DK3571225T3 - Forbedrede serumalbuminbindere - Google Patents

Forbedrede serumalbuminbindere Download PDF

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Publication number
DK3571225T3
DK3571225T3 DK18707848.0T DK18707848T DK3571225T3 DK 3571225 T3 DK3571225 T3 DK 3571225T3 DK 18707848 T DK18707848 T DK 18707848T DK 3571225 T3 DK3571225 T3 DK 3571225T3
Authority
DK
Denmark
Prior art keywords
serum albumin
improved serum
albumin binders
binders
improved
Prior art date
Application number
DK18707848.0T
Other languages
English (en)
Inventor
Stephanie Staelens
Soren Steffensen
An Cerdobbel
Erika Morizzo
Original Assignee
Ablynx Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ablynx Nv filed Critical Ablynx Nv
Application granted granted Critical
Publication of DK3571225T3 publication Critical patent/DK3571225T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK18707848.0T 2017-01-17 2018-01-17 Forbedrede serumalbuminbindere DK3571225T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762446988P 2017-01-17 2017-01-17
PCT/EP2018/051083 WO2018134235A1 (en) 2017-01-17 2018-01-17 Improved serum albumin binders

Publications (1)

Publication Number Publication Date
DK3571225T3 true DK3571225T3 (da) 2024-11-04

Family

ID=61521465

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18707848.0T DK3571225T3 (da) 2017-01-17 2018-01-17 Forbedrede serumalbuminbindere

Country Status (21)

Country Link
US (2) US11414481B2 (da)
EP (3) EP3571225B1 (da)
JP (3) JP7219220B2 (da)
KR (2) KR20240013861A (da)
CN (2) CN110191896B (da)
AU (2) AU2018209151B2 (da)
BR (1) BR112019014599A2 (da)
CA (1) CA3050575A1 (da)
DK (1) DK3571225T3 (da)
ES (1) ES2991459T3 (da)
FI (1) FI3571225T3 (da)
HR (1) HRP20241469T1 (da)
HU (1) HUE068790T2 (da)
IL (2) IL267894B2 (da)
LT (1) LT3571225T (da)
MX (2) MX2019008496A (da)
PT (1) PT3571225T (da)
RS (1) RS66117B1 (da)
SG (2) SG10202108972RA (da)
SI (1) SI3571225T1 (da)
WO (1) WO2018134235A1 (da)

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Also Published As

Publication number Publication date
HUE068790T2 (hu) 2025-01-28
IL267894B2 (en) 2024-10-01
PT3571225T (pt) 2024-11-05
JP7628996B2 (ja) 2025-02-12
WO2018134235A8 (en) 2024-03-21
RU2019125831A (ru) 2021-02-19
CN117285623A (zh) 2023-12-26
EP4442707A3 (en) 2024-12-25
EP3571225A1 (en) 2019-11-27
US20230060574A1 (en) 2023-03-02
BR112019014599A2 (pt) 2020-03-03
IL312292A (en) 2024-06-01
RS66117B1 (sr) 2024-11-29
SI3571225T1 (sl) 2025-03-31
MX2023005374A (es) 2023-05-22
EP3571225B1 (en) 2024-08-07
HRP20241469T1 (hr) 2025-01-03
WO2018134235A1 (en) 2018-07-26
CA3050575A1 (en) 2018-07-26
SG10202108972RA (en) 2021-09-29
AU2018209151A1 (en) 2019-07-25
EP4442707A2 (en) 2024-10-09
ES2991459T3 (es) 2024-12-03
SG11201906264YA (en) 2019-08-27
JP2023025232A (ja) 2023-02-21
JP2025026992A (ja) 2025-02-26
IL267894B1 (en) 2024-06-01
US11414481B2 (en) 2022-08-16
RU2019125831A3 (da) 2021-03-09
AU2018209151B2 (en) 2025-02-27
IL267894A (en) 2019-09-26
LT3571225T (lt) 2024-11-11
MX2019008496A (es) 2019-09-18
KR20190104608A (ko) 2019-09-10
JP7219220B2 (ja) 2023-02-07
KR20240013861A (ko) 2024-01-30
EP4442709A2 (en) 2024-10-09
AU2025203430A1 (en) 2025-06-05
FI3571225T3 (fi) 2024-10-31
CN110191896B (zh) 2023-09-29
JP2020515518A (ja) 2020-05-28
KR102662499B1 (ko) 2024-05-02
CN110191896A (zh) 2019-08-30
EP4442709A3 (en) 2024-12-25
US20190367597A1 (en) 2019-12-05

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