DK3484599T3 - Oprensningsfremgangsmåde og anvendelser deraf - Google Patents

Oprensningsfremgangsmåde og anvendelser deraf Download PDF

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Publication number
DK3484599T3
DK3484599T3 DK17735571.6T DK17735571T DK3484599T3 DK 3484599 T3 DK3484599 T3 DK 3484599T3 DK 17735571 T DK17735571 T DK 17735571T DK 3484599 T3 DK3484599 T3 DK 3484599T3
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DK
Denmark
Prior art keywords
purification process
purification
Prior art date
Application number
DK17735571.6T
Other languages
English (en)
Inventor
Thomas Müller-Späth
Lars Aumann
Michael Bavand
Original Assignee
Chromacon Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56418392&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3484599(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chromacon Ag filed Critical Chromacon Ag
Application granted granted Critical
Publication of DK3484599T3 publication Critical patent/DK3484599T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/10Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1807Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using counter-currents, e.g. fluidised beds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/10Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/30Partition chromatography
    • B01D15/305Hydrophilic interaction chromatography [HILIC]
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361Ion-exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847Multimodal interactions
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/60Construction of the column
    • G01N30/6034Construction of the column joining multiple columns
    • G01N30/6039Construction of the column joining multiple columns in series
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/42Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/428Frontal mode
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/60Construction of the column
    • G01N30/6052Construction of the column body
    • G01N30/6069Construction of the column body with compartments or bed substructure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
DK17735571.6T 2016-07-13 2017-07-10 Oprensningsfremgangsmåde og anvendelser deraf DK3484599T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16179273 2016-07-13
PCT/EP2017/067190 WO2018011102A1 (en) 2016-07-13 2017-07-10 Purification method and uses thereof

Publications (1)

Publication Number Publication Date
DK3484599T3 true DK3484599T3 (da) 2020-06-15

Family

ID=56418392

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17735571.6T DK3484599T3 (da) 2016-07-13 2017-07-10 Oprensningsfremgangsmåde og anvendelser deraf

Country Status (5)

Country Link
US (1) US11180526B2 (da)
EP (1) EP3484599B1 (da)
CN (1) CN109475789B (da)
DK (1) DK3484599T3 (da)
WO (1) WO2018011102A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10432559B2 (en) 2016-10-24 2019-10-01 Snap Inc. Generating and displaying customized avatars in electronic messages
EP3546475A1 (en) * 2018-03-27 2019-10-02 Sanofi Full flow-through process for purifying recombinant proteins
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
EP3991820A1 (en) * 2020-11-03 2022-05-04 Sartorius Stedim Biotech GmbH System for membrane chromatography
CN112451996B (zh) * 2020-11-10 2021-09-24 浙江大学 一种多柱连续流层析捕获蛋白的优化方法
EP4408561B1 (en) * 2021-09-28 2025-04-16 ChromaCon AG Purification method and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3220164A (en) * 1962-07-18 1965-11-30 Perkin Elmer Corp Recirculation chromatography
CA2044242A1 (en) * 1989-10-27 1991-04-28 Pall Corporation Sorbing apparatus with guard bed
DE19711173A1 (de) 1997-03-18 1998-09-24 Sartorius Gmbh Verfahren und Anlage für die adsorptive Stofftrennung
DE19812821B4 (de) * 1998-03-24 2006-09-07 Forschungszentrum Jülich GmbH Vorrichtung und Verfahren für frontchromatographische Dekontamination
US7901581B2 (en) 2007-06-15 2011-03-08 Ge Healthcare Bio-Sciences Ab Chromatography method
CA2748348A1 (en) * 2009-01-06 2010-07-15 Chromacon Ag Multifraction purification processes and devices for such processes
US7988859B2 (en) * 2009-02-05 2011-08-02 Chromatan Inc. Countercurrent tangential chromatography methods, systems, and apparatus
KR101152036B1 (ko) 2010-04-27 2012-06-08 (주)셀트리온 컬럼 순환 및 시료 연속주입법을 이용한 단백질 a 크로마토그래피 정제 방법
EP2500073A1 (en) * 2011-03-17 2012-09-19 ChromaCon AG Method for identification and purification of multi-specific polypeptides
WO2013083482A1 (en) 2011-12-05 2013-06-13 Chromacon Ag Chromatographic method for the separation of fatty acid mixtures
DK2772289T3 (da) * 2013-03-01 2015-08-10 Chromacon Ag Kromatografisk fremgangsmåde til berigelse og isolering
US10948483B2 (en) * 2013-04-08 2021-03-16 Chromacon Ag Method for control, monitoring and/or optimization of a chromatographic process
US10099156B2 (en) 2013-04-08 2018-10-16 Chromacon Ag Chromatographic purification method
CN103331036B (zh) * 2013-06-21 2014-11-26 浙江大学宁波理工学院 一种从混合物中分离与富集目标组分的色谱分离方法
US20160074775A1 (en) * 2014-09-11 2016-03-17 Pall Corporation Continuous chromatography method and system

Also Published As

Publication number Publication date
EP3484599A1 (en) 2019-05-22
CN109475789A (zh) 2019-03-15
US20200031863A1 (en) 2020-01-30
CN109475789B (zh) 2020-06-05
EP3484599B1 (en) 2020-04-22
US11180526B2 (en) 2021-11-23
WO2018011102A1 (en) 2018-01-18

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