DK368382A - Fremgangsmaade til fremstilling af ergolinderivater - Google Patents

Fremgangsmaade til fremstilling af ergolinderivater Download PDF

Info

Publication number: DK368382A
Authority: DK; Denmark
Prior art keywords: hydrogen; carbon atoms; procedure; preparation; ergoline
Prior art date: 1981-09-03

Application number

DK368382A

Other languages

English (en)

Other versions

DK161646B (da

DK161646C (da

Inventor

Gerhard Sauer

Gregor Haffer

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-09-03

Filing date

1982-08-17

Publication date

1983-03-04

1982-08-17 Application filed by Schering Ag filed Critical Schering Ag

1983-03-04 Publication of DK368382A publication Critical patent/DK368382A/da

1991-07-29 Publication of DK161646B publication Critical patent/DK161646B/da

1992-01-06 Application granted granted Critical

1992-01-06 Publication of DK161646C publication Critical patent/DK161646C/da

Links

AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000000520 N-substituted aminocarbonyl group Chemical group [*]NC(=O)* 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
125000005265 dialkylamine group Chemical group 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
239000012948 isocyanate Substances 0.000 abstract 1
150000002513 isocyanates Chemical class 0.000 abstract 1
ACKFDYCQCBEDNU-UHFFFAOYSA-J lead(2+);tetraacetate Chemical compound [Pb+2].CC([O-])=O.CC([O-])=O.CC([O-])=O.CC([O-])=O ACKFDYCQCBEDNU-UHFFFAOYSA-J 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000002798 polar solvent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK368382A 1981-09-03 1982-08-17 Fremgangsmaade til fremstilling af ergolinderivater og farmaceutisk acceptable salte heraf DK161646C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3135305		1981-09-03
DE3135305A DE3135305C2 (de)	1981-09-03	1981-09-03	Verfahren zur Herstellung von 8-Ergolinyl-harnstoffen

Publications (3)

Publication Number	Publication Date
DK368382A true DK368382A (da)	1983-03-04
DK161646B DK161646B (da)	1991-07-29
DK161646C DK161646C (da)	1992-01-06

Family

ID=6141023

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK368382A DK161646C (da)	1981-09-03	1982-08-17	Fremgangsmaade til fremstilling af ergolinderivater og farmaceutisk acceptable salte heraf

Country Status (17)

Country	Link
US (1)	US4748248A (da)
EP (1)	EP0074921B1 (da)
JP (1)	JPS5855483A (da)
AT (1)	ATE11289T1 (da)
AU (1)	AU555576B2 (da)
CA (1)	CA1175813A (da)
CS (1)	CS241122B2 (da)
DD (1)	DD203544A5 (da)
DE (2)	DE3135305C2 (da)
DK (1)	DK161646C (da)
ES (1)	ES8305361A1 (da)
GR (1)	GR76897B (da)
HU (1)	HU186969B (da)
IE (1)	IE53437B1 (da)
IL (1)	IL66679A (da)
SU (1)	SU1272988A3 (da)
YU (1)	YU199282A (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3151912A1 (de) *	1981-12-23	1983-06-30	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3309493A1 (de) *	1983-03-14	1984-09-20	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel
HU195810B (en) *	1984-12-24	1988-07-28	Sandoz Ag	Process for preparing new 8alpha-acyl-amino-ergoline derivatives and pharmaceutical compositions containing such compounds
DE3915950A1 (de) *	1989-05-12	1990-11-15	Schering Ag	8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
US20060171795A1 (en) *	2005-01-28	2006-08-03	Cromwell Stephen D	Substantial embedment of metallic debris
JP2010119349A (ja) *	2008-11-20	2010-06-03	Shinichi Okamoto	即席のパンなどの穀物粉加工食品の製造方法
JP6856532B2 (ja)	2015-01-20	2021-04-07	エックスオーシーファーマシューティカルズインコーポレイテッドＸｏｃＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ	エルゴリン化合物およびその使用
JP2018502889A (ja) *	2015-01-20	2018-02-01	エックスオーシーファーマシューティカルズインコーポレイテッドＸｏｃＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ	イソエルゴリン化合物およびその使用
EP3630758A1 (en)	2017-06-01	2020-04-08	Xoc Pharmaceuticals, Inc	Ergoline derivatives for use in medicine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0021206B1 (de) *	1979-06-13	1983-06-22	Schering Aktiengesellschaft	Neue (Ergolin-yl)-N', N'-diäthylharnstoff-Derivate, ihre Herstellung und sie enthaltende Arzneimittel

1981
- 1981-09-03 DE DE3135305A patent/DE3135305C2/de not_active Expired
1982
- 1982-08-03 SU SU823470940A patent/SU1272988A3/ru active
- 1982-08-17 DK DK368382A patent/DK161646C/da not_active IP Right Cessation
- 1982-08-23 AT AT82730112T patent/ATE11289T1/de not_active IP Right Cessation
- 1982-08-23 DE DE8282730112T patent/DE3261963D1/de not_active Expired
- 1982-08-23 EP EP82730112A patent/EP0074921B1/en not_active Expired
- 1982-08-30 IL IL66679A patent/IL66679A/xx unknown
- 1982-08-31 DD DD82242909A patent/DD203544A5/de unknown
- 1982-08-31 AU AU87863/82A patent/AU555576B2/en not_active Ceased
- 1982-09-01 ES ES515428A patent/ES8305361A1/es not_active Expired
- 1982-09-01 GR GR69181A patent/GR76897B/el unknown
- 1982-09-02 HU HU822824A patent/HU186969B/hu not_active IP Right Cessation
- 1982-09-02 CA CA000410636A patent/CA1175813A/en not_active Expired
- 1982-09-03 IE IE2156/82A patent/IE53437B1/en not_active IP Right Cessation
- 1982-09-03 CS CS826422A patent/CS241122B2/cs unknown
- 1982-09-03 YU YU01992/82A patent/YU199282A/xx unknown
- 1982-09-03 JP JP57152871A patent/JPS5855483A/ja active Granted
1985
- 1985-12-13 US US06/808,804 patent/US4748248A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IE822156L (en)	1983-03-03
DE3135305A1 (de)	1983-03-10
ATE11289T1 (de)	1985-02-15
IL66679A0 (en)	1982-12-31
JPS5855483A (ja)	1983-04-01
EP0074921B1 (en)	1985-01-16
ES515428A0 (es)	1983-05-01
CS241122B2 (en)	1986-03-13
IE53437B1 (en)	1988-11-09
SU1272988A3 (ru)	1986-11-23
CA1175813A (en)	1984-10-09
IL66679A (en)	1986-04-29
YU199282A (en)	1985-03-20
DD203544A5 (de)	1983-10-26
CS642282A2 (en)	1985-07-16
DE3135305C2 (de)	1983-07-21
HU186969B (en)	1985-10-28
DK161646B (da)	1991-07-29
AU8786382A (en)	1983-03-10
EP0074921A1 (en)	1983-03-23
DK161646C (da)	1992-01-06
GR76897B (da)	1984-09-04
DE3261963D1 (en)	1985-02-28
AU555576B2 (en)	1986-10-02
JPH0239511B2 (da)	1990-09-05
US4748248A (en)	1988-05-31
ES8305361A1 (es)	1983-05-01

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Legal Events

Date	Code	Title	Description
1993-04-26	PBP	Patent lapsed