DK3513191T3 - Identifikation og isolering af humane otiske progenitorer - Google Patents

Identifikation og isolering af humane otiske progenitorer Download PDF

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Publication number
DK3513191T3
DK3513191T3 DK17771536.4T DK17771536T DK3513191T3 DK 3513191 T3 DK3513191 T3 DK 3513191T3 DK 17771536 T DK17771536 T DK 17771536T DK 3513191 T3 DK3513191 T3 DK 3513191T3
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DK
Denmark
Prior art keywords
isolation
identification
human otic
otic progenitors
progenitors
Prior art date
Application number
DK17771536.4T
Other languages
English (en)
Inventor
Carlos Marcelo Nicolas Rivolta
Sarah Louise Boddy
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Univ Sheffield
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Publication of DK3513191T3 publication Critical patent/DK3513191T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/7452—Thrombomodulin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
DK17771536.4T 2016-09-15 2017-09-14 Identifikation og isolering af humane otiske progenitorer DK3513191T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1615714.1A GB201615714D0 (en) 2016-09-15 2016-09-15 Otic progenitor identification and isolation
PCT/GB2017/052707 WO2018051092A1 (en) 2016-09-15 2017-09-14 Human otic progenitor identification and isolation

Publications (1)

Publication Number Publication Date
DK3513191T3 true DK3513191T3 (da) 2021-07-05

Family

ID=57288819

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17771536.4T DK3513191T3 (da) 2016-09-15 2017-09-14 Identifikation og isolering af humane otiske progenitorer

Country Status (28)

Country Link
US (2) US11634687B2 (da)
EP (1) EP3513191B1 (da)
JP (1) JP7134488B2 (da)
KR (1) KR102409178B1 (da)
CN (1) CN109716133B (da)
AU (1) AU2017328903B2 (da)
CA (1) CA3034529A1 (da)
CL (1) CL2019000682A1 (da)
CO (1) CO2019002095A2 (da)
CY (1) CY1124285T1 (da)
DK (1) DK3513191T3 (da)
ES (1) ES2877795T3 (da)
GB (1) GB201615714D0 (da)
HR (1) HRP20211049T1 (da)
HU (1) HUE055453T2 (da)
IL (1) IL265288B2 (da)
LT (1) LT3513191T (da)
MA (1) MA46424B1 (da)
MX (1) MX2019002995A (da)
PL (1) PL3513191T3 (da)
PT (1) PT3513191T (da)
RS (1) RS62083B1 (da)
RU (1) RU2768720C2 (da)
SG (1) SG11201901410SA (da)
SI (1) SI3513191T1 (da)
SM (1) SMT202100378T1 (da)
WO (1) WO2018051092A1 (da)
ZA (1) ZA201902342B (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201615714D0 (en) * 2016-09-15 2016-11-02 Univ Of Sheffield The Otic progenitor identification and isolation
GB202213060D0 (en) 2022-09-07 2022-10-19 Rinri Therapeutics Ltd Surgical method for treatment of auditory disease or condition
GB202214291D0 (en) 2022-09-29 2022-11-16 Rinri Therapeutics Ltd Laminin culture protocol
CN116162589B (zh) * 2022-12-30 2025-10-03 西北工业大学 干细胞及其制备方法和应用、及标记组合物及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2379683A1 (en) 1999-07-20 2001-01-25 University Of Southern California Identification of pluripotent pre-mesenchymal, pre-hematopoietic progenitor cell
US6436704B1 (en) 2000-04-10 2002-08-20 Raven Biotechnologies, Inc. Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
US6534052B1 (en) 2000-09-05 2003-03-18 Yong-Fu Xiao Cardiac function comprising implantation of embryonic stem cell in which differentiation has been initiated
AU2002303437A1 (en) 2001-04-20 2002-11-05 Children's Hospital Of Orange County Isolation of neural stem cells using gangliosides and other surface markers
US8673634B2 (en) 2003-11-13 2014-03-18 Massachusetts Eye & Ear Infirmary Method for the treatment of hearing loss
US20070250942A1 (en) 2006-04-07 2007-10-25 Cold Spring Harbor Laboratory Non-human transgenic mammals useful for identifying and assessing neural stem/progenitor cells
CN101668848B (zh) * 2007-04-26 2014-10-22 雷蒙特亚特特拉维夫大学有限公司 来自口腔粘膜的多能自体干细胞和使用方法
GB2450747A (en) * 2007-07-06 2009-01-07 Univ Sheffield Treatment of sensorineural hearing loss
RU2525223C2 (ru) * 2009-06-08 2014-08-10 Иалоджик Кореа Инк. Способ стимулирования области волосковых сенсорных клеток
EP2667881A4 (en) * 2011-01-24 2015-04-22 Univ Leland Stanford Junior METHOD FOR IN VITRO GENERATION OF INTERNAL CELLS
JP6468843B2 (ja) * 2012-02-17 2019-02-13 ザ スキーペンズ アイ リサーチ インスティチュート ヒト網膜前駆細胞の表現型プロファイル
CA2876868A1 (en) * 2012-06-13 2013-12-19 Stemgent, Inc. Methods of preparing pluripotent stem cells
GB201615714D0 (en) * 2016-09-15 2016-11-02 Univ Of Sheffield The Otic progenitor identification and isolation

Also Published As

Publication number Publication date
ZA201902342B (en) 2021-09-29
JP2019533138A (ja) 2019-11-14
WO2018051092A1 (en) 2018-03-22
IL265288A (en) 2019-05-30
CN109716133B (zh) 2023-04-28
EP3513191A1 (en) 2019-07-24
EP3513191B1 (en) 2021-04-28
BR112019004749A2 (pt) 2019-05-28
KR20190051971A (ko) 2019-05-15
MX2019002995A (es) 2019-09-18
IL265288B2 (en) 2024-03-01
AU2017328903A1 (en) 2019-03-07
MA46424A (fr) 2019-07-24
MA46424B1 (fr) 2021-07-29
CY1124285T1 (el) 2022-07-22
CN109716133A (zh) 2019-05-03
RU2019110990A (ru) 2020-10-15
US20190185813A1 (en) 2019-06-20
US20230313134A1 (en) 2023-10-05
PT3513191T (pt) 2021-07-05
CO2019002095A2 (es) 2019-05-31
CL2019000682A1 (es) 2019-06-07
IL265288B1 (en) 2023-11-01
HUE055453T2 (hu) 2021-11-29
PL3513191T3 (pl) 2021-10-25
HRP20211049T1 (hr) 2021-10-01
SI3513191T1 (sl) 2021-09-30
RU2019110990A3 (da) 2020-12-09
KR102409178B1 (ko) 2022-06-14
AU2017328903B2 (en) 2023-07-06
GB201615714D0 (en) 2016-11-02
RU2768720C2 (ru) 2022-03-24
US12209254B2 (en) 2025-01-28
US11634687B2 (en) 2023-04-25
LT3513191T (lt) 2021-08-10
SG11201901410SA (en) 2019-03-28
CA3034529A1 (en) 2018-03-22
RS62083B1 (sr) 2021-08-31
JP7134488B2 (ja) 2022-09-12
SMT202100378T1 (it) 2021-09-14
ES2877795T3 (es) 2021-11-17

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