DK367987D0 - 1,2,3,3a,8,8a-hexahydro-3a,8(og 1,3a,8)-di(og tri)methylpyrrolooe2,3-baaindoler, deres fremstilling og anvendelse som laegemidler - Google Patents
1,2,3,3a,8,8a-hexahydro-3a,8(og 1,3a,8)-di(og tri)methylpyrrolooe2,3-baaindoler, deres fremstilling og anvendelse som laegemidlerInfo
- Publication number
- DK367987D0 DK367987D0 DK367987A DK367987A DK367987D0 DK 367987 D0 DK367987 D0 DK 367987D0 DK 367987 A DK367987 A DK 367987A DK 367987 A DK367987 A DK 367987A DK 367987 D0 DK367987 D0 DK 367987D0
- Authority
- DK
- Denmark
- Prior art keywords
- loweralkyl
- methyl
- hydrogen
- arylloweralkyl
- baa
- Prior art date
Links
- 229940126601 medicinal product Drugs 0.000 title 1
- -1 arylloweralkyl Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 125000004658 aryl carbonyl amino group Chemical group 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000006883 memory enhancing effect Effects 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88599186A | 1986-07-16 | 1986-07-16 | |
| US07/049,894 US4791107A (en) | 1986-07-16 | 1987-05-15 | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK367987D0 true DK367987D0 (da) | 1987-07-15 |
| DK367987A DK367987A (da) | 1988-01-17 |
Family
ID=26727666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK367987A DK367987A (da) | 1986-07-16 | 1987-07-15 | 1,2,3,3a,8,8a-hexahydro-3a,8(og 1,3a,8)-di(og tri)methylpyrrolooe2,3-baaindoler, deres fremstilling og anvendelse som laegemidler |
Country Status (15)
| Country | Link |
|---|---|
| US (9) | US4791107A (da) |
| EP (1) | EP0253372B1 (da) |
| JP (1) | JP2716099B2 (da) |
| KR (1) | KR960003614B1 (da) |
| AT (1) | ATE112278T1 (da) |
| AU (1) | AU612583B2 (da) |
| CA (1) | CA1307788C (da) |
| DE (1) | DE3750596T2 (da) |
| DK (1) | DK367987A (da) |
| ES (1) | ES2060585T3 (da) |
| HU (1) | HU206717B (da) |
| IE (1) | IE64429B1 (da) |
| IL (1) | IL83190A0 (da) |
| NZ (1) | NZ221060A (da) |
| PT (1) | PT85334B (da) |
Families Citing this family (59)
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|---|---|---|---|---|
| US5306825A (en) * | 1984-03-01 | 1994-04-26 | Consiglio Nazionale Delle Ricerche | Physostigmine derivatives with acetylcholinesterase inhibition properties, and the relative production process |
| US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
| IT1225462B (it) * | 1987-04-03 | 1990-11-14 | Mediolanum Farmaceutici Srl | Sali organici di derivati della fisostigmina |
| US5280032A (en) * | 1989-02-14 | 1994-01-18 | Toyama Chemical Co., Ltd. | 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same |
| US4971992A (en) * | 1989-03-27 | 1990-11-20 | Hoechst-Roussel Pharmaceuticals Inc. | Carbonate derivatives of eseroline |
| US5387590A (en) * | 1989-08-30 | 1995-02-07 | Pfizer Inc. | Benzazabicyclic carbamates as novel cholinesterase inhibitors |
| US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
| US4937341A (en) * | 1989-09-28 | 1990-06-26 | Hoechst-Roussel Pharmaceuticals Inc. | Process for preparing N-aminocarbarbamates related to physostigmine |
| US5260452A (en) * | 1989-11-03 | 1993-11-09 | Hoechst-Roussel Pharmaceuticals Inc. | 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof |
| US5177101A (en) * | 1989-11-30 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine |
| US5077289A (en) * | 1989-11-30 | 1991-12-31 | Hoechst Roussel Pharmaceuticals Inc. | Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine |
| US5840915A (en) * | 1990-01-22 | 1998-11-24 | Hoechst Marion Roussel, Inc. | Process for the enatioselective synthesis of intermediates used |
| DK0438796T3 (da) | 1990-01-22 | 1999-05-25 | Hoechst Marion Roussel Inc | Fremgangsmåde til enantioselektiv syntese af alkylerede oxindoler, som anvendes som mellemprodukter ved fremstilling af phy |
| US5521320A (en) * | 1990-01-22 | 1996-05-28 | Hoechst-Roussel Pharmaceuticals Incorporated | Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine |
| US4983616A (en) * | 1990-02-01 | 1991-01-08 | Hoechst-Roussel Pharmaceuticals Inc. | Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related compounds |
| TW197442B (da) * | 1990-02-08 | 1993-01-01 | Pfizer | |
| US5428043A (en) * | 1990-02-08 | 1995-06-27 | Pfizer Inc. | Tricyclic-cyclic amines as novel cholinesterase inhibitors |
| US5216017A (en) * | 1990-05-11 | 1993-06-01 | Hoechst-Roussel Pharmaceuticals Incorporated | Pyrrolo[2,3-b]indole-ketones and analogs |
| AU634654B2 (en) * | 1990-05-11 | 1993-02-25 | Hoechst-Roussel Pharmaceuticals Incorporated | Pyrrolo(2,3-b)indole-ketones and analogs, a process for their preparation and their use as medicaments |
| AU634380B2 (en) * | 1990-05-17 | 1993-02-18 | Hoechst-Roussel Pharmaceuticals Incorporated | Alpha-oxopyrrolo(2,3-b)indole acetic acids, esters, amides and related analogs, a process for their preparation and their use as medicaments |
| RU2124516C1 (ru) * | 1990-06-27 | 1999-01-10 | Хехст Марион Рассел Инк. | Тетрагидроизохинолинкарбаматы 1,2,3,3а,8,8а-гексагидро-1,3а-8-триметилпирроло (2,3-b)индола, фармацевтическая композиция и способ ингибирования ацетилхолинэстеразы |
| JPH0720933B2 (ja) * | 1990-07-12 | 1995-03-08 | ファイザー・インコーポレーテッド | インダノピロリジンカルバメート |
| US5102891A (en) * | 1990-07-23 | 1992-04-07 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates |
| IT1243917B (it) * | 1990-11-20 | 1994-06-28 | Mediolanum Farmaceutici Spa | Derivati della fisostigmina |
| ES2201050T3 (es) * | 1991-09-26 | 2004-03-16 | The Government Of The Usa As Represented By The Secretary Of Department Of Health And Human Services | Compuestos que presentan una inhibicion selectiva de la acteil-colinesterasa. |
| US5171750A (en) * | 1991-09-26 | 1992-12-15 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted phenserines as specific inhibitors of acetylcholinesterase |
| US5153193A (en) * | 1991-10-01 | 1992-10-06 | Hoechst-Roussel Pharmaceuticals Incorporated | Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs |
| US5206260A (en) * | 1991-11-07 | 1993-04-27 | Merck & Co., Inc. | Hexahydropyrrolo[2,3-b]indole derivatives |
| IT1253007B (it) * | 1991-12-31 | 1995-07-10 | Aesculapius Farma Srl | Derivati dell'eserolina ad attivita' anticolinesterasica,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
| JP2873898B2 (ja) * | 1992-04-13 | 1999-03-24 | 富山化学工業株式会社 | ベンゾ［ｂ］チオフェン−５−イル誘導体もしくはその光学活性体またはそれらの塩並びにそれらの製造法 |
| IT1260506B (it) * | 1992-06-01 | 1996-04-09 | Stefano Maiorana | Processo per la preparazione di eseretolo |
| IT1254996B (it) * | 1992-06-25 | 1995-10-11 | Mediolanum Farmaceutici Srl | Esteri amminoalchilcarbammici dell'eserolina atti all'impiego come anticolinesterasici e relativo procedimento di preparazione |
| NZ248180A (en) * | 1992-07-21 | 1995-02-24 | Hoechst Roussel Pharma | Process for the preparation of physostigmine carbamate derivatives |
| DE4226263A1 (de) * | 1992-08-08 | 1994-02-10 | Boehringer Ingelheim Kg | Verfahren zur Herstellung von 1,3-Dialkyl-5-hydroxyoxindolen und deren Etherderivaten |
| US5409948A (en) * | 1992-11-23 | 1995-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating cognitive disorders with phenserine |
| US5571929A (en) * | 1994-12-07 | 1996-11-05 | The United States Of America As Represented By The Department Of Health And Human Services | Resolution and reduction of physostigmine intermediates and derivatives |
| US5665880A (en) * | 1996-10-31 | 1997-09-09 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseretholes |
| US5677457A (en) * | 1996-12-19 | 1997-10-14 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseroline ethers |
| CZ297533B6 (cs) * | 1997-07-09 | 2007-01-03 | Axonyx | Použití inhibitorů butyrylcholinesterázy pro léčbu a diagnostiku Alzheimerovy choroby a demence |
| CN1278264A (zh) | 1997-10-10 | 2000-12-27 | 奇斯药制品公司 | 制备具有选择性脑抗胆碱酯酶活性的金丝灵氨基羰基衍生物的方法 |
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| US6495700B1 (en) | 2002-01-09 | 2002-12-17 | Axonyx, Inc. | Process for producing phenserine and its analog |
| US7415565B2 (en) * | 2002-10-31 | 2008-08-19 | Ring Technology Enterprises, Llc | Methods and systems for a storage system with a program-controlled switch for routing data |
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| RU2393148C2 (ru) * | 2004-11-08 | 2010-06-27 | Эмкюр Фармасьютикалз Лимитед | Способ получения (s)-3-[(1-диметиламино)этил]-фенил-n-этил-n-метил-карбамата |
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| EP3628315A1 (en) | 2018-09-28 | 2020-04-01 | Université de Caen Normandie | Combination of acetylcholinesterase inhibitor and 5-ht4 receptor agonist as neuroprotective agent in the treatment of neurodegenerative diseases |
| WO2021142221A1 (en) * | 2020-01-10 | 2021-07-15 | The Regents Of The University Of California | Compositions and methods for the treatment of neurodegenerative diseases |
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|---|---|---|---|---|
| US2678899A (en) * | 1952-04-11 | 1954-05-18 | Kremcrs Urban Co | Stable solution of physostigmine |
| US2909530A (en) * | 1958-09-26 | 1959-10-20 | Grace W R & Co | Physostigmine derivatives |
| NL6608066A (da) * | 1965-06-17 | 1966-12-19 | ||
| US3547947A (en) * | 1967-04-21 | 1970-12-15 | Sandoz Ag | Nitrogen-containing tricyclic compounds |
| US3551450A (en) * | 1967-04-21 | 1970-12-29 | Sandoz Ag | 3-(2-aminoalkyl)-2-hydroxy-3-phenyl-indolines |
| US3547945A (en) * | 1967-04-21 | 1970-12-15 | Sandoz Ag | 3-phenyloxindole derivatives |
| US3897451A (en) * | 1973-04-27 | 1975-07-29 | Univ Ohio State Res Found | Synthesis of oxindoles from anilines and intermediates therein |
| IT1109003B (it) * | 1977-09-20 | 1985-12-16 | Univ Firenze | Derivati dell 1 2 3 8 3 a 8 a esai dropirrolo 23 b indolo |
| CA1137489A (en) * | 1977-09-20 | 1982-12-14 | Alessandro Bartolini | Derivatives of 1,2,3,3a,8,8a-hexadydropyrrolo (2,3-b) indole |
| US4278667A (en) * | 1980-06-02 | 1981-07-14 | Chromalloy American Corporation | Method of treating tardive dyskinesia by oral dosage form of a physostigmine compound |
| US5306825A (en) * | 1984-03-01 | 1994-04-26 | Consiglio Nazionale Delle Ricerche | Physostigmine derivatives with acetylcholinesterase inhibition properties, and the relative production process |
| IT1199076B (it) * | 1984-03-01 | 1988-12-30 | Consiglio Nazionale Ricerche | Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione |
| US4765985A (en) * | 1985-03-05 | 1988-08-23 | Ciba-Geigy Corporation | Devices and methods for treating memory impairment |
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| US4760083A (en) * | 1986-04-10 | 1988-07-26 | E. I. Dupont De Nemours & Company | 3,3-disubstituted indolines |
| US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
| IT1225462B (it) * | 1987-04-03 | 1990-11-14 | Mediolanum Farmaceutici Srl | Sali organici di derivati della fisostigmina |
| US5187165A (en) * | 1987-05-15 | 1993-02-16 | Hoechst-Roussel Pharmaceuticals Inc. | Memory enhancing and analgesic 1,2,3a,8,8a-hexahydro-3a,8(and 1,3a,8)-di(and tri)methylpyrrolo[2,3-b]indoles |
| JPH0781624B2 (ja) * | 1987-10-23 | 1995-09-06 | 株式会社クボタ | 作業車の走行用伝動構造 |
| DK168069B1 (da) * | 1987-11-11 | 1994-01-31 | Hoffmann La Roche | Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne |
| US4900748A (en) * | 1988-03-04 | 1990-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Carbamates related to (-)-physostigmine as cholinergic agents |
| US4971992A (en) * | 1989-03-27 | 1990-11-20 | Hoechst-Roussel Pharmaceuticals Inc. | Carbonate derivatives of eseroline |
| US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
| US4937341A (en) * | 1989-09-28 | 1990-06-26 | Hoechst-Roussel Pharmaceuticals Inc. | Process for preparing N-aminocarbarbamates related to physostigmine |
| US5260452A (en) * | 1989-11-03 | 1993-11-09 | Hoechst-Roussel Pharmaceuticals Inc. | 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof |
| US5177101A (en) * | 1989-11-30 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine |
| US5077289A (en) * | 1989-11-30 | 1991-12-31 | Hoechst Roussel Pharmaceuticals Inc. | Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine |
| US4983616A (en) * | 1990-02-01 | 1991-01-08 | Hoechst-Roussel Pharmaceuticals Inc. | Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related compounds |
| US5091541A (en) * | 1990-02-01 | 1992-02-25 | Hoechst-Roussel Pharmaceuticals Inc. | Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related compounds |
| US5216017A (en) * | 1990-05-11 | 1993-06-01 | Hoechst-Roussel Pharmaceuticals Incorporated | Pyrrolo[2,3-b]indole-ketones and analogs |
| US5264587A (en) * | 1990-05-17 | 1993-11-23 | Hoechst-Roussel Pharmaceuticals Incorporated | Method of preparing α-oxopyrrolo[2,3-b]indole acetic acids and derivatives |
| US5173497A (en) * | 1990-05-17 | 1992-12-22 | Hoechst-Roussel Pharmaceuticals Incorporated | Alpha-oxopyrrolo[2,3-B]indole acetic acids, esters, amides and related analogs |
| RU2124516C1 (ru) * | 1990-06-27 | 1999-01-10 | Хехст Марион Рассел Инк. | Тетрагидроизохинолинкарбаматы 1,2,3,3а,8,8а-гексагидро-1,3а-8-триметилпирроло (2,3-b)индола, фармацевтическая композиция и способ ингибирования ацетилхолинэстеразы |
| EP0513703A3 (en) * | 1991-05-13 | 1993-01-13 | Magis Farmaceutici S.P.A. | Carbamate esters of eseroline having anticholinesterase activity, a process for their preparation and relative pharmaceutical compositions containing them as the active principle |
| US5171750A (en) * | 1991-09-26 | 1992-12-15 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted phenserines as specific inhibitors of acetylcholinesterase |
| US5206260A (en) * | 1991-11-07 | 1993-04-27 | Merck & Co., Inc. | Hexahydropyrrolo[2,3-b]indole derivatives |
| US5302721A (en) * | 1992-07-21 | 1994-04-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Method of preparation of physostigmine carbamate derivatives from eseretholes |
-
1987
- 1987-05-15 US US07/049,894 patent/US4791107A/en not_active Expired - Lifetime
- 1987-07-14 NZ NZ221060A patent/NZ221060A/en unknown
- 1987-07-14 HU HU873208A patent/HU206717B/hu not_active IP Right Cessation
- 1987-07-14 IL IL83190A patent/IL83190A0/xx unknown
- 1987-07-15 DK DK367987A patent/DK367987A/da not_active Application Discontinuation
- 1987-07-15 DE DE3750596T patent/DE3750596T2/de not_active Expired - Fee Related
- 1987-07-15 CA CA000542153A patent/CA1307788C/en not_active Expired - Fee Related
- 1987-07-15 KR KR1019870007631A patent/KR960003614B1/ko not_active Expired - Fee Related
- 1987-07-15 ES ES87110184T patent/ES2060585T3/es not_active Expired - Lifetime
- 1987-07-15 AU AU75668/87A patent/AU612583B2/en not_active Ceased
- 1987-07-15 IE IE191187A patent/IE64429B1/en not_active IP Right Cessation
- 1987-07-15 AT AT87110184T patent/ATE112278T1/de not_active IP Right Cessation
- 1987-07-15 PT PT85334A patent/PT85334B/pt not_active IP Right Cessation
- 1987-07-15 EP EP87110184A patent/EP0253372B1/en not_active Expired - Lifetime
- 1987-07-15 JP JP62175005A patent/JP2716099B2/ja not_active Expired - Fee Related
-
1992
- 1992-10-16 US US07/962,079 patent/US5547977A/en not_active Expired - Fee Related
- 1992-10-16 US US07/962,080 patent/US5663190A/en not_active Expired - Fee Related
- 1992-10-28 US US07/967,534 patent/US5541216A/en not_active Expired - Fee Related
-
1995
- 1995-06-06 US US08/466,013 patent/US5639892A/en not_active Expired - Fee Related
- 1995-06-07 US US08/483,700 patent/US5550254A/en not_active Expired - Fee Related
- 1995-06-07 US US08/486,256 patent/US5541340A/en not_active Expired - Fee Related
- 1995-06-07 US US08/483,696 patent/US5550253A/en not_active Expired - Fee Related
- 1995-06-07 US US08/479,197 patent/US5621114A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0253372B1 (en) | 1994-09-28 |
| IL83190A0 (en) | 1987-12-31 |
| HUT47275A (en) | 1989-02-28 |
| DE3750596D1 (de) | 1994-11-03 |
| NZ221060A (en) | 1990-11-27 |
| AU7566887A (en) | 1988-01-21 |
| US5550253A (en) | 1996-08-27 |
| DE3750596T2 (de) | 1995-03-23 |
| IE871911L (en) | 1988-01-16 |
| DK367987A (da) | 1988-01-17 |
| IE64429B1 (en) | 1995-08-09 |
| AU612583B2 (en) | 1991-07-18 |
| JPS6323881A (ja) | 1988-02-01 |
| US5547977A (en) | 1996-08-20 |
| KR880001656A (ko) | 1988-04-25 |
| EP0253372A2 (en) | 1988-01-20 |
| CA1307788C (en) | 1992-09-22 |
| PT85334B (pt) | 1990-04-30 |
| US5639892A (en) | 1997-06-17 |
| ES2060585T3 (es) | 1994-12-01 |
| US4791107A (en) | 1988-12-13 |
| US5541216A (en) | 1996-07-30 |
| US5663190A (en) | 1997-09-02 |
| JP2716099B2 (ja) | 1998-02-18 |
| PT85334A (en) | 1987-08-01 |
| US5550254A (en) | 1996-08-27 |
| KR960003614B1 (ko) | 1996-03-20 |
| HU206717B (en) | 1992-12-28 |
| EP0253372A3 (en) | 1989-11-08 |
| US5541340A (en) | 1996-07-30 |
| ATE112278T1 (de) | 1994-10-15 |
| US5621114A (en) | 1997-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |