DK366686D0 - Polypeptider og -derivater indeholdende oxa- og ozahomocyclostatinsamt bis(t-butoxycarbonyl)-derivater af phenylalanyl-histadin til anvendelse som mellemprodukter ved deres fremstilling - Google Patents

Polypeptider og -derivater indeholdende oxa- og ozahomocyclostatinsamt bis(t-butoxycarbonyl)-derivater af phenylalanyl-histadin til anvendelse som mellemprodukter ved deres fremstilling

Info

Publication number
DK366686D0
DK366686D0 DK366686A DK366686A DK366686D0 DK 366686 D0 DK366686 D0 DK 366686D0 DK 366686 A DK366686 A DK 366686A DK 366686 A DK366686 A DK 366686A DK 366686 D0 DK366686 D0 DK 366686D0
Authority
DK
Denmark
Prior art keywords
derivatives
ozahomocyclostatin
histadine
phenylalanyl
butoxycarbonyl
Prior art date
Application number
DK366686A
Other languages
English (en)
Other versions
DK366686A (da
Inventor
Dennis Jay Hoover
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/762,099 external-priority patent/US4668769A/en
Application filed by Pfizer filed Critical Pfizer
Publication of DK366686D0 publication Critical patent/DK366686D0/da
Publication of DK366686A publication Critical patent/DK366686A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK366686A 1985-08-02 1986-08-01 Polypeptider og -derivater indeholdende oxa- og ozahomocyclostatinsamt bis(t-butoxycarbonyl)-derivater af phenylalanyl-histadin til anvendelse som mellemprodukter ved deres fremstilling DK366686A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/762,099 US4668769A (en) 1985-08-02 1985-08-02 Oxa- and azahomocyclostatine polypeptides
US06/780,353 US4599198A (en) 1985-08-02 1985-09-26 Intermediates in polypeptide synthesis

Publications (2)

Publication Number Publication Date
DK366686D0 true DK366686D0 (da) 1986-08-01
DK366686A DK366686A (da) 1987-03-20

Family

ID=27117072

Family Applications (1)

Application Number Title Priority Date Filing Date
DK366686A DK366686A (da) 1985-08-02 1986-08-01 Polypeptider og -derivater indeholdende oxa- og ozahomocyclostatinsamt bis(t-butoxycarbonyl)-derivater af phenylalanyl-histadin til anvendelse som mellemprodukter ved deres fremstilling

Country Status (14)

Country Link
US (1) US4599198A (da)
EP (1) EP0211580A3 (da)
KR (1) KR890003602B1 (da)
AU (3) AU569821B2 (da)
CA (1) CA1305175C (da)
DK (1) DK366686A (da)
ES (1) ES2001056A6 (da)
FI (1) FI863153A7 (da)
GR (1) GR862009B (da)
HU (1) HU204284B (da)
IE (1) IE862072L (da)
IL (1) IL79570A0 (da)
NZ (2) NZ228380A (da)
PT (1) PT83123B (da)

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DE122007000045I2 (de) 1992-08-25 2011-07-21 Gd Searle Llc Gd Searle Llc Darunavir oder pharmazeutisch vertragliche Salze, Hydroxyethylaminosulfonamide verwendbar als InhibiEster oder Prodrugs davon. toren retroviraler Proteasen.
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US7141609B2 (en) * 1992-08-25 2006-11-28 G.D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
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US5830897A (en) * 1992-08-27 1998-11-03 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
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US5578606A (en) 1992-10-30 1996-11-26 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
US6337398B1 (en) 1992-10-30 2002-01-08 G.D. Searle & Co. Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
AU5547094A (en) 1992-10-30 1994-05-24 G.D. Searle & Co. Hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors
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US5514801A (en) * 1992-12-29 1996-05-07 Monsanto Company Cyclic sulfone containing retroviral protease inhibitors
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US5750648A (en) * 1993-08-20 1998-05-12 G.D. Searle & Co. Retroviral protease inhibitors and combinations thereof
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US5831117A (en) * 1995-01-20 1998-11-03 G. D. Searle & Co. Method of preparing retroviral protease inhibitor intermediates
DE69637380T2 (de) 1995-01-20 2009-09-17 G.D. Searle Llc, Chicago Bis-sulfonamid-hydroxyethylamino-derivate als inhibitoren retroviraler proteasen
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US5985870A (en) * 1995-03-10 1999-11-16 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
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US6407134B1 (en) 1995-03-10 2002-06-18 G. D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
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Also Published As

Publication number Publication date
EP0211580A3 (en) 1989-08-09
AU6079086A (en) 1987-05-14
AU598913B2 (en) 1990-07-05
KR870002161A (ko) 1987-03-30
NZ217067A (en) 1990-08-28
ES2001056A6 (es) 1988-04-16
FI863153A7 (fi) 1987-02-03
KR890003602B1 (ko) 1989-09-27
PT83123B (pt) 1989-03-30
EP0211580A2 (en) 1987-02-25
NZ228380A (en) 1990-08-28
AU1239288A (en) 1988-06-02
AU6385090A (en) 1991-01-10
DK366686A (da) 1987-03-20
US4599198A (en) 1986-07-08
IL79570A0 (en) 1986-10-31
CA1305175C (en) 1992-07-14
PT83123A (en) 1986-09-01
GR862009B (en) 1986-12-23
FI863153A0 (fi) 1986-08-01
HUT41815A (en) 1987-05-28
IE862072L (en) 1987-02-02
HU204284B (en) 1991-12-30
AU633629B2 (en) 1993-02-04
AU569821B2 (en) 1988-02-18

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