DK3470400T3 - Krystallinske former af ozanimod og ozanimodhydrochlorid samtfremgangsmåder til fremstilling deraf - Google Patents

Krystallinske former af ozanimod og ozanimodhydrochlorid samtfremgangsmåder til fremstilling deraf Download PDF

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Publication number
DK3470400T3
DK3470400T3 DK17812728.8T DK17812728T DK3470400T3 DK 3470400 T3 DK3470400 T3 DK 3470400T3 DK 17812728 T DK17812728 T DK 17812728T DK 3470400 T3 DK3470400 T3 DK 3470400T3
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Denmark
Prior art keywords
ozanimod
processes
preparation
crystalline forms
hydrochloride
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DK17812728.8T
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English (en)
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DK3470400T5 (da
Inventor
Minhua Chen
Yanfeng Zhang
Xiaoting Zhai
Kaiqiang Yan
Chaohui Yang
Xiaoyu Zhang
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Receptos Llc
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Application filed by Receptos Llc filed Critical Receptos Llc
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Publication of DK3470400T3 publication Critical patent/DK3470400T3/da
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK17812728.8T 2016-06-14 2017-06-14 Krystallinske former af ozanimod og ozanimodhydrochlorid samt fremgangsmåder til fremstilling deraf DK3470400T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610416179 2016-06-14
CN201610493910 2016-06-29
PCT/CN2017/088314 WO2017215617A1 (zh) 2016-06-14 2017-06-14 奥扎莫德的晶型、其盐酸盐的晶型及其制备方法

Publications (2)

Publication Number Publication Date
DK3470400T3 true DK3470400T3 (da) 2025-06-16
DK3470400T5 DK3470400T5 (da) 2025-06-30

Family

ID=60663299

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17812728.8T DK3470400T5 (da) 2016-06-14 2017-06-14 Krystallinske former af ozanimod og ozanimodhydrochlorid samt fremgangsmåder til fremstilling deraf

Country Status (15)

Country Link
US (2) US11111223B2 (da)
EP (2) EP4566676A3 (da)
CN (2) CN114957157A (da)
DK (1) DK3470400T5 (da)
ES (1) ES3022204T3 (da)
FI (1) FI3470400T3 (da)
HR (1) HRP20250558T1 (da)
HU (1) HUE072197T2 (da)
LT (1) LT3470400T (da)
PL (1) PL3470400T3 (da)
PT (1) PT3470400T (da)
RS (1) RS66905B1 (da)
SI (1) SI3470400T1 (da)
SM (1) SMT202500228T1 (da)
WO (1) WO2017215617A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4566676A3 (en) 2016-06-14 2025-11-05 Receptos LLC Crystalline forms of ozanimod and ozanimod hydrochloride, and processes for preparation thereof
CN109563059A (zh) * 2016-08-19 2019-04-02 苏州科睿思制药有限公司 奥扎莫德的晶型及其制备方法
WO2018050091A1 (zh) 2016-09-14 2018-03-22 苏州科睿思制药有限公司 奥扎莫德盐酸盐的晶型及其制备方法
US12459907B2 (en) 2017-05-22 2025-11-04 Egis Gyogyszergyar Zrt. Process for the production of ozanimod
CN109280035B (zh) * 2017-07-19 2023-06-09 广东东阳光药业有限公司 奥扎莫德的多晶型及其制备方法
EP3677575A4 (en) 2017-08-31 2020-07-15 Crystal Pharmaceutical (Suzhou) Co., Ltd. CRYSTALLINE FORM OF OZANIMODHYDROCHLORIDE AND PRODUCTION METHOD THEREFOR
CN107840830A (zh) * 2017-09-20 2018-03-27 广东东阳光药业有限公司 盐酸奥扎莫德无水晶型i
WO2019094409A1 (en) 2017-11-07 2019-05-16 Teva Pharmaceuticals International Gmbh Salts and solid state forms of ozanimod
WO2020152718A1 (en) * 2019-01-25 2020-07-30 Mylan Laboratories Limited Polymorphic forms 5-[3-[(1s)-2,3-dihydro-1-[(2-hydroxyethyl) amino]-1h-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile
US12404256B2 (en) 2019-07-16 2025-09-02 Synthon B.V. Process for preparing ozanimod
US12398112B2 (en) 2020-04-02 2025-08-26 Synthon B.V. Crystalline form of ozanimod hydrochloride
WO2023152767A1 (en) 2022-02-11 2023-08-17 Mylan Laboratories Limited Polymorphic forms of ozanimod hydrochloride
EP4720047A1 (en) * 2023-05-31 2026-04-08 Química Sintética, S.A. Amorphous and crystalline form of ozanimod hydrochloride

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3782991A1 (en) 2008-05-14 2021-02-24 The Scripps Research Institute Novel modulators of sphingosine phosphate receptors
KR101582910B1 (ko) 2008-05-14 2016-01-08 더 스크립스 리서치 인스티튜트 스핑고신 포스페이트 수용체의 신규한 모듈레이터
MX2012005560A (es) * 2009-11-13 2012-10-05 Receptos Inc Moduladores selectivos del receptor de esfingosina 1 fosfato y metodos de sintesis quiral.
WO2015066515A1 (en) 2013-11-01 2015-05-07 Receptos, Inc. Selective sphingosine 1 phosphate receptor modulators and combination therapy therewith
EP3280703A1 (en) * 2015-04-06 2018-02-14 Auspex Pharmaceuticals, Inc. Deuterium-substituted oxadiazoles
EP4566676A3 (en) 2016-06-14 2025-11-05 Receptos LLC Crystalline forms of ozanimod and ozanimod hydrochloride, and processes for preparation thereof
CN109563059A (zh) 2016-08-19 2019-04-02 苏州科睿思制药有限公司 奥扎莫德的晶型及其制备方法
CN108137516A (zh) 2016-09-14 2018-06-08 杭州领业医药科技有限公司 奥扎莫德的晶型、其制备方法及药物组合物
WO2018050091A1 (zh) 2016-09-14 2018-03-22 苏州科睿思制药有限公司 奥扎莫德盐酸盐的晶型及其制备方法
WO2018184185A1 (zh) * 2017-04-07 2018-10-11 杭州领业医药科技有限公司 奥扎莫德加成盐晶型、制备方法及药物组合物和用途
EP3677575A4 (en) 2017-08-31 2020-07-15 Crystal Pharmaceutical (Suzhou) Co., Ltd. CRYSTALLINE FORM OF OZANIMODHYDROCHLORIDE AND PRODUCTION METHOD THEREFOR
CN107840830A (zh) 2017-09-20 2018-03-27 广东东阳光药业有限公司 盐酸奥扎莫德无水晶型i

Also Published As

Publication number Publication date
EP3470400A1 (en) 2019-04-17
US11680050B2 (en) 2023-06-20
CN114957157A (zh) 2022-08-30
CN109219597A (zh) 2019-01-15
EP3470400A4 (en) 2019-04-17
US20190337908A1 (en) 2019-11-07
DK3470400T5 (da) 2025-06-30
PL3470400T3 (pl) 2025-08-04
RS66905B1 (sr) 2025-07-31
WO2017215617A1 (zh) 2017-12-21
ES3022204T3 (en) 2025-05-28
EP3470400B1 (en) 2025-04-02
EP4566676A2 (en) 2025-06-11
HUE072197T2 (hu) 2025-10-28
EP4566676A3 (en) 2025-11-05
LT3470400T (lt) 2025-07-10
HRP20250558T1 (hr) 2025-07-04
US20200157065A1 (en) 2020-05-21
US11111223B2 (en) 2021-09-07
SI3470400T1 (sl) 2025-09-30
PT3470400T (pt) 2025-04-29
FI3470400T3 (fi) 2025-06-13
SMT202500228T1 (it) 2025-07-22

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