DK3610875T3 - Opioid-receptor (mor) agonistsalt, fumaratsalt i-krystalform deraf og fremgangsmåde til fremstilling deraf - Google Patents

Opioid-receptor (mor) agonistsalt, fumaratsalt i-krystalform deraf og fremgangsmåde til fremstilling deraf Download PDF

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Publication number
DK3610875T3
DK3610875T3 DK18784878.3T DK18784878T DK3610875T3 DK 3610875 T3 DK3610875 T3 DK 3610875T3 DK 18784878 T DK18784878 T DK 18784878T DK 3610875 T3 DK3610875 T3 DK 3610875T3
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Prior art keywords
salt
mother
making
crystal form
opioid receptor
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Application number
DK18784878.3T
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English (en)
Inventor
Lin Wang
Likun Wang
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Jiangsu Hengrui Medicine Co
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Publication of DK3610875T3 publication Critical patent/DK3610875T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK18784878.3T 2017-04-14 2018-04-13 Opioid-receptor (mor) agonistsalt, fumaratsalt i-krystalform deraf og fremgangsmåde til fremstilling deraf DK3610875T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710242119 2017-04-14
PCT/CN2018/082935 WO2018188643A1 (zh) 2017-04-14 2018-04-13 一种阿片样物质受体(mor)激动剂的盐、其富马酸盐i晶型及制备方法

Publications (1)

Publication Number Publication Date
DK3610875T3 true DK3610875T3 (da) 2020-12-21

Family

ID=63792318

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18784878.3T DK3610875T3 (da) 2017-04-14 2018-04-13 Opioid-receptor (mor) agonistsalt, fumaratsalt i-krystalform deraf og fremgangsmåde til fremstilling deraf

Country Status (23)

Country Link
US (2) US11014914B2 (da)
EP (1) EP3610875B1 (da)
JP (1) JP7153030B6 (da)
KR (1) KR20190140962A (da)
CN (1) CN110049980B (da)
AU (1) AU2018251119B2 (da)
BR (1) BR112019021447A2 (da)
CA (1) CA3057383A1 (da)
CY (1) CY1124063T1 (da)
DK (1) DK3610875T3 (da)
ES (1) ES2828636T3 (da)
HR (1) HRP20210022T1 (da)
HU (1) HUE053244T2 (da)
LT (1) LT3610875T (da)
MX (1) MX383989B (da)
MY (1) MY196571A (da)
PL (1) PL3610875T3 (da)
PT (1) PT3610875T (da)
RS (1) RS61193B1 (da)
SI (1) SI3610875T1 (da)
TW (1) TWI682929B (da)
UA (1) UA124400C2 (da)
WO (1) WO2018188643A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3610875B1 (en) * 2017-04-14 2020-10-07 Jiangsu Hengrui Medicine Co., Ltd. Opioid receptor (mor) agonist salt, fumarate salt i crystal form thereof and preparation method thereof
MX388643B (es) * 2017-04-14 2025-03-20 Jiangsu Hengrui Medicine Co Composicion farmaceutica que contiene agonista de mor y agonista de kor, y sus usos
CN111836807A (zh) * 2018-04-28 2020-10-27 四川科伦博泰生物医药股份有限公司 氧杂螺环类化合物及其制备方法和用途
WO2020073984A1 (zh) * 2018-10-12 2020-04-16 江苏恒瑞医药股份有限公司 一种阿片样物质受体(mor)激动剂的结晶形式及制备方法
WO2020073985A1 (zh) * 2018-10-12 2020-04-16 江苏恒瑞医药股份有限公司 一种阿片样物质受体(mor)激动剂的结晶形式及制备方法
CN111662284B (zh) * 2019-03-06 2021-08-10 上海海雁医药科技有限公司 双杂环取代的氧杂螺环衍生物、其制法与医药上的用途
KR20210113824A (ko) 2020-03-09 2021-09-17 건국대학교 산학협력단 뮤 오피오이드 수용체의 활성화제를 유효성분으로 포함하는 기분 장애의 예방용 조성물
WO2023284788A1 (zh) * 2021-07-13 2023-01-19 上海海雁医药科技有限公司 Mor受体激动剂的药学上可接受的盐、其多晶型物及其用途
CN117624138A (zh) * 2022-08-29 2024-03-01 江苏恒瑞医药股份有限公司 一种氧杂螺环类衍生物的可药用盐、晶型及制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2688403T1 (sl) 2011-03-23 2017-08-31 Trevena, Inc. Ligandi opioidnih receptorjev in metode uporabe in izdelave istega
WO2017063509A1 (zh) 2015-10-15 2017-04-20 江苏恒瑞医药股份有限公司 氧杂螺环类衍生物、其制备方法及其在医药上的应用
EP3610875B1 (en) * 2017-04-14 2020-10-07 Jiangsu Hengrui Medicine Co., Ltd. Opioid receptor (mor) agonist salt, fumarate salt i crystal form thereof and preparation method thereof

Also Published As

Publication number Publication date
WO2018188643A1 (zh) 2018-10-18
AU2018251119A1 (en) 2019-11-07
US20210130332A1 (en) 2021-05-06
JP2020516642A (ja) 2020-06-11
HUE053244T2 (hu) 2021-06-28
MX383989B (es) 2025-03-14
EP3610875A1 (en) 2020-02-19
BR112019021447A2 (pt) 2020-05-05
AU2018251119B2 (en) 2021-07-29
CN110049980B (zh) 2020-10-20
SI3610875T1 (sl) 2021-02-26
PT3610875T (pt) 2020-11-25
MX2019012251A (es) 2019-11-28
MY196571A (en) 2023-04-19
TWI682929B (zh) 2020-01-21
US20200048229A1 (en) 2020-02-13
PL3610875T3 (pl) 2021-04-19
JP7153030B2 (ja) 2022-10-13
EP3610875A4 (en) 2020-02-19
US11014914B2 (en) 2021-05-25
CA3057383A1 (en) 2018-10-18
LT3610875T (lt) 2020-11-25
CN110049980A (zh) 2019-07-23
ES2828636T3 (es) 2021-05-27
EP3610875B1 (en) 2020-10-07
UA124400C2 (uk) 2021-09-08
KR20190140962A (ko) 2019-12-20
JP7153030B6 (ja) 2023-07-24
CY1124063T1 (el) 2022-03-24
RS61193B1 (sr) 2021-01-29
RU2019136088A (ru) 2021-05-14
TW201837033A (zh) 2018-10-16
RU2019136088A3 (da) 2021-06-16
HRP20210022T1 (hr) 2021-03-05

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