DK349287A - (2-dimethylamino-ethyl)(2-((2-methylthio-phenyl)(phenylmethyl)amino)-2-oxo-ethyl)carbamater eller urinstofderivater, fremgangsmaade til fremstilling og anvendelse som laegemiddel af saadanne forbindelser - Google Patents

(2-dimethylamino-ethyl)(2-((2-methylthio-phenyl)(phenylmethyl)amino)-2-oxo-ethyl)carbamater eller urinstofderivater, fremgangsmaade til fremstilling og anvendelse som laegemiddel af saadanne forbindelser

Info

Publication number: DK349287A
Authority: DK; Denmark
Prior art keywords: group; preparation; ethyl; methylthio; phenyl
Prior art date: 1986-07-08

Application number

DK349287A

Other languages

Danish (da)

English (en)

Other versions

DK349287D0 (da

Inventor

Nigel Beeley

Gerard Cremer

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-08

Filing date

1987-07-07

Publication date

1988-01-09

1987-07-07 Application filed by Synthelabo filed Critical Synthelabo

1987-07-07 Publication of DK349287D0 publication Critical patent/DK349287D0/da

1988-01-09 Publication of DK349287A publication Critical patent/DK349287A/da

Links

-1 (2-DIMETHYLAMINO-ETHYL) (2 - ((2-METHYLTHIO-PHENYL) (PHENYLMETHYL) AMINO) -2-OXO-ETHYL) Chemical class 0.000 title abstract 4
KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 4
238000004519 manufacturing process Methods 0.000 title 1
239000000126 substance Substances 0.000 title 1
230000002485 urinary effect Effects 0.000 title 1
125000005843 halogen group Chemical group 0.000 abstract 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
229940127291 Calcium channel antagonist Drugs 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000005605 benzo group Chemical group 0.000 abstract 1
239000000480 calcium channel blocker Substances 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
150000003672 ureas Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Emergency Medicine (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicinal Preparation (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK349287A 1986-07-08 1987-07-07 (2-dimethylamino-ethyl)(2-((2-methylthio-phenyl)(phenylmethyl)amino)-2-oxo-ethyl)carbamater eller urinstofderivater, fremgangsmaade til fremstilling og anvendelse som laegemiddel af saadanne forbindelser DK349287A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8609887A FR2601363B1 (fr)	1986-07-08	1986-07-08	(dimethylamino)-2 ethyl) ((((methylthio)-2 phenyl) (phenylmethyl)amino)-2 oxo-2 ethyl) carbamates ou urees, leur preparation et leur application en therapeutique.

Publications (2)

Publication Number	Publication Date
DK349287D0 DK349287D0 (da)	1987-07-07
DK349287A true DK349287A (da)	1988-01-09

Family

ID=9337176

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK349287A DK349287A (da)	1986-07-08	1987-07-07	(2-dimethylamino-ethyl)(2-((2-methylthio-phenyl)(phenylmethyl)amino)-2-oxo-ethyl)carbamater eller urinstofderivater, fremgangsmaade til fremstilling og anvendelse som laegemiddel af saadanne forbindelser

Country Status (19)

Country	Link
US (1)	US4840967A (cs)
EP (1)	EP0252810B1 (cs)
JP (1)	JPS6323856A (cs)
KR (1)	KR880001587A (cs)
AT (1)	ATE62669T1 (cs)
AU (1)	AU595340B2 (cs)
CA (1)	CA1277330C (cs)
CS (1)	CS357891A3 (cs)
DE (1)	DE3769384D1 (cs)
DK (1)	DK349287A (cs)
FI (1)	FI85583C (cs)
FR (1)	FR2601363B1 (cs)
GR (1)	GR3002081T3 (cs)
HU (1)	HU196169B (cs)
IL (1)	IL83092A (cs)
NO (1)	NO164593C (cs)
NZ (1)	NZ220987A (cs)
PT (1)	PT85280B (cs)
ZA (1)	ZA874945B (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2641279B1 (fr) *	1989-01-03	1991-02-22	Synthelabo	Derives de n-(amino-2 ethyl) n-(((methylthio-2 phenyl) (phenylmethyl)amino)-2 oxo ethyl)amides et carbamates, leur preparation et leur application en therapeutique
JPH02290464A (ja) *	1989-04-28	1990-11-30	Takagi Ind Co Ltd	瞬間湯沸器
EP0903341A1 (en) *	1997-07-22	1999-03-24	Akzo Nobel N.V.	"Novel ortho-mercaptoaniline compounds"
US6221913B1 (en) *	1998-01-21	2001-04-24	Zymogenetics, Inc.	Dialkyl ureas as calcitonin mimetics
CN1610659A (zh) *	2001-12-27	2005-04-27	大正制药株式会社	羧酸衍生物
FR2885129B1 (fr) *	2005-04-29	2007-06-15	Proskelia Sas	Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation.
JP2010512417A (ja) *	2006-12-11	2010-04-22	ワイスエルエルシー	イオンチャネルモジュレータ−
RU2517190C2 (ru) *	2008-08-13	2014-05-27	Внтрисерч Аб	Применение производных пептида wnt5-a для лечения меланомы и рака желудка
EP2726880B1 (en)	2011-07-01	2019-04-17	Wntresearch AB	Treatment of prostate cancer and a method for determining the prognosis for prostate cancer patients
ES2993327T3 (en) *	2014-08-06	2024-12-27	Ascendis Pharma As	Prodrugs comprising an aminoalkyl glycine linker

1986
- 1986-07-08 FR FR8609887A patent/FR2601363B1/fr not_active Expired
1987
- 1987-07-01 DE DE8787401523T patent/DE3769384D1/de not_active Expired - Fee Related
- 1987-07-01 EP EP87401523A patent/EP0252810B1/fr not_active Expired - Lifetime
- 1987-07-01 AT AT87401523T patent/ATE62669T1/de not_active IP Right Cessation
- 1987-07-06 IL IL83092A patent/IL83092A/xx unknown
- 1987-07-07 JP JP62169610A patent/JPS6323856A/ja active Pending
- 1987-07-07 US US07/070,580 patent/US4840967A/en not_active Expired - Fee Related
- 1987-07-07 HU HU873054A patent/HU196169B/hu unknown
- 1987-07-07 FI FI873009A patent/FI85583C/fi not_active IP Right Cessation
- 1987-07-07 PT PT85280A patent/PT85280B/pt not_active IP Right Cessation
- 1987-07-07 KR KR1019870007251A patent/KR880001587A/ko not_active Withdrawn
- 1987-07-07 AU AU75294/87A patent/AU595340B2/en not_active Ceased
- 1987-07-07 NZ NZ220987A patent/NZ220987A/xx unknown
- 1987-07-07 ZA ZA874945A patent/ZA874945B/xx unknown
- 1987-07-07 DK DK349287A patent/DK349287A/da not_active Application Discontinuation
- 1987-07-07 CA CA000541475A patent/CA1277330C/en not_active Expired - Fee Related
- 1987-07-07 NO NO872832A patent/NO164593C/no unknown
1991
- 1991-06-06 GR GR91400752T patent/GR3002081T3/el unknown
- 1991-11-25 CS CS913578A patent/CS357891A3/cs unknown

Also Published As

Publication number	Publication date
FR2601363B1 (fr)	1988-10-21
EP0252810B1 (fr)	1991-04-17
PT85280B (pt)	1990-03-30
NO872832D0 (no)	1987-07-07
PT85280A (fr)	1987-08-01
US4840967A (en)	1989-06-20
NZ220987A (en)	1989-12-21
FI873009A7 (fi)	1988-01-09
DE3769384D1 (de)	1991-05-23
EP0252810A3 (en)	1988-09-07
FR2601363A1 (fr)	1988-01-15
NO164593B (no)	1990-07-16
AU595340B2 (en)	1990-03-29
HUT44482A (en)	1988-03-28
FI85583C (fi)	1992-05-11
ZA874945B (en)	1988-02-24
NO872832L (no)	1988-01-11
ATE62669T1 (de)	1991-05-15
CS357891A3 (en)	1992-12-16
IL83092A0 (en)	1987-12-31
DK349287D0 (da)	1987-07-07
FI85583B (fi)	1992-01-31
EP0252810A2 (fr)	1988-01-13
GR3002081T3 (en)	1992-12-30
JPS6323856A (ja)	1988-02-01
FI873009A0 (fi)	1987-07-07
HU196169B (en)	1988-10-28
AU7529487A (en)	1988-01-14
NO164593C (no)	1990-10-24
KR880001587A (ko)	1988-04-25
IL83092A (en)	1991-11-21
CA1277330C (en)	1990-12-04

Legal Events

Date	Code	Title	Description
1992-10-12	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
DK0442820T3 (da)	1996-02-05	Benzimidazol- og azabenzimidazolderivater, som er thromboxan-receptor-antagonister, fremgangsmåder til deres fremstilling, syntesemellemprodukter og farmaceutiske præparater med indhold deraf
DK349287D0 (da)	1987-07-07	(2-dimethylamino-ethyl)(2-((2-methylthio-phenyl)(phenylmethyl)amino)-2-oxo-ethyl)carbamater eller urinstofderivater, fremgangsmaade til fremstilling og anvendelse som laegemiddel af saadanne forbindelser
DK1034174T3 (da)	2003-09-22	Azaringetherderivater og disses anvendelse som nikotin-ACh-receptormodulatorer
FI844333A0 (fi)	1984-11-05	11-substituerade 5h,11h-pyrrolo/2,1-c/ /1,4/benzoxazepiner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
ES2039221T3 (es)	1996-07-16	Procedimiento para producir derivados de piridazinona.
DK420682A (da)	1983-03-25	Fremgangsmaade til fremstilling af triazoloquinazoloner eller salte deraf
DK333380A (da)	1981-02-03	Fremgangsmaade til fremstilling af 3-amino-1-benzoxepin-derivater eller syreadditionssalte deraf
PT84161B (pt)	1989-07-31	Processo para a preparacao de derivados de 3-acilaminometil-imidazo-{1,2-a}-piridinas e de composicoes farmaceuticas que os contem
DK563681A (da)	1982-06-21	Fremgangsmaade til fremstilling af 2-phenylacylaminomethyl-1h-2,3-dihydro-1,4-benzodiazepin-forbindelser eller deres optiske isomere eller syreadditionssalte deraf
PT92494A (pt)	1990-06-29	Processo para a preparacao de novos derivados do indol
ES8802028A1 (es)	1988-03-16	Procedimiento para preparar dihidropiridinas.
PT81314B (pt)	1987-11-30	Processo para a obtencao de derivados de tiadiazole activos sobre o sistema nervoso central
ATE80608T1 (de)	1992-10-15	N-alkyl-derivate von 2-amino-6,7dimethoxytetralin, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen mit antihypertensiver wirkung.
ES2014975B3 (es)	1990-08-01	Nuevas 1,4 iento para su obtencion, asi como su utilizacion como medicamentos.
SE8904107D0 (sv)	1989-12-05	Kemiska foereningar
ES8802027A1 (es)	1988-03-16	Procedimiento para preparar dihidropiridinas.
EA200100633A1 (ru)	2001-10-22	Производные бензофурана, их получение и применение
EA200300302A1 (ru)	2003-10-30	Новые производные индолина, способ их получения и фармацевтические композиции, содержащие их
AR009122A1 (es)	2000-03-08	Derivados de cafalosporin pridinio, procedimiento para su preparacion, preparaciones farmaceuticas que los contienen y empleo de dichos derivados
ES548497A0 (es)	1986-03-16	Procedimiento para preparar compuestos de 3-amino-2,3-dihi- dro-1-benzoxepina
CO4230104A1 (es)	1995-10-19	Derivados de amina, proceso para su preparacion y composi- cion farmaceutica que los contiene
KR920014808A (ko)	1992-08-25	신규한 퀴놀린계 화합물과 그 제조방법