-hæmmende komponenter til konfektureprodukter | |
| DK3202769T3 (da) | Fremgangsmåde til oprensning af phosphaplatinforbindelser | |
| DK2854792T3 (da) | Sammensætning til forebyggelse af hovedpiner |