ES2613700T3 - Inhibidores de la aldosa reductasa y usos de los mismos - Google Patents
Inhibidores de la aldosa reductasa y usos de los mismos Download PDFInfo
- Publication number
- ES2613700T3 ES2613700T3 ES11807523T ES11807523T ES2613700T3 ES 2613700 T3 ES2613700 T3 ES 2613700T3 ES 11807523 T ES11807523 T ES 11807523T ES 11807523 T ES11807523 T ES 11807523T ES 2613700 T3 ES2613700 T3 ES 2613700T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- formula
- reductase inhibitors
- aldose reductase
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un compuesto de fórmula (I)**Fórmula** en la que R1 es H, alquilo (C1-C6), hidroxialquilo (C1-C6) o amino (C1-C6)-alquilo; X1 es N o CR3; X2 es N o CR4; X3 es N o CR5; X4 es N o CR6; con la condición de que dos o tres de X1, X2, X3 o X4 sean N; Y es un enlace, C>=O, C>=S, C>=NH o C>=N-alquilo (C1-C4); Z es**Fórmula** A1 es NR11, O, S o CH2; A2 es N o CH; A3 es NR11, O o S; R3 a R10 son independientemente hidrógeno, halógeno, ciano, acilo, haloalquilo, haloalcoxi, haloalquiltio, trifluoroacetilo, alquilo (C1-C4), alcoxi (C1-C4), alquiltio (C1-C4), alquil (C1-C4)-sulfinilo o alquil (C1-C4)-sulfonilo; o dos de R3 a R6 o dos de R7 a R10 tomados conjuntamente son alquilen (C1-C4)-dioxi; y R11 es hidrógeno, alquilo C1-C4 o C(O)O-alquilo (C1-C4); o una sal o solvato farmacéuticamente aceptable del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36509810P | 2010-07-16 | 2010-07-16 | |
| PCT/US2011/044038 WO2012009553A1 (en) | 2010-07-16 | 2011-07-14 | Aldose reductase inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2613700T3 true ES2613700T3 (es) | 2017-05-25 |
Family
ID=45469805
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11807523T Active ES2613700T3 (es) | 2010-07-16 | 2011-07-14 | Inhibidores de la aldosa reductasa y usos de los mismos |
| ES19194956T Active ES2931319T3 (es) | 2010-07-16 | 2011-07-14 | Inhibidores de aldosa reductasa y usos de los mismos |
| ES16187936T Active ES2769950T3 (es) | 2010-07-16 | 2011-07-14 | Inhibidores de la aldosa reductasa y usos de los mismos |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES19194956T Active ES2931319T3 (es) | 2010-07-16 | 2011-07-14 | Inhibidores de aldosa reductasa y usos de los mismos |
| ES16187936T Active ES2769950T3 (es) | 2010-07-16 | 2011-07-14 | Inhibidores de la aldosa reductasa y usos de los mismos |
Country Status (15)
| Country | Link |
|---|---|
| EP (4) | EP3597650B1 (es) |
| JP (4) | JP5934206B2 (es) |
| CN (2) | CN105732640B (es) |
| AU (1) | AU2011279058B2 (es) |
| CA (1) | CA2804640C (es) |
| DK (3) | DK3597650T3 (es) |
| ES (3) | ES2613700T3 (es) |
| HR (1) | HRP20221430T1 (es) |
| HU (3) | HUE031506T2 (es) |
| LT (1) | LT3597650T (es) |
| PL (3) | PL2593456T3 (es) |
| PT (1) | PT3597650T (es) |
| RS (1) | RS63796B1 (es) |
| SI (1) | SI3597650T1 (es) |
| WO (1) | WO2012009553A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8916563B2 (en) | 2010-07-16 | 2014-12-23 | The Trustees Of Columbia University In The City Of New York | Aldose reductase inhibitors and uses thereof |
| HUE031506T2 (en) * | 2010-07-16 | 2017-07-28 | Univ Columbia | Aldose reductase inhibitors and their use |
| US12653825B2 (en) | 2010-07-16 | 2026-06-16 | The Trustees Of Columbia University In The City Of New York | Aldose reductase inhibitors and uses thereof |
| US20140228319A1 (en) * | 2013-02-13 | 2014-08-14 | Banavara L. Mylari | Water soluble salts of aldose reductase inhibitors for treatment of diabetic complications |
| ES2966094T3 (es) | 2016-06-21 | 2024-04-18 | Univ Columbia | Compuestos 4-oxo-3,4-dihidrotieno[3,4-d]piridazina como inhibidores de la aldosa reductasa y métodos de uso de los mismos |
| IL272246B2 (en) | 2017-07-28 | 2026-01-01 | Applied Therapeutics Inc | History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications |
| CN108101883B (zh) * | 2018-01-31 | 2018-11-13 | 佳木斯大学附属第一医院 | 一种用于防治糖尿病视网膜病变的药物及其制备方法 |
| WO2020167937A1 (en) * | 2019-02-12 | 2020-08-20 | Applied Therapeutics, Inc. | Methods for treating cutaneous aging |
| CN113454084B (zh) * | 2019-02-28 | 2023-08-29 | 石药集团中奇制药技术（石家庄）有限公司 | 醛糖还原酶抑制剂的盐及其制备方法和应用 |
| CN113840825A (zh) | 2019-04-01 | 2021-12-24 | 应用治疗公司 | 醛糖还原酶抑制剂 |
| MX2021013511A (es) | 2019-05-07 | 2022-02-23 | Univ Miami | Tratamiento y deteccion de neuropatias heredadas y trastornos asociados. |
| KR20230005944A (ko) | 2020-05-01 | 2023-01-10 | 어플라이드 테라퓨틱스 인크. | 소르비톨 데히드로게나제 결핍 치료를 위한 알도스 리덕타제 억제제 |
| EP4211136B1 (en) * | 2020-09-08 | 2025-08-20 | Assia Chemical Industries Ltd. | Solid state forms of at-001 and process for preparation thereof |
| CN116265463B (zh) * | 2021-12-16 | 2025-08-05 | 石药集团中奇制药技术（石家庄）有限公司 | 一种醛糖还原酶抑制剂的晶型及其制备方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5304A (en) | 1847-09-25 | Improvement in preparing and hardening raw hides | ||
| US557A (en) | 1838-01-09 | James macgregor | ||
| US4939140A (en) | 1985-11-07 | 1990-07-03 | Pfizer Inc. | Heterocyclic oxophthalazinyl acetic acids |
| CA1299178C (en) * | 1985-11-07 | 1992-04-21 | Banavara Lakshmana Mylari | Heterocyclic oxophtalazinyl acetic acids |
| IL80475A (en) * | 1985-11-07 | 1993-01-31 | Pfizer | Heterocyclic-substituted 4-oxo (or thio)-3h- phthalazinyl-acetic acid derivatives and pharmaceutical compositions containing them |
| WO1989006651A1 (en) * | 1988-01-19 | 1989-07-27 | Pfizer Inc. | 1h-indazole-3-acetic acids as aldose reductase inhibitors |
| US4954629A (en) * | 1989-05-11 | 1990-09-04 | Pfizer Inc. | Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof |
| US4996204A (en) * | 1989-05-11 | 1991-02-26 | Pfizer Inc. | Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors |
| FR2647676A1 (fr) * | 1989-06-05 | 1990-12-07 | Union Pharma Scient Appl | Nouveaux derives de pyridazinone, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase |
| FI922308L (fi) * | 1989-12-15 | 1992-05-21 | Pfizer | Substituerade oxoftalazinylaettiks- syror och deras analoger. |
| JPH0495025A (ja) | 1990-08-08 | 1992-03-27 | Asahi Chem Ind Co Ltd | アルドースリダクターゼ阻害剤 |
| CN1200106A (zh) | 1995-08-28 | 1998-11-25 | 美国家用产品公司 | 苯氧基乙酸类化合物用作醛糖还原酶抑制剂和抗高血糖药 |
| AP2000001929A0 (en) * | 1998-03-31 | 2000-09-30 | Inst For Pharm Discovery Inc | Substituted indolealkanoic acids. |
| EP0982306A3 (en) | 1998-08-21 | 2000-07-05 | Pfizer Products Inc. | Polymorph of zopolrestat monohydrate |
| US6570013B2 (en) | 2000-02-16 | 2003-05-27 | Pfizer Inc | Salts of zopolrestat |
| EP1469851B1 (en) | 2002-01-23 | 2006-10-11 | Eli Lilly And Company | Melanocortin receptor agonists |
| HUE031506T2 (en) * | 2010-07-16 | 2017-07-28 | Univ Columbia | Aldose reductase inhibitors and their use |
-
2011
- 2011-07-14 HU HUE11807523A patent/HUE031506T2/en unknown
- 2011-07-14 EP EP19194956.9A patent/EP3597650B1/en active Active
- 2011-07-14 DK DK19194956.9T patent/DK3597650T3/da active
- 2011-07-14 PL PL11807523T patent/PL2593456T3/pl unknown
- 2011-07-14 PL PL19194956.9T patent/PL3597650T3/pl unknown
- 2011-07-14 EP EP11807523.3A patent/EP2593456B1/en active Active
- 2011-07-14 HU HUE16187936A patent/HUE047346T2/hu unknown
- 2011-07-14 ES ES11807523T patent/ES2613700T3/es active Active
- 2011-07-14 DK DK16187936T patent/DK3192796T3/da active
- 2011-07-14 PL PL16187936T patent/PL3192796T3/pl unknown
- 2011-07-14 AU AU2011279058A patent/AU2011279058B2/en active Active
- 2011-07-14 PT PT191949569T patent/PT3597650T/pt unknown
- 2011-07-14 ES ES19194956T patent/ES2931319T3/es active Active
- 2011-07-14 LT LTEP19194956.9T patent/LT3597650T/lt unknown
- 2011-07-14 CN CN201610124090.4A patent/CN105732640B/zh not_active Expired - Fee Related
- 2011-07-14 CA CA2804640A patent/CA2804640C/en active Active
- 2011-07-14 EP EP22183971.5A patent/EP4124620A1/en active Pending
- 2011-07-14 WO PCT/US2011/044038 patent/WO2012009553A1/en not_active Ceased
- 2011-07-14 CN CN201180034944.5A patent/CN103052637B/zh active Active
- 2011-07-14 RS RS20221062A patent/RS63796B1/sr unknown
- 2011-07-14 ES ES16187936T patent/ES2769950T3/es active Active
- 2011-07-14 JP JP2013520752A patent/JP5934206B2/ja active Active
- 2011-07-14 EP EP16187936.6A patent/EP3192796B1/en active Active
- 2011-07-14 DK DK11807523.3T patent/DK2593456T3/en active
- 2011-07-14 HR HRP20221430TT patent/HRP20221430T1/hr unknown
- 2011-07-14 SI SI201132072T patent/SI3597650T1/sl unknown
- 2011-07-14 HU HUE19194956A patent/HUE060473T2/hu unknown
-
2016
- 2016-01-14 JP JP2016005570A patent/JP6165897B2/ja active Active
-
2017
- 2017-06-20 JP JP2017120238A patent/JP6306251B2/ja active Active
-
2018
- 2018-03-07 JP JP2018040694A patent/JP6430670B2/ja active Active
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