DK3450545T5 - Pluripotente stamceller opnået ved ikke-viral omprogrammering - Google Patents
Pluripotente stamceller opnået ved ikke-viral omprogrammering Download PDFInfo
- Publication number
- DK3450545T5 DK3450545T5 DK18200217.0T DK18200217T DK3450545T5 DK 3450545 T5 DK3450545 T5 DK 3450545T5 DK 18200217 T DK18200217 T DK 18200217T DK 3450545 T5 DK3450545 T5 DK 3450545T5
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- DK
- Denmark
- Prior art keywords
- stem cells
- pluripotent stem
- cells obtained
- viral reprogramming
- reprogramming
- Prior art date
Links
- 210000001778 pluripotent stem cell Anatomy 0.000 title 1
- 230000008672 reprogramming Effects 0.000 title 1
- 230000003612 virological effect Effects 0.000 title 1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/604—Klf-4
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/605—Nanog
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/608—Lin28
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Transplantation (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10836208P | 2008-10-24 | 2008-10-24 | |
| EP09744285.9A EP2356221B1 (en) | 2008-10-24 | 2009-10-23 | Pluripotent stem cells obtained by non-viral reprogramming |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK3450545T3 DK3450545T3 (da) | 2023-10-02 |
| DK3450545T5 true DK3450545T5 (da) | 2024-09-09 |
Family
ID=41698343
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09744285.9T DK2356221T3 (da) | 2008-10-24 | 2009-10-23 | Pluripotente stamceller opnået ved ikke-viral omprogrammering |
| DK18200217.0T DK3450545T5 (da) | 2008-10-24 | 2009-10-23 | Pluripotente stamceller opnået ved ikke-viral omprogrammering |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09744285.9T DK2356221T3 (da) | 2008-10-24 | 2009-10-23 | Pluripotente stamceller opnået ved ikke-viral omprogrammering |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8268620B2 (da) |
| EP (2) | EP3450545B1 (da) |
| JP (5) | JP2012506702A (da) |
| CN (2) | CN105802917A (da) |
| CA (1) | CA2741090C (da) |
| DK (2) | DK2356221T3 (da) |
| ES (1) | ES2959327T3 (da) |
| IL (1) | IL212433B (da) |
| SG (1) | SG10201600234PA (da) |
| WO (1) | WO2010048567A1 (da) |
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| BRPI0619794B8 (pt) | 2005-12-13 | 2022-06-14 | Univ Kyoto | Uso de um fator de reprogramação, agente para a preparação de uma célula-tronco pluripotente induzida a partir de uma célula somática e métodos para preparar uma célula- tronco pluripotente induzida método e para preparar uma célula somática e uso de células-tronco pluripotentes induzidas |
| US20090227032A1 (en) * | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| DK3399025T3 (da) | 2007-03-23 | 2025-06-16 | Wisconsin Alumni Res Found | Omprogrammering af somatiske celler |
| JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
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| SG10201400329YA (en) | 2008-05-02 | 2014-05-29 | Univ Kyoto | Method of nuclear reprogramming |
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| CA2741090C (en) * | 2008-10-24 | 2018-10-16 | Wisconsin Alumni Research Foundation | Pluripotent stem cells obtained by non-viral reprogramming |
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| EP2348104A1 (en) * | 1999-08-05 | 2011-07-27 | Mcl Llc | Multipotent adult stem cells and methods for isolation |
| GB2414480B (en) | 2003-02-07 | 2007-06-27 | Wisconsin Alumni Res Found | Directed genetic modifications of human stem cells |
| US8278104B2 (en) * | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| DK3399025T3 (da) * | 2007-03-23 | 2025-06-16 | Wisconsin Alumni Res Found | Omprogrammering af somatiske celler |
| JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| EP2072618A1 (en) | 2007-12-14 | 2009-06-24 | Johannes Gutenberg-Universität Mainz | Use of RNA for reprogramming somatic cells |
| CN101250502A (zh) * | 2008-04-01 | 2008-08-27 | 中国科学院上海生命科学研究院 | 一种诱导的多潜能干细胞的制备方法 |
| SG10201400329YA (en) | 2008-05-02 | 2014-05-29 | Univ Kyoto | Method of nuclear reprogramming |
| EP3279314A1 (en) | 2008-06-04 | 2018-02-07 | Cellular Dynamics International, Inc. | Methods for the production of ips cells using non-viral approach |
| JP2011525794A (ja) * | 2008-06-26 | 2011-09-29 | 国立大学法人大阪大学 | ｉＰＳ細胞の製造方法および製造キット |
| WO2010012077A1 (en) * | 2008-07-28 | 2010-02-04 | Mount Sinai Hospital | Compositions, methods and kits for reprogramming somatic cells |
| CA2741090C (en) * | 2008-10-24 | 2018-10-16 | Wisconsin Alumni Research Foundation | Pluripotent stem cells obtained by non-viral reprogramming |
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- 2009-10-23 JP JP2011533384A patent/JP2012506702A/ja not_active Withdrawn
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- 2009-10-23 DK DK09744285.9T patent/DK2356221T3/da active
- 2009-10-23 WO PCT/US2009/061935 patent/WO2010048567A1/en not_active Ceased
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2016
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2021
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| Publication number | Publication date |
|---|---|
| EP3450545A1 (en) | 2019-03-06 |
| JP6312638B2 (ja) | 2018-04-18 |
| US8268620B2 (en) | 2012-09-18 |
| CN102239249A (zh) | 2011-11-09 |
| US20190330654A1 (en) | 2019-10-31 |
| ES2959327T3 (es) | 2024-02-23 |
| JP2012506702A (ja) | 2012-03-22 |
| JP2021094040A (ja) | 2021-06-24 |
| DK2356221T3 (da) | 2019-02-18 |
| IL212433A0 (en) | 2011-06-30 |
| JP6861189B2 (ja) | 2021-04-21 |
| WO2010048567A1 (en) | 2010-04-29 |
| CA2741090A1 (en) | 2010-04-29 |
| EP3450545B1 (en) | 2023-08-23 |
| SG10201600234PA (en) | 2016-02-26 |
| JP2018174945A (ja) | 2018-11-15 |
| IL212433B (en) | 2019-08-29 |
| CN105802917A (zh) | 2016-07-27 |
| JP2015213522A (ja) | 2015-12-03 |
| JP7165228B2 (ja) | 2022-11-02 |
| JP2016220686A (ja) | 2016-12-28 |
| US20100184227A1 (en) | 2010-07-22 |
| US20130217117A1 (en) | 2013-08-22 |
| EP2356221A1 (en) | 2011-08-17 |
| EP2356221B1 (en) | 2018-11-21 |
| DK3450545T3 (da) | 2023-10-02 |
| CA2741090C (en) | 2018-10-16 |
| US20220010331A1 (en) | 2022-01-13 |
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