DK3506882T3 - Fremstilling af størrelseskontrollerede mikropartikler - Google Patents
Fremstilling af størrelseskontrollerede mikropartikler Download PDFInfo
- Publication number
- DK3506882T3 DK3506882T3 DK17758869.6T DK17758869T DK3506882T3 DK 3506882 T3 DK3506882 T3 DK 3506882T3 DK 17758869 T DK17758869 T DK 17758869T DK 3506882 T3 DK3506882 T3 DK 3506882T3
- Authority
- DK
- Denmark
- Prior art keywords
- manufacture
- size
- controlled microparticles
- microparticles
- controlled
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasonic imaging preparations
- A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasonic imaging preparations
- A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16186356 | 2016-08-30 | ||
| PCT/EP2017/071788 WO2018041906A1 (en) | 2016-08-30 | 2017-08-30 | Preparation of size-controlled microparticles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3506882T3 true DK3506882T3 (da) | 2022-03-21 |
Family
ID=56842765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17758869.6T DK3506882T3 (da) | 2016-08-30 | 2017-08-30 | Fremstilling af størrelseskontrollerede mikropartikler |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10918605B2 (da) |
| EP (1) | EP3506882B1 (da) |
| JP (1) | JP7197465B2 (da) |
| KR (1) | KR102474554B1 (da) |
| CN (1) | CN109640951B (da) |
| AU (1) | AU2017317646B2 (da) |
| DK (1) | DK3506882T3 (da) |
| ES (1) | ES2908708T3 (da) |
| IL (1) | IL265070B (da) |
| WO (1) | WO2018041906A1 (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107999155A (zh) * | 2017-12-25 | 2018-05-08 | 四川蓝光英诺生物科技股份有限公司 | 微流控芯片及其控制方法、液滴生成装置和微球制备装置 |
| CN111836650B (zh) * | 2018-03-07 | 2024-06-18 | 博莱科瑞士股份有限公司 | 尺寸可控微泡的制备 |
| KR102180629B1 (ko) * | 2018-12-24 | 2020-11-20 | 서강대학교 산학협력단 | 세포외 소포 기반의 초음파 조영제용 마이크로버블 및 이의 제조방법 |
| KR102044676B1 (ko) * | 2019-03-27 | 2019-11-14 | 주식회사 씨트리 | 생체적합성 고분자 기반 아픽사반 함유 미립구의 제조방법 |
| EP3990033B1 (en) | 2019-06-25 | 2023-12-06 | Bracco Suisse SA | Freeze-dried composition for preparing calibrated gas-filled microvesicles |
| JP7712878B2 (ja) * | 2019-06-25 | 2025-07-24 | ブラッコ・スイス・ソシエテ・アノニム | 校正されたガス充填微小胞を調製するための凍結乾燥組成物 |
| CN116897055A (zh) * | 2020-12-27 | 2023-10-17 | 索尔斯蒂斯制药有限公司 | 用于混合旨在用于体内使用的磷脂组合物的筒 |
| NL2027237B1 (en) * | 2020-12-27 | 2022-07-21 | Solstice Pharmaceuticals B V | Process for controlled manufacturing of mono-disperse microbubbles |
| WO2022139583A1 (en) * | 2020-12-27 | 2022-06-30 | Solstice Pharmaceuticals B.V. | A cartridge for mixing a phospholipid composition intended for intracorporeal use |
| CN114011478B (zh) * | 2021-02-20 | 2023-06-02 | 中国海洋石油集团有限公司 | 一种多功能微流控芯片及其制作方法 |
| CN117479962A (zh) | 2021-07-14 | 2024-01-30 | 博莱科瑞士股份有限公司 | 阳离子标准化尺寸充气微泡 |
| WO2025125516A1 (en) | 2023-12-13 | 2025-06-19 | Bracco Suisse Sa | Calibrated gas-filled microvesicles with ligand |
| NL2036721B1 (en) * | 2023-12-29 | 2025-07-15 | Univ Twente | Controlling the stability of microbubbles |
| WO2025252942A1 (en) | 2024-06-06 | 2025-12-11 | Bracco Suisse Sa | Anionic gas-filled microvesicles with calibrated sizes |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0751496B2 (ja) * | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | リポソ−ムの製造法 |
| US7083572B2 (en) * | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
| PL182223B1 (pl) | 1993-12-15 | 2001-11-30 | Bracco Research Sa | Biokompatybilna faza rozproszona do otrzymywania srodka kontrastowego do badan ultradzwiekowych, srodek kontrastowy do badan ultradzwiekowych, suchy preparat srodka kontrastowego oraz dwuskladnikowy zestaw do otrzymywania srodka kontrastowego do badan ultradzwiekowych PL PL PL |
| US20020159951A1 (en) * | 1997-05-06 | 2002-10-31 | Unger Evan C. | Novel targeted compositions for diagnostic and therapeutic use |
| EP1590006B1 (en) | 2003-02-04 | 2010-09-08 | Bracco Suisse SA | Ultrasound contrast agents and process for the preparation thereof |
| CA2543296A1 (en) * | 2003-10-31 | 2005-05-12 | Point Biomedical Corporation | Reconstitutable microsphere compositions useful as ultrasonic contrast agents |
| PL2504105T3 (pl) * | 2009-11-24 | 2021-06-28 | Opko Diagnostics, Llc | Mieszanie i dostarczanie płynów w układach mikroprzepływowych |
| WO2012098937A1 (ja) * | 2011-01-21 | 2012-07-26 | 国立大学法人 神戸大学 | リポソームの製造方法 |
| GB201111082D0 (en) | 2011-06-29 | 2011-08-10 | Univ Leeds | Bubble generation |
| US9782733B2 (en) | 2012-03-22 | 2017-10-10 | Universiteit Twente | Apparatus and method for mass producing a monodisperse microbubble agent |
-
2017
- 2017-08-30 ES ES17758869T patent/ES2908708T3/es active Active
- 2017-08-30 EP EP17758869.6A patent/EP3506882B1/en active Active
- 2017-08-30 US US16/327,519 patent/US10918605B2/en active Active
- 2017-08-30 IL IL265070A patent/IL265070B/en unknown
- 2017-08-30 JP JP2019508185A patent/JP7197465B2/ja active Active
- 2017-08-30 CN CN201780052322.2A patent/CN109640951B/zh active Active
- 2017-08-30 AU AU2017317646A patent/AU2017317646B2/en active Active
- 2017-08-30 DK DK17758869.6T patent/DK3506882T3/da active
- 2017-08-30 KR KR1020197008825A patent/KR102474554B1/ko active Active
- 2017-08-30 WO PCT/EP2017/071788 patent/WO2018041906A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US10918605B2 (en) | 2021-02-16 |
| CN109640951A (zh) | 2019-04-16 |
| KR20190042681A (ko) | 2019-04-24 |
| EP3506882A1 (en) | 2019-07-10 |
| AU2017317646B2 (en) | 2023-07-06 |
| US20190175516A1 (en) | 2019-06-13 |
| CA3032062A1 (en) | 2018-03-08 |
| EP3506882B1 (en) | 2022-01-12 |
| AU2017317646A1 (en) | 2019-02-21 |
| WO2018041906A1 (en) | 2018-03-08 |
| JP7197465B2 (ja) | 2022-12-27 |
| CN109640951B (zh) | 2023-08-25 |
| KR102474554B1 (ko) | 2022-12-06 |
| JP2019526551A (ja) | 2019-09-19 |
| ES2908708T3 (es) | 2022-05-03 |
| IL265070B (en) | 2022-09-01 |
| IL265070A (da) | 2019-04-30 |
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