DK3553088T3 - Humaniseret anti-kallikrein-2-antistof - Google Patents

Humaniseret anti-kallikrein-2-antistof

Info

Publication number: DK3553088T3
Authority: DK; Denmark
Prior art keywords: kallikrein; antibody; humanized anti; humanized
Prior art date: 2013-11-19

Application number

DK19161698.6T

Other languages

English (en)

Inventor

Sven-Erik Strand

Urpo Juhani Lamminmäki

Kjell Sjöström

Pär Oskar Vilhelmsson Timmermand

Amanda Thuy Tran

Original Assignee

Janssen Biotech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-11-19

Filing date

2014-11-19

Publication date

2026-04-27

2013-11-19 Priority claimed from GB1320408.6A external-priority patent/GB2520353A/en

2014-02-05 Priority claimed from GB201401973A external-priority patent/GB201401973D0/en

2014-11-19 Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc

2026-04-27 Application granted granted Critical

2026-04-27 Publication of DK3553088T3 publication Critical patent/DK3553088T3/da

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1075—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being against an enzyme
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Physics & Mathematics (AREA)
Epidemiology (AREA)
Optics & Photonics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cell Biology (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Food Science & Technology (AREA)
Microbiology (AREA)
Analytical Chemistry (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Biotechnology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)

DK19161698.6T 2013-11-19 2014-11-19 Humaniseret anti-kallikrein-2-antistof DK3553088T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB1320408.6A GB2520353A (en)	2013-11-19	2013-11-19	Antibody polypeptides and uses thereof
GB201401973A GB201401973D0 (en)	2014-02-05	2014-02-05	Antibody polypeptides and uses thereof
EP14814696.2A EP3071595B1 (en)	2013-11-19	2014-11-19	Humanised anti kallikrein-2 antibody

Publications (1)

Publication Number	Publication Date
DK3553088T3 true DK3553088T3 (da)	2026-04-27

Family

ID=52114029

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK14814696.2T DK3071595T3 (da)	2013-11-19	2014-11-19	Humaniseret anti-kallikrein-2-antistof
DK19161698.6T DK3553088T3 (da)	2013-11-19	2014-11-19	Humaniseret anti-kallikrein-2-antistof

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK14814696.2T DK3071595T3 (da)	2013-11-19	2014-11-19	Humaniseret anti-kallikrein-2-antistof

Country Status (24)

Country	Link
US (3)	US10100125B2 (da)
EP (2)	EP3553088B1 (da)
JP (4)	JP6599859B2 (da)
KR (3)	KR102442738B1 (da)
CN (2)	CN112898431B (da)
AU (3)	AU2014351611B2 (da)
BR (1)	BR112016011025B1 (da)
CA (1)	CA2930493A1 (da)
CY (1)	CY1121900T1 (da)
DK (2)	DK3071595T3 (da)
ES (1)	ES2728515T3 (da)
FI (1)	FI3553088T3 (da)
HR (1)	HRP20191095T1 (da)
HU (1)	HUE043875T2 (da)
IL (5)	IL297678B2 (da)
LT (1)	LT3071595T (da)
MX (2)	MX383543B (da)
PL (1)	PL3071595T3 (da)
PT (1)	PT3071595T (da)
RS (1)	RS58831B1 (da)
RU (1)	RU2687163C1 (da)
SI (1)	SI3071595T1 (da)
SM (1)	SMT201900338T1 (da)
WO (1)	WO2015075445A1 (da)

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US12326453B2 (en)	2014-03-28	2025-06-10	Opko Diagnostics, Llc	Compositions and methods for active surveillance of prostate cancer
WO2016160545A1 (en)	2015-03-27	2016-10-06	Opko Diagnostics, Llc	Prostate antigen standards and uses thereof
WO2017087826A1 (en) *	2015-11-18	2017-05-26	Memorial Sloan Kettering Cancer Center	Systems, methods, and compositions for imaging androgen receptor axis activity in carcinoma, and related therapeutic compositions and methods
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KR102317805B1 (ko) *	2017-03-30	2021-10-27	이씨에스-프로가스트린 에스에이	전립선암을 검출하기 위한 조성물 및 방법
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AU2020322221A1 (en)	2019-07-26	2022-03-24	Janssen Biotech, Inc.	Anti-hK2 chimeric antigen receptor (CAR)
BR112022001368A2 (pt)	2019-07-26	2022-05-24	Janssen Biotech Inc	Proteínas que compreendem domínios de ligação ao antígeno de peptidase 2 relacionada à calicreína e seus usos
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CN116249714A (zh)	2020-05-27	2023-06-09	詹森生物科技公司	包含cd3抗原结合结构域的蛋白质及其用途
EP4182353A1 (en)	2020-07-17	2023-05-24	Janssen Biotech, Inc.	Anti-idiotypic antibodies against anti-klk2 antibodies
UY39510A (es) *	2020-11-10	2022-05-31	Janssen Biotech Inc	Compuestos macrocíclicos y métodos para usarlos
CN112608365B (zh) *	2020-12-22	2021-07-30	吉林省特医食品生物科技有限公司	一种减轻体重的发酵型小分子肽及其制备方法和应用
CN114790245A (zh) *	2021-01-25	2022-07-26	成都康弘生物科技有限公司	一种抗体及其用途
JP2024503924A (ja) *	2021-01-27	2024-01-29	ヤンセンバイオテツク，インコーポレーテツド	カリクレイン関連ペプチダーゼ２抗原結合ドメインを含む免疫コンジュゲート及びその使用
WO2022165130A1 (en) *	2021-01-28	2022-08-04	Astria Therapeutics, Inc.	Plasma kallikrein antibodies and uses thereof
US20230011134A1 (en) *	2021-05-27	2023-01-12	Janssen Biotech, Inc.	Compositions and methods for the treatment of prostate cancer
CA3240194A1 (en)	2021-11-09	2023-05-19	Edward Cleator	Macrocyclic compounds and methods of making the same
JP2024543046A (ja)	2021-11-09	2024-11-19	ヤンセンバイオテツク，インコーポレーテツド	大環状化合物及びその診断上の使用
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2014
- 2014-11-19 SM SM20190338T patent/SMT201900338T1/it unknown
- 2014-11-19 KR KR1020167016169A patent/KR102442738B1/ko active Active
- 2014-11-19 FI FIEP19161698.6T patent/FI3553088T3/fi active
- 2014-11-19 WO PCT/GB2014/053420 patent/WO2015075445A1/en not_active Ceased
- 2014-11-19 AU AU2014351611A patent/AU2014351611B2/en active Active
- 2014-11-19 ES ES14814696T patent/ES2728515T3/es active Active
- 2014-11-19 KR KR1020237029468A patent/KR102894975B1/ko active Active
- 2014-11-19 CN CN202011566401.5A patent/CN112898431B/zh active Active
- 2014-11-19 EP EP19161698.6A patent/EP3553088B1/en active Active
- 2014-11-19 MX MX2016006561A patent/MX383543B/es unknown
- 2014-11-19 HR HRP20191095TT patent/HRP20191095T1/hr unknown
- 2014-11-19 BR BR112016011025-0A patent/BR112016011025B1/pt active IP Right Grant
- 2014-11-19 EP EP14814696.2A patent/EP3071595B1/en active Active
- 2014-11-19 HU HUE14814696A patent/HUE043875T2/hu unknown
- 2014-11-19 RU RU2016124229A patent/RU2687163C1/ru active
- 2014-11-19 CN CN201480072422.8A patent/CN105980404B/zh active Active
- 2014-11-19 DK DK14814696.2T patent/DK3071595T3/da active
- 2014-11-19 CA CA2930493A patent/CA2930493A1/en active Pending
- 2014-11-19 US US15/036,170 patent/US10100125B2/en active Active
- 2014-11-19 PL PL14814696T patent/PL3071595T3/pl unknown
- 2014-11-19 IL IL297678A patent/IL297678B2/en unknown
- 2014-11-19 JP JP2016532031A patent/JP6599859B2/ja active Active
- 2014-11-19 SI SI201431143T patent/SI3071595T1/sl unknown
- 2014-11-19 IL IL311788A patent/IL311788B2/en unknown
- 2014-11-19 LT LTEP14814696.2T patent/LT3071595T/lt unknown
- 2014-11-19 DK DK19161698.6T patent/DK3553088T3/da active
- 2014-11-19 PT PT14814696T patent/PT3071595T/pt unknown
- 2014-11-19 KR KR1020227003223A patent/KR102574537B1/ko active Active
- 2014-11-19 RS RS20190729A patent/RS58831B1/sr unknown
2016
- 2016-05-11 IL IL245617A patent/IL245617B/en active IP Right Grant
- 2016-05-19 MX MX2021007006A patent/MX2021007006A/es unknown
2018
- 2018-08-30 US US16/117,522 patent/US11230609B2/en active Active
2019
- 2019-06-20 CY CY20191100645T patent/CY1121900T1/el unknown
- 2019-10-02 JP JP2019181801A patent/JP7051777B2/ja active Active
2020
- 2020-07-20 AU AU2020207775A patent/AU2020207775B2/en active Active
- 2020-11-04 IL IL278493A patent/IL278493B2/en unknown
2021
- 2021-09-16 US US17/476,683 patent/US12404343B2/en active Active
2022
- 2022-01-13 JP JP2022003634A patent/JP7592654B2/ja active Active
2023
- 2023-08-30 AU AU2023222879A patent/AU2023222879A1/en active Pending
2024
- 2024-11-19 JP JP2024201463A patent/JP2025019101A/ja active Pending
2025
- 2025-09-28 IL IL323633A patent/IL323633A/en unknown

Also Published As

Publication number	Publication date
US20220064333A1 (en)	2022-03-03
IL278493A (en)	2022-12-01
AU2014351611A1 (en)	2016-06-30
AU2014351611B2 (en)	2020-04-23
KR20160096621A (ko)	2016-08-16
FI3553088T3 (fi)	2026-04-21
EP3071595A1 (en)	2016-09-28
JP2016540503A (ja)	2016-12-28
EP3071595B1 (en)	2019-03-20
ES2728515T3 (es)	2019-10-25
HUE043875T2 (hu)	2019-09-30
PT3071595T (pt)	2019-06-11
RS58831B1 (sr)	2019-07-31
JP7051777B2 (ja)	2022-04-11
IL311788A (en)	2024-05-01
HRP20191095T1 (hr)	2019-09-20
BR112016011025A2 (pt)	2017-12-05
BR112016011025A8 (pt)	2018-01-30
KR102442738B1 (ko)	2022-09-15
IL323633A (en)	2025-11-01
RU2687163C1 (ru)	2019-05-07
CA2930493A1 (en)	2015-05-28
IL297678A (en)	2022-12-01
JP7592654B2 (ja)	2024-12-02
JP2025019101A (ja)	2025-02-06
IL245617B (en)	2021-02-28
DK3071595T3 (da)	2019-07-01
IL311788B1 (en)	2025-11-01
LT3071595T (lt)	2019-05-10
CN112898431B (zh)	2024-05-28
IL278493B2 (en)	2023-04-01
AU2023222879A1 (en)	2023-09-14
JP2020022470A (ja)	2020-02-13
BR112016011025B1 (pt)	2024-01-23
IL297678B2 (en)	2024-09-01
CY1121900T1 (el)	2020-10-14
AU2020207775A1 (en)	2020-08-06
KR102574537B1 (ko)	2023-09-06
RU2016124229A (ru)	2017-12-25
EP3553088A1 (en)	2019-10-16
US10100125B2 (en)	2018-10-16
JP6599859B2 (ja)	2019-10-30
US11230609B2 (en)	2022-01-25
US20160369009A1 (en)	2016-12-22
IL245617A0 (en)	2016-06-30
WO2015075445A1 (en)	2015-05-28
EP3553088B1 (en)	2026-03-04
US20190169312A1 (en)	2019-06-06
CN105980404B (zh)	2021-01-12
CN105980404A (zh)	2016-09-28
SMT201900338T1 (it)	2019-07-11
PL3071595T3 (pl)	2019-09-30
IL297678B1 (en)	2024-05-01
IL311788B2 (en)	2026-03-01
JP2022062048A (ja)	2022-04-19
AU2020207775B2 (en)	2023-06-15
KR102894975B1 (ko)	2025-12-04
US12404343B2 (en)	2025-09-02
MX2021007006A (es)	2021-09-08
KR20230132599A (ko)	2023-09-15
MX383543B (es)	2025-03-14
MX2016006561A (es)	2016-12-12
SI3071595T1 (sl)	2019-08-30
KR20220020406A (ko)	2022-02-18
CN112898431A (zh)	2021-06-04

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