DK3538554T3 - Antigenbindende proteiner som antagonister af leptinreceptor - Google Patents

Antigenbindende proteiner som antagonister af leptinreceptor

Info

Publication number
DK3538554T3
DK3538554T3 DK17801273.8T DK17801273T DK3538554T3 DK 3538554 T3 DK3538554 T3 DK 3538554T3 DK 17801273 T DK17801273 T DK 17801273T DK 3538554 T3 DK3538554 T3 DK 3538554T3
Authority
DK
Denmark
Prior art keywords
antagonists
antigen
binding proteins
leptin receptor
leptin
Prior art date
Application number
DK17801273.8T
Other languages
English (en)
Inventor
Jesper Gromada
Panayiotis Stevis
Judith ALTAREJOS
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Application granted granted Critical
Publication of DK3538554T3 publication Critical patent/DK3538554T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK17801273.8T 2016-11-08 2017-11-08 Antigenbindende proteiner som antagonister af leptinreceptor DK3538554T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662419062P 2016-11-08 2016-11-08
PCT/US2017/060690 WO2018089532A1 (en) 2016-11-08 2017-11-08 Antigen-binding proteins that antagonize leptin receptor

Publications (1)

Publication Number Publication Date
DK3538554T3 true DK3538554T3 (da) 2025-09-08

Family

ID=60409473

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17801273.8T DK3538554T3 (da) 2016-11-08 2017-11-08 Antigenbindende proteiner som antagonister af leptinreceptor

Country Status (29)

Country Link
US (3) US10550192B2 (da)
EP (2) EP3538554B1 (da)
JP (4) JP7042816B2 (da)
KR (1) KR102563568B1 (da)
CN (1) CN110167965A (da)
AU (2) AU2017359439B2 (da)
CA (1) CA3043365A1 (da)
CL (3) CL2019001263A1 (da)
CO (1) CO2019004672A2 (da)
DK (1) DK3538554T3 (da)
EA (1) EA201991075A1 (da)
ES (1) ES3040144T3 (da)
FI (1) FI3538554T3 (da)
HR (1) HRP20251165T1 (da)
HU (1) HUE073276T2 (da)
IL (2) IL266426B (da)
LT (1) LT3538554T (da)
MA (1) MA45801B1 (da)
MX (2) MX2019005397A (da)
MY (2) MY203682A (da)
PH (1) PH12019500988A1 (da)
PL (1) PL3538554T3 (da)
PT (1) PT3538554T (da)
RS (1) RS67214B1 (da)
SG (1) SG10201913470SA (da)
SI (1) SI3538554T1 (da)
SM (1) SMT202500327T1 (da)
UA (1) UA127678C2 (da)
WO (1) WO2018089532A1 (da)

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TW202417497A (zh) 2015-10-12 2024-05-01 美商再生元醫藥公司 活化瘦素受體的抗原結合蛋白
EA201991075A1 (ru) 2016-11-08 2019-10-31 Антигенсвязывающие белки, которые проявляют антагонизм в отношении лептинового рецептора
KR20200100089A (ko) 2017-12-18 2020-08-25 리제너론 파마슈티칼스 인코포레이티드 렙틴 수용체 및/또는 gp130에 결합하는 이중 특이적 항원 결합 분자 및 이의 사용 방법
LT3773713T (lt) 2018-04-06 2025-08-25 Regeneron Pharmaceuticals, Inc. Leptino receptoriaus agonistinis antikūnas, skirtas kaulų masės didinimui subjektui, kuriam pasireiškia medžiagų apykaitos sutrikimas arba hipoleptinemija
WO2020016160A1 (en) * 2018-07-16 2020-01-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Method to treat neurological diseases
MX2021007394A (es) 2018-12-18 2021-07-15 Regeneron Pharma Composiciones y metodos para aumentar el peso corporal y la masa muscular magra mediante el uso de antagonistas contra el receptor de leptina, gdf8 y activina a.
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
US12616618B2 (en) * 2020-07-17 2026-05-05 Sumitomo Seika Chemicals Co., Ltd. Absorber with particles having water absorption and wettability properties
MX2023002995A (es) * 2020-09-15 2023-05-19 Regeneron Pharma Uso de agonistas de lepr para el dolor.
CN118436632B (zh) * 2024-07-05 2024-08-30 四川大学华西第二医院 Teriflunomide在制备预防和/或治疗原发性纤毛不动综合征的药物中的用途

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CA2244693A1 (en) 1996-01-23 1997-07-31 Progenitor, Inc. Methods for using the obese gene and its gene product to stimulate hematopoietic development
US7067472B1 (en) 1996-06-04 2006-06-27 The Scripps Research Institute Diagnostic and therapeutic methods related to regulating energy mobilization with OB protein and OB antibodies
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TW202417497A (zh) 2015-10-12 2024-05-01 美商再生元醫藥公司 活化瘦素受體的抗原結合蛋白
EA201991075A1 (ru) 2016-11-08 2019-10-31 Антигенсвязывающие белки, которые проявляют антагонизм в отношении лептинового рецептора

Also Published As

Publication number Publication date
FI3538554T3 (fi) 2025-09-24
MY191256A (en) 2022-06-10
SI3538554T1 (sl) 2025-10-30
HUE073276T2 (hu) 2026-01-28
ES3040144T3 (en) 2025-10-28
IL272358B (en) 2022-02-01
IL272358A (en) 2020-03-31
JP7042816B2 (ja) 2022-03-28
PL3538554T3 (pl) 2025-10-27
US11535675B2 (en) 2022-12-27
KR20190075133A (ko) 2019-06-28
HRP20251165T1 (hr) 2025-11-21
RS67214B1 (sr) 2025-10-31
MA45801B1 (fr) 2021-11-30
US20180127508A1 (en) 2018-05-10
JP2024109952A (ja) 2024-08-14
MX2019005397A (es) 2019-10-09
CA3043365A1 (en) 2018-05-17
AU2025201454A1 (en) 2025-04-10
AU2017359439A1 (en) 2019-05-23
JP2020504078A (ja) 2020-02-06
JP2023093753A (ja) 2023-07-04
SMT202500327T1 (it) 2025-11-10
IL266426A (en) 2019-06-30
EA201991075A1 (ru) 2019-10-31
LT3538554T (lt) 2025-10-10
MA45801A1 (fr) 2020-07-29
KR102563568B1 (ko) 2023-08-04
CL2020000549A1 (es) 2020-08-28
EP4613772A2 (en) 2025-09-10
JP2022031969A (ja) 2022-02-22
MY203682A (en) 2024-07-12
EP3538554B1 (en) 2025-08-13
SG10201913470SA (en) 2020-03-30
JP7611292B2 (ja) 2025-01-09
IL266426B (en) 2020-11-30
EP3538554A1 (en) 2019-09-18
CN110167965A (zh) 2019-08-23
PH12019500988A1 (en) 2019-08-19
US10550192B2 (en) 2020-02-04
CL2020001023A1 (es) 2020-10-09
CL2019001263A1 (es) 2019-09-27
MX2023011233A (es) 2023-10-03
EP4613772A3 (en) 2025-12-24
US20200123264A1 (en) 2020-04-23
CO2019004672A2 (es) 2019-07-31
AU2017359439B2 (en) 2024-11-28
UA127678C2 (uk) 2023-11-29
PT3538554T (pt) 2025-09-01
WO2018089532A1 (en) 2018-05-17
US20230235068A1 (en) 2023-07-27

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