DK3597650T3 - Aldosereduktasehæmmere og anvendelser deraf - Google Patents

Aldosereduktasehæmmere og anvendelser deraf Download PDF

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Publication number
DK3597650T3
DK3597650T3 DK19194956.9T DK19194956T DK3597650T3 DK 3597650 T3 DK3597650 T3 DK 3597650T3 DK 19194956 T DK19194956 T DK 19194956T DK 3597650 T3 DK3597650 T3 DK 3597650T3
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DK
Denmark
Prior art keywords
reductase inhibitors
aldose reductase
aldose
inhibitors
reductase
Prior art date
Application number
DK19194956.9T
Other languages
English (en)
Inventor
Andrew Wasmuth
Donald W Landry
Shi Xian Deng
Ravichandran Ramasamy
Ann Marie Schmidt
Banavara L Mylari
Original Assignee
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Application granted granted Critical
Publication of DK3597650T3 publication Critical patent/DK3597650T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
DK19194956.9T 2010-07-16 2011-07-14 Aldosereduktasehæmmere og anvendelser deraf DK3597650T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36509810P 2010-07-16 2010-07-16
EP16187936.6A EP3192796B1 (en) 2010-07-16 2011-07-14 Aldose reductase inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
DK3597650T3 true DK3597650T3 (da) 2022-11-21

Family

ID=45469805

Family Applications (3)

Application Number Title Priority Date Filing Date
DK16187936T DK3192796T3 (da) 2010-07-16 2011-07-14 Aldosereduktaseinhibitorer og anvendelser deraf
DK11807523.3T DK2593456T3 (da) 2010-07-16 2011-07-14 Aldosereduktaseinhibitorer og anvendelser deraf
DK19194956.9T DK3597650T3 (da) 2010-07-16 2011-07-14 Aldosereduktasehæmmere og anvendelser deraf

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK16187936T DK3192796T3 (da) 2010-07-16 2011-07-14 Aldosereduktaseinhibitorer og anvendelser deraf
DK11807523.3T DK2593456T3 (da) 2010-07-16 2011-07-14 Aldosereduktaseinhibitorer og anvendelser deraf

Country Status (15)

Country Link
EP (4) EP4124620A1 (da)
JP (4) JP5934206B2 (da)
CN (2) CN103052637B (da)
AU (1) AU2011279058B2 (da)
CA (1) CA2804640C (da)
DK (3) DK3192796T3 (da)
ES (3) ES2931319T3 (da)
HR (1) HRP20221430T1 (da)
HU (3) HUE031506T2 (da)
LT (1) LT3597650T (da)
PL (3) PL2593456T3 (da)
PT (1) PT3597650T (da)
RS (1) RS63796B1 (da)
SI (1) SI3597650T1 (da)
WO (1) WO2012009553A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8916563B2 (en) 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
PL2593456T3 (pl) * 2010-07-16 2017-06-30 The Trustees Of Columbia University In The City Of New York Inhibitory reduktazy aldozowej i ich zastosowania
WO2014126885A1 (en) * 2013-02-13 2014-08-21 Mylari Banavara L Water soluble salts of aldose reductase inhibitors for treatment of diabetic complications
IL283809B2 (en) * 2016-06-21 2024-01-01 Univ Columbia Compounds for use in a method of treating neuropathy, retinopathy, nephropathy, or cardiomyopathy
IL272246B2 (en) 2017-07-28 2026-01-01 Applied Therapeutics Inc History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications
CN108101883B (zh) * 2018-01-31 2018-11-13 佳木斯大学附属第一医院 一种用于防治糖尿病视网膜病变的药物及其制备方法
WO2020167937A1 (en) * 2019-02-12 2020-08-20 Applied Therapeutics, Inc. Methods for treating cutaneous aging
CN113454084B (zh) * 2019-02-28 2023-08-29 石药集团中奇制药技术（石家庄）有限公司 醛糖还原酶抑制剂的盐及其制备方法和应用
AU2020254610A1 (en) * 2019-04-01 2021-11-18 Applied Therapeutics Inc. Inhibitors of aldose reductase
CN113966396A (zh) 2019-05-07 2022-01-21 迈阿密大学 遗传性神经病和相关障碍的治疗和检测
CN115996725A (zh) 2020-05-01 2023-04-21 应用治疗公司 用于治疗山梨糖醇脱氢酶缺乏症的醛糖还原酶抑制剂
US20230322786A1 (en) * 2020-09-08 2023-10-12 Teva Pharmaceuticals International Gmbh Solid state forms of at-001 and process for preparation thereof
CN116265463B (zh) * 2021-12-16 2025-08-05 石药集团中奇制药技术（石家庄）有限公司 一种醛糖还原酶抑制剂的晶型及其制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US557A (en) 1838-01-09 James macgregor
US5304A (en) 1847-09-25 Improvement in preparing and hardening raw hides
CA1299178C (en) * 1985-11-07 1992-04-21 Banavara Lakshmana Mylari Heterocyclic oxophtalazinyl acetic acids
ES2032749T3 (es) * 1985-11-07 1993-03-01 Pfizer Inc. Acidos oxoftalazinil-aceticos heterociclicos.
US4939140A (en) 1985-11-07 1990-07-03 Pfizer Inc. Heterocyclic oxophthalazinyl acetic acids
WO1989006651A1 (en) * 1988-01-19 1989-07-27 Pfizer Inc. 1h-indazole-3-acetic acids as aldose reductase inhibitors
US4954629A (en) 1989-05-11 1990-09-04 Pfizer Inc. Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof
US4996204A (en) * 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
FR2647676A1 (fr) * 1989-06-05 1990-12-07 Union Pharma Scient Appl Nouveaux derives de pyridazinone, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase
US5304557A (en) 1989-12-15 1994-04-19 Pfizer Inc. Substituted oxoophthalazinyl acetic acids and analogs thereof
JPH0495025A (ja) 1990-08-08 1992-03-27 Asahi Chem Ind Co Ltd アルドースリダクターゼ阻害剤
BR9610207A (pt) 1995-08-28 1999-02-02 American Home Prod Acidos fenóxi acéticos como inibidores da aldose redutase e agentes anti-hiperglicêmicos
SK7522001A3 (en) * 1998-03-31 2002-02-05 Inst For Pharm Discovery Inc Substituted indolealkanoic acids
EP0982306A3 (en) 1998-08-21 2000-07-05 Pfizer Products Inc. Polymorph of zopolrestat monohydrate
US6570013B2 (en) 2000-02-16 2003-05-27 Pfizer Inc Salts of zopolrestat
JP2005527492A (ja) 2002-01-23 2005-09-15 イーライ・リリー・アンド・カンパニー メラノコルチン受容体アゴニスト
PL2593456T3 (pl) * 2010-07-16 2017-06-30 The Trustees Of Columbia University In The City Of New York Inhibitory reduktazy aldozowej i ich zastosowania

Also Published As

Publication number Publication date
DK3192796T3 (da) 2019-12-09
JP2017200937A (ja) 2017-11-09
PL2593456T3 (pl) 2017-06-30
JP2018087253A (ja) 2018-06-07
CN105732640A (zh) 2016-07-06
JP2013531062A (ja) 2013-08-01
HRP20221430T1 (hr) 2023-01-06
EP3597650B1 (en) 2022-09-07
JP6306251B2 (ja) 2018-04-04
HUE031506T2 (en) 2017-07-28
WO2012009553A1 (en) 2012-01-19
ES2613700T3 (es) 2017-05-25
LT3597650T (lt) 2022-12-12
EP2593456A1 (en) 2013-05-22
EP3192796B1 (en) 2019-09-04
ES2931319T3 (es) 2022-12-28
HK1223925A1 (zh) 2017-08-11
AU2011279058B2 (en) 2015-10-01
CA2804640A1 (en) 2012-01-19
CN105732640B (zh) 2019-01-08
JP2016106107A (ja) 2016-06-16
EP4124620A1 (en) 2023-02-01
EP2593456B1 (en) 2016-11-30
HUE060473T2 (hu) 2023-03-28
SI3597650T1 (sl) 2023-02-28
RS63796B1 (sr) 2022-12-30
JP6430670B2 (ja) 2018-11-28
CA2804640C (en) 2018-09-25
EP2593456A4 (en) 2013-10-30
DK2593456T3 (da) 2017-02-06
EP3192796A1 (en) 2017-07-19
CN103052637B (zh) 2016-03-23
CN103052637A (zh) 2013-04-17
HUE047346T2 (hu) 2020-04-28
PL3192796T3 (pl) 2020-06-15
JP6165897B2 (ja) 2017-07-19
ES2769950T3 (es) 2020-06-29
EP3597650A1 (en) 2020-01-22
JP5934206B2 (ja) 2016-06-15
AU2011279058A1 (en) 2013-01-24
PL3597650T3 (pl) 2023-02-06
PT3597650T (pt) 2022-12-16

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