DK3630977T3 - Fremgangsmåder og sammensætninger til at fremme produktionen af proteiner indeholdende ikke-naturlige aminosyrer - Google Patents

Fremgangsmåder og sammensætninger til at fremme produktionen af proteiner indeholdende ikke-naturlige aminosyrer Download PDF

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DK3630977T3
DK3630977T3 DK18734359.5T DK18734359T DK3630977T3 DK 3630977 T3 DK3630977 T3 DK 3630977T3 DK 18734359 T DK18734359 T DK 18734359T DK 3630977 T3 DK3630977 T3 DK 3630977T3
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promoting
compositions
production
methods
amino acids
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DK18734359.5T
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DK3630977T5 (da
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Sigeng Chen
Yingchun Lu
Feng Tian
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Ambrx Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
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    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
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  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK18734359.5T 2017-06-02 2018-06-02 Fremgangsmåder og sammensætninger til at fremme produktionen af proteiner indeholdende ikke-naturlige aminosyrer DK3630977T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762514754P 2017-06-02 2017-06-02
PCT/US2018/035764 WO2018223108A1 (en) 2017-06-02 2018-06-02 Methods and compositions for promoting non-natural amino acid-containing protein production

Publications (2)

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DK3630977T3 true DK3630977T3 (da) 2024-04-15
DK3630977T5 DK3630977T5 (da) 2024-09-02

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US (2) US11851662B2 (da)
EP (2) EP4382124A3 (da)
JP (3) JP7245786B2 (da)
KR (3) KR102662379B1 (da)
CN (2) CN117286182A (da)
AU (1) AU2018275152B2 (da)
BR (1) BR112019025476A2 (da)
CA (1) CA3065137A1 (da)
DK (1) DK3630977T5 (da)
ES (1) ES2978044T3 (da)
FI (1) FI3630977T3 (da)
HR (1) HRP20240344T1 (da)
HU (1) HUE067136T2 (da)
IL (1) IL270906A (da)
LT (1) LT3630977T (da)
MX (2) MX2019014286A (da)
MY (1) MY202215A (da)
PL (1) PL3630977T3 (da)
PT (1) PT3630977T (da)
RS (1) RS65370B1 (da)
SI (1) SI3630977T1 (da)
SM (1) SMT202400125T1 (da)
WO (1) WO2018223108A1 (da)

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PL3630977T3 (pl) 2017-06-02 2024-06-24 Ambrx, Inc. Sposoby i kompozycje promujące produkcję białek zawierających nienaturalne aminokwasy
MX2020010104A (es) 2018-03-29 2020-11-06 Ambrx Inc Conjugados de farmaco-anticuerpo anti-antigeno de membrana especifico de prostata (psma) humanizado.
CA3111576A1 (en) 2018-09-11 2020-03-19 Ambrx, Inc. Interleukin-2 polypeptide conjugates and their uses
KR102910209B1 (ko) 2018-12-21 2026-01-09 제넨테크, 인크. 세포사멸에 내성인 세포주를 사용한 폴리펩티드 생산 방법
CN111117944B (zh) * 2019-11-22 2022-05-24 中农威特生物科技股份有限公司 一种用于规模化悬浮培养的抗凋亡mdck宿主细胞株及其建立方法
CA3184747A1 (en) * 2020-06-24 2021-12-30 Genentech, Inc. Apoptosis resistant cell lines
CN112375774A (zh) * 2020-10-26 2021-02-19 浙江新码生物医药有限公司 一种重组蛋白表达用工程菌株的构建方法
CN112575005A (zh) * 2021-01-04 2021-03-30 昆明理工大学 一种提高烟草重金属镉胁迫抗性和降低镉富集的方法
TW202342106A (zh) 2022-02-09 2023-11-01 日商第一三共股份有限公司 環境應答性遮蔽抗體及其利用
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JP2026504093A (ja) 2023-01-16 2026-02-03 アンブレツクス・インコーポレイテツド 抗ｃｄ７０抗体薬物コンジュゲート
WO2024241086A1 (en) 2023-05-24 2024-11-28 Ambrx, Inc. Pegylated bovine interferon lambda and methods of use thereof
AU2024329469A1 (en) 2023-08-22 2026-04-09 Ambrx, Inc. Anti-psma adc conjugate compositions and methods of use thereof
WO2025147710A1 (en) * 2024-01-05 2025-07-10 Northwestern University Orthogonal translation systems and methods for identifying components thereof
WO2026058210A1 (en) * 2024-09-12 2026-03-19 Janssen Biotech, Inc. Model system and biomarkers to prevent lactate runaway
CN121652263A (zh) * 2026-02-06 2026-03-13 中国医学科学院北京协和医院 非天然氨基酸修饰的蛋白质及相关生物材料、制备方法和应用

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GB201419109D0 (en) * 2014-10-27 2014-12-10 Medical Res Council Incorporation of unnatural amino acids into proteins
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NZ760107A (en) 2024-03-22
SMT202400125T1 (it) 2024-05-14
AU2018275152A1 (en) 2020-01-16
KR102705871B1 (ko) 2024-09-11
SI3630977T1 (sl) 2024-05-31
KR20240063184A (ko) 2024-05-09
MY202215A (en) 2024-04-17
MX2019014286A (es) 2020-01-27
CA3065137A1 (en) 2018-12-06
EP3630977B1 (en) 2024-02-21
AU2018275152B2 (en) 2025-01-23
MX2023004927A (es) 2023-05-17
KR20200011979A (ko) 2020-02-04
KR102662379B1 (ko) 2024-04-29
PT3630977T (pt) 2024-04-24
EP4382124A2 (en) 2024-06-12
US20210017527A1 (en) 2021-01-21
FI3630977T3 (fi) 2024-04-24
CN117286182A (zh) 2023-12-26
JP2020522247A (ja) 2020-07-30
HRP20240344T1 (hr) 2024-05-24
CN110959041B (zh) 2023-09-29
JP2025061014A (ja) 2025-04-10
ES2978044T3 (es) 2024-09-04
LT3630977T (lt) 2024-04-25
US12577575B2 (en) 2026-03-17
WO2018223108A1 (en) 2018-12-06
EP3630977A1 (en) 2020-04-08
US11851662B2 (en) 2023-12-26
US20240167044A1 (en) 2024-05-23
IL270906A (en) 2020-01-30
DK3630977T5 (da) 2024-09-02
CN110959041A (zh) 2020-04-03
PL3630977T3 (pl) 2024-06-24
JP7245786B2 (ja) 2023-03-24
JP7617162B2 (ja) 2025-01-17
HUE067136T2 (hu) 2024-10-28
BR112019025476A2 (pt) 2020-06-23
JP2023075254A (ja) 2023-05-30
EP4382124A3 (en) 2024-10-16
RS65370B1 (sr) 2024-04-30
KR20240140174A (ko) 2024-09-24

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