DK3597650T3 - Aldosereduktasehæmmere og anvendelser deraf - Google Patents

Aldosereduktasehæmmere og anvendelser deraf Download PDF

Info

Publication number
DK3597650T3
DK3597650T3 DK19194956.9T DK19194956T DK3597650T3 DK 3597650 T3 DK3597650 T3 DK 3597650T3 DK 19194956 T DK19194956 T DK 19194956T DK 3597650 T3 DK3597650 T3 DK 3597650T3
Authority
DK
Denmark
Prior art keywords
reductase inhibitors
aldose reductase
aldose
inhibitors
reductase
Prior art date
Application number
DK19194956.9T
Other languages
English (en)
Inventor
Andrew Wasmuth
Donald W Landry
Shi Xian Deng
Ravichandran Ramasamy
Ann Marie Schmidt
Banavara L Mylari
Original Assignee
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Application granted granted Critical
Publication of DK3597650T3 publication Critical patent/DK3597650T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK19194956.9T 2010-07-16 2011-07-14 Aldosereduktasehæmmere og anvendelser deraf DK3597650T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36509810P 2010-07-16 2010-07-16
EP16187936.6A EP3192796B1 (en) 2010-07-16 2011-07-14 Aldose reductase inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
DK3597650T3 true DK3597650T3 (da) 2022-11-21

Family

ID=45469805

Family Applications (3)

Application Number Title Priority Date Filing Date
DK19194956.9T DK3597650T3 (da) 2010-07-16 2011-07-14 Aldosereduktasehæmmere og anvendelser deraf
DK16187936T DK3192796T3 (da) 2010-07-16 2011-07-14 Aldosereduktaseinhibitorer og anvendelser deraf
DK11807523.3T DK2593456T3 (da) 2010-07-16 2011-07-14 Aldosereduktaseinhibitorer og anvendelser deraf

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK16187936T DK3192796T3 (da) 2010-07-16 2011-07-14 Aldosereduktaseinhibitorer og anvendelser deraf
DK11807523.3T DK2593456T3 (da) 2010-07-16 2011-07-14 Aldosereduktaseinhibitorer og anvendelser deraf

Country Status (15)

Country Link
EP (4) EP3597650B1 (da)
JP (4) JP5934206B2 (da)
CN (2) CN105732640B (da)
AU (1) AU2011279058B2 (da)
CA (1) CA2804640C (da)
DK (3) DK3597650T3 (da)
ES (3) ES2613700T3 (da)
HR (1) HRP20221430T1 (da)
HU (3) HUE031506T2 (da)
LT (1) LT3597650T (da)
PL (3) PL2593456T3 (da)
PT (1) PT3597650T (da)
RS (1) RS63796B1 (da)
SI (1) SI3597650T1 (da)
WO (1) WO2012009553A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8916563B2 (en) 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
HUE031506T2 (en) * 2010-07-16 2017-07-28 Univ Columbia Aldose reductase inhibitors and their use
US12653825B2 (en) 2010-07-16 2026-06-16 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
US20140228319A1 (en) * 2013-02-13 2014-08-14 Banavara L. Mylari Water soluble salts of aldose reductase inhibitors for treatment of diabetic complications
ES2966094T3 (es) 2016-06-21 2024-04-18 Univ Columbia Compuestos 4-oxo-3,4-dihidrotieno[3,4-d]piridazina como inhibidores de la aldosa reductasa y métodos de uso de los mismos
IL272246B2 (en) 2017-07-28 2026-01-01 Applied Therapeutics Inc History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications
CN108101883B (zh) * 2018-01-31 2018-11-13 佳木斯大学附属第一医院 一种用于防治糖尿病视网膜病变的药物及其制备方法
WO2020167937A1 (en) * 2019-02-12 2020-08-20 Applied Therapeutics, Inc. Methods for treating cutaneous aging
CN113454084B (zh) * 2019-02-28 2023-08-29 石药集团中奇制药技术（石家庄）有限公司 醛糖还原酶抑制剂的盐及其制备方法和应用
CN113840825A (zh) 2019-04-01 2021-12-24 应用治疗公司 醛糖还原酶抑制剂
MX2021013511A (es) 2019-05-07 2022-02-23 Univ Miami Tratamiento y deteccion de neuropatias heredadas y trastornos asociados.
KR20230005944A (ko) 2020-05-01 2023-01-10 어플라이드 테라퓨틱스 인크. 소르비톨 데히드로게나제 결핍 치료를 위한 알도스 리덕타제 억제제
EP4211136B1 (en) * 2020-09-08 2025-08-20 Assia Chemical Industries Ltd. Solid state forms of at-001 and process for preparation thereof
CN116265463B (zh) * 2021-12-16 2025-08-05 石药集团中奇制药技术（石家庄）有限公司 一种醛糖还原酶抑制剂的晶型及其制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304A (en) 1847-09-25 Improvement in preparing and hardening raw hides
US557A (en) 1838-01-09 James macgregor
US4939140A (en) 1985-11-07 1990-07-03 Pfizer Inc. Heterocyclic oxophthalazinyl acetic acids
CA1299178C (en) * 1985-11-07 1992-04-21 Banavara Lakshmana Mylari Heterocyclic oxophtalazinyl acetic acids
IL80475A (en) * 1985-11-07 1993-01-31 Pfizer Heterocyclic-substituted 4-oxo (or thio)-3h- phthalazinyl-acetic acid derivatives and pharmaceutical compositions containing them
WO1989006651A1 (en) * 1988-01-19 1989-07-27 Pfizer Inc. 1h-indazole-3-acetic acids as aldose reductase inhibitors
US4954629A (en) * 1989-05-11 1990-09-04 Pfizer Inc. Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof
US4996204A (en) * 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
FR2647676A1 (fr) * 1989-06-05 1990-12-07 Union Pharma Scient Appl Nouveaux derives de pyridazinone, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase
FI922308L (fi) * 1989-12-15 1992-05-21 Pfizer Substituerade oxoftalazinylaettiks- syror och deras analoger.
JPH0495025A (ja) 1990-08-08 1992-03-27 Asahi Chem Ind Co Ltd アルドースリダクターゼ阻害剤
CN1200106A (zh) 1995-08-28 1998-11-25 美国家用产品公司 苯氧基乙酸类化合物用作醛糖还原酶抑制剂和抗高血糖药
AP2000001929A0 (en) * 1998-03-31 2000-09-30 Inst For Pharm Discovery Inc Substituted indolealkanoic acids.
EP0982306A3 (en) 1998-08-21 2000-07-05 Pfizer Products Inc. Polymorph of zopolrestat monohydrate
US6570013B2 (en) 2000-02-16 2003-05-27 Pfizer Inc Salts of zopolrestat
EP1469851B1 (en) 2002-01-23 2006-10-11 Eli Lilly And Company Melanocortin receptor agonists
HUE031506T2 (en) * 2010-07-16 2017-07-28 Univ Columbia Aldose reductase inhibitors and their use

Also Published As

Publication number Publication date
CN103052637A (zh) 2013-04-17
PL3597650T3 (pl) 2023-02-06
HUE060473T2 (hu) 2023-03-28
EP2593456B1 (en) 2016-11-30
JP6430670B2 (ja) 2018-11-28
CA2804640A1 (en) 2012-01-19
HUE031506T2 (en) 2017-07-28
HRP20221430T1 (hr) 2023-01-06
PL3192796T3 (pl) 2020-06-15
JP6306251B2 (ja) 2018-04-04
CA2804640C (en) 2018-09-25
SI3597650T1 (sl) 2023-02-28
JP5934206B2 (ja) 2016-06-15
EP4124620A1 (en) 2023-02-01
JP2017200937A (ja) 2017-11-09
CN105732640A (zh) 2016-07-06
JP2013531062A (ja) 2013-08-01
HK1223925A1 (zh) 2017-08-11
JP6165897B2 (ja) 2017-07-19
DK2593456T3 (da) 2017-02-06
ES2769950T3 (es) 2020-06-29
EP3192796A1 (en) 2017-07-19
ES2931319T3 (es) 2022-12-28
AU2011279058B2 (en) 2015-10-01
JP2016106107A (ja) 2016-06-16
HUE047346T2 (hu) 2020-04-28
CN105732640B (zh) 2019-01-08
RS63796B1 (sr) 2022-12-30
WO2012009553A1 (en) 2012-01-19
JP2018087253A (ja) 2018-06-07
CN103052637B (zh) 2016-03-23
EP3597650B1 (en) 2022-09-07
EP2593456A1 (en) 2013-05-22
PT3597650T (pt) 2022-12-16
AU2011279058A1 (en) 2013-01-24
DK3192796T3 (da) 2019-12-09
ES2613700T3 (es) 2017-05-25
LT3597650T (lt) 2022-12-12
EP2593456A4 (en) 2013-10-30
EP3597650A1 (en) 2020-01-22
PL2593456T3 (pl) 2017-06-30
EP3192796B1 (en) 2019-09-04

Similar Documents

Publication Publication Date Title
DK3192796T3 (da) Aldosereduktaseinhibitorer og anvendelser deraf
DK2594567T3 (da) Heterocykliske alkynylbenzenforbindelser og anvendelser deraf
PT2323120T (pt) Painéis móveis e métodos relacionados
HRP20160737T1 (hr) Anti-her3-protutijela i njihove uporabe
SMT201500271B (it) Inibitori di neprilisina
DK3178818T3 (da) Pyrazolylquinoxalinkinasehæmmere
FR2941796B3 (fr) Ordinateur portable
PT2730564T (pt) Aminas heterocíclicas e suas utilizações
BR112012017441A2 (pt) compostos e métodos
BR112013012078A2 (pt) inibidores de nampt e rock
DK3091034T3 (da) Anti-CD40-antistoffer og anvendelser deraf
DK3292874T3 (da) Anti-mesothelin-immunkonjugater og anvendelser deraf
DK3415157T3 (da) N-acyldipeptidderivater og anvendelser deraf
SMT201600319B (it) Metodi di selezione e amplificazione di polinucleotidi
IL219085A (en) Solid precursor delivery assemblies and related methods
BR112013014952A2 (pt) inibidores de neprilisina
DK2544679T3 (da) Pde10-inhibitorer og relaterede sammensætninger og fremgangsmåder
DK2805746T3 (da) Alkylamido-forbindelser og anvendelser deraf
BRPI1013338A2 (pt) processos e intermediários
IL257069B (en) Inhibitors of apoptosis and uses thereof
DK2642992T3 (da) Forbindelser og anvendelse deraf
EP2613438A4 (en) AMPLIFIER
BR112013009579A2 (pt) método e comprimido
DK2556055T3 (da) Ship-hæmmere og anvendelser deraf
LT2506840T (lt) Hipoksija sukeliančio faktoriaus inhibitorių naudojimas