DK3294865T3 - Fremgangsmåder til fremstilling af epimeraser og benzylisoquinolinalkaloider - Google Patents

Fremgangsmåder til fremstilling af epimeraser og benzylisoquinolinalkaloider Download PDF

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Publication number
DK3294865T3
DK3294865T3 DK16793332.4T DK16793332T DK3294865T3 DK 3294865 T3 DK3294865 T3 DK 3294865T3 DK 16793332 T DK16793332 T DK 16793332T DK 3294865 T3 DK3294865 T3 DK 3294865T3
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Prior art keywords
epimerases
processes
production
benzylisoquinoline alkaloids
benzylisoquinoline
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DK16793332.4T
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English (en)
Inventor
Christina D Smolke
Stephanie Galanie
Isis Trenchard
Catherine Thodey
Yanran Li
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Univ Leland Stanford Junior
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    • C—CHEMISTRY; METALLURGY
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    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y501/00—Racemaces and epimerases (5.1)
    • C12Y501/99—Racemaces and epimerases (5.1) acting on other compounds (5.1.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01247—Codeinone reductase (NADPH) (1.1.1.247)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y501/00—Racemaces and epimerases (5.1)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK16793332.4T 2015-05-08 2016-05-09 Fremgangsmåder til fremstilling af epimeraser og benzylisoquinolinalkaloider DK3294865T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562159122P 2015-05-08 2015-05-08
US201562174475P 2015-06-11 2015-06-11
PCT/US2016/031506 WO2016183023A1 (en) 2015-05-08 2016-05-09 Methods of producing epimerases and benzylisoquinoline alkaloids

Publications (1)

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DK3294865T3 true DK3294865T3 (da) 2023-05-08

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US (2) US11859225B2 (da)
EP (2) EP3294865B1 (da)
JP (3) JP7266966B2 (da)
CN (1) CN107960102A (da)
AU (3) AU2016261490B2 (da)
CA (1) CA2983445A1 (da)
DK (1) DK3294865T3 (da)
ES (1) ES2945359T3 (da)
GB (1) GB2555044B (da)
HK (1) HK1246354A1 (da)
IL (1) IL255136B2 (da)
WO (1) WO2016183023A1 (da)

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US20240218408A1 (en) 2024-07-04
US11859225B2 (en) 2024-01-02
IL255136B1 (en) 2023-05-01
US12497638B2 (en) 2025-12-16
CA2983445A1 (en) 2016-11-17
AU2016261490A1 (en) 2017-11-09
AU2019246920B2 (en) 2022-05-12
EP3294865A4 (en) 2019-06-26
ES2945359T3 (es) 2023-06-30
US20180163241A1 (en) 2018-06-14
EP4253525A2 (en) 2023-10-04
HK1246354A1 (zh) 2018-09-07
CN107960102A (zh) 2018-04-24
EP4253525A3 (en) 2023-10-18
IL255136B2 (en) 2023-09-01
BR112017023816A2 (pt) 2018-07-31
NZ775919A (en) 2025-03-28
JP7266966B2 (ja) 2023-05-01
WO2016183023A1 (en) 2016-11-17
GB2555044A (en) 2018-04-18
GB201719939D0 (en) 2018-01-17
AU2022215268B2 (en) 2025-04-10
AU2022215268A1 (en) 2022-09-01
EP3294865B1 (en) 2023-04-12
JP2018515093A (ja) 2018-06-14
KR20180016396A (ko) 2018-02-14
JP2024038497A (ja) 2024-03-19
AU2016261490B2 (en) 2019-10-31
EP3294865A1 (en) 2018-03-21
GB2555044B (en) 2021-03-17
AU2019246920A1 (en) 2019-11-14
IL255136A0 (en) 2017-12-31
JP2021129587A (ja) 2021-09-09

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