DK362083D0 - 4-quinolinderivater og fremgangsmade til fremstilling deraf - Google Patents
4-quinolinderivater og fremgangsmade til fremstilling derafInfo
- Publication number
- DK362083D0 DK362083D0 DK3620/83A DK362083A DK362083D0 DK 362083 D0 DK362083 D0 DK 362083D0 DK 3620/83 A DK3620/83 A DK 3620/83A DK 362083 A DK362083 A DK 362083A DK 362083 D0 DK362083 D0 DK 362083D0
- Authority
- DK
- Denmark
- Prior art keywords
- trifluoromethyl
- bis
- procedures
- preparing
- quinolyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- XEEQGYMUWCZPDN-DOMZBBRYSA-N (-)-(11S,2'R)-erythro-mefloquine Chemical compound C([C@@H]1[C@@H](O)C=2C3=CC=CC(=C3N=C(C=2)C(F)(F)F)C(F)(F)F)CCCN1 XEEQGYMUWCZPDN-DOMZBBRYSA-N 0.000 abstract 1
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 abstract 1
- IORZJOJSTUVEQE-UHFFFAOYSA-N 2-hex-5-enylisoindole-1,3-dione Chemical compound C1=CC=C2C(=O)N(CCCCC=C)C(=O)C2=C1 IORZJOJSTUVEQE-UHFFFAOYSA-N 0.000 abstract 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229960001962 mefloquine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH539382 | 1982-09-10 | ||
| CH539382 | 1982-09-10 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK362083D0 true DK362083D0 (da) | 1983-08-08 |
| DK362083A DK362083A (da) | 1984-03-11 |
| DK160499B DK160499B (da) | 1991-03-18 |
| DK160499C DK160499C (da) | 1991-08-26 |
Family
ID=4292814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK362083A DK160499C (da) | 1982-09-10 | 1983-08-08 | Fremgangsmaade til fremstilling af mefloquin og mellemprodukt til anvendelse herved |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4544748A (da) |
| EP (1) | EP0103259B1 (da) |
| JP (1) | JPS5967283A (da) |
| AT (1) | ATE18222T1 (da) |
| DE (1) | DE3362313D1 (da) |
| DK (1) | DK160499C (da) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2498497A (en) * | 1949-06-10 | 1950-02-21 | Sterling Drug Inc | 2[2(phthalimido)ethyl]pyridines |
| FR2381044A1 (fr) * | 1977-02-17 | 1978-09-15 | Hoffmann La Roche | Procede pour la preparation de mefloquine |
-
1983
- 1983-08-08 DK DK362083A patent/DK160499C/da not_active IP Right Cessation
- 1983-08-22 US US06/525,341 patent/US4544748A/en not_active Expired - Fee Related
- 1983-09-06 DE DE8383108778T patent/DE3362313D1/de not_active Expired
- 1983-09-06 EP EP83108778A patent/EP0103259B1/de not_active Expired
- 1983-09-06 AT AT83108778T patent/ATE18222T1/de not_active IP Right Cessation
- 1983-09-07 JP JP58163400A patent/JPS5967283A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DK160499C (da) | 1991-08-26 |
| ATE18222T1 (de) | 1986-03-15 |
| DE3362313D1 (en) | 1986-04-03 |
| EP0103259A1 (de) | 1984-03-21 |
| DK362083A (da) | 1984-03-11 |
| JPS5967283A (ja) | 1984-04-16 |
| JPH0427985B2 (da) | 1992-05-13 |
| US4544748A (en) | 1985-10-01 |
| DK160499B (da) | 1991-03-18 |
| EP0103259B1 (de) | 1986-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment | ||
| PBP | Patent lapsed |