DK3500664T3 - Fremgangsmåde til differentiering af pluripotente celler - Google Patents
Fremgangsmåde til differentiering af pluripotente celler Download PDFInfo
- Publication number
- DK3500664T3 DK3500664T3 DK17758363.0T DK17758363T DK3500664T3 DK 3500664 T3 DK3500664 T3 DK 3500664T3 DK 17758363 T DK17758363 T DK 17758363T DK 3500664 T3 DK3500664 T3 DK 3500664T3
- Authority
- DK
- Denmark
- Prior art keywords
- pluripotent cells
- differentiating pluripotent
- differentiating
- cells
- pluripotent
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/405—Cell cycle regulated proteins, e.g. cyclins, cyclin-dependant kinases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/73—Hydrolases (EC 3.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/80—Hyaluronan
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Psychology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Developmental Biology & Embryology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662375590P | 2016-08-16 | 2016-08-16 | |
| PCT/US2017/047124 WO2018035214A1 (en) | 2016-08-16 | 2017-08-16 | Methods for differentiating pluripotent cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3500664T3 true DK3500664T3 (da) | 2021-12-06 |
Family
ID=59714142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17758363.0T DK3500664T3 (da) | 2016-08-16 | 2017-08-16 | Fremgangsmåde til differentiering af pluripotente celler |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10590383B2 (da) |
| EP (3) | EP4328301A3 (da) |
| JP (2) | JP7120993B2 (da) |
| KR (2) | KR102625865B1 (da) |
| CN (2) | CN109844102B (da) |
| AU (2) | AU2017313065B2 (da) |
| CA (1) | CA3033205A1 (da) |
| DK (1) | DK3500664T3 (da) |
| ES (1) | ES2901379T3 (da) |
| WO (1) | WO2018035214A1 (da) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2562406B (en) | 2016-01-12 | 2020-09-02 | Cedars Sinai Medical Center | A method of non destructive monitoring of biological processes in microfluidic tissue culture systems |
| US11913022B2 (en) | 2017-01-25 | 2024-02-27 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
| US11767513B2 (en) | 2017-03-14 | 2023-09-26 | Cedars-Sinai Medical Center | Neuromuscular junction |
| JP7494119B2 (ja) * | 2018-03-07 | 2024-06-03 | ソルボンヌ・ユニヴェルシテ | 網膜始原細胞の効率的増幅のための組成物及び方法 |
| CN108456659B (zh) | 2018-03-14 | 2020-05-05 | 浙江霍德生物工程有限公司 | 3d大脑类器官的制备方法 |
| EP4700387A2 (en) | 2018-03-23 | 2026-02-25 | Cedars-Sinai Medical Center | Methods of use of islet cells |
| WO2019195800A1 (en) | 2018-04-06 | 2019-10-10 | Cedars-Sinai Medical Center | Novel differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells |
| WO2019195798A1 (en) | 2018-04-06 | 2019-10-10 | Cedars-Sinai Medical Center | Human pluripotent stem cell derived neurodegenerative disease models on a microfluidic chip |
| JP2021523888A (ja) | 2018-04-30 | 2021-09-09 | シーダーズ−サイナイ メディカル センター | パーキンソン病におけるpkc経路 |
| EP3972617A4 (en) * | 2019-05-23 | 2023-06-07 | The McLean Hospital Corporation | AUTOLOGOUS CELL REPLACEMENT THERAPY FOR PARKINSON'S DISEASE |
| CN121227633A (zh) * | 2019-08-29 | 2025-12-30 | 纪念斯隆-凯特琳癌症中心 | 中脑多巴胺神经元的产生和分离方法 |
| AU2020350408A1 (en) * | 2019-09-20 | 2022-04-07 | Korea Research Institute Of Bioscience And Biotechnology | Production method for induced dopaminergic neuronal progenitors, using direct reprogramming |
| IL296665A (en) | 2020-03-25 | 2022-11-01 | Sana Biotechnology Inc | Hypoimmune neural cells for the treatment of disorders and conditions of the nervous system |
| CN116635047A (zh) * | 2020-06-26 | 2023-08-22 | 米纳瓦生物技术公司 | 用于从多能干细胞衍生多巴胺能神经元的方法 |
| IL299405A (en) * | 2020-06-26 | 2023-02-01 | Minerva Biotechnologies Corp | Methods for deriving dopaminergic neurons from pluripotent stem cells |
| US20230323293A1 (en) * | 2020-08-17 | 2023-10-12 | Institute Of Zoology, Chinese Academy Of Sciences | Expansion culture medium and culture method for neural cells |
| CN114292814A (zh) * | 2020-09-22 | 2022-04-08 | 上海跃赛生物科技有限公司 | 一种多能干细胞分化为中脑黒质多巴胺能神经细胞的方法 |
| TWI808661B (zh) | 2021-03-05 | 2023-07-11 | 日商旭化成股份有限公司 | 氧化還原液流電池用電極及氧化還原液流電池用電極之製造方法 |
| CA3213988A1 (en) * | 2021-04-07 | 2022-10-13 | Christopher MCMAHON | Dopaminergic precursor cells and methods of use |
| CN115873797B (zh) * | 2021-09-29 | 2024-08-13 | 北京干细胞与再生医学研究院 | 一种视网膜色素上皮细胞的扩增培养基及培养方法 |
| WO2024085215A1 (ja) * | 2022-10-20 | 2024-04-25 | 株式会社ケイファーマ | 神経幹細胞/神経前駆細胞の新規製造方法 |
| FR3151340A1 (fr) * | 2023-07-21 | 2025-01-24 | Treefrog Therapeutics | Différenciation neurale à partir de cellules pluripotentes |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| AU5734998A (en) | 1997-01-10 | 1998-08-03 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
| US20020168766A1 (en) | 2000-01-11 | 2002-11-14 | Gold Joseph D. | Genetically altered human pluripotent stem cells |
| AU5676701A (en) | 2000-05-16 | 2001-11-26 | Kyowa Hakko Kogyo Co. Ltd. | Novel method of inducing the differentiation of embryonic stem cells into ectodermal cells and use thereof |
| US20020009743A1 (en) | 2000-05-17 | 2002-01-24 | Carpenter Melissa K. | Neural progenitor cell populations |
| DK1370553T3 (da) | 2001-03-23 | 2006-09-11 | Bayer Corp | Rho-kinase-inhibitorer |
| MY142915A (en) | 2001-03-23 | 2011-01-31 | Bayer Healthcare Llc | Rho-kinase inhibitors |
| WO2003006950A2 (en) | 2001-07-12 | 2003-01-23 | Geron Corporation | Cells of the cardiomyocyte lineage produced from human pluripotent stem cells |
| US20030211603A1 (en) | 2001-08-14 | 2003-11-13 | Earp David J. | Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells |
| US20040014755A1 (en) | 2002-01-10 | 2004-01-22 | Dhanapalan Nagarathnam | Rho-kinase inhibitors |
| WO2003062227A1 (en) | 2002-01-23 | 2003-07-31 | Bayer Pharmaceuticals Corporation | Rho-kinase inhibitors |
| CA2473510A1 (en) | 2002-01-23 | 2003-07-31 | Bayer Pharmaceuticals Corporation | Pyrimidine derivatives as rho-kinase inhibitors |
| EP1562935B1 (de) | 2002-10-28 | 2006-09-06 | Bayer HealthCare AG | Heteroaryloxy-substituierte phenylaminopyrimidine als rho-kinaseinhibitoren |
| WO2005080554A1 (ja) | 2004-02-23 | 2005-09-01 | Kyoto University | 胚性幹細胞の分化調節方法 |
| US8492147B2 (en) | 2004-06-18 | 2013-07-23 | Riken | Method of inducing the differentiation of embryonic stem cells into nerve by serum-free suspension culture |
| KR20070058584A (ko) | 2004-09-08 | 2007-06-08 | 위스콘신 얼럼나이 리서어치 화운데이션 | 인간 배아 줄기 세포의 배양 |
| US20070116680A1 (en) | 2005-11-18 | 2007-05-24 | Rensselaer Polytechnic Institute | Stem cells within gel microenvironments |
| JP5419279B2 (ja) | 2007-01-17 | 2014-02-19 | ウィスコンシン アラムニ リサーチ ファンデーション | 改良された幹細胞の培養 |
| KR101648019B1 (ko) | 2008-06-04 | 2016-08-16 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | 비-바이러스 접근법을 사용한 iPS 세포의 생산 방법 |
| JP5604766B2 (ja) | 2008-12-05 | 2014-10-15 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 多能性細胞の神経分化のための方法および培地 |
| US8642334B2 (en) * | 2009-02-17 | 2014-02-04 | Memorial Sloan Kettering Cancer Center | Methods of neural conversion of human embryonic stem cells |
| CA2764373C (en) | 2009-06-05 | 2019-11-19 | FUJIFILM Cellular Dynamics, Inc. | Reprogramming t cells and hematophietic cells |
| US9487752B2 (en) | 2011-03-30 | 2016-11-08 | Cellular Dynamics International, Inc. | Priming of pluripotent stem cells for neural differentiation |
| PT2773748T (pt) * | 2011-11-04 | 2020-03-26 | Memorial Sloan Kettering Cancer Center | Neurónios dopaminérgicos (da) do mesencéfalo para enxerto |
| JP6419073B2 (ja) | 2013-08-06 | 2018-11-07 | 武田薬品工業株式会社 | ドパミン神経細胞の製造方法 |
| EP3071685A4 (en) * | 2013-11-21 | 2017-07-05 | Memorial Sloan Kettering Cancer Center | Specification of functional cranial placode derivatives from human pluripotent stem cells |
| US9694036B2 (en) | 2014-03-21 | 2017-07-04 | Cellular Dynamics International, Inc. | Production of midbrain dopaminergic neurons and methods for the use thereof |
| US9830679B2 (en) | 2014-03-25 | 2017-11-28 | Google Llc | Shared virtual reality |
| EP4070803B1 (en) * | 2015-06-01 | 2025-10-08 | Memorial Sloan-Kettering Cancer Center | Methods of in vitro differentiation of midbrain dopamine (mda) neurons |
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2017
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- 2017-08-16 JP JP2019508965A patent/JP7120993B2/ja active Active
- 2017-08-16 KR KR1020197007694A patent/KR102487142B1/ko active Active
- 2017-08-16 EP EP23202144.4A patent/EP4328301A3/en active Pending
- 2017-08-16 CN CN201780063703.0A patent/CN109844102B/zh active Active
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- 2017-08-16 AU AU2017313065A patent/AU2017313065B2/en active Active
- 2017-08-16 US US15/678,432 patent/US10590383B2/en active Active
- 2017-08-16 WO PCT/US2017/047124 patent/WO2018035214A1/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| CN109844102B (zh) | 2023-11-10 |
| ES2901379T3 (es) | 2022-03-22 |
| CA3033205A1 (en) | 2018-02-22 |
| CN117467608A (zh) | 2024-01-30 |
| EP4328301A3 (en) | 2024-06-19 |
| EP3500664B1 (en) | 2021-09-22 |
| WO2018035214A8 (en) | 2018-05-03 |
| EP3500664A1 (en) | 2019-06-26 |
| JP7600165B2 (ja) | 2024-12-16 |
| US20180051248A1 (en) | 2018-02-22 |
| CN109844102A (zh) | 2019-06-04 |
| JP2019531062A (ja) | 2019-10-31 |
| US20200172862A1 (en) | 2020-06-04 |
| EP4001403A1 (en) | 2022-05-25 |
| JP2022078245A (ja) | 2022-05-24 |
| KR20220088800A (ko) | 2022-06-28 |
| JP7120993B2 (ja) | 2022-08-17 |
| US10590383B2 (en) | 2020-03-17 |
| KR20190039434A (ko) | 2019-04-11 |
| AU2021225187B2 (en) | 2024-01-04 |
| KR102487142B1 (ko) | 2023-01-12 |
| AU2017313065A1 (en) | 2019-02-28 |
| AU2017313065B2 (en) | 2021-06-24 |
| KR102625865B1 (ko) | 2024-01-16 |
| EP4328301A2 (en) | 2024-02-28 |
| WO2018035214A1 (en) | 2018-02-22 |
| AU2021225187A1 (en) | 2021-09-30 |
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